• The fatal human dose for ingested arsenic trioxide is 70 to 180 milligrams (mg) or about 600 micrograms per kilograms (kg)/day [ATSDR 2007]. (cdc.gov)
  • Ingested arsenic trioxide is quickly absorbed and can be extremely hazardous. (cdc.gov)
  • Arsenic trioxide (an odorless, tasteless, white or transparent, nonflammable solid) is one of the most toxic and prevalent forms of arsenic. (cdc.gov)
  • In the past people used inorganic forms of arsenic in pesticides and paint pigment. (cdc.gov)
  • These forms of arsenic are considered to be non-toxic or considerably less toxic than inorganic arsenic. (cdc.gov)
  • Organic and inorganic forms of arsenic can be found in soil, both naturally occurring and due to the use of cyanide-containing pesticides prior to the 1970's. (pickyourown.org)
  • The chemical speciation of arsenic influences its toxicity and many organic forms of arsenic are presumed to have lower toxicity, such as in certain types of seafood, but most of the arsenic found in drinking water and rice is inorganic-the most toxic form. (biomedcentral.com)
  • The authors performed a cross-sectional analysis to evaluate the association between arsenic exposure from drinking water and blood pressure using baseline data of 10,910 participants in the Health Effects of Arsenic Longitudinal Study in Bangladesh (October 2000-May 2002). (nih.gov)
  • But iron is likely unsafe when taken by mouth in high doses. (webmd.com)
  • But high doses of iron are likely unsafe for children. (webmd.com)
  • The pigment is also capable of emitting a poisonous gas, which in high doses, can cause death by cellular failure. (smithsonianmag.com)
  • At high doses, arsenic causes vomiting, convulsions and eventually coma. (usf.edu)
  • It is lethal in very high doses. (drinktap.org)
  • And so he was, the big copper racehorse, born in New Zealand, trained in Australia, whose dazzling speed made him one of those unexpected beacons of hope during the Great Depression and who, according to a report published in an international chemistry journal in April, was killed by a massive dose of arsenic. (scienceblogs.com)
  • So she finished her initial plan and re-poisoned her mother with a massive dose of arsenic. (ghostvillage.com)
  • Drinking water is a major source of arsenic exposure in south-east Asia and western South America where high levels of arsenic occur naturally in groundwater. (umaine.edu)
  • The source of arsenic exposure cannot be identified in many cases. (cdc.gov)
  • Once upon a time - by which I mean the 19th century - people spilled the poison arsenic into their lives with free and merry hands. (scienceblogs.com)
  • Instead, they propose that the arsenic may have been applied during the 19th century as a method of warding off insects and vermin. (smithsonianmag.com)
  • Arsenic occurs naturally in soil and many kinds of rock (especially minerals and ores that contain copper and lead) as inorganic arsenic. (cdc.gov)
  • Arsenic, a naturally occurring element, can combine with either inorganic or organic substances to form many different compounds. (cdc.gov)
  • These compounds occur either naturally, or as a result of mining, ore smelting, or when using arsenic for industrial purposes. (cdc.gov)
  • This is especially true in areas with water sources that naturally have higher levels of inorganic arsenic. (cdc.gov)
  • Arsenic is tasteless and odorless, and occurs naturally in the Earth's soils, rocks and minerals. (drinktap.org)
  • The lawsuit claims that the above wines contain as much as 500% more than what is acceptable in drinking water, and I'm honestly not sure how dangerous that is for human consumption, because trace amounts of arsenic naturally occur in most of the beverages and foods that we ingest on a daily basis. (wineweekly.com)
  • Arsenic is a trace element that occurs naturally in rocks and is present in soils and water. (biomedcentral.com)
  • New research from Human Rights Watch shows that drinking water supplies in rural areas are widely contaminated with naturally occurring arsenic, affecting some 20 million people. (ifhhro.org)
  • The National Health and Nutrition Examination Survey (2003-2004) measured levels of total arsenic and speciated arsenic in urine of a representative sample of the U.S. population. (cdc.gov)
  • describe the tests you would order for patients exposed to arsenic. (cdc.gov)
  • Arsenic-associated diseases typically have a long latency period, so that many patients exposed to arsenic are asymptomatic for years. (cdc.gov)
  • However, patients exposed to arsenic levels higher than that had a significant loss of lung function - comparable to decades of smoking tobacco - putting them at increased risk of developing serious respiratory disease. (voanews.com)
  • Following is the full, complete list of wines that allegedly contain dangerous amounts of arsenic, according to a lawsuit filed in Los Angeles, California. (wineweekly.com)
