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  • kinetics
  • This study will determine whether there is an increase in the anti-HIV antibody titers when GM-CSF is used as an adjuvant with ALVAC-HIV vCP205 and will also examine the kinetics and magnitude of the HIV-specific CTL response. (clinicaltrials.gov)
  • different doses
  • DBA/1 mice were immunized for the development of CIA and treated at different times, and with different doses, with neutralizing mAb to GM-CSF or isotype control mAb. (nih.gov)
  • To determine the effectiveness and safety of dextran sulfate (DS) as a treatment for patients with AIDS, AIDS related complex (ARC), or asymptomatic HIV infection with or without persistent generalized lymphadenopathy (PGL), and to determine antiviral activity at different doses of DS. (clinicaltrials.gov)
  • Patients who have completed 16 treatments under Fisons study no. 87-71 entitled, 'A Double-Blind Group Comparative Study To Evaluate the Safety and Effectiveness of Three Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP. (clinicaltrials.gov)
  • assays
  • After termination of the pregnancy, analysis of blood from the abortus confirmed the diagnosis of severe hemophilia B. We conclude that very sensitive immunologic assays, such as the one described here, will prove useful in prenatal diagnosis of severe hemophilia B, since determination of factor IX activity in fetoscopic samples is unrealiable because of possible contamination with thromboplastic material. (lu.se)
  • Rheumatoid
  • We show here with peripheral blood monocytes from normal volunteers and from patients with rheumatoid arthritis by using IL-1R antagonist to block autoinduction and IL-1alpha stimulation to simulate autoinduction that approximately 40% of IL-1beta released from LPS-stimulated cells is attributable to autoinduction and that GLA reduces autoinduction of IL-1beta while leaving the initial IL-1beta response to LPS intact. (umassmed.edu)
  • Clinical
  • There was a dose-related suppression of the clinical score, with mice receiving 300 ?g anti-GM-CSF mAb showing a marked reduction of disease (Fig. 1a). (nih.gov)
  • Dose-related reduction in allergen-specific T cells associates with clinical response of atopic dermatitis to methotrexate. (ox.ac.uk)
  • The primary endpoint of the study was the achievement at week 4 of a Paulus 20% response, an amalgam of six clinical, observational, and laboratory variables. (ox.ac.uk)
  • This phase 1 trial assessed the safety, immunogenicity, and clinical activity of escalating doses of CDX-1401 with the Toll-like receptor (TLR) agonists resiquimod (TLR7/8) and Hiltonol (poly-ICLC, TLR3) in 45 patients with advanced malignancies refractory to available therapies. (nih.gov)
  • Thus, intervention strategies may be directly assessed, as opposed to being inferred based upon immunologic and clinical parameters. (usda.gov)
  • mice
  • Mice were treated i.p. with increasing doses of anti-GM-CSF (30, 100, and 300 ?g) beginning at day 21, and then every second day until day 31. (nih.gov)
  • Control mice received the highest dose (300 ?g) of control mAb. (nih.gov)
  • Dose, timing, schedule, and the choice of targeted epitope alter the efficacy of anti-CD22 immunotherapy in mice bearing human lymphoma xenografts. (nih.gov)
  • Early treatment (low tumor volume, non-established tumors) was at least as effective as the same dose and schedule of HB22.7 given to mice with small established tumors, Fig. 2. (nih.gov)
  • Combinations
  • Treatment induced humoral and cellular immunity to NY-ESO-1 in patients with confirmed NY-ESO-1-expressing tumors across various dose levels and adjuvant combinations. (nih.gov)
  • immune responses
  • Recent studies have clearly demonstrated an association of T cell central memory and IL-17 effector immune responses to vaccine-elicited protection of cattle upon subsequent infection with M. bovis. (usda.gov)
  • This chapter covers experimental biology approaches used for the evaluation of the immunopathogenesis of M. bovis infection in cattle, specific details on innate and adaptive immune responses to vaccination/infection, discoveries in host genetic factors to resistance and susceptibility, and aspects of transmission of bovine tuberculosis between cattle and wildlife reservoirs. (usda.gov)
  • survival
  • The effect of combination splenectomy and low-dose FK506 therapy on graft survival after liver allograft transplantation in rats. (biomedsearch.com)
  • Splenectomy alone somewhat prolonged the survival (13.4 +/- 2.0 days), and low-dose FK506 therapy moderately prolonged it (22.7 +/- 7 days). (biomedsearch.com)
  • cells
  • Splenectomy or other immunosuppressive methods affecting B cells can be a supplement for immunosuppression when using reduced-dose FK506. (biomedsearch.com)
  • The accessory cell requirements for a given T cell response may be examined in vitro by using highly purified lymph node T cells. (ox.ac.uk)
  • Transferred cells exhibited direct evidence of antileukemic activity in two patients: a transient response in one patient with advanced progressive disease and the induction of a prolonged remission in a patient with minimal residual disease (MRD). (nih.gov)
  • To evaluate the anti-HIV activity of PMPA prodrug, as demonstrated by increases in CD4 cell counts and decreases in HIV RNA, when administered orally as a single dose and daily for 4 weeks to HIV-infected patients with CD4 cell counts of 200 or more cells/mm3. (clinicaltrials.gov)
  • Additionally, gamma delta T cells from M. bovis-infected cattle proliferate and produce IFN-gamma in response to a peptide cocktail from immunodominant M. bovis proteins. (usda.gov)
  • severe
  • In the more severe reactions, the foci of endothelial destruction may be so numerous as to overlap, resulting in complete immunologic destruction of the entire endothelium. (arvojournals.org)
  • disease
  • Disease severity is dose and time dependent, closely mimicking natural infection of cattle. (usda.gov)
  • route
  • This study provided data as to an optimal dose, route, schedule and interval between doses of HB22.7. (nih.gov)
  • levels
  • CONCLUSIONS: These findings suggest that the association between antenatal depression and infant cortisol reactivity is dose-dependent and U-shaped, implying that infants exposed to both low and high levels of maternal depression showed greater reactivity. (ox.ac.uk)