Doses of propofol. Medical search. Frequent questions

Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. (dovepress.com)
Propofol is an intravenous (IV) anesthetic medication widely used in for procedural sedation, in operating rooms, and intensive care units (ICUs). (biomedcentral.com)
Prior to the administration of medications, clinicians must know the level of sedation required for a given procedure and the appropriate dose of the pharmacologic agent or agents chosen. (medscape.com)
Eight (0.7%) patients developed transient oxygen desaturation only as an adverse effect of ketamine-propofol drug combination with 50% procedures utilizing propofol 1 mg/kg for sedation. (iasp-pain.org)
Propofol (2,6-diisopropylphenol) is an intravenous anesthetic widely used in surgery or intensive care units to induce and maintain anesthesia as well as sedation [ 2 ]. (degruyter.com)
Propofol, a general anesthetic, has been suggested to be effective for the treatment of migraine headaches in adults when used in subanesthetic doses (lower doses than those used for anesthesia or sedation). (drugpatentwatch.com)
In some locations, the procedures previously performed using propofol must now be performed using an alternative agent for sedation, which may require different prescribing parameters, preparation, storage, dosing, patient monitoring, and recovery from its effects. (ismp.org)
Elderly patients are at greater risk of developing constipation, sedation, and confusion when treated with opioids, and it is reasonable to adjust doses to account for age-related changes in pharmacokinetics. (saem.org)
Once the model is externally validated, the effect of post-transplant time on clearance and the sedation status may be considered in routine dosing management. (unav.edu)
Background: Sedation and analgesia are recommended during targeted temperature management (TTM) after cardiac arrest, but there are few data to provide guidance on dosing to bedside clinicians. (lu.se)
We evaluated differences in patient-level sedation and analgesia dosing in an international multicenter TTM trial to better characterize current practice and clinically important outcomes. (lu.se)
Conclusions: There is significant variation in choice of drug, dosing, and titration when providing sedation and analgesics between centers. (lu.se)
Sedation and analgesia dosing and titration were associated with delayed awakening, incidence of clinical seizures, and survival, but the causal relation of these findings cannot be proven. (lu.se)

One small study in a Colorado hospital, published in May in the Journal of the American Osteopathic Association, found that pot consumers needed more of several common types of anesthetics - an average of 14 percent more fentanyl, 20 percent more midazolam, and 220 percent more propofol - during endoscopic procedures than noncannabis users. (bostonglobe.com)
Before intubating a patient, a prescriber gave verbal orders to a nurse for doses of midazolam, vecuronium, propofol, and ketamine. (ismp.org)
Most important for the state's case: Rogers testified it was his conclusion that the cause of death was "acute propofol intoxication" exacerbated by two sedatives given by Murray-lorazepam and midazolam-and that the manner of death was homicide. (thedailybeast.com)
We recorded cumulative doses of sedative and analgesic drugs at 12, 24, and 48 h and normalized to midazolam and fentanyl equivalents. (lu.se)

Abstrate: We investigated the impact of the type of neurological disorder on the required propofol dose for anesthesia and the time to emerge from anesthesia during dental treatment in patients with autism (AU), cerebral palsy (CP), and intellectual disability (ID), some of whom also had epilepsy. (anesthesiaexperts.com)
The propofol dose required for anesthesia, time to emerge, and modeled propofol blood concentration at emergence were evaluated. (anesthesiaexperts.com)
Conclusion: The propofol dose required for anesthesia and the time to emerge from anesthesia are not affected by the type of neurological disorder, but are affected by antiepileptic use. (anesthesiaexperts.com)
We recommended a dose of 0.2 mg/kg IV esketamine before induction of anesthesia to reduce the pain of propofol injection. (biomedcentral.com)
The burning pain from propofol infusion travels along the blood vessels, causing discomfort and anxiety in patients, and may even result in a traumatic anesthesia experience, making propofol infusion-related pain the major problem encountered in clinical anesthesia practice [ 3 ]. (biomedcentral.com)
Anesthesia was induced with propofol 2. (druglib.com)
Cannabis consumers often need higher doses of anesthesia to become sedated and stay unconscious, recent studies show, and more anesthesia can in turn lead to an increased risk of complications. (bostonglobe.com)
Epidural analgesia combined with inhalatory anesthesia may provide advantages over the conventional routes of analgesic administration (intravenous or intramuscular), including reduction of the doses of the inhalant agents required to produce anaesthesia and thus the side effects derived from higher doses 1 1. (scielo.br)
Epidural methadone in dogs undergoing pelvic limb surgical procedures resulted in greater decreases in the EtISO required to maintain anesthesia compared with the same doses administered intravenously 2 2. (scielo.br)
Epidural anesthesia with bupivacaine, bupivacaine and fentanyl, or bupivacaine and sufentanil during intravenous administration of propofol for ovariohysterectomy in dogs. (scielo.br)
Moreover, it is difficult to determine what percent of single dose vials are being swabbed during routine practice of anesthesia. (apsf.org)

