• The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Cancer treatments such as chemotherapy and radiation therapy can cause problems with mental functions, such as concentration, memory and the ability to multitask (to keep track of and do different tasks at the same time). (lls.org)
  • You have a higher chance of having nausea and vomiting if you have more than one type of treatment, such as when chemotherapy is given with radiation therapy. (cancer.ca)
  • Highly emetogenic chemotherapy: 24mg once 30 mins before start of single-day chemotherapy (multi-day, single-dose not studied). (empr.com)
  • Moderately emetogenic chemotherapy: 8mg every 8hrs for 2 doses beginning 30 mins before chemotherapy, then 8mg every 12hrs for 1-2 days after chemotherapy completed. (empr.com)
  • Also known as the conditioning regimen, the preparatory stage of cord blood transplants involves high doses of chemotherapy and in some cases radiation treatment, which is used to treat the whole body in a process known as total body irradiation (TBI). (pregnancy-info.net)
  • Cancer treatments, such as chemotherapy or radiation therapy can cause nausea and vomiting. (cancer.org)
  • Some patients receive total body irradiation (TBI) in addition to chemotherapy. (ucsfhealth.org)
  • The transplant of blood stem cells or bone marrow will be infused one to three days after the last chemotherapy or radiation dose. (ucsfhealth.org)
  • The body feels the effects of the chemotherapy or radiation about a week after a BMT. (ucsfhealth.org)
  • Active, relapsed, or refractory AML was defined for the sake of the trial as primary induction failure after ≥ 2 cycles of therapy including chemotherapy or ≥ 2 cycles of venetoclax (Venclexta) with a hypomethylating agent or low-dose cytarabine, first early relapse after first CR of less than 6 months, relapse refractory to salvage chemotherapy regimen, or second or subsequent relapse. (onclive.com)
  • The main treatments are surgery to remove the cancer, radiation therapy , and chemotherapy . (healthwise.net)
  • List of orphan source incidents Ciudad Juárez cobalt-60 contamination incident 1990 Clinic of Zaragoza radiotherapy accident Goiânia accident List of civilian radiation accidents Nuclear and radiation accidents and incidents Nuclear safety and security "Sources and Effects of Ionizing Radiation: 2008 UNSCEAR Report" (PDF). (wikipedia.org)
  • gives some additional hints that whole-body irradiation with low doses enhances the in situ vaccine effects of locally applied radiotherapy. (frontiersin.org)
  • and radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. (empr.com)
  • Total body irradiation: 8mg 1-2hrs before each fraction of radiotherapy administered each day. (empr.com)
  • Single high-dose fraction radiotherapy to abdomen: 8mg 1-2hrs before radiotherapy, then 8mg every 8hrs after 1st dose for 1-2 days after radiation completed. (empr.com)
  • Residents are involved with simulations and special procedures, including but not limited to: 3D-conformal radiotherapy, intensity modulated radiation therapy (IMRT), computed tomography (CT) and conventional simulation, stereotactic radiosurgery/Gamma-Knife radiosurgery, intraoperative brachytherapy, high dose rate remote afterloading brachytherapy, total body irradiation (TBI), total skin electron beam radiotherapy and interstitial/intracavitary treatment throughout their training. (yale.edu)
  • Chicago, IL - November 10, 2009 - Clinicians using RapidArc® radiotherapy technology for fast, precise, non-invasive cancer treatments have found that they are able to substantially reduce scatter dose to surrounding healthy tissues, according to several presentations and posters presented this week at the annual meeting of the American Society for Radiation Oncology (ASTRO) in Chicago. (varian.com)
  • With RapidArc, doctors were able to quickly administer image-guided radiotherapy or radiosurgery treatments using fewer monitor units, which translates to less total body irradiation during treatment. (varian.com)
  • Becker, S. J. , Patel, R. R. & Mackie, T. R. Increased skin dose with the use of a custom mattress for prone breast radiotherapy. (umaryland.edu)
  • Background: Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to high-dose radiation have not been fully characterized. (ewha.ac.kr)
  • Besides the 3-dimensional conformal radiation therapy (3D CRT), they regularly perform all the most modern radiotherapy techniques: intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and stereotactic techniques like stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). (onko-i.si)
  • Clinical departments of the Division of Radiotherapy provide hospital care to patients that require care during or after treatment (poor general state, additional diagnostic examinations, and treatment of radiation therapy side effects). (onko-i.si)
  • In recent years, with significant advances in conventional radiotherapy, it has possible to reduce the dose to healthy tissue. (irnitc.ir)
  • During the first year of the program, residents generally rotate through the radiation oncology services at the parent institution, Yale-New Haven Hospital. (yale.edu)
  • Hence, trainees are exposed to all clinical subspecialties of radiation oncology. (yale.edu)
  • The Yale-New Haven Hospital radiation oncology training program provides residents with all of the training necessary to meet the requirements for successful completion of the training program, and eligibility for the American Board of Radiology (ABR) examination. (yale.edu)
  • Lawrence and Memorial Cancer Center in Waterford (approximately 50 minutes from Yale) provides experience in general radiation oncology in a community hospital setting. (yale.edu)
