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  • On 20 June 2014, Hirst announced that she had left Capital, bringing Hirsty's Daily Dose to an end after 11 years on air - the final edition aired a week before the announcement. (wikipedia.org)
  • Hirsty's Daily Dose had two podcasts in its history. (wikipedia.org)
  • Even the ICRP stated that: 'The permissible doses can therefore be expected to produce effects [illnesses] that could be detectable only by statistical methods applied to large groups. (abs-cbn.com)
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  • This page provides information on the high-dose seasonal flu vaccine, Fluzone High-Dose external icon . (cdc.gov)
  • What is Fluzone High-Dose vaccine? (cdc.gov)
  • Fluzone High-Dose is three-component (trivalent) inactivated flu vaccine, manufactured by Sanofi Pasteur Inc. Fluzone High-Dose is licensed specifically for people 65 years and older. (cdc.gov)
  • Fluzone High-Dose contains four times the antigen (the part of the vaccine that helps your body build up protection against flu viruses) of standard-dose inactivated influenza vaccines. (cdc.gov)
  • The higher dose of antigen in the vaccine is intended to give older people a better immune response, and therefore, better protection against flu. (cdc.gov)
  • As with all flu vaccines, Fluzone High-Dose is not recommended for persons with a history of severe allergic reaction to the vaccine or to components other than eggs. (cdc.gov)
  • Fluzone High-Dose contains four times the amount of antigen (the part of the vaccine that prompts the body to make antibody) contained in standard-dose inactivated influenza vaccines. (cdc.gov)
  • Data from clinical trials comparing Fluzone (a trivalent standard dose vaccine) to Fluzone High-Dose (a trivalent high-dose vaccine) among persons aged 65 years or older indicate that a stronger immune response (i.e., higher antibody levels) occurs after vaccination with Fluzone High-Dose. (cdc.gov)
  • A study published in the New England Journal of Medicine external icon indicated that the high-dose vaccine was 24.2% more effective in preventing flu in adults 65 years of age and older relative to a standard-dose vaccine. (cdc.gov)
  • Does Fluzone High-Dose offer better protection than the adjuvanted flu vaccine? (cdc.gov)
  • To date, there have been no randomized studies comparing Fluzone High-Dose with FLUAD (the adjuvanted influenza vaccine). (cdc.gov)
  • To address this public health problem, the Advisory Committee on Immunization Practices (ACIP) reviewed the available evidence and determined that a third dose of measles, mumps, rubella (MMR) vaccine is safe and effective at preventing mumps. (cdc.gov)
  • During its October 2017 meeting, ACIP recommended a third dose of a mumps virus-containing vaccine* for persons previously vaccinated with 2 doses who are identified by public health authorities as being part of a group or population at increased risk for acquiring mumps because of an outbreak. (cdc.gov)
  • In response to multiple measles outbreaks in the late 1980s, in 1989 ACIP recommended routine administration of 2 doses of MMR vaccine for children, with the first dose administered at ages 12 through 15 months and the second at ages 4 through 6 years ( 5 ). (cdc.gov)
  • However, in 2006, mumps outbreaks primarily affecting populations with high coverage with 2 doses of MMR vaccine in midwestern states and colleges resulted in 6,584 reported mumps cases that year ( 6 ). (cdc.gov)
  • In addition, ACIP recommended that a second dose of mumps vaccine should be considered in outbreak settings for children aged 1-4 years and adults who have received 1 dose of vaccine, depending on the epidemiology of the outbreak (e.g., the age groups affected or institutions involved). (cdc.gov)
  • To assist state and local health departments in responding to mumps outbreaks, CDC issued guidance on use of a third dose of MMR vaccine in the 2012 Manual for the Surveillance of Vaccine-Preventable Diseases . (cdc.gov)
  • Additional evidence on effectiveness and safety of the third dose of MMR vaccine recently became available and was presented to ACIP during 2017. (cdc.gov)
  • This report summarizes the evidence considered by ACIP regarding use of a third dose of a mumps virus-containing vaccine during outbreaks and provides the recommendation for its use among persons who are at increased risk for acquiring mumps because of an outbreak. (cdc.gov)
  • and effectiveness, immunogenicity, and safety of a third dose of MMR vaccine. (cdc.gov)
  • Also assessed were stakeholders' values attributed to the perceived benefits and harms of a third dose of MMR vaccine, acceptability, and implementation considerations regarding use of a third dose of MMR vaccine. (cdc.gov)
  • The vaccines shipped to both sites and to a few other places around the nation are the first of some 195 million doses the U.S. government has purchased from five vaccine manufacturers, the Centers for Disease Control and Prevention 's Dr. Jay Butler told reporters at the Indianapolis event. (cnn.com)
  • Butler said vaccine makers will ship 10 million to 20 million doses per week over the next couple of months. (cnn.com)
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  • Researchers have also examined "ultra-low-doses" of naltrexone at microgram, nanogram, and picogram doses, that are co-administered with opioid analgesics with the goal of increasing pain relief and reducing side effects. (wikipedia.org)
  • As with any other dietary supplement, zinc can cause unpleasant side effects when taken in high doses, so consult your doctor to determine the appropriate dosage for you. (livestrong.com)
