Doses toxicity epirubicin. Medical search. Frequent questions

Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. (wikipedia.org)
Systemic toxicities of anthracyclines (myelosuppression, mucositis, nausea/vomiting) are seen in patients with non-intact bladders. (worthingtoncaron.com)
Anthracyclines technically are also antibiotics, although their high toxicity precludes their use as such. (wikidoc.org)
In the use of chemotherapy drugs, anthracyclines, such as doxorubicin and epirubicin, are generally used in combination with drugs such as cyclophosphamide, epirubicin, and fluorouracil. (encyclopedia.pub)
Epirubicin is an antineoplastic drug that belongs to the class anthracyclines. (mrmed.in)

It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. (wikipedia.org)
Epirubicin [Ellence] has a unique AE. (freezingblue.com)
It was also more effective than a three-drug regimen that included epirubicin ( Ellence , Pfizer) in addition to oxaliplatin and capecitabine. (medscape.com)

In limited-stage SCLC, the overall survival rate has been significantly improved by adding dose-hyperfractionated thoracic radiotherapy and prophylactic cranial irradiation to systemic chemotherapy. (ersjournals.com)
Epirubicin is part of the anthracycline class of drugs and has a higher molecular weight resulting in reduced systemic absorption and toxicity [4]. (uk.com)
As reviewed in the present paper, the investigated targeted drug delivery systems have proven to be more effective than free drugs by enhancing efficacy and reducing the systemic toxicity of therapy. (brieflands.com)
Despite regimens with acceptable toxicity profiles are needed, with increasing evidence that the appropriate management of fit increasing attention toward patient convenience and quality patients should be with systemic chemotherapy, nocombination has yet emerged as the standard of care. (aboutdrugspdf.com)
In fact, reducing the planned dose intensity of systemic adjuvant chemotherapy regimens by as little as 15% has been shown to significantly reduce time to progression and overall survival rates in women with metastatic breast cancer [ 5 ]. (hindawi.com)

Three large randomized studies have directly compared the epirubicin-containing regimen fluorouracil/epirubicin/cyclophosphamide (FEC) with CMF in the adjuvant setting. (wikipedia.org)
With the addition of granulocytecolony-stimulating factor (G-CSF [Neupogen]) to the regimen,patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be reported with thefinal results of this phase I study. (cancernetwork.com)
This combination regimen in patients with upper gastrointestinalmalignancies and breast cancer will be investigated as partof phase II studies, once the dose-limiting toxicity is determined. (cancernetwork.com)
With the addition of granulocyte colony-stimulating factor (G-CSF [Neupogen]) to the regimen, patients received epirubicin at clinically relevant doses after dose-escalation. (cancernetwork.com)
After this the investigators adopted a 3 weeks on, 1 week off approach that resulted in less intense hematological toxicity compared with the weekly regimen. (medpagetoday.com)
We suggest that the FE 120 C plus G-CSF is an effective and innovative regimen for PBSC mobilization in breast cancer patients, and high-dose CTCb therapy with PBSC support is a safe and well-tolerated treatment modality. (johnshopkins.edu)
A combination of capecitabine and oxaliplatin is a commonly used regimen in my clinic, and to know that we can reduce doses without sacrificing benefit will allow me to give this therapy to more patients than before," he said. (medscape.com)
The low incidence of adverse effects and chemotherapy dose changes, delays, and withdrawals supports the use of lenograstim as effective primary prophylaxis in South African patients being treated with a docetaxel-based regimen. (hindawi.com)

In comparison to this the Epirubicin therapy contains fluorouracil/epirubicin/cyclophosphamide (FEC). (wikipedia.org)
Patients with high-risk BC were treated within the SUCCESS-A trial with either three cycles of 5-fluorouracil, epirubicin, and cyclophosphamide followed by three cycles of docetaxel or three cycles of FEC followed by three cycles of docetaxel and gemcitabine. (bvsalud.org)
As with other cytotoxic agents, Epirubicin Hydrochloride Injection at the recommended dose in combination with cyclophosphamide and fluorouracil can produce severe leukopenia and neutropenia. (recallguide.org)
She received neoadjuvant chemotherapy with 5-fluorouracil, epirubicin, and cyclophosphamide followed by paclitaxel. (iiarjournals.org)
In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
This study sought to retrospectively characterize outcomes for patients with node-negative and node-positive breast cancer receiving adjuvant trastuzumab in combination with docetaxel/cyclophosphamide (DCH), docetaxel/carboplatin/trastuzumab (TCH), or fluorouracil/epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (FEC-DH) chemotherapy in Alberta, Canada, from 2007 through 2014. (jnccn.org)
To date, chemotherapy relies heavily upon 5-fluorouracil (5-FU) and/or Oxaliplatin is a third-generation platinum derivative with cisplatin, with 5-FU-cisplatin (CF) and epirubicin-cisplatin- a more favorable toxicity profile than cisplatin [4]. (aboutdrugspdf.com)