  • This experience provides all residents with a broad base of clinical experience in radiation oncology. (yale.edu)
  • Lawrence and Memorial Cancer Center is directed and staffed by Yale University radiation oncology faculty who rotate between this center and Yale-New Haven Hospital. (yale.edu)
  • Dr. Becker joined us, in 2014, from the NYU Langone Medical Center where he was a physicist in the Department of Radiation Oncology and scholar at the NYU Institute for Innovations in Medical Education. (umaryland.edu)
  • Departments of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. (aacrjournals.org)
  • Gamma (γ)-rays are highly penetrating electromagnetic ionizing radiation that have been extensively applied in diagnostic radiography, radiation oncology, and military weapons [ 1 ]. (biomedcentral.com)
  • Technical Innovations and Patient Support in Radiation Oncology. (lu.se)
  • Clinical and Translational Radiation Oncology. (lu.se)
  • Physics and imaging in radiation oncology. (lu.se)
  • Years later the effects of nuclear fallout from Fukushima will have diverse effects on the population and animals following a series of low dose exposures. (beforeitsnews.com)
  • Weighted quantile sum (WQS) regression was applied to evaluate the dose-effect relationship between urinary lead, cadmium, and arsenic exposures and blood pressure and the effect weight of each metal on blood pressure. (bvsalud.org)
  • The human body can be irradiat- 1.602 × 10-19 J). The ionization and cal human exposures. (who.int)
  • The effects of radiation are radiation have concentrated on low- -particle with an energy of 2 MeV directly related to the dose received has an LET of about 180 keV/m. dose exposures, typical y of 0.1 Gy by individual cel s or organs, and All types of ionizing radiation in- (= 0.1 J/kg) and below. (who.int)
  • Radiation therapy uses ionizing radiation to kill cancer cells. (lls.org)
  • Radiation therapy can also affect fertility for both men and women. (lls.org)
  • Since 1984, PSI has operated (initially as SIN) the centre for Proton Therapy for treating patients with eye melanomas and other tumours located deep inside the body. (wikipedia.org)
  • The likelihood that radiation therapy will cause nausea and vomiting depends mostly on the area of the body being treated and the dose of radiation. (cancer.ca)
  • Most hospitals in the US maintain some supply of radiation exposure treatment drugs like Leukine, which is a prescription medication and is given by medical professionals to patients, said Dr. Nelson Chao, professor of medicine and immunology and chief of the division of cellular therapy and bone marrow transplant at Duke University. (localnews8.com)
  • High-dose stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) kill tumor cells not only through directly damaging DNA but also by causing vascular damage and increasing tumor hypoxia, thereby inducing indirect/secondary tumor cell death. (aapm.org)
  • Drugs that travel through the body are more likely to cause nausea and vomiting than treatment that only affects one area of the body, such as radiation therapy. (cancer.org)
  • Evaluate neuropsychologic outcome upon completion of protocol therapy in patients who have reached the ages of 3 and 7 years, with special attention to the outcome in infants who received total-body irradiation. (knowcancer.com)
  • Throughout the first year of training, the resident performs new patient consultations, gathers experience in the technical aspects of radiation therapy, and subsequently follows patients through the treatment course and post-treatment follow-up under the close supervision of the attending physician. (yale.edu)
  • You will be admitted to the hospital on the day your high-dose preparative therapy begins. (ucsfhealth.org)
  • This radiation therapy is intended to destroy remaining cancer cells and further suppress the immune system. (ucsfhealth.org)
  • After, patients remain on radiation isolation for several days before receiving fludarabine conditioning therapy (30 mg/m 2 /day for 3 days) and finally low-dose total body irradiation (200 cGy) prior to HCT. (onclive.com)
  • The reduction in treatment time is a benefit to image-guided radiation therapy (IGRT) and consequently to SBRT," the researchers assert. (varian.com)
  • Khvostunov IK, Saenko VA, Krylov V, Rodichev A, Yamashita S. Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer . (hhs.gov)
  • Tell us what would your next step be if a senior member of your team disagreed with your judgment on a patient's radiation therapy? (globalguideline.com)
  • Together with the maintenance staff of these machines, medical physicians perform calibrations of radiation therapy machines and implement the quality assurance programme for the whole division. (onko-i.si)
  • The department plays a vital role in the introduction of new radiation therapy techniques and the acquisition and calibration of new radiation therapy machines. (onko-i.si)
  • IO is the only hospital in Slovenia that performs all radiation therapy procedures, regardless of their complexity, in adult and paediatric cancer patients alike. (onko-i.si)
  • For some years now, the Department of Brachyradiotherapy has been known as Varian's reference centre for teaching the newest brachytherapy techniques, known for its pioneering work in the field of building and applying individual applicators for the radiation therapy of gynaecological tumours. (onko-i.si)
  • In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation have been shown to inhibit bone formation and increase the risk of fractures. (biomedcentral.com)
  • In conventional radiation therapy, photon beam is typically used for treatment. (irnitc.ir)
