Dose of oral rarely first dose may cause idiosyncratic reactions. Medical search. Frequent questions

Patients may down-titrate to lower doses based on tolerability. (medicines.org.uk)
Three-times-a-day dosing may improve tolerability. (pocketdrugguide.com)
Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)

Warfarin therapy is associated with rare instances of idiosyncratic, clinically apparent liver injury that are usually mild and rapidly reversible on stopping. (nih.gov)
Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)

Doses between 2 and 20 mg/day should be administered either as a single dose or in divided doses. (pillintrip.com)
The usual starting dose of AVANDIA is 4 mg administered either as a single dose once daily or in divided doses twice daily. (healthyplace.com)
On the other hand, for some carcinogens, it has been experimentally shown that the fractionation of a single dose into several exposures with the same total dose may be more effective in producing tumours. (iloencyclopaedia.org)

Although most drugs causing parkinsonism do so in a dose-related manner, there is an enormous variation in individual susceptibility, so even very small doses may cause parkinsonism. (medlink.com)
This means that no threshold exists and that even small doses represent a risk. (iloencyclopaedia.org)

Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process. (wikipedia.org)
If toxicity develops before seizures are controlled, the dose is reduced to the pretoxicity dose. (msdmanuals.com)
PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. (hindawi.com)
Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
Toxicity rating is an arbitrary grading of doses or exposure levels causing toxic effects. (iloencyclopaedia.org)

Idiosyncratic cutaneous atrophy of the long-acting injectable form, has increased. (myjuicecup.com)
Medroxyprogesterone, as injectable contraceptive or oral hormone replacement therapy (HRT), may elevate serum retinol levels, possibly RBP. (interactionsguide.com)

Aspirin is rapidly absorbed and almost totally hydrolyzed to salicylic acid following oral administration. (themeditary.com)

The herb kava has caused a number of cases of idiosyncratic liver injury, ranging everywhere from asymptomatic to fatal. (wikipedia.org)
The risk of liver injury is influenced by several factors including the dose ingested, concurrent alcohol or other drug intake, interval between ingestion and antidote, etc. (wikipedia.org)

Although individual analgesics rarely induce liver damage due to their widespread use, NSAIDs have emerged as a major group of drugs exhibiting hepatotoxicity. (wikipedia.org)
In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications). (medscape.com)
If the patient is receiving valproate at the time of initiation, starting doses and doses during titration should be cut in half, whereas if they are receiving enzyme-inducing anti-epileptic drugs such as phenytoin, carbamazepine or phenobarbital, doses can be doubled. (pocketdrugguide.com)
To determine the initial dose, consideration should be given to the patient's age, severity of symptoms and previous response to other neuroleptic drugs. (pillintrip.com)
Patients who are elderly or debilitated or those with previously reported adverse reactions to neuroleptic drugs may require less Haloperidol-Richter solution and half the normal starting dose may be sufficient for therapeutic response. (pillintrip.com)
These disadvantages still exist, but the activity of chloramphenicol against bacteria (e.g., staphylococci) that are resistant to other oral drugs has created increased use of chloramphenicol in recent years. (veteriankey.com)

Dose titration has to be performed cautiously to ensure that high doses are not poorly tolerated through overly rapid up-titration. (medicines.org.uk)
The aim of dose titration is to block activity of vasopressin at the renal V2 receptor as completely and constantly as possible, while maintaining acceptable fluid balance (see section 4.4). (medicines.org.uk)

In refractory patients, doses may be as high as 500-1000 mg/day. (pocketdrugguide.com)

Promethazine with Codeine Oral Solution contains codeine, Schedule controlled substance. (drugcentral.org)
Reserve Promethazine with Codeine Oral Solution for use in adult patients for whom the benefits of cough suppression are expected to outweigh the risks, and in whom an adequate assessment of the etiology of the cough has been made. (drugcentral.org)
Assess each patients risk prior to prescribing Promethazine with Codeine Oral Solution, prescribe Promethazine with Codeine Oral Solution for the shortest duration that is consistent with individual patient treatment goals, monitor all patients regularly for the development of addiction or abuse, and refill only after reevaluation of the need for continued treatment. (drugcentral.org)
Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Promethazine with Codeine Oral Solution. (drugcentral.org)
Consider these risks when prescribing or dispensing Promethazine with Codeine Oral Solution. (drugcentral.org)
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, including codeine, one of the active ingredients in Promethazine with Codeine Oral Solution. (drugcentral.org)
Codeine produces dose-related respiratory depression by directly acting on the brain stem respiratory center that controls respiratory rhythm and may produce irregular and periodic breathing. (drugcentral.org)

For example, if antiseizure medications are stopped prematurely, seizure activity may increase during the pregnancy and eventually expose the fetus to several medications at doses higher than those originally used to control the condition. (medscape.com)
Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. (buyonlinegabapentin.com)

Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, bullous dermatitis and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome have been reported with oral terbinafine use. (nih.gov)
If signs or symptoms of drug reaction occur, treatment with terbinafine tablets should be discontinued. (nih.gov)
WARNINGS - On very rare occasions, the first dose of carisoprodol has been followed by idiosyncratic reactions with symptoms appearing within minutes or hours. (themeditary.com)
Contains sodium metabisulfate, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. (themeditary.com)
After initiation of AVANDIA, and after dose increases, observe patients carefully for signs and symptoms of heart failure (including excessive, rapid weight gain, dyspnea, and/or edema). (healthyplace.com)

Following single doses of 500 mg and 1000 mg, average peak serum concentrations were approximately 16 and 28 mcg/mL, respectively. (nih.gov)
These serotypes are detected based on the agglutination reaction to serum specific to them. (statpearls.com)

Terbinafine tablets are contraindicated in individuals with a history of allergic reaction to oral terbinafine because of the risk of anaphylaxis. (nih.gov)
Drug-induced death of the filaria can result in a severe allergic reaction due to the release of foreign protein. (entokey.com)

These treatments are applied by the oral and maxillofacial apex legends aim lock script in our clinic in accordance with the indications and needs of each individual patient. (xpharma.pt)

Others (eg, lamotrigine , topiramate ) must be started at a relatively low dose and gradually increased over several weeks to the standard therapeutic dose, based on the patient's lean body mass. (msdmanuals.com)
Type A reactions (dose-related)-These reactions are an exaggerated, but otherwise normal pharmacological responses to the effects of the medicines given in therapeutic dose, cause significant morbidity but are rarely severe. (gpatindia.com)

Idiosyncratic (type B) injury occurs without warning, when agents cause non-predictable hepatotoxicity in susceptible individuals, which is not related to dose and has a variable latency period. (wikipedia.org)
Adverse drug reaction (ADR)- The World Health Organization defines an ADR as "any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function. (gpatindia.com)

Clearance of salicylic acid in the high-dose range is sensitive to urinary pH ( see Drug Interactions ) and is reduced by renal dysfunction. (themeditary.com)
The main side-effect experienced by patients while taking megestrol acetate, particularly at high doses, is weight gain, which is usually not associated with water retention, but which is secondary to an increased appetite and food intake. (tajgenerics.com)
Constipation and urinary frequency have also been reported in patients who received high doses of megestrol acetate in clinical trials. (tajgenerics.com)
Conservative practice suggests avoiding retinol administration at high doses unless otherwise indicated. (interactionsguide.com)

Keep these considerations in mind if your doctor prescribes gabapentin oral capsule for you. (buyonlinegabapentin.com)

The use of diethylcarbamazine eye drops for treatment of ocular onchocerciasis produces dose-related inflammatory reactions similar to those seen with systemic use of the drug. (entokey.com)

Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. (theodora.com)

Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. (theodora.com)

The appropriate dose of any drug is the lowest dose that stops all seizures and has the fewest adverse effects, regardless of blood drug level. (msdmanuals.com)
Determine the drug dose using clinical criteria (the lowest dose that stops seizures and has the fewest adverse effects), regardless of blood levels. (msdmanuals.com)

Further increases in the dose of AVANDIA should be accompanied by careful monitoring for adverse events related to fluid retention [see Boxed Warning and WARNINGS and PRECAUTIONS ]. (healthyplace.com)
as dose increases, the response follows an ascending curve that will usually reach a plateau at a 100% response. (iloencyclopaedia.org)

Internationally, data on the incidence of adverse hepatic drug reactions in the general population remains unknown. (medscape.com)
It is not considered to be a first-line drug because of its potential for serious idiosyncratic side-effects, including potentially fatal aplastic anaemia (incidence of 1 in 3000) and hepatic failure (incidence of 1 in 10000). (pocketdrugguide.com)

When AVANDIA is added to existing therapy, the current dose(s) of the agent(s) can be continued upon initiation of therapy with AVANDIA. (healthyplace.com)

The dose toxic to the liver is quite variable from person to person and is often thought to be lower in chronic alcoholics. (wikipedia.org)
Megestrol acetate is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. (tajgenerics.com)
Major toxic ocular effects may occur with long-term oral administration of these amebicidal agents, especially in children. (entokey.com)
This reaction in the eye may be so marked that toxic amblyopia follows. (entokey.com)
The dose-response curve for most toxic effects (when studied in large populations) has a sigmoid shape. (iloencyclopaedia.org)
The target dose is more exactly associated with the toxic effect. (iloencyclopaedia.org)

There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses. (theodora.com)
At the conclusion of today's session the participant will be able to describe the evidence for the association between opioid dose and opioid therapy benefits and harms, compare and contrast immediate release and extended release long acting opioid formulations, identify methods for calculating morphine milligram equivalent doses, list the steps for titrating opioid and specific dose thresholds, and identify best practices for opioid tapering and discontinuation. (cdc.gov)