Only three drugs-epirubicin, ifosfamide and dacarbazine (DTIC) have effective activity in patients with soft tissue sarcoma, and the response rate is about 20%3-4 in the second phase study. (inclinicaltrials.com)
A Phase II clinical study on the efficacy and toxicity of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. (inclinicaltrials.com)

Researchers found that 4 of the 37 evaluable patients achieved a response, all of which were after progression on prior topoisomerase 2 inhibitors, such as doxorubicin and epirubicin. (cancertherapyadvisor.com)

Despite this proven efficacy, and its longer shelf life, epirubicin is not as commonly used as MMC. (uk.com)
Because inhibition of histone deacetylase appears to improve the efficacy of topoisomerase 2 inhibitors, researchers sought to evaluate panobinostat combined with epirubicin in patients with refractory sarcoma. (cancertherapyadvisor.com)
Purpose: To determine the safety and efficacy of multiple cycles of dose-intensive, nonablative chemotherapy in women with poor-prognosis breast cancer. (tau.ac.il)
Furthermore, they can lead to delays and dose reductions in chemotherapy treatment, thereby potentially compromising the efficacy of chemotherapy and, consequently, patient outcome [ 10 ]. (hindawi.com)

Epirubicin then stabilizes the topoisomerase II-DNA complex, resulting in irreversible DNA strand breakage, leading to cell death. (wikipedia.org)

Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)
Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
The purpose of the study was to investigate the antitumour activity and toxicity of high dose (120 mg m-2) single agent epirubicin therapy in untreated extensive small cell lung cancer patients. (nih.gov)
Out of 80 patients entered, 71 were evaluable for both antitumour activity and toxicity, 4 only for toxicity and 5 were lost for follow-up. (nih.gov)
In thisopen-label phase I study, irinotecan was administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 to 7 and epirubicin starting at a dose of40 mg/m2 and escalating by 10 mg/m2 in cohorts of three patients forthose with metastatic adenocarcinomas. (cancernetwork.com)
However, the risk of toxicity is greater in this group than in patients with good performance status. (ersjournals.com)
The aim of this study is to investigate the feasibility and determine the pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunction. (ucy.ac.cy)
Purpose: To evaluate the activity and toxicity of the combination of paclitaxel given by three-hour infusion, and carboplatin as first- line chemotherapy in patients with advanced breast cancer (ABC). (ucy.ac.cy)
Dose reductions were performed in 9.5% of the patients. (bvsalud.org)
Nine patients died on study (one of which was deemed to be treatment related), and three patients ceased treatment due to toxicity or distant metastasis. (medpagetoday.com)
Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
In a retrospective survey, including 9144 patients, mostly with solid tumors in advanced stages, the probability of developing CHF increased with increasing cumulative doses of Epirubicin Hydrochloride Injection (Figure 5). (recallguide.org)
Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma. (cancertherapyadvisor.com)
Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma who are refractory to anthracycline-based therapy, a study published in the journal Annals of Oncology has shown. (cancertherapyadvisor.com)
Researchers also conducted a dose expansion at the maximum tolerated dose of panobinostat in the 20 patients with sarcoma. (cancertherapyadvisor.com)
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma [published online ahead of print February 21, 2016]. (cancertherapyadvisor.com)
High-dose therapy followed by peripheral blood stem cell (PBSC) support was performed in 29 patients with primary high-risk (Group I) or chemoresponsive metastatic (Group II) breast cancer patients. (johnshopkins.edu)
Group II patients had to achieve minimal residual disease (MRD) by induction chemotherapy before being considered eligible for PBSC mobilization and high-dose therapy. (johnshopkins.edu)
After high-dose CTCb (cyclophosphamide 6000 mg/m 2 , thiothepa 500 mg/m 2 , carboplatin 800 mg/m 2 , in 4 days), patients received PBSC infusion and daily C-CSF 300 μg subcutaneous injection. (johnshopkins.edu)
The patients with locally advanced or metastatic leiomyosarcoma who are inoperable are enrolled, aiming at the effectiveness and safety of temozolomide for injection combined with epirubicin as the first-line treatment for advanced leiomyosarcoma. (inclinicaltrials.com)
Patients and Methods: Women with stage II breast cancer and 10 or more involved nodes or four or more involved nodes and estrogen receptor- negative tumors and women with stage III disease received three cycles of epirubicin 200 mg/m 2 and cyclophosphamide 4 g/m 2 , with progenitor cell and filgrastim support every 28 days (n = 79) or 21 days (n = 20). (tau.ac.il)
The major toxicity was severe, reversible myelosuppression that was more prolonged with successive cycles, and this did not differ between patients given treatment every 28 days and those treated every 21 days. (tau.ac.il)
Two patients (2%) died of acute toxicity. (tau.ac.il)
Over the last years, the hpv mouth symptoms pictures of the cardiac toxicity of anticancer treatment has markedly increased due to improvements in patient survival, aging of the population including cancer patients and the introduction of new anticancer drugs with unique toxicities. (leacurinaturiste.ro)
In the largest trial so far to be conducted in frail elderly patients with advanced gastroesophageal cancer, a lower dose of chemotherapy produced similar outcomes but with less toxicity than the standard dose used for patients with this condition. (medscape.com)
Patients in level B received 80% of doses given to patients in level A. Patients in level C received 60% of the level-A doses. (medscape.com)
Level C produced the best OTU results, owing to lower side effects and better quality of life for the patients who received the lower dose. (medscape.com)
Key words: advanced gastric cancer, chemotherapy, oxaliplatin, pemetrexed, phase II trial addition, cisplatin-based combinations are difficult toadminister in this often-debilitated population and have the Patients suffering from advanced gastric cancer (AGC) remain potential for severe toxicity. (aboutdrugspdf.com)
This phase II/III trial compares the side effects and activity of oral azacitidine in combination with the standard drug therapy (reduced dose rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone [R-miniCHOP]) versus R-miniCHOP alone in treating patients 75 years or older with newly diagnosed diffuse large B cell lymphoma . (uci.edu)
Two (0.5%) patients and 32 (8.1%) patients had dose delayed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
Four (1.0%) patients and 32 (8.1%) patients had a dose changed due to febrile neutropenia and neutropenia, respectively. (hindawi.com)
Furthermore, lenograstim may increase the patient's exposure to chemotherapy allowing patients to receive optimal dosing and duration of treatment, benefitting survival. (hindawi.com)
Male patients with female partners of reproductive potential should use effective birth control during the treatment and for 3 months after the last dose. (mrmed.in)
Cohort K enrolled 79 patients with MSI-H endometrial carcinoma and Cohort D enrolled 11 patients with MSI-H endometrial carcinoma for a total of 90 pooled patients who received KEYTRUDA as monotherapy (200 mg fixed dose every three weeks). (businesswire.com)
Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)

Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
Safety profile of docetaxel regimens includes toxicities, particularly a high risk of neutropenia and febrile neutropenia. (hindawi.com)
Based on this evidence, guidelines published by the American Society of Clinical Oncology and the European Organisation for Research and Treatment of Cancer state that when the overall risk of FN is 20% or greater, especially on "dose dense" regimens, primary prophylaxis with G-CSFs is justified [ 10 , 13 ]. (hindawi.com)

Anthracycline-induced cardiac toxicity may be manifested by early (or acute) or late (delayed) events. (recallguide.org)
Early cardiac toxicity of epirubicin consists mainly of sinus tachycardia and/or ECG abnormalities such as non-specific ST-T wave changes, but tachyarrhythmias, including premature ventricular contractions and ventricular tachycardia, bradycardia, as well as atrioventricular and bundle-branch block have also been reported. (recallguide.org)
Delayed cardiac toxicity results from a characteristic cardiomyopathy that is manifested by reduced LVEF and/or signs and symptoms of congestive heart failure (CHF) such as tachycardia, dyspnea, pulmonary edema, dependent edema, hepatomegaly, ascites, pleural effusion, gallop rhythm. (recallguide.org)

Nausea and vomiting may be less severe if doses are taken on an empty stomach at bedtime. (worthingtoncaron.com)
However, major severe toxicity, thereby limiting its clinical application. (aboutdrugspdf.com)
Do not take this injection if you are allergic to Epirubicin or any other ingredients of this medicine, pregnant or breastfeeding, or have severe liver and bladder problems.Store Epirubicin in the refrigerator (2°C to 8°C). Do not freeze. (mrmed.in)