  • The group consists of research expertise across medical imaging, nuclear medicine and radiation therapy - all playing specific roles in diagnosis, staging, treatment and follow-up of cancers. (edu.au)
  • Radiation therapy is used in treatment of approximately 50% of cancer patients and contributes towards 40% of cancer cures. (edu.au)
  • investigation of the role and behaviour of clonogenic cancer stem cells during fractionated radiation therapy. (edu.au)
  • as the novel state-of-the-art radiation therapy beam modality currently being developed in Adelaide and in Australia. (edu.au)
  • In collaboration with the Future Industries Institute, we're also looking at the implementation and use of metallic nanoparticles (such as gold) as radio-sensitisers in radiation therapy for cancer, with the aim to maximise the damage to cancer cells while protecting healthy tissues. (edu.au)
  • Because radiation is most harmful to quickly growing cells, radiation therapy damages cancer cells more easily than normal cells. (medlineplus.gov)
  • Brachytherapy delivers radiation therapy directly to where cancer cells inside the breast are located. (medlineplus.gov)
  • It does not treat the entire breast, which is why it is called "partial breast" radiation therapy or partial breast brachytherapy. (medlineplus.gov)
  • High-dose rate therapy (HDR brachytherapy) is provided as an outpatient using the remote machine, again usually over 5 or so days. (medlineplus.gov)
  • Intraoperative radiation therapy is delivered in the operating room while you are asleep after breast tissue is removed. (medlineplus.gov)
  • The radiation therapy is given after lumpectomy (also called) a partial mastectomy. (medlineplus.gov)
  • This approach is called adjuvant (additional) radiation therapy because it is adding a treatment beyond surgery. (medlineplus.gov)
  • Because these techniques are not as well studied as whole-breast radiation therapy, there is not full agreement about who is most likely to benefit. (medlineplus.gov)
  • While low radiation doses mostly seem to enhance immune cell infiltration into tumors, higher doses do induce immunogenic cancer cell death, and create an immune stimulatory micro-environment for the attracted immune cells. (frontiersin.org)
  • Higher doses of radiation are more likely to cause nausea or vomiting. (cancer.ca)
  • although other agencies and researchers sometimes include up to 5 fold higher doses under the same title. (cdc.gov)
  • For more information, see CDC's fact sheet "Acute Radiation Syndrome" at emergency.cdc.gov/radiation/ars.htm . (cdc.gov)
  • The adaptive response is effective for chromosome induction, acute death, and tumorigenesis induced by high doses of radiation. (go.jp)
  • The company said it is helping to ramp up supply in Europe of Leukine, a drug to treat acute radiation syndrome (ARS), or radiation sickness from exposure to high dose radiation during a nuclear emergency. (localnews8.com)
  • Leukine isn't the only drug to treat acute radiation exposure in the United States. (localnews8.com)
  • Amgen did not respond to requests for comment about whether the company is increasing supplies of its acute radiation exposure treatment drugs. (localnews8.com)
  • But Leukine (whose generic name is sargramostim) is not currently approved for use in Europe to treat acute radiation syndrome. (localnews8.com)
  • Hopefully that would be within 24 hours," said Chao who is also a member of the Radiation Injury Treatment Network, a national network of medical centers with expertise managing acute radiation syndrome following a mass casualty disaster involving radiological, nuclear, or chemical agents. (localnews8.com)
  • The FDA's Orphan Drug Designation is aimed at advancing treatments for rare diseases, including Acute Radiation Syndrome (ARS), which currently has limited treatment options. (nwahomepage.com)
  • ROCKVILLE, Md , Nov. 20, 2023 /PRNewswire/ -- NeoImmuneTech, Inc. (NIT or "NeoImmuneTech"), a clinical-stage T cell-focused biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for their investigational drug NT-I7 (efineptakin alfa) (rhIL-7-hyFc) for the treatment of Acute Radiation Syndrome (ARS). (nwahomepage.com)
  • Acute Radiation Syndrome (ARS) is an acute illness caused by irradiation of the entire body by a high dose of penetrating radiation in a very short period of time (typically a matter of minutes or less). (nwahomepage.com)
  • Gamma or photon radiation exposure from a terrorist nuclear event or radiation dispersal device would make the victim at risk for Acute Radiation Syndrome, depending on the dose received. (globalguideline.com)
  • Acute radiation syndrome (ARS) is an illness in humans involving multiple organ systems caused by total- or partial-body exposure to radiation of greater than 2 Gy at a high dose rate. (biomedcentral.com)
  • Amgen has a target action date of January 28 for its Nplate for Hematopoietic Syndrome of Acute Radiation Syndrome (H-ARS). (pharmalive.com)
  • Ciliary body melanomas can push the iris diaphragm anteriorly, or they can infiltrate the trabecular meshwork, producing acute angle closure. (medscape.com)
  • These results strongly indicate that radiation-induced vascular damage plays an important role in the response of tumors to SBRT and SRS. (aapm.org)
  • This study was designed to identify molecular changes induced by focal high-dose irradiation using a mouse model of SBRT. (ewha.ac.kr)
  • an exposure to radiation that occurred in a matter of minutes rather than in longer, continuing exposure over a period of time. (cdc.gov)
  • Exposure to radiation, radon gas, or air pollution also puts you at risk. (healthwise.net)
  • While exposure to radiation can be lifesaving in certain settings, it can also potentially result in long-lasting adverse effects, particularly to hematopoietic and immune cells. (cdc.gov)