Patients have to be maintained on the highest tolerable tolvaptan dose. (medicines.org.uk)
Although approved for a dosing period of less than 10 days, patients used it for longer periods. (medscape.com)
Typical doses for patients with newly diagnosed epilepsy are 100-200 mg/day. (pocketdrugguide.com)
ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
14,067 total patients), comparing AVANDIA to some other approved oral antidiabetic agents or placebo, have not confirmed or excluded this risk. (healthyplace.com)
All patients should start AVANDIA at the lowest recommended dose. (healthyplace.com)
For patients who respond inadequately following 8 to 12 weeks of treatment, as determined by reduction in fasting plasma glucose (FPG), the dose may be increased to 8 mg daily as monotherapy or in combination with metformin, sulfonylurea, or sulfonylurea plus metformin. (healthyplace.com)
If patients report hypoglycemia, the dose of the sulfonylurea should be decreased. (healthyplace.com)
Patients with concurrent participation in any clinical study involving a non-approved investigational product or where the dosing of panitumumab was determined by the protocol were excluded. (xpharma.pt)

The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (theodora.com)
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. (theodora.com)

Adverse drug reactions are classified as type A (intrinsic or pharmacological) or type B (idiosyncratic). (wikipedia.org)

The initial dose is 60 mg tolvaptan per day as a split-dose regimen of 45 mg + 15 mg (45 mg taken upon waking and prior the morning meal and 15 mg taken 8 hours later). (medicines.org.uk)
The initial dose is to be titrated upward to a split-dose regimen of 90 mg tolvaptan (60 mg + 30 mg) per day and then to a target split-dose regimen of 120 mg tolvaptan (90 mg + 30 mg) per day, if tolerated, with at least weekly intervals between titrations. (medicines.org.uk)

Side Effect-Any unintended effect of a pharmaceutical product occurring at doses normally used in humans which is related to the pharmacological properties of the medicine. (gpatindia.com)
Type B reactions (non-dose related)-These reactions are bizarre and unpredictable with no relation to dose or pharmacological action of the medicine and are often allergic in nature. (gpatindia.com)

Their success in clearing or inactivating a pathogen will depend on the amount of antibodies produced and on the extent to which those antibodies are effective at countering the strain of the pathogen involved, since different strains may be differently susceptible to a given immune reaction. (webot.org)

however, severe reactions depend in large part on which organism is being treated. (entokey.com)
An increase in dose may in- crease the intensity of an effect, or a more severe effect may result. (iloencyclopaedia.org)

Several dose-response curves can be drawn for a chemical-one for each type of effect. (iloencyclopaedia.org)

Dose-related side-effects include insomnia, decreased appetite and weight loss, ataxia, Gastrointestinal upset and headache. (pocketdrugguide.com)
As the oral cavity serves as an entry to the gastrointestinal. (annals.edu.sg)

The typical dose is 5 mg daily for 2 to 4 days followed by 2 to 10 mg daily, based upon measurements of prothrombin time aiming at an international normalized ratio (INR) value of 2 to 3. (nih.gov)

To report SUSPECTED ADVERSE REACTIONS, contact Camber Pharmaceuticals, Inc at 1-866-495-8330 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)

Cefadroxil Capsules USP is a semisynthetic cephalosporin antibiotic intended for oral administration. (nih.gov)
Cefadroxil is rapidly absorbed after oral administration. (nih.gov)
Medication error -Administration of a medicine or dose that differs from the written order. (gpatindia.com)
It is available as a two-layered, white and yellow, oval-shaped tablet for oral administration. (themeditary.com)
A rarely encountered side effect of prolonged administration of megestrol acetate is urticaria, presumably an idiosyncratic reaction to the drug. (tajgenerics.com)
Chloramphenicol has the disadvantage of a narrow margin of safety in dogs and cats, and necessity of frequent administration in dogs to maintain adequate concentrations (three or four times daily oral administration). (veteriankey.com)

Common dose-related side-effects of lamotrigine include mild tremor, double vision, headache and insomnia. (pocketdrugguide.com)

The urine antibiotic concentration, following a 1 g dose, was maintained well above the MIC of susceptible urinary pathogens for 20 to 22 hours. (nih.gov)

Call your doctor for medical advice about serious side effects or adverse reactions. (rxlist.com)
By contrast, side effects are known reactions to a medicine and are typically listed in the medicine's labeling. (gpatindia.com)
The availability of oral, non-vitamin K based anticoagulants that provide similar protection against thrombosis but have fewer adverse side effects and do not require regular monitoring of INR has decreased the use of warfarin, particularly in the elderly who are most prone to bleeding complications. (nih.gov)