Epirubicin is also capable of generating cytotoxic free radicals, which are very reactive against DNA, cell membranes and mitochondria. (wikipedia.org)
Epirubicin Hydrochloride Injection should be administered only under the supervision of qualified physicians experienced in the use of cytotoxic therapy. (recallguide.org)
For which cytotoxic drugs is renal damage the dose-limiting toxicity? (freezingblue.com)
Epirubicin inhibits DNA, RNA, and protein synthesis by exerting cytotoxic activity. (mrmed.in)

These agents also form covalent cross-links in DNA, more typically at the 0-6 position of guanine as the most important DNA adduct site, and have the primary adverse effects of myelosuppression and GI toxicity. (vin.com)

The combination of irinotecan (Camptosar), epirubicin, andcapecitabine (Xeloda) has shown an acceptable toxicity profile. (cancernetwork.com)

Delayed myelosuppression is the dose-limiting toxicity. (worthingtoncaron.com)
myelosuppression, gastrointestinal toxicity, and sterile hemorrhagic cystitis (cyclophosphamide and iphosphamide. (vin.com)
myelosuppression and gastrointestinal toxicity (especially methotrexate). (vin.com)

The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)
This was statistically significant for MMC and epirubicin in tumours with low risk of recurrence and progression. (uk.com)
As with MMC, there is evidence to support a single immediate post-resection dose of epirubicin in low-risk tumours with an increase in the recurrence free interval of 38% compared with both no treatment and placebo [5]. (uk.com)

The initial dose of Herzuma is 4 mg/kg over 90 minute IV infusion, then 2 mg/kg over 30 minute IV infusion weekly for 12 weeks (with paclitaxel or docetaxel) or 18 weeks (with docetaxel and carboplatin ). (rxlist.com)

It is suggested that it is necessary to at least double the dose of chemotherapy to detect a clinically relevant effect. (wikipedia.org)
Because paclitaxel has very little aqueous solubility, a Cremophor /ethanol vehicle is used, but its toxicity limits the amount of paclitaxel that can be clinically administered [ 10 - 12 ]. (oncotarget.com)

A dose-dependent, reversible leukopenia and/or neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin and represents the most common acute dose-limiting toxicity of this drug. (recallguide.org)
Before initiating the treatment, inform your physician if you have kidney or liver problems, recent vaccination, or if you have any acute toxicities such as acute inflammation of the mouth, low white blood cell count, platelet count, or any infections. (mrmed.in)

Administration of trastuzumab products can result in serious and fatal infusion reactions and pulmonary toxicity. (rxlist.com)
Each multiple-dose vial of HERZUMA delivers 420 mg trastuzumab-pkrb, 839 mg α,α-trehalose dihydrate, 9.5 mg L-histidine HCl, 6.1 mg L-histidine, and 1.7 mg polysorbate 20. (rxlist.com)

Monitoring for potential cardiotoxicity is also important, especially with greater cumulative exposure to epirubicin. (recallguide.org)
This toxicity appears to be dependent on the cumulative dose of Epirubicin Hydrochloride Injection and represents the cumulative dose-limiting toxicity of the drug. (recallguide.org)
This cardiotoxicity is related to a patient's cumulative lifetime dose. (wikidoc.org)
A patient's lifetime dose is calculated during treatment, and anthracycline treatment is usually stopped (or at least re-evaluated by the oncologist) upon reaching the maximum cumulative dose of the particular anthracycline. (wikidoc.org)
Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)

The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
The median survival rates markedly better than those achieved with epirubicin monotherapy. (wikipedia.org)
A 2003 clinical trial at the National Cancer Institute, for example, found that there were no significant differences in overall survival between those getting high-dose Avastin, low-dose Avastin, and no supplemental Avastin at all. (the-medical-dictionary.com)
The lowest dose tested was noninferior in terms of progression-free survival, and it produced less toxicity," commented lead author Peter S. Hall, MB ChB, MRCP, PhD, a medical oncologist at the University of Edinburgh, United Kingdom. (medscape.com)
The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: A systematic review and meta-analysis of randomized controlled trials. (trillium.de)

This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
Treatment delays or dose reductions for toxicity occurred in 10% and 5% of cycles, respectively. (aboutdrugspdf.com)

incr risk of fatal pulmonary toxicity. (freezingblue.com)

Participants received panobinostat 20 to 60 mg orally on days 1, 3, and 5, followed by epirubicin 75 mg/m 2 intravenously on day 5 in 3-week cycles. (cancertherapyadvisor.com)
Epirubicin is an intravenously administered drug. (mrmed.in)