  • The large amounts of tumor antigens and various immune factors released as a result of the direct tumor cell death and indirect tumor cell death because of vascular dysfunction after high-dose irradiation elevate anticancer immunity. (aapm.org)
  • In the vast majority of cases, RapidArc treatments for prostate cancer result in equal or better tumor coverage with less dose to the bladder and rectum, compared to conventional fixed-field IMRT, according to a research team from the Finsen Centre * in Copenhagen, Denmark. (varian.com)
  • The team observed that tumor coverage is comparable between the two approaches, however, RapidArc reduces treatment duration and the amount of dose going to normal tissues throughout the body. (varian.com)
  • Background Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor's response to immunotherapy, when combined with high-dose radiation to another tumor. (bmj.com)
  • We investigated the ability of docetaxel to enhance in vivo tumor radioresponse and influence radiation injury to normal tissue. (aacrjournals.org)
  • Mice bearing in their legs 8-mm isotransplants of a murine mammary carcinoma, designated MCA-4, were treated with 33 mg/kg docetaxel i.v., 9-21 Gy single-dose local tumor irradiation, or both (in which case radiation was given 9 or 48 h after docetaxel). (aacrjournals.org)
  • Docetaxel enhanced tumor radioresponse by a factor of 1.45 when the drug was given 9 h before radiation and 2.33 when it was given 48 h before. (aacrjournals.org)
  • Thus, docetaxel given within 2 days before irradiation acted as a potent enhancer of tumor radioresponse and increased the therapeutic gain of irradiation. (aacrjournals.org)
  • As a result, a limited amount of the dose is delivered to healthy tissue and some to the tumor / cancerous tissue. (irnitc.ir)
  • Ciliary body melanoma is a rare tumor. (medscape.com)
  • Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)
  • They can be classified as anterior uveal melanomas when the tumor arises in the iris and as posterior uveal melanomas when it arises in either the choroid or the ciliary body. (medscape.com)
  • Wong best defines it, in 1997 as a slow-healing radiation-induced ischemic necrosis of variable extent occurring in the absence of local primary tumor necrosis, recurrence, or metastatic disease 2 . (bvsalud.org)
  • Five individuals received significant overdoses of radiation from the 200-gigabecquerel cobalt-60 capsule, four of whom died. (wikipedia.org)
  • In this study, nonhuman primates were exposed to either 12.0 Gy cobalt-60 gamma (total-body irradiation, TBI) or X-ray (partial-body irradiation, PBI) 24 h after administration of a potential radiation medical countermeasure, gamma-tocotrienol (GT3). (biomedcentral.com)
  • This study investigated hematopoietic recovery and immune function in rhesus macaques Cross-sectionally (at a single time point) 2 to 5 years after exposure to a single large dose (6.5 to 8.4 Gray) of total body radiation (TBI) derived from linear accelerator-derived photons (2 MeV, 80 cGy/minute) or Cobalt 60-derived gamma irradiation (60 cGy/min). (cdc.gov)
  • For example, comment on the shape of the dose- traversing, producing chemical and cobalt-60 -rays have an LET of response curve and the associated biological damage. (who.int)
  • Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
  • Sixteen evaluable patients with advanced hematologic malignancies were treated with twice daily TBI using a high-energy source (18-24 MV). The first patient cohort ( n = 11) received a total dose of 14.4 Gy in nine fractions, and the second cohort ( n = 5) received doses escalated to 15.3 Gy. (nature.com)
  • Total body irradiation for individuals undergoing a hematopoietic stem cell transplant can cause ovary or testes failure, leading to fertility issues. (lls.org)
  • Radiation to the whole body ( total body irradiation ) has a higher chance of causing nausea and vomiting. (cancer.ca)
  • Total-body irradiation (TBI) with 0.02-0.25 Gy has been reported to have antitumor effects. (go.jp)
  • Pediatric patients would benefit from shortened treatment times, potentially reducing the use of anesthesia," they concluded, adding that the decreased total body irradiation could also potentially reduce the number of late effects, including the risk of secondary malignancies later in life. (varian.com)
  • Twenty-six (of 155) patients received low-dose radiation (1-20 Gy total), either as scatter from high-dose radiation or from intentional treatment of a second isocenter with low-dose radiation, were evaluated for response. (bmj.com)
  • Results The 26 patients had a total of 83 lesions for comparison (38 receiving low-dose, 45 receiving no-dose). (bmj.com)
  • Poirier Y, Becker SJ , Decesaris C, Gerry AJ, Culberson W, Draeger E, Johnstone C, Vujaskovic Z, Jackson The Impact of Radiation Energy on Dose Homogeneity and Organ Dose as a Function of Animal Size in the Gottingen Minipig Total Body Irradiation Model. (umaryland.edu)
  • They also regularly use the total body irradiation (TBI) technique. (onko-i.si)
  • Also worth pointing out is the total body irradiation translation technique using a linear accelerator, designed by local professionals. (onko-i.si)
  • To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)
  • It even appears that in many cases effects on the same cellular function vary with changes of total dose and dose delivery rate, while they also depend on genetic makeup of the organism as well (e.g. (cdc.gov)
  • Photons are beams of electromagnetic radiation (just like visible light or radio waves but with much more energy). (irnitc.ir)
  • Energy can travel through space in the form of electromagnetic radiation. (medscape.com)