If seizures continue, the daily dose is increased by small increments. (msdmanuals.com)
Then, another drug is added at a low dose, which is gradually increased until seizures are controlled. (msdmanuals.com)

The reaction is treated by reducing the dose or withholding the medicine and considering alternative therapy. (gpatindia.com)
It is unlikely that the dose of metformin will require adjustment due to hypoglycemia during combination therapy with AVANDIA. (healthyplace.com)
5.13) Paradoxical Reactions: Monitor during therapy. (drugcentral.org)

but at higher doses Jacovides (1923) described optic-nerve and retinal ischemic changes with pupillary, accommodation, vision and visual field abnormalities. (entokey.com)

Type A drug reaction accounts for 80% of all toxicities. (wikipedia.org)
Rarely, an antiseizure drug that is effective for one seizure type may aggravate another seizure type. (msdmanuals.com)
Dose should be tailored to the patient's tolerance of the drug. (msdmanuals.com)
The term adverse drug effect is interchangeable with adverse drug reaction. (gpatindia.com)
Approximately 75% of the idiosyncratic drug reactions result in liver transplantation or death. (medscape.com)
This demonstrates the importance of postmarketing surveillance to identify reactions that are not reported or are underreported in drug trials. (medscape.com)

ESTRATEST® Tablets: Each dark green, capsule shaped, sugar-coated oral tablet contains: 1.25 mg of Esterified Estrogens, USP and 2.5 mg of Methyltestosterone, USP. (theodora.com)
ESTRATEST® H.S. (Half-Strength) Tablets: Each light green, capsule shaped, sugar-coated oral tablet contains: 0.625 mg of Esterified Estrogens, USP and 1.25 mg of Methyltestosterone, USP. (theodora.com)

Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. (globalrph.com)

Bacterial loads are currently in the treatment with immunosuppressive doses. (myjuicecup.com)

In normal circumstances, this metabolite is detoxified by conjugating with glutathione in phase 2 reaction. (wikipedia.org)
The tissue dose is the amount of substance in a specific tissue and the target dose is the amount of substance (usually a metabolite) bound to the critical molecule. (iloencyclopaedia.org)

More definitively, tests like polymerase chain reaction (PCR) and matrix-associated laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) are done to determine capsule types. (statpearls.com)

An unexpected ADR refers to a reaction, the nature or severity of which is not consistent with domestic labeling or market authorization, or is unexpected from characteristics of the medicine. (gpatindia.com)

Troglitazone (Rezulin) and trovafloxacin (Trovan) are two prime examples of idiosyncratic hepatotoxins pulled from market. (wikipedia.org)

Jinarc is to be administered twice daily in split dose regimens of 45 mg + 15 mg, 60 mg + 30 mg or 90 mg + 30 mg. (medicines.org.uk)
The second daily dose can be taken with or without food. (medicines.org.uk)
According to these split dose regimens the total daily doses are 60 mg, 90 mg, or 120 mg. (medicines.org.uk)
AVANDIA may be administered at a starting dose of 4 mg either as a single daily dose or in 2 divided doses. (healthyplace.com)
The total daily dose of AVANDIA should not exceed 8 mg. (healthyplace.com)

Tablets and capsules have similar oral absorption in dogs. (veteriankey.com)

exposure dose , which is the air concentration of pollutant inhaled during a certain time period (in work hygiene usually eight hours), or the retained or absorbed dose (in industrial hygiene also called the body burden ), which is the amount present in the body at a certain time during or after exposure. (iloencyclopaedia.org)
The theoretical dose according to Haber's law is D = ct, where D is dose, c is concentration of the xenobiotic in the air and t the duration of exposure to the chemical. (iloencyclopaedia.org)

Anatomy12

Organisms13

Diseases33

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment81

Psychiatry and Psychology3

Phenomena and Processes36

Disciplines and Occupations1

Information Science7

Named Groups2

Health Care38

Geographicals1

Tolerability3

Clinically2

Single-dose3

Small doses2

Toxicity5

Injectable2

Aspirin1

Liver injury2

Drugs6

Titration2

Refractory1

Codeine7

Medications3

Symptoms5

Serum2

Allergic reaction2

Indications1

Therapeutic dose2

Occurs2

High4

Considerations1

Produces1

Clinical trials1

Shortest duration1

Adverse effects2

Increases2

Hepatic2

Initiation1

Toxic6

Equivalent2

Patients9

Medroxyprogesterone2

Intrinsic1

Initial dose2

Pharmacological2

Immune1

Severe2

Curves1

Gastrointestinal2

Typical1

Pharmaceuticals1

Administration6

Lamotrigine1

Susceptible1

Side effects3

Seizures2

Therapy3

Higher1

Drug6

Tablet contains2

Synthetic1

Treatment1

Metabolite2

Capsule1

Severity1

Examples1

Daily5

Tablets1

Concentration2