• Side effects are similar between induction and consolidation chemotherapy. (healthline.com)
  • In a phase Ib trial (2215-CL-0103) reported in the Journal of Clinical Oncology, Keith W. Pratz, MD, and colleagues found that incorporation of the FLT3 inhibitor gilteritinib into intensive induction and consolidation chemotherapy and its use as single-agent maintenance therapy were associated. (ascopost.com)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • Exploring biological phenomenon that underlie clinical efficacy and safety issues in allogeneic hematopoietic cell transplantation, mostly used a s immunotherapy of haematological cancers, and of autologous hematopoietic cell transplantation to support the administration of high-dose consolidation chemotherapy in selected subsets of patients with solid tumours. (ebmt.org)
  • Randomized phase II trial on primary chemotherapy with high-dose methotrexate and high-dose cytarabine with or without thiotepa, and with or without rituximab, followed by brain irradiation vs. high-dose chemotherapy supported by autologous stem cells transplantation for immunocompetent patients with newly diagnosed primary cns lymphoma. (clinicaltrialsregister.eu)
  • High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
  • Neoadjuvant chemotherapy is the type used before surgery. (healthline.com)
  • The term induction chemotherapy is often used interchangeably with the term neoadjuvant chemotherapy, even among cancer researchers. (healthline.com)
  • The term neoadjuvant chemotherapy should be used to refer to chemotherapy before surgery. (healthline.com)
  • Neoadjuvant chemotherapy , which is chemotherapy before surgery, is being used increasingly more often to treat breast cancer that has spread locally. (healthline.com)
  • Impact of dynamic 18F-FDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after neoadjuvant chemotherapy: a feasibility study. (uni-heidelberg.de)
  • Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. (biomedcentral.com)
  • We analyzed the long-term results of high-dose cytarabine-anthracycline consolidation chemotherapy without maintenance treatment and examined the effect of major prognostic factors, including age, sex, history of preleukemia, and cytogenetics. (elsevierpure.com)
  • One hundred twenty-three patients were eligible for high-dose cytarabine-based consolidation administered in two to three courses. (elsevierpure.com)
  • Our results show an improved LFS for younger patients treated with high-dose cytarabine-based consolidation. (elsevierpure.com)
  • Doctors may use a combination of chemotherapy drugs, such as cytarabine, and an anthracycline drug, such as daunorubicin. (medicalnewstoday.com)
  • 75 years old) followed by cytarabine consolidations and/or allogeneic stem-cell transplantation (ASCT). (dovepress.com)
  • The reduced-intensity chemotherapy backbone consists of three 28-day cycles of vincristine and dexamethasone for the induction phase, six 28-day cycles of alternating cytarabine (even-numbered cycles) and methotrexate (odd-numbered cycles), and eleven 28-day cycles of vincristine and prednisone for the maintenance phase. (confex.com)
  • The FLT3 inhibitors sorafenib, midostaurin, quizartinib and gilteritinib have been tested in monotherapy in several settings including refractory or relapsed AML (R/R AML), post-transplant maintenance as well as in combination with intensive chemotherapy (ICT) or non-intensity regimens. (dovepress.com)
  • Multidrug chemotherapy regimens including high-dose IV methotrexate (1 g/m2 to 8 g/m2) may result in long-lasting responses. (msdmanuals.com)
  • The association between chemotherapy regimens and survival endpoints, including distant metastasis-free survival (DMFS), overall survival (OS) and disease-free survival (DFS), were evaluated and adjusted with PS. (biomedcentral.com)
  • Concurrent chemotherapy radiation therapy is when chemotherapy and radiation therapy are performed together. (healthline.com)
  • A 2016 study found evidence that patients with stage 2 or stage 3 non-small cell lung cancer may benefit from induction chemotherapy before concurrent chemotherapy and radiation therapy. (healthline.com)
  • Received weekly cisplatin 40 mg m2 for 5 to 6 cycles as concurrent chemotherapy with radiation therapy. (who.int)
  • Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • The parents, who quite naturally have a hard time watching their child suffer, hear about some quackery or other that promises to treat their child without the side effects of chemotherapy. (sciencebasedmedicine.org)
  • In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)
  • Which consisted of daily oral chemotherapy, monthly out patient chemotherapy, spinal taps, lumbar punctures and intrathecal chemotherapy, and high dose steroids. (stbaldricks.org)
  • 2. CNS PROPHYLACTIC THERAPY: Treatment of the CNS consists of prophylactic therapy using intrathecal chemotherapy with methotrexate, cytarbine and hydrocortisone. (slideshare.net)
  • Adjuvant chemotherapy is used after other treatments to shrink remaining cancer cells. (healthline.com)
  • High-risk features such as stage IC, higher grade, or clear-cell histology should prompt consideration of adjuvant chemotherapy. (medscape.com)
  • If differentiation syndrome is suspected, immediately initiate high-dose corticosteroids and hemodynamic monitoring until resolution. (centerwatch.com)
  • Treatment includes corticosteroids, chemotherapy, and radiation therapy. (msdmanuals.com)
  • The following patients were excluded from the study: those who had been previously admitted within the last month, immunosuppressed patients, those with acquired immunodeficiency syndrome or patients receiving chemotherapy or corticosteroids (equivalent doses of prednisone ≥20 mg·day −1 ). (ersjournals.com)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1. (uc.edu)
  • Occurs after the induction chemotherapy/surgery phase of high-risk neuroblastoma treatment. (neuroblastoma-info.com)
  • During consolidation therapy, chemotherapy drugs are administered in higher doses . (healthline.com)
  • If you receive higher doses during consolidation therapy, you may experience more severe side effects. (healthline.com)
  • A randomized controlled trial, incorporating a GA and comparing age-adapted HCT-ASCT treatment with conventional chemotherapy is needed. (biomedcentral.com)
  • The primary objective is to demonstrate that intensified chemotherapy followed by consolidating HCT-ASCT is superior to conventional chemotherapy with rituximab, MTX, procarbazine (R-MP) followed by maintenance with procarbazine in terms of progression free survival (PFS). (biomedcentral.com)
  • The role of ASCT consolidation after salvage therapy remains controversial and may benefit only a subset of patients with relapsed MCL. (medscape.com)
  • Acute leukemias are often treated with induction therapy and consolidation chemotherapy once the cancer is in remission. (healthline.com)
  • The goal of consolidation is to keep you in remission. (oncolink.org)
  • The purpose of this study is to evaluate the rate of complete MRD response by flow cytometry after 4 weekly doses of daratumumab-hyaluronidase (Day 29) among patients with MRD positive T-ALL in hematologic morphologic complete remission or complete remission with incomplete hematologic recovery. (mayo.edu)
  • Acute leukemia requires intensive treatment involving several courses of chemotherapy to attain a full remission. (disabilitybenefitscenter.org)
  • Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
  • Toxicity of consolidation chemotherapy included treatment-related death in nine patients and serious neurotoxicity in five. (elsevierpure.com)
  • However, the trial also showed increased toxicity with IP chemotherapy versus IV chemotherapy. (medscape.com)
  • The GOG 252 authors concluded that the toxicity and patient-reported outcomes support selection of the regimen consisting of IV carboplatin AUC 6 day 1, dose-dense paclitaxel 80 mg/m 2 IV once weekly, and bevacizumab 15 mg/kg IV day 1 given in 3-week cycles. (medscape.com)
  • Dose adjustments and dose delays of one or both agents were allowed based on toxicity. (baycitycapital.com)
  • Efforts to overcome chemotherapy resistance by including multidrug resistance modifiers (e.g., cyclosporin or its analogue PSC 833) in the induction schedule have as yet not met with reproducible success in prospective comparative studies. (ashpublications.org)
  • Chemotherapy is a drug therapy that's used to treat many different types of cancer. (healthline.com)