  • Electromagnetic radiation is composed of massless waves of oscillating electric and magnetic fields. (medscape.com)
  • All patients received high-dose etoposide (60 mg/kg) and allogeneic stem cell transplantation following the TBI. (nature.com)
  • But the injectable medication can also be administered as a life-saving measure for patients exposed to dangerous levels of radiation outside of medical treatment: The drug can increase the chances of survivability if given in the critical 48 to 96 hours after initial exposure to a high dose of radiation from a nuclear blast or nuclear fallout. (localnews8.com)
  • The treatment dose is higher compared to patients who are not undergoing a cord blood transplant. (pregnancy-info.net)
  • Investigators sought to prove with this study that targeted radiation to the marrow with apamistamab, a radioactive iodine ( 131 I)-labeled anti-CD45 antibody, could enable the successful engraftment of patients despite active disease in the marrow. (onclive.com)
  • Patients in the investigational arm received a dosimetric dose of apamistamab (≤ 20 mCi) approximately 19 days prior to HCT followed by a therapeutic dose of apamistamab, which is individually calculated for each patient based on an upper limit of 24 Gy to the liver. (onclive.com)
  • The RapidArc treatments also use much fewer monitor units-a two to three-fold decrease-which means that less scattered, non-therapeutic radiation is delivered during these treatments, which took, on average, 1.25 minutes to deliver once patients were positioned for treatment. (varian.com)
  • Patients receiving high doses of radiation can't produce enough new white blood cells, red blood cells, and platelets, which is called myelosuppression. (pharmalive.com)
  • Patients who die from ciliary body melanoma die because of distant metastasis rather than local spread. (medscape.com)
  • In the SIERRA trial, patient-specific dosimetry was used to generate an individualized therapeutic dose to target marrow and spare non-hematopoietic organs. (onclive.com)
  • Radiation induced damage to the normal tissues can be partially reduced by the use of radioprotectors that reduce the damaging effects of radiation, including radiation-induced lethality (4,22,38). (tfljournal.org)
  • Radiation Exposure and Contamination Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (merckmanuals.com)
  • Given its high calcium content, bone tissue is sensitive to ionizing radiation and absorbs nearly 40% more radiation than the surrounding tissues [ 2 ]. (biomedcentral.com)
  • Depending on the sensitivity of healthy tissues and the amount of irradiation, sides effects may occur. (irnitc.ir)
  • reports of the National Research Council's committee on the Biological Effects of Ionizing Radiation. (cdc.gov)
  • This will allow the investigator to take a probabilistic approach to analysis of cytogenetic data, which can be considered highly appropriate for biological dose estimation. (bioone.org)
  • A wide range of biological changes may follow the irradiation of animals. (beforeitsnews.com)
  • Riecke A, Ruf CG, Meineke V. Assessment of radiation damage-the need for a multiparametric and integrative approach with the help of both clinical and biological dosimetry . (hhs.gov)
  • Gray can be used for any type of radiation (e.g., alpha, beta, neutron, gamma), but it does not describe the biological effects of different radiations. (globalguideline.com)
  • The development of advanced molecular biodosimetry methods, those that measure biological response, such as transcriptomics, to screen large populations of radiation-exposed victims is key to improving survival outcomes during radiological mass casualty scenarios. (biomedcentral.com)
  • Our group is renowned for world-class radio-biological modelling of radiation interactions with cells and cancers to predict biological outcomes post irradiation. (edu.au)
  • A logical approach to remedy the situation for low dose research was to conduct well controlled animal studies with hundreds of animals, nevertheless, even after many such studies were completed our understanding of biological basis for risk from low dose radiation exposure is still not conclusive. (cdc.gov)
  • The efficiency sential y uniform after whole-body izing (i.e. removing electrons from) in causing damage and subsequent exposure to being highly heteroge- atoms or molecules of the medium biological effects is related not only neous in the case of non-uniform to the amount of energy transferred being traversed. (who.int)
  • 1993. Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage. (cdc.gov)
  • It is possible to almost completely eliminate a number of different pathogens from food by treating that food with exposure to electron or gamma radiation. (atomicinsights.com)
  • Therefore, they must have been continually exposed to alpha and beta particles as well as to the intense penetrating gamma radiation emitted by radium and its daughter products, including radon. (cdc.gov)
  • A priming X-ray exposure to 0.05-0.10 Gy or 0.3-0.5 Gy imparts radioresistance (decrease in bone marrow death rate after high-dose X-rays) in mice 2-2.5 months or 9-17 days postexposure, respectively. (go.jp)
  • ARS is an illness that occurs following a high dose of radiation exposure, leading to severe damage to the bone marrow and the immune system. (nwahomepage.com)
  • Differential pathway activation was also identified across PBI and TBI, pointing towards altered molecular response for different degrees of bone marrow sparing and radiation doses. (biomedcentral.com)
  • Myelosuppression happens when radiation damages internal organs, including bone marrow. (pharmalive.com)
  • The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. (biomedcentral.com)