Reduces the pain of propofol injection and has preservative properties. (cdc.gov)

Propofol has gradually become the most common sedative-hypnotic drug used in painless gastroscopy due to its rapid effect, short half-life, and good sedative effect, but it has disadvantages such as a weak analgesic effect and suppression of respiratory and circulatory systems. (dovepress.com)
Propofol is particularly suitable for outpatient and same-day surgeries because of its strong sedative and hypnotic effects, fast onset, quick recovery, and low incidence of postoperative nausea and vomiting (PONV). (biomedcentral.com)
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. (wikipedia.org)
Therefore, we conclude that ketamine and propofol are safe and effective as both sedative and an analgesic in procedures on pediatric oncology patients. (iasp-pain.org)

Condensation was noted on the stopper of vials of propofol and inside the flip top cap which raised concerns about the drug's potential sterility (Figures 1 and 2). (apsf.org)
4 The recommendation to swab the vials of propofol and Diprivan ® may be due to its formulation in a white, oil-in-water emulsion. (apsf.org)

Ketamine can attenuate pain associated with IV propofol injection through local and central analgesic effects. (biomedcentral.com)
Thirty gynecological patients undergoing hysteroscopic surgery were enrolled in a sequential method to determine the effective dose of esticketamine for analgesic propofol injection in order of operation. (biomedcentral.com)
The OPRM1 A118G polymorphism does not play a significant role in post-operative fentanyl analgesic dose or post-operative nausea, vomiting and dizziness in patients undergoing radical gastrectomy. (spandidos-publications.com)
In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose. (scielo.br)
Determination of the analgesic dose-response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients. (scielo.br)

Intravenous (IV) lidocaine during surgery can reduce the demand for propofol and the incidence of cardiopulmonary complications. (dovepress.com)
IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction. (dovepress.com)
Further, incidence of propofol-related infection declined from 39 to 9 infections per year in the USA, after the introduction of EDTA into clinical use in 1996 ( 18 ). (cdc.gov)
When drugs are used as adjuncts, decreasing the dose of each respective drug is important, so as to decrease the incidence of adverse effects. (medscape.com)
VPA serious adverse effects are reported to have a significant and dose-dependent incidence, many associated with VPA-induced hyper-ammonemia. (unav.edu)
We also compared dosing with time to awakening, incidence of clinical seizures, and survival. (lu.se)

During induction, the target dose of esketamine was first given via venous access in the left hand of the patient, and 30 s later, a fixed dose of 2 mg/kg (1 ml/s) of propofol was given. (biomedcentral.com)
This study aimed to compare the effect of no muscle relaxants and reduced-dose rocuronium on the anesthetic induction and emergence with fentanyl in children undergoing adenotonsillectomy. (druglib.com)
Reduced-dose rocuronium has been reported to provide optimal anesthetic induction without delayed recovery. (druglib.com)
Conclusion PSE enabled the induction of regular-dose interferon therapy in patients with HCV cirrhosis and thrombocytopenia. (go.jp)
The ABM-based propofol induction dose has a high success rate in normal, overweight and obese patients . (bvsalud.org)

are high doses always required? (elsevier.es)
Also, EDTA is nephrotoxic at high doses (2-3 g/d). (cdc.gov)
It is generally associated with high doses (>4 mg/kg per hour or >67 mcg/kg per minute) and prolonged use (>48 hours) though it has been reported with high-dose short-term infusions. (wikipedia.org)