  • Other inorganic arsenic compounds may vary somewhat in relative toxicity, and organic arsenic compounds appear to be essentially nontoxic. (cdc.gov)
  • Some organic arsenic compounds may be used as pesticides or as additives in animal feed. (cdc.gov)
  • Organic arsenic compounds exist mainly in fish and shellfish. (cdc.gov)
  • Exposure to organic arsenic compounds happens when people eat seafood. (cdc.gov)
  • Other sources of inorganic arsenic exposure include contact with contaminated soil or dust, or with wood preserved with arsenic compounds. (cdc.gov)
  • There is increasing evidence that dietary inorganic arsenic makes an important contribution to total inorganic arsenic exposure, particularly when inorganic arsenic concentrations in water are low. (nationalacademies.org)
  • Given that a great deal of epidemiologic research concerning the health effects of inorganic arsenic exposure from drinking water has been conducted in South Asian and Taiwanese populations, for whom rice is a dietary staple, the committee recommends that the contribution of inorganic arsenic intake from rice be considered in interpreting findings from those regions. (nationalacademies.org)
  • Contaminated soil may also be a source of significant arsenic exposure in children, although it is not likely that children would ingest sufficient arsenic-contaminated soil to cause significant acute toxicity. (cdc.gov)
  • Arsenic trioxide injection may cause encephalopathy (confusion, memory problems, and other difficulties caused by abnormal brain function). (medlineplus.gov)
  • These highlights do not include all the information needed to use ARSENIC TRIOXIDE INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for ARSENIC TRIOXIDE INJECTION. (nih.gov)
  • The problem with the product is that it contains high levels of lead and arsenic that could be toxic to both fetus and mother. (scienceblogs.com)
  • She also is serving as the principal investigator of the Colorado Smelter lead and arsenic exposure investigation in Pueblo. (cdc.gov)
  • By measuring arsenic in urine, scientists can estimate the amount of arsenic that has entered people's bodies within the past two or three days. (cdc.gov)
  • The Dr. Oz Show" did an episode in which they talked about the amount of arsenic in children's apple juice. (pickyourown.org)
  • OSHA PEL (permissible exposure limit) = 10 µg/m 3 as an 8-hour TWA concentration (as As) for inorganic arsenic (OSHA 2006). (cdc.gov)
  • Acute oliguric renal failure occurs because concentration of arsenic in the proximal tubules and binding to proteins of tubular epithelium damages the tubules. (medscape.com)
  • In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. (wikipedia.org)
  • A time-weighted well arsenic concentration (TWA) based on current and past use of drinking wells was derived. (nih.gov)
  • Of all the food components of the US Market Basket Survey, rice-particularly rice grown in the south central United States-has the highest concentration of inorganic arsenic (Schoof et al. (nationalacademies.org)
  • been associated with urinary arsenic concentration, including inorganic arsenic and its metabolites monomethyl arsenic (MMA) and dimethyl arsenic (DMA), in pregnant women (Gilbert-Diamond et al. (nationalacademies.org)
  • The team found that the drinking water in the town contained extremely high levels of arsenic - about 20 times higher than the maximum concentration recommended by the World Health Organization. (usf.edu)
  • Standard risk assessment paradigms show that arsenic regulations for drinking water should target a maximum concentration of nearly zero to prevent excessive lung and bladder cancer risks (among others). (biomedcentral.com)
  • Arsine is the gaseous and the most toxic form of the element, arsenic. (cdc.gov)
  • Arsine toxicity is different from arsenic toxicity. (cdc.gov)
  • In the reported cases, arsine was formed as a by-product of a chemical reaction between a base metal, an arsenic impurity, and an acid. (haz-map.com)
  • Arsenic was used to strengthen lead and, in the glassmaking industry, to reduce discoloration caused by trace amounts of iron. (medscape.com)
  • Finding measurable amounts of arsenic in urine does not mean those levels cause an adverse health effect. (cdc.gov)
  • The study was part of a long-term project conducted in Bangladesh, where nearly half the population - some 77 million people - live in areas where groundwater wells contain harmful amounts of arsenic. (voanews.com)
  • Given that some children drink up to half a litre of fruit juice per day [ 3 ] and that lactose-intolerant people may consume significant amounts of rice milk drinks, the resulting dose of arsenic would be higher than the level considered safe. (biomedcentral.com)