  • This study suggested that melatonin could protect CBSCs against γ-ray radiation and assist in the healing of postradiation bone defects. (biomedcentral.com)
  • Ionizing radiation has been reported to be closely associated with bone metabolism. (biomedcentral.com)
  • However, the mechanisms of radiation-induced bone loss at the cellular level are yet to be fully elucidated. (biomedcentral.com)
  • 1998. Food preservation using ionizing radiation. (cdc.gov)
  • Those who reported the study of worker exposure endeavored to ascertain the doses being received (or not received) by all categories of personnel involved in essentially every activity involving ionizing radiation within the Clinic and the hospital. (ratical.org)
  • the amount of energy deposited by ionizing radiation in a unit mass of tissue. (cdc.gov)
  • ionizing radiation from natural sources, such as terrestrial radiation due to radionuclides in the soil or cosmic radiation originating in outer space. (cdc.gov)
  • The ATM-dependent DNA damage checkpoint plays a pivotal role in cellular response to ionizing radiation. (bioone.org)
  • The concept was extended and applied to ionizing radiation, high doses of which are harmful. (go.jp)
  • Radiation hormesis and adaptive response provide a new scope in the risk assessment and medical application of ionizing radiation. (go.jp)
  • Air kerma the initial kinetic energy of the primary ionizing particles (photoelectrons, Compton electrons, positron/negatron pairs from photon radiation, and scattered nuclei from fast neutrons) produced by the interaction of the incident uncharged radiation in a small volume of air, when it is irradiated by an x-ray beam. (globalguideline.com)
  • The risk of exposure of the general public or military personnel to high levels of ionizing radiation from nuclear weapons or radiological accidents is a dire national security matter. (biomedcentral.com)
  • Ionizing radiation can also be in the form of particulate radiation, which includes subatomic l charged or neutral particles traveling near the speed of light and therefore with high very high kinetic energy. (medscape.com)
  • The generality of induction of Two major issues faced when city in humans is clear, but in other and response to radiation damage studying radiation carcinogenesis is cases the data are few or non-exist- is discussed for all types of ionizing that radiation-induced cancers are ent. (who.int)
  • Many of the ed either from external sources or excitation events are much closer in vitro and in vivo studies investi- through internal exposure as a re- together for low-energy charged par- gating the mechanisms underlying sult of ingestion, inhalation, dermal ticles, which are considered to be cancer risk from exposure to ionizing absorption, or injection of radionu- high-LET radiation. (who.int)
  • The nature of ionizing these effects can vary significant- fects, including DNA damage, chro- radiation ly, depending on the resulting dose mosomal aberrations, mutations, cell distribution or distribution of radionu- transformation, and cell killing (NRC, Ionizing radiation is a term used for clides throughout the body. (who.int)
  • Ionizing radia- distribution of internal radionuclides per unit mass (the absorbed dose, tions are usual y classified as either that emit short-range -particles or expressed in units of gray, where electro magnetic or particulate. (who.int)
  • But mice pretreated at this priming dose did not show a marked recovery of peripheral blood cell counts after challenging irradiation with mid- or sublethal X-ray doses (a significant, albeit slight, increase in the blood cell counts in the preirradiated group was observed after a lower challenging exposure to 5.0 Gy). (go.jp)
  • Mice deficient in apoE ( Apoe −/− ) can be used to assess the potential role of apoE in the effects of cranial irradiation on hippocampal function. (bioone.org)
  • Radiation-induced impairments in hippocampal function may be more pronounced in female Apoe −/− mice and more pronounced in mice irradiated and tested cognitively later in life. (bioone.org)
  • Treatment of mice with rosemary extract prior to irradiation is reported herein to prolong life and reduce the symptoms of radiation sickness. (tfljournal.org)
  • The present investigation reports the radiomodulatory effect of Rosmarinus officinalis (rosemary) leaf extract against radiation-induced hematological alterations in Swiss albino mice at various post-autopsy intervals (i.e., between 24 hours to day 30). (tfljournal.org)
  • the mice were treated with 33 mg/kg docetaxel i.v. 3, 9, or 48 h before irradiation. (aacrjournals.org)
  • United Nations Scientific Committee on the Effects of Atomic Radiation. (wikipedia.org)
  • 1986. Carcinogenic effects of radiation on the human skin. (cdc.gov)
  • Nevertheless, these features might impact both, toxic effects of radiation and a better T cell-mediated treatment response. (frontiersin.org)
  • No consistent interactive effects were seen at lower temperatures or longer durations of RF irradiation at Tc 41 degrees. (cdc.gov)
  • There may be tremendous practical value to understanding how to neutralize or reduce the damaging (and lethal) effects of radiation on the human body. (tfljournal.org)
  • In light of the various nuclear power plant accident, military and terrorism scenarios that have entered the world consciousness over the past two generations, there is tremendous practical value to understanding how to neutralize or reduce the damaging (and lethal) effects of radiation on the body. (tfljournal.org)
  • Research on the use of plant extracts to protect against radiation exposure is not widely known, however the low toxicity and minimal side effects of many plant products are well known in both western science and traditional medicine. (tfljournal.org)