Propofol is a powerful anesthetic and memory loss agent that can be fatal in large doses. (joins.com)
Jurors believed that Murray was negligent in delivering the powerful anesthetic propofol to Jackson. (essence.com)

R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)

She said the singer complained he couldn't sleep, and on Easter Sunday asked her to help him obtain Diprivan, a brand name for propofol. (today.com)
1 The package inserts for both propofol and Diprivan ® recommend that strict aseptic techniques be used in preparing and administering the agents and that vials be disinfected with 70% isopropyl alcohol prior to administration. (apsf.org)
Of note, both propofol and Diprivan ® also contain disodium edetate (0.005%) to retard the rate of growth of microorganisms in the event of accidental extrinsic contamination. (apsf.org)
Thus for patient safety, we believe that providers should routinely swab propofol and Diprivan ® vials prior to administering these agents and be aware of another drug that may look similar. (apsf.org)

The ranges of fentanyl dose in the 128 patients at 24 and 48 h after surgery were 5.4-17.3 µg/kg and 12.4‑29.9 µg/kg, respectively. (spandidos-publications.com)
There were no significant differences in fentanyl dose or adverse effects, including nausea, vomiting and dizziness, for the OPRM1 A118G polymorphism (P>0.05). (spandidos-publications.com)
Several authors identified that subjects with the G allele of the OPRM1 A118G SNP were less sensitive to fentanyl or the fentanyl dose was greater compared to subjects with the AA allele, with regard to post-operative pain management or labor analgesia ( 11 - 14 ). (spandidos-publications.com)
Palmer CM, Cork RC, Hays R, Van Maren G, Alves D. The dose-response relation of intrathecal fentanyl for labor analgesia. (scielo.br)
Propofol (70%) and fentanyl (51%) were most frequently used. (lu.se)

The 'propofol infusion syndrome': myth or menace? (wikipedia.org)

We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. (dovepress.com)
IV lidocaine reduced the total and maintenance propofol dose in Group L ( p (dovepress.com)

Low-dose ketamine (0.5 mg/kg) and propofol (2 mg/kg) were administered. (iasp-pain.org)
Conclusion According to the results of our study, the majority of the pediatric patients responded and reported no adverse events during the procedure with ketamine and propofol. (iasp-pain.org)
Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response. (nih.gov)
The prescriber thought the concentration of ketamine was 30 mg/mL and told the nurse to remove two vials from the automated dispensing cabinet (ADC) to provide a 60 mg dose. (ismp.org)
And at low doses, it provides a certain amount of NMDA inhibition, similar to ketamine . (medscape.com)

The aim of this work was to evaluate fortuitous electrocardiographic alterations in dogs, promoted by increasing dose of propofol administrated by continuous infusion, associated or not to nitrous oxide. (vin.com)
Concomitantly, continuous infusion of propofol (0.4mg/kg/min) was initiated using an infusion pump. (vin.com)
We conclude that continuous infusion of propofol on these studied rates does not promote significant alterations in the electrocardiogram, and both anesthetic protocols analyzed could be safe methods to be used in patients with some cardiac damage. (vin.com)
propofol) are preferred to benzodiazepines (by either continuous infusion or bolus dosing). (who.int)

His attorneys argued that Jackson gave himself the fatal dose. (essence.com)
His attorneys contend Jackson was desperate for sleep and gave himself the fatal dose of propofol when his doctor left the room. (today.com)

The mechanism of action is poorly understood but may involve the impairment of mitochondrial fatty acid metabolism by propofol. (wikipedia.org)
The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)

Early recognition of the syndrome and discontinuation of the propofol infusion reduces morbidity and mortality. (wikipedia.org)

Rogers said it just didn't make sense that Jackson awoke from propofol slumber and gave himself another fatal dose during the two minutes that Murray claimed he was out of the room. (thedailybeast.com)