  • People can also be exposed to inorganic arsenic by eating such foods as rice and some fruit juices. (cdc.gov)
  • Probabilistic exposure modeling that used NHANES dietary data from 2003-2004 coupled with duplicate diet and biomarker measurements estimated that the major contributors to dietary inorganic arsenic intake are vegetables (24%), fruit juices and fruits (18%), and rice (17%) (Xue et al. (nationalacademies.org)
  • 2010). Indeed, the lay press has recently called attention to the issue of inorganic arsenic in fruit juices and rice (Consumer Reports 2012a,b), creating concern in the US public. (nationalacademies.org)
  • Where does the arsenic in fruit juices come from? (biomedcentral.com)
  • The higher concentrations of arsenic in fruit juices are presumed to arise from the arsenic remaining in the soils of orchards where the As-pesticides were spread. (biomedcentral.com)
  • In the Fourth National Report on Human Exposure to Environmental Chemicals (Fourth Report) , CDC scientists measured total arsenic, and seven different forms (or species) of arsenic. (cdc.gov)
  • NHANES results found DMA and arsenobetaine to be the major components of urinary total arsenic levels. (cdc.gov)
  • The minimal lethal dose is in the range of 1 to 3 mg/kg [ATSDR 2007]. (cdc.gov)
  • Some comparison values used by ATSDR scientists include ATSDR's environmental media evaluation guides (EMEG), reference dose media evaluation guides (RMEG), and cancer risk evaluation guides (CREG). (cdc.gov)
  • A high dose of the metallic poison arsenic can also bring on severe nausea and painful stomach cramps. (scienceblogs.com)
  • One of the most repeated rules in toxicology is this: the dose makes the poison. (scienceblogs.com)
  • Concentrated doses of the chemical can be fatal - one reason it's long been a popular poison for assassins and unhappy widows . (time.com)
  • The Telegraph' s Lucinda Hawksley adds that individuals even ate vegetables sprayed with arsenic-laced insecticides, or meat dipped in the poison in an effort to stave off flies. (smithsonianmag.com)
  • For centuries, arsenic was the go-to poison for murder. (usf.edu)
  • This breakfast included a strong dose of arsenic rat poison mixed in with the cottage cheese. (ghostvillage.com)
  • Arsenic is a poison that, when ingested in high enough doses, can be fatal. (wineweekly.com)
  • Arsenic exposure has been linked to a number of human diseases including diabetes, skin lesions, cardiovascular disease and cancer. (umaine.edu)
  • Arsenic has been linked to cancer, cardiovascular disease and cognitive deficits. (voanews.com)
  • Arsenic (As) and other metals are considered to be among the ten chemicals of major public health concern by the WHO, and some authors have linked them to cardiovascular disease. (scielo.org.pe)
  • An estimated 43,000 Bangladeshis die each year from arsenic-induced illnesses like cancer, cardiovascular disease and lung disease. (ifhhro.org)
  • Ingestion is the most important route of acute exposure of arsenic trioxide. (cdc.gov)
  • Chronic toxicity from ingestion or inhalation of arsenic may be occupational or environmental. (medscape.com)
  • Documented cases of arsenic poisoning have been associated with ingestion of traditional Chinese herbal balls, Korean herbal preparations used to treat hemorrhoids, and kelp supplements. (medscape.com)
  • LaDou, p. 264] Hemolysis has been reported in cases of poisoning by ingestion of arsenic and copper. (haz-map.com)
  • Unusually large doses of inorganic arsenic can cause symptoms ranging from nausea, vomiting, and diarrhea to dehydration and shock. (cdc.gov)
  • Arsenic trioxide may cause a serious or life-threatening group of symptoms called APL differentiation syndrome. (medlineplus.gov)
  • Patients with acute promyelocytic leukemia (APL) treated with arsenic trioxide have experienced symptoms of differentiation syndrome, which may be life-threatening or fatal. (nih.gov)
  • If patients go to village health clinics with symptoms of arsenic exposure, they are told nothing can be done for them. (ifhhro.org)
  • Statistically significant induction of Foxm1, Cdc6 and Cdc25a expression was seen even at concentrations as low as l0ppb of arsenic. (umaine.edu)
  • Arsenic concentrations in lung tissues from F0, F1 and F2 mice were detected by inductively coupled plasma mass spectroscopy (ICP- MS). (umaine.edu)
  • F1 and F2 males show increased cell proliferation at concentrations as low as 10ppb suggesting a transgenerational effect of arsenic. (umaine.edu)
  • Arsenic trioxide has no odor and thus provides no warning of hazardous airborne concentrations. (cdc.gov)
  • A large body of epidemiological evidence correlates hair mercury concentrations to blood mercury levels and both of these to fish consumption in a dose-response fashion. (cdc.gov)