  • Recently, interest has generated in developing the potential drugs of plant origin for the amelioration of radiation effects. (tfljournal.org)
  • Plants and their products are well known to have an advantage over the synthetic compounds in terms of their potential low/no toxicity at the effective dose with minimum or no side effects (3,9,33,34,41). (tfljournal.org)
  • For example, if doses of a chemo drug that causes nausea and vomiting are given close together, there's less time for the person to recover from the effects of the last dose before the next one is given. (cancer.org)
  • However, mixed metal exposure often exists in the actual working environment, and the interactive effects of polymetallic interactions on blood pressure and the dose-effect relationship remain unclear yet. (bvsalud.org)
  • Investigation of health effects of low doses of radiation as a field of study has been riddled by difficulties since its inception. (cdc.gov)
  • and use it to develop models of radiation effects that would be based on concrete facts. (cdc.gov)
  • radiation has many effects on an organism as a whole –some of them pro-cancer, some anti-cancer. (cdc.gov)
  • Effects of prior radiation on production and export of new T cells by the thymus was dependent on age at the time of analysis, with evidence of interaction with radiation dose for CD8+ T cells. (cdc.gov)
  • Thus, any resulting health effects cannot be attributed to a specific cause but were probably the consequence of a combination of all the radiation insults to that individual. (cdc.gov)
  • The goal is to limit side effects of radiation to a smaller volume of normal tissue. (medlineplus.gov)
  • High-dose radiation to the spleen can increase the risk of developing repeated bacterial infections. (lls.org)
  • Conclusions Low-dose radiation may increase systemic response rates of metastatic disease treated with high-dose radiation and immunotherapy. (bmj.com)
  • Conclusions: Focal exposure of lung tissue to high-dose radiation induced expression of genes associated with organ development and the immune response. (ewha.ac.kr)
  • While still in the hospital, the patient's body temperature will be taken four times a day, as fever is an indicator of infection. (pregnancy-info.net)
  • As photon penetrates the patient's body, the emitted dose by the photon beam gradually decreases. (irnitc.ir)
  • In: Radiation carcinogenesis. (cdc.gov)
  • Radiation, carcinogenesis and DNA alterations. (cdc.gov)
  • Very few studies are conducted to bridge this gap and consider how a realistic model of DNA damage could be integrated into a realistic model of radiation carcinogenesis. (cdc.gov)
  • Women under age 30 who had radiation to the breast area are at risk for developing breast cancer 15 to 20 years after treatment. (lls.org)
  • Breast irradiation in women with early stage invasive breast cancer following breast conservation surgery. (mcmaster.ca)
  • This reflects the complexity and diversity of mechanisms of radiation-induced immune modulation. (frontiersin.org)
  • This standard presents data recommended for computing the biologically relevant dosimetric quantity in photon and neutron radiation fields. (ansi.org)
  • Therefore, they do not damage living tissue when outside the body. (cdc.gov)
  • As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body. (frontiersin.org)
  • A team from the Brown Cancer Center at the University of Louisville reported that a two-arc RapidArc plan offers the same level of dose homogeneity and tissue sparing as fixed-field IMRT. (varian.com)
  • The new international system (SI) unit of radiation dose, expressed as absorbed energy per unit mass of tissue. (globalguideline.com)
  • This pattern of gene expression was also observed in non-irradiated neighboring areas of lung tissue, indicating a global lung response to focal high-dose irradiation. (ewha.ac.kr)
  • However, minimize the dose to healthy tissue especially organ at risk has always been the goal of researchers in this field. (irnitc.ir)
  • We conclude that TBI dose escalation above the previously used 13.5 Gy dose is feasible using a high-energy source and high-dose etoposide. (nature.com)
  • Interactions of radiofrequency radiation-induced hyperthermia and 2-methoxyethanol teratogenicity in rats. (cdc.gov)
  • Furthermore, the UV-radiation sensitivity phenotype of lsm1 Δ is partially rescued by mutations in genes involved in 3′ to 5′ mRNA degradation, and mutations predicted to function in RNA interactions confer the most UV-radiation sensitivity. (bioone.org)
  • International Journal of Radiation Biology, 1998, vol. 73, no. 4, p.437 Online: http://www.reocities.com/CapeCanaveral/Hangar/8929/Seminars/2009_05_RadiationAccidents.pdf Archived 2014-10-06 at the Wayback Machine Andrews, Gould A. (1964). (wikipedia.org)
  • It is evident that a linear-quadratic formula has no place in describing DNA damage caused by low dose radiation, but it is less clear that we should try to develop formulas rooted in molecular and cellular biology instead. (cdc.gov)
  • This agent is being developed as a radiation MCM for H-ARS following the US FDA Animal Rule since the efficacy of such agents cannot be investigated in a clinical setting under phase II and phase III due to ethical reasons [ 14 ]. (biomedcentral.com)
  • In an emergency situation, such as a nuclear attack, he said first responders would quickly administer the drug to as many people as possible who've encountered extreme radiation exposure. (localnews8.com)
  • While researching answers to comments made on the Atomic Insights post titled Healthy doses of radiation, I found a book titled Nuclear Shadowboxing: Legacies and Challenges. (atomicinsights.com)