  • Keep reading as we take a look at when induction chemotherapy may be used and how it compares to consolidation therapy and other types of chemotherapy. (healthline.com)
  • The combination of chemotherapy drugs administered is often similar as during induction therapy. (healthline.com)
  • The duration you undergo consolidation therapy varies widely between people, but it may last 4 to 8 weeks . (healthline.com)
  • Targeted drug therapy may also be suitable if AML does not respond to chemotherapy. (medicalnewstoday.com)
  • some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
  • We report a survival case of invasive splenic mucormycosis involving the liver caused by Rhizopus microsporus in a patient during consolidation therapy for acute monocytic leukemia (AML-M 5 ). (frontiersin.org)
  • He was treated with chemotherapy per protocol Children's Oncology Group Protocol ARST0332 and proton beam therapy to the involved mediastinum, pericardium, and heart. (allenpress.com)
  • 3. INTENSIFICATION OR CONSOLIDATION THERAPY: After complete induction is obtained, a period of intensified treatment is administered to eradicate residual leukemic cells, this is followed by delayed intensification to prevent emergence of resistant leukemia clones. (slideshare.net)
  • In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of Neupogen therapy. (medicines.org.uk)
  • Consolidation therapy is used to kill any cancer cells that may be left in the body. (neuroblastoma-info.com)
  • LP-irinotecan TACE was conducted in 42% of patients as salvage therapy, 20% as an intensification treatment, 16% as a first-line treatment, 14% a consolidation treatment and 8% combination treatment with ablation with curative intent. (springer.com)
  • For HIV/AIDS, new evidence that antiretroviral therapy prevents transmission of HIV sparked significant revision and consolidation of all related WHO policy advice, further simplifying treatment protocols and streamlining operational demands. (who.int)
  • METHODS: We retrospectively recorded radiological evaluations following RT-CT, symptoms related to disease progression (avoiding any sign due to radiotherapy or chemotherapy) and the change of therapeutic strategy. (bvsalud.org)
  • The safety and efficacy of Neupogen are similar in adults and children receiving cytotoxic chemotherapy. (medicines.org.uk)
  • The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)
  • Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
  • However, she continued to deteriorate and a chest CT scan showed extensive consolidation in the right upper and middle lobes, now with peripheral consolidation in the left lung. (bmj.com)
  • all patients with this histologic subtype should be considered for chemotherapy. (medscape.com)
  • This involves giving chemotherapy in cycles followed by a period of rest in between to allow the body to recover. (medicalnewstoday.com)
  • Consolidation: Administer 0.15 mg/kg/day intravenously daily for 5 days per week during weeks 1-4 of each 8-week cycle for a total of 4 cycles in combination with tretinoin. (centerwatch.com)
  • Patients will be randomized 2:1 to ponatinib 30 mg/d or imatinib 600 mg/d PO with reduced-intensity chemotherapy in induction (Cycles 1-3), consolidation (Cycles 4-9), and maintenance (Cycles 10-20). (confex.com)
  • Vosaroxin dose was reduced to 70 mg/m2 in consolidation cycles, which were repeated in approximately four to five week intervals for a total of up to seven cycles. (baycitycapital.com)
  • The questionnaire consisted of 40 questions regarding center characteristics, clinical indications, doses, and treatment techniques of re-RT for LR rectal cancer. (bvsalud.org)
  • In randomised clinical trials, a subcutaneous dose of 230 µg/m 2 /day (4.0 to 8.4 µg/kg/day) was used. (medicines.org.uk)
  • I. To determine the levels of expression of c-KIT and its ligand, stem cell factor (SCF) in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
  • To determine the levels of expression of AKT2 and its activated form, phospho-AKT2, in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
  • Prediction of chemotherapy outcome in patients with metastatic soft tissue sarcomas based on dynamic FDG PET (dPET) and a multiparameter analysis. (uni-heidelberg.de)