  • The US Geological Survey, in a study of all major aquifers in the United States, estimated that 7% of household wells have arsenic concentrations that exceed the Environmental Protection Agency's maximum contaminant level (MCL) of 10 ppb, leaving roughly 4.2 million people with the responsibility of taking corrective action themselves (Ayotte et al. (nationalacademies.org)
  • 2007). A recent evaluation of data on 2,323 children 6-17 years old who participated in 2003-2008 NHANES studies found that children who reported consuming rice had urinary arsenic concentrations that were nearly 40% higher than concentrations in those who did not consume rice (Davis et al. (nationalacademies.org)
  • To estimate the effect of these concentrations on mortality, we fitted Besag, York and Mollié models, which included, as explanatory variables, each town's chromium and arsenic soil levels, estimated by kriging. (springer.com)
  • This methodology provides a bi- ologically based approach by taking into consideration the pharmacokinetics in humans and reported therapeutic or toxic blood concentrations to guide in the selection of the internal dose-metric. (cdc.gov)
  • FDAC) in 1938 or those that require dose selection on the basis of therapeutic blood concentrations. (cdc.gov)
  • Arsenic in water is colorless, tasteless, and odorless. (ifhhro.org)
  • Op . ( Opium in large doses is the best antidote in poisoning), Pulsatilla Puls . (abchomeopathy.com)
  • Arsenic compounds exist in a number of inorganic and organic forms. (cdc.gov)
  • Physical and chemical properties vary among the various arsenic compounds of toxicological concern. (cdc.gov)
  • the guidelines for decontamination and medical treatment are applicable for exposure to arsenic and inorganic arsenic compounds, including arsenic trioxide. (cdc.gov)
  • Inorganic arsenic compounds have been used as pesticides, but can no longer be used in agriculture. (cdc.gov)
  • Inorganic arsenic and arsenic compounds are considered to be cancer-causing chemicals. (cdc.gov)
  • An approach for deriving occupational exposure limits (OEL) for pharmaceutical compounds is the application of safety factors to the most appropriate pre-clinical toxicity endpoint or the lowest therapeutic dose (LTD) in humans. (cdc.gov)
  • The Committee made recommendations on the risks to health associated with six important contaminants in food (acrylamide, arsenic, deoxynivalenol, furan, mercury, and perchlorate). (who.int)
  • Some herbal products have been found to contain high levels of toxic heavy metals such as arsenic, lead, or mercury. (cdc.gov)
  • In some of the herbal combinations used, heavy metals (mainly lead, mercury, and arsenic) are included. (msdmanuals.com)
  • Monitoring of mercury, arsenic, and lead in traditional Asian herbal preparations on the Dutch market and estimation of associated risks. (msdmanuals.com)
  • He has also collaborated with U.S. EPA Region 10 on several projects, including the development of streamlined, risk-based screening software for indirect exposure to incinerator emissions, and compilation of seafood arsenic speciation and toxicity data. (exponent.com)
  • It is a nonirritating gas with a mild odor (odorless at low doses) that is used in the semiconductor and metals refining industries. (cdc.gov)
  • High-level exposures to arsenic and heavy metals have been found to be associated with multiple cancer types, including bladder, colon, kidney, liver, lung, skin and prostate, by numerous epidemiological studies (Naujokas et al. (springer.com)
  • For low- and intermediate-risk patients, induction therapy should consist of ATRA and arsenic trioxide (ATO) without chemotherapy. (medscape.com)
  • [ 1 ] The combination of arsenic trioxide with ATRA may be considered for patients who are not candidates for anthracycline-based therapy. (medscape.com)
  • The report also contains general considerations, in particular on the principles of estimating dietary exposure from epidemiological studies, and on the modelling of dose-response data. (who.int)
  • Use of this methodology can be limited when there are inadequate pre-clinical toxicity data or lack of a well-defined therapeutic dose, and does not include pharmacokinetic considerations. (cdc.gov)
  • The objective of the present study is to assess the association between levels of chromium and arsenic in soil and the cancer mortality. (springer.com)
  • The results showed a statistical association in men and women alike, between arsenic soil levels and mortality due to cancers of the stomach, pancreas, lung and brain and non-Hodgkin's lymphomas (NHL). (springer.com)
  • The residual arsenic from the pesticides in the soil is taken up by the plant roots and partly transferred to the fruit. (biomedcentral.com)
  • Hemolysis after high-dose lead exposure may occur in workers who remove lead paint. (haz-map.com)