  • The medical radiations group is involved in the investigation and translation of various imaging modalities for the diagnosis of various cancers, and of novel radiation modalities to treat cancers. (edu.au)
  • non-radiation-induced cancers. (cdc.gov)
  • [5] Another team from the University of Virginia found that the treatment of peripheral lung lesions using RapidArc is dosimetrically equivalent to fixed-gantry IMRT, however, "low dose spillage trended toward improvement, which may reduce the incidence of symptomatic radiation-induced pneumonitis. (varian.com)
  • an assessment of radioactive materials that may be present inside a person's body through analysis of the person's blood, urine, feces, or sweat. (cdc.gov)
  • For all types of MCWs, contamination refers to agent present on an epithelial surface (external contamination) or in depots within the body (internal contamination). (merckmanuals.com)
  • Internal contamination most commonly refers only to radioactive particles in the body rather than other MCW agents. (merckmanuals.com)
  • Specifically, this standard is intended for use by radiation shielding designers for the calculation of effective dose. (ansi.org)
  • Fit coefficients are given for evaluating whole-body effective dose per unit fluence for photons with energy 10 keV to 10 GeV and for neutrons with energy 0.001 eV to 10 GeV. (ansi.org)
  • What is effective dose? (globalguideline.com)
  • Effective dose is a calculated quantity developed by the ICRP (1991) for purposes of radiation protection. (globalguideline.com)
  • The effective dose is assumed to be related to the risk of a radiation-induced cancer or a severe hereditary effect. (globalguideline.com)
  • a serious illness caused by receiving a dose greater than 75 rads of penetrating radiation to the body in a short time (usually minutes). (cdc.gov)
  • While experts suggest this is some type of "mystery illness" affecting our horses, they are not 100% sure of the cause, but Fukushima radiation hasn't even been thrown on the table due to the extent of cover-up from this major disaster. (beforeitsnews.com)
  • Food irradiation can prevent food borne illness caused by microorganisms like eColi. (atomicinsights.com)
  • In general, when the dose is the same, being exposed to ricin by injection has the greatest potential for causing illness, followed by inhalation, and then ingestion. (cdc.gov)
  • Other areas of research include development of new dosimetry and microdosimetry detectors to measure radiation dose at a cellular level. (edu.au)
  • show that exposing cells of the adaptive immune system, namely T cells, to radiation even results in their Ca2 + -dependent activation. (frontiersin.org)
  • A high intensity preparatory regimen also enables the suppression of the immune system, which is important since it prevents the body from attacking the transplanted cells. (pregnancy-info.net)
  • Although the number was small, genes that were up-regulated after focal irradiation were associated with immune-related functions. (ewha.ac.kr)
  • Taken together, these data show that dose-related changes in peripheral blood cells and immune responses to both novel and recall antigens can be detected 2 to 5 years after exposure to whole body radiation. (cdc.gov)
  • Longer term follow-up data on this cohort and independent validation will be helpful to determine whether these changes persist or whether additional changes become evident with increasing time since radiation, particularly as animals begin to develop aging-related changes in immune function. (cdc.gov)
  • We can presume that the measure being obtained is that of whole-body radiation, and that hence the breasts would have received some radiation from anterior, lateral, and posterior entry of x-rays. (ratical.org)
  • As a reference point, we can note that the so-called maximum permissible dose for exposure of the whole body to x, gamma, and beta radiation was 0.3 R per week, as recommended by the International Commission on Radiological Protection. (ratical.org)
  • One hour and 17 minutes following a 4.3 mCi (158 MBq) intravenous (IV) injection of 68 Ga DOTATATE, the patient underwent a 10-minute, single-bed, whole-body PET/CT acquisition on a Biograph Vision Quadra ™ scanner. (siemens-healthineers.com)
  • Whole-body PET MIP images show extensive metastases throughout the body ranging from the vertex to the thighs, including multiple metastases in the thorax, liver, intestines, spine, pelvis, and bilateral femur. (siemens-healthineers.com)
  • Eventually this is harmful to the whole body, and may cause death. (cdc.gov)
  • Partial breast irradiation only treats some but not all of the breast, focusing on the area where the cancer is most likely to return, usually around the surgical cavity. (medlineplus.gov)
  • We studied the feasibility and toxicity of escalating the doses of fractionated TBI above our previous prescription of 13.5 Gy. (nature.com)
  • The authors conclude that RF radiation can interact with 2ME to enhance 2ME developmental toxicity at a relatively low dose in rats. (cdc.gov)
  • Dr. Jerry Cuttler provided a copy of an open letter signed by 23 members or affiliate members of SARI - Scientists for Accurate Radiation Information that describes important information about the use of a specific regimen of whole (or half) body low dose radiation as a treatment in the continuing battle against cancer. (atomicinsights.com)
  • A few people get lung cancer after being exposed to other harmful substances, including asbestos , radioactive dust, radon , or radiation such as X-rays. (healthwise.net)
  • Cancer cells multiply faster than normal cells in the body. (medlineplus.gov)