  • Conversely, a sufficiently low dose of any compound will produce no significant effects that can be experimentally determined, no matter how sophisticated or extensive the experiment. (springer.com)
  • Extrapolating the effects of high doses to those of low doses does not reflect reality at all. (irsn.fr)
  • What will be the consequences of better knowledge of the effects of low doses? (irsn.fr)
  • Whereas the becquerel (Bq) measures the activity of nuclear matter and the gray (Gy) measures the dose physically absorbed by matter, the sievert enables the impact of radiation on living matter to be evaluated, thus enabling the comparison of the effects of the same dose delivered by different types of radiation on organisms, organs or tissues which do not have the same sensitivity to radiation. (irsn.fr)
  • A new model shows that the standard practice of treating infections with the highest tolerable dose of anti-microbial medications may not be best for preventing the evolution of drug resistance in all cases. (psu.edu)
  • High doses of medications are effective at combatting the first of these evolutionary processes. (psu.edu)
  • Over-the-counter medications are typically accompanied by a set of instructions directing the patient to take a certain small dose, followed by another small dose if their symptoms don't subside. (wikipedia.org)
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  • According to the University of Maryland Medical Center, very high doses can decrease immunity, particularly in older adults, and increase the level of bad cholesterol in the blood. (livestrong.com)
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  • Day and Read showed that the optimal approach to combatting the evolution of drug resistance will be either to use the highest dose that is safe or to use the lowest dose that is effective. (psu.edu)
  • We're extending that old rule of thumb to say that the best practice will either be the highest dose or the lowest dose of a drug," said Read. (psu.edu)
  • In other words, LD50 means the lowest dose at which a material kills half of the test subjects. (scienceblogs.com)
  • The 5 rem per 30 years was set as the average dose to a population, with a maximum of 0.5 rem (5 msV) per year for any individual member of the public. (abs-cbn.com)
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  • These outbreaks prompted ACIP to formally recommend a routine 2-dose mumps vaccination policy for school-aged children (i.e., kindergarten-grade 12) and adults at high risk (i.e., students at post-high school educational institutions, health care personnel, and international travelers) in 2006 ( 7 ). (cdc.gov)
  • The guidance was based on limited data and provided criteria for health departments regarding when to consider use of a third dose in specifically identified target populations. (cdc.gov)
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  • More information about Fluzone High-Dose is available on the Food and Drug Administration (FDA) web site. (cdc.gov)
  • Who can receive Fluzone High-Dose? (cdc.gov)
  • In the United States, Fluzone High-Dose is licensed only for persons aged 65 years and older. (cdc.gov)
  • What is the difference between Fluzone High-Dose and Fluzone Quadrivalent? (cdc.gov)
  • Fluzone High-Dose and Fluzone Quadrivalent are both injectable influenza vaccines made to protect against the flu viruses most likely to cause illness for that particular flu season. (cdc.gov)
  • Are there benefits of Fluzone High-Dose compared to standard dose seasonal flu vaccines for adults 65 years and older? (cdc.gov)
  • A separate study published in The Lancet Respiratory Medicine external icon reported that Fluzone High-dose was associated with a lower risk of hospital admissions compared with standard-dose Fluzone for people aged 65 years or older, especially those living in long-term care facilities. (cdc.gov)
  • How safe is Fluzone High-Dose? (cdc.gov)
  • Some adverse events (which are also reported after regular flu vaccines) were reported more frequently after vaccination with Fluzone High-Dose than after standard-dose inactivated influenza vaccines. (cdc.gov)
  • Most people had minimal or no adverse events after receiving the Fluzone High-Dose. (cdc.gov)
  • Personal testimonials describing low-dose naltrexone as a cure for multiple sclerosis are not supported by high quality evidence in large randomised , double-blind , placebo-controlled clinical trials. (wikipedia.org)
  • Conditions like sickle cell anemia, anorexia nervosa, stomach ulcers, attention deficit-hyperactivity disorder and age-related macular degeneration might require doses as high as 220 mg per day. (livestrong.com)
  • Only take these high doses under the supervision of your doctor. (livestrong.com)
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  • The correct dosage for a patient is dependent on their individual reaction to both chemicals, and therefore the dosing must be continually adjusted once treatment is initiated to find the right balance. (wikipedia.org)
  • Organizations promoting low-dose naltrexone have advocated it as a treatment for a variety of medical conditions. (wikipedia.org)
  • General rule is longer the overall duration of treatment greater is the dose required to produce a particular effect. (slideshare.net)
  • Dose-response relationships have received a generic treatment in all general textbooks of toxicology, such as those by Loomis (1974), Doull et al . (springer.com)
  • Do low doses present risks? (irsn.fr)
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