Those with impaired renal function received 75% of the suggested doses of capecitabine. (medscape.com)

MFP improved the therapeutic effects of suboptimal doses of Nab-paclitaxel or PEG-LD in murine and human carcinomas with higher levels of PRA than PRB. (oncotarget.com)

Conclusion: Multiple cycles of dose-intensive, nonablative chemotherapy is a feasible and safe approach. (tau.ac.il)
Treatment repeats every 21 days for cycles 1-5 in the absence of disease progression or unacceptable toxicity. (uci.edu)
Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. (uci.edu)

The mechanism of action of epirubicin is similar to that of doxorubicin and other anthracycline drugs. (wikipedia.org)

The observed clinical differences between epirubicin and doxorubicin can be explained by the pharmacokinetic differences based on the different affinity to DNA and lipophilicity, as there is no indication that different mechanisms are involved in their activity. (wikipedia.org)
These effects do not usually predict subsequent development of delayed cardiotoxicity, are rarely of clinical importance, and are generally not considered an indication for the suspension of epirubicin treatment. (recallguide.org)
There is strong and consistent clinical evidence to show that granulocyte-colony stimulating factors (G-CSFs) reduce the risk of chemotherapy-induced neutropenia and therefore complicated neutropenia and can be used to maintain chemotherapy at the desired dose intensity or density and minimize delays in treatment [ 11 ]. (hindawi.com)
Myelotoxicity and dose intensity of chemotherapy: Reporting practices from randomized clinical trials. (trillium.de)

The investigators collected tumor tissue during the study, both before and after the first dose of panitumumab, to identify biomarkers that could predict pCR. (medpagetoday.com)
Although this has historically been performed in a single fraction, multi-fraction approaches such as fraction radiosurgery (FSRS) and staged radiosurgery (SSRS) have been recently examined as alternative approaches for larger lesions to permit better tumor control without increased toxicity. (iiarjournals.org)
Definitive SRS has historically been performed in a single fraction, with dose limited by tumor size in order to minimize toxicity ( 2 ). (iiarjournals.org)
Because tumor control is related to dose, multi-fraction approaches have been proposed for larger lesions to reduce recurrence without increasing toxicity. (iiarjournals.org)
The challenge is to increase chemotherapeutic concentrations within the tumor environment while decreasing the general toxicity. (oncotarget.com)

Unlike MMC, there has been no proven role for epirubicin beyond the initial postoperative instillation [4]. (uk.com)

If it occurs, delayed cardiotoxicity usually develops late in the course of therapy with Epirubicin Hydrochloride Injection or within 2 to 3 months after completion of treatment, but later events (several months to years after treatment termination) have been reported. (recallguide.org)
Panobinostat and epirubicin treatment…may reverse anthracycline resistance," the authors wrote. (cancertherapyadvisor.com)
No major treatment-related toxicities were noted. (johnshopkins.edu)
Do not breastfeed during the treatment and for 7 days after the last dose. (mrmed.in)

Total and differential WBC, red blood cell (RBC), and platelet counts should be assessed before and during each cycle of therapy with Epirubicin Hydrochloride Injection. (recallguide.org)

Results showed that thrombocytopenia, febrile neutropenia, and fatigue were dose-limiting toxicities at 60 mg of panobinostat, making 50 mg the maximum tolerated dose. (cancertherapyadvisor.com)
These improvements in outcome are very welcome, yet they do have associated substantial toxicities, especially a moderate-to-high risk of neutropenia or febrile neutropenia (FN) [ 8 ]. (hindawi.com)

Sequential and simultaneous dosing modalities were investigated and the annexin V/propidium iodide assay, in concert with fluorescence microscopy, was employed to visualize cells undergoing apoptosis. (biomedcentral.com)

What are the precautions of epirubicin? (mrmed.in)

Epirubicin Alters DNA Methylation Profiles Related to Cardiotoxicity. (mpg.de)

In drawbacks of oxaliplatin-based doublets are the inconvenienceof the 5-FU dosing schedule and the requirement for centralvenous access catheter and infusion device. (aboutdrugspdf.com)

A 40mg dose is used in 40ml sterile water, administered intravesically unless there is a contraindication (suspected bladder wall perforation or muscle invasive disease). (uk.com)

Your doctor will decide the dose and duration of the therapy based on your disease severity and condition. (mrmed.in)

Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)

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