The purpose of our study is to determine the half effective dose (ED 50 ), 95% effective dose (ED 95 ), and 99% effective dose (ED 99 ) of esketamine for attenuating propofol injection pain using Dixon's up-and-down method to provide a reference for optimal dose selection for surgeries and procedures. (biomedcentral.com)
We are a leading Wholesale Trader of Amoxicillin Potassium Clavulanate, Caspofungin Acetate, Propotec 20ml (Propofol INJ), Hepapro 25,000 IU Injection (Heparin Sodium Injection IP 25,000 IU/5ml), Terlipressin 10ml and OSIVIR-250MG (ACYCLOVIR INTRAVENOUS INJECTION) from Mumbai, India. (indiamart.com)

The 20 patients received propofol shots for procedures on their skin," said a police officer. (joins.com)
According to authorities, 21 patients at a clinic in Gangnam received propofol shots for cosmetic procedures between 12 p.m. to 3:30 p.m. on Monday. (joins.com)
Research into how patients are treated at the end of their life found that more than a third of Australian surgeons reported giving drugs at doses higher than necessary to relieve suffering for terminal patients, with the ambiguous intention of hastening death. (theconversation.com)
It is reasonable to consider a lower dose (e.g., 0.05 mg/kg) in patients who are older or sicker. (saem.org)
Because different patients will require different doses to relieve their pain, morphine can be safely titrated using doses of 0.025-0.05 mg/kg every 5-15 minutes following the initial bolus. (saem.org)
Scaling drug doses to obese patients by total body mass (TBM) results in overdose. (bvsalud.org)
We aimed to determine the success rate of inducing anaesthesia in normal, overweight and obese patients with propofol , using an adjusted body mass scalar (ABM), which embodies the increased FFM of obese patients . (bvsalud.org)
Cette étude clinique en double aveugle évaluait l'incidence des nausées et des vomissements après une chirurgie de la cataracte avec anesthésie par voie intraveineuse chez 100 patients auxquels un placebo (eau saline), du métoclopramide (10 mg), de la dexaméthasone (8 mg) ou les deux médicaments associés avaient été administrés de manière randomisée avant l'opération. (who.int)
L'association du métoclopramide et de la dexaméthasone a considérablement réduit les nausées et vomissements, non seulement en salle de réveil mais également dans les 24 heures qui suivent, et est recommandée pour les groupes à haut risque, notamment pour les patients opérés en ambulatoire. (who.int)
Patients-- Patients with severe and complicated malaria received 4 doses of intravenous artesunate 2.4 mg/kg under a treatment protocol implemented by the Centers for Disease Control and Prevention (CDC). (cdc.gov)

Migraine: The recommended starting dose is 250 mg twice daily, thereafter increasing to a maximum of 1,000 mg/day as needed ( 2.3 ). (nih.gov)
Initial retrospective review of the investigators experience with propofol for migraine in children suggests that it is safe and may be more effective than standard treatments used in the emergency department. (drugpatentwatch.com)
I recently came across an article by Dr Rick Pescatore in Emergency Medicine News [ 1 ] related to the use of low-dose propofol to treat headache in the ED. It immediately caught my attention because treating migraine and other types of headache is a common part of emergency medicine practice. (medscape.com)

Although several factors, including gender, age, weight, organ function and disease severity lead to differences in individual response to drugs, a number of studies have suggested that the inter-individual variability in drug dose may be mainly due to genetic factors ( 2 - 4 ). (spandidos-publications.com)
The propofol shortage offers another example of asking practitioners to quickly acclimate to the use of a new high-alert drug, thus increasing the risk of an error. (ismp.org)
In fact, propofol has become the drug of choice within many protocols for procedures. (ismp.org)
Propofol is a safe drug. (medscape.com)

Can you review the basic pharmacology of propofol? (medscape.com)

Propofol, a widely used anesthetic, could be used in a death row execution scheduled for next month. (medicaldaily.com)

Propofol has GABA potentiation, which probably provides a certain amount of direct analgesia. (medscape.com)

They should be administered initially as a bolus dose estimated by the patient's weight and titrated every 5-15 minutes following reassessment of the patient's subjective description of their pain. (saem.org)

Prosecutors claim Jackson died from a lethal dose of Propofol, a strong anesthetic which Murray's admitted to administering to Jackson to help him sleep. (radaronline.com)
Murray's attorneys counter that Jackson might have drank or injected himself with the deadly dose while the doctor -- who'd just given him a dose -- was out of the room. (radaronline.com)
Murray's most grievous act, according to the prosecution, was that he dared to bring the hospital-only anesthetic propofol into a private home and use it without the proper monitoring and resuscitation equipment. (thedailybeast.com)
The defense theory is that Jackson self-administered extra drugs and propofol on the last night of his life without Murray's knowledge and caused his own death. (thedailybeast.com)