  • In chronic exposures, particular clues to arsenic poisoning may be provided by dermatologic and neurologic findings. (cdc.gov)
  • There's no treatment for chronic arsenic poisoning. (usf.edu)
  • Our results suggest that chronic exposure arising from low levels of arsenic and chromium in topsoil could be a potential risk factor for developing cancer. (springer.com)
  • And this is pure water, free of arsenic and any other toxic substance. (scienceblogs.com)
  • Instead, the analysis revealed that the layer of green was saturated in arsenic, a highly toxic substance known to irritate the stomach, intestines and lungs, as well as induce nausea, diarrhea and skin changes. (smithsonianmag.com)
  • In acute arsenic poisoning, death is usually due to cardiovascular collapse and hypovolemic shock. (cdc.gov)
  • Mee's lines may be visible in the fingernails several weeks to months after acute arsenic poisoning. (cdc.gov)
  • Arsenic trioxide dust is readily absorbed from the lungs, but inhaled quantities are usually insufficient to cause acute systemic toxicity. (cdc.gov)
  • The current study examined the effect of low-dose, environmentally relevant levels of arsenic (10 to 500 ppb) on transplacentally exposed mice (F1) and the next generation (F2) which focused on altered regulation of the normal cell cycle. (umaine.edu)
  • Biomonitoring studies on levels of arsenic provide physicians and public health officials with reference values. (cdc.gov)
  • These reference values help experts determine if people have been exposed to higher levels of arsenic than are found in the general population. (cdc.gov)
  • Health concerns relating to current estimated levels of intake were identified for acrylamide, arsenic and furan. (who.int)
  • Then, they correlated that with the patients' arsenic levels. (voanews.com)
  • Mummies dating back 400 to 7,000 years have been found in the region with high levels of arsenic in their hair. (usf.edu)
  • So it's likely the population in San Antonio de los Cobres had been living with high levels of arsenic for many, many generations," Broberg says. (usf.edu)
  • Chromium and arsenic topsoil levels (partial extraction) were determined by ICP-MS at 13,317 sampling points. (springer.com)
  • Today laws restrict using arsenic-containing pesticides, wood preservatives, and medicines. (cdc.gov)
  • In North America, DDT began to replace arsenic pesticides in the early 1950s. (biomedcentral.com)
  • Data from the F1 generation support in vitro studies of arsenic-related cell cycle dysregulation done in other laboratories. (umaine.edu)
  • Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro . (centerwatch.com)
  • The data reflect relative background contributions of inorganic and seafood-related arsenic exposures in the U.S. population [Caldwell et al. (cdc.gov)
  • The fatal dose of ingested arsenic in humans is difficult to determine from case reports, and it depends upon many factors (e.g., solubility, valence state, etc. (cdc.gov)
  • At one time, people in southern Austria reportedly found that eating arsenic had a "tonic" effect and were able to ingest without toxicity what would usually be a fatal dose. (medscape.com)
  • A fatal dose for humans can be as low as 1.5 milligrams per kilogram of body weight. (pickyourown.org)
  • These findings indicate that the effect of low-level arsenic exposure on blood pressure is nonlinear and may be more pronounced in persons with lower intake of nutrients related to arsenic metabolism and cardiovascular health. (nih.gov)
  • Iron is likely safe for most people when used in doses below the tolerable upper intake level (UL) of 45 mg elemental iron daily. (webmd.com)
  • Arsenic and Old Rice: Should We Worry About a Toxic Chemical in a Popular Food? (time.com)
  • As a result, wells are often denied to villages suffering arsenic contamination and allocated instead to areas near political allies and supporters, where water quality is already good. (ifhhro.org)
  • Findings from this study suggest transplacental arsenic exposure alters the expression of genes involved in regulation of the cell cycle and may be a probable mechanism involved in causing human diseases. (umaine.edu)
  • Studies have not found organic arsenic in seafood to be toxic to humans. (cdc.gov)
  • Cyanide toxicity is experienced by humans at doses of around 0.5-3.5 milligrams per kilogram of body weight. (pickyourown.org)
  • Temporarily withhold arsenic trioxide. (nih.gov)
  • Withhold arsenic trioxide until resolution and resume at reduced dose for QTc prolongation. (nih.gov)
  • Withhold arsenic trioxide for certain elevations in AST, alkaline phosphatase and bilirubin and resume at reduced dose upon resolution. (nih.gov)
  • 2022. Somatic loss of the Y chromosome is associated with arsenic exposure among Bangladeshi men. (nih.gov)
  • 2022. Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults. (nih.gov)