  • She was commenced speculatively on quadruple antituberculous chemotherapy and oral steroids and intravenous cefotaxime. (bmj.com)
  • Daily dosing with Neupogen should continue until the expected neutrophil nadir is passed and the neutrophil count has recovered to the normal range. (medicines.org.uk)
  • A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL Rochester, Minn., Jacksonville, Fla. (mayo.edu)
  • Ponatinib dose will be reduced to 15 mg once minimal residual disease (MRD)-negative CR is achieved. (confex.com)
  • EA9181, A Phase III Randomized Trial of Steroids+Tyrosine Kinase Inhibitor Induction With Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults Rochester, Minn. This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. (mayo.edu)
  • This partially randomized phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. (mayo.edu)
  • Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia. (mayo.edu)
  • The objective of this study is to assess the safety and tolerability, including the maximum tolerated dose, of ASP2215 in subjects with relapsed or treatment-refractory acute myeloid leukemia (AML). (mayo.edu)
  • Children who get chemotherapy to treat some types of cancer have an increased risk of developing leukemia later on. (texaschildrens.org)
  • 9 Therefore, with the conventional approach, the chemotherapy intensity has been raised to the limit of tolerance, and further improvements in outcomes and reduction of adverse effects will require novel therapeutic approaches. (haematologica.org)
  • The PhALLCON trial (NCT03589326) is a randomized study that compares efficacy and safety of first-line ponatinib versus imatinib with reduced-intensity chemotherapy. (confex.com)
  • Patients randomized 2:1 to ponatinib or imatinib with reduced-intensity chemotherapy. (confex.com)
  • Doctors may also recommend this treatment to those with relapsed or resistant AML after they undergo re-induction chemotherapy. (medicalnewstoday.com)
  • Patients younger than 60 who were unsuited for standard chemotherapy were also eligible. (baycitycapital.com)
  • The unaltered survival implies that low-dose weekly oxaliplatin was unable to further eliminate tumour micrometastasis, providing a rationale for intensified systemic treatment. (biomedcentral.com)
  • Prognostic markers predict treatment related mortality (TRM), resistance to chemotherapy or survival. (ghrnet.org)
  • All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)
  • Gradual discontinuation or reduction of a therapeutic dose of a particular drug over a period of time. (bvsalud.org)
  • Consolidation chemotherapy is administered after initial treatment to target cancers cells that may still be in your body. (healthline.com)
  • Chemicals in chemotherapy drugs target cells that rapidly divide, such as cancer cells. (healthline.com)
  • The severity of side effects tends to relate to the dose of drugs you're receiving. (healthline.com)
  • This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)
  • Doctors may give targeted drugs along with chemotherapy. (medicalnewstoday.com)
  • The degree to which immunosuppressive drugs cause clinically significant immunodeficiency generally is dose related and varies by drug. (cdc.gov)
  • Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)
  • Chemotherapy for AML is broken down into three phases: induction phase, consolidation (or intensification), and maintenance phase. (oncolink.org)
  • A Phase 2 study of ponatinib with chemotherapy in newly diagnosed Ph+ ALL reported improved long-term outcomes versus a second-generation tyrosine kinase inhibitor (TKI) (Sasaki 2016). (confex.com)
  • As previously announced, the Phase 2 cohort of the Phase 1b/2 was initiated in October 2013, following successful completion of a Phase 1b open-label, single-arm dose optimization phase. (baycitycapital.com)
  • A total dose of 90-100 Gy as EqD2 dose (α/ß = 5 Gy) was delivered by 46% of the respondents considering the previous treatment. (bvsalud.org)
  • i A total dose of 45 Gy for EBRT to the pelvis ii If brachytherapy is used, normal tissues should be limited with 2 cc rectal dose 75 Gy, sigmoid 2 cc dose 75 Gy, and 2 cc bladder dose 90 Gy. (who.int)
  • Induction chemotherapy may be used to treat people with esophageal cancer that has spread to surrounding tissues. (healthline.com)