The prolonged onset of action of fospropofol (≈4-13 min, because of it must first undergo metabolism to propofol) compared with the prodrug propofol (≈40 s). (cdc.gov)

10. Abelson AL, Armitage-Chan E, Lindsey JC, Wetmore LA. A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. (scielo.br)
In addition, Exparel™ a new white aqueous suspension of multivesicular liposomes containing bupivacaine may look similar to propofol (Figure 3) also carries no similar recommendation. (apsf.org)

Commonly used drugs include propofol, an intravenous anaesthetic, or barbiturates such as Nembutal. (theconversation.com)

and on his left leg, there is another bruise from the permanent intravenous port Murray had installed behind his knee to facilitate his nightly dose of propofol. (thedailybeast.com)
They told a judge Tuesday that after the character witnesses, they will only call two experts to try to counter prosecution experts who said Murray acted recklessly by giving Jackson the anesthetic propofol as a sleep aid. (today.com)

But using alternative medications, dosage strengths, or dosage forms often requires different dosing, preparation, and administration considerations, which only adds to the complexity of care. (ismp.org)

The initial dose of esketamine was 0.2 mg/kg, and the gradient of adjacent dose was 0.02 mg/kg. (biomedcentral.com)
Small doses of esketamine combined with propofol can be safely and effectively used for hysteroscopic surgery. (biomedcentral.com)
Herein, we investigated the role of esketamine in propofol-induced brain injury. (degruyter.com)
A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
The effects caused by propofol were attenuated by esketamine. (degruyter.com)
Esketamine activated the mature brain-derived neurotrophic factor/tropomyosin receptor kinase B/phosphatidylinositide 3-kinase (mBDNF/TrkB/PI3K) signaling pathway in propofol-administrated rats. (degruyter.com)
Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
However, whether esketamine has an effect on propofol-induced brain injury has not been investigated. (degruyter.com)

The intensive care unit (ICU) was extremely busy at the time, so the nurse prepared the doses and quickly returned to the patient's room. (ismp.org)

We compared number of medications used, dosing, and titration among centers by using multivariable models, including common severity of illness factors. (lu.se)

Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling. (nih.gov)

In 2015, a Korean woman was injected with tainted propofol during a cosmetic surgery procedure at a clinic in Gangnam, which led to septic shock and her death. (joins.com)

Propofol Injectable Emulsion, USP Condensation. (apsf.org)
Propofol Injectable Emulsion, USP. (apsf.org)

Mania: Initial dose is 750 mg daily, increasing as rapidly as possible to achieve therapeutic response or desired plasma level (2.1). (nih.gov)
Complex Partial Seizures in Adults and Children 10 years of age or older: Initial dose is 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to 10 mg/kg/day to achieve optimal clinical response. (nih.gov)

The association between PRIS and propofol infusions is generally noted at infusions higher than 4 mg.kg for greater than 48 hours. (wikipedia.org)

Because of water solubility, eliminates some of the known lipid emulsion-associated disadvantages of propofol, including the risk for infection ( 38 ). (cdc.gov)

Organisms1

Diseases1

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes7

Health Care3

Sedation13

Midazolam4

Anesthesia11

Pain of propofol injection1

Sedative4

Vials of propofol2

Analgesic5

Incidence6

Induction5

High doses3

Powerful anesthetic2

Sevoflurane1

Diprivan4

Fentanyl5

Infusion syndrome1

Lidocaine2

Ketamine5

Continuous infusion4

Gave himself the fatal dose2

Impairment2

Reduces1

Fatal dose1

Injection2

Patients10

Migraine3

Drug4

Pharmacology1

Widely1

Analgesia1

Bolus dose1

Murray's4

Undergo1

Bupivacaine2

Drugs1

Murray2

Considerations1

Esketamine9

Patient's1

Severity1

Anaesthetic1

Procedure1

Injectable2

Initial dose2

Higher1

Emulsion1