• however, because fentanyl is so potent, multiple doses might be necessary. (wikipedia.org)
  • Spinal administration of hyperbaric bupivacaine with fentanyl may be the optimal combination. (wikipedia.org)
  • Sequential intrathecal injection of fentanyl and hyperbaric bupivacaine at different rates: does it make a difference? (ekja.org)
  • Arm 2 (MD Group): Spinal Anesthesia with dose of 0.5% hyperbaric Bupivacaine chosen accorded to height and weight following a modified Harten's chart table + 25 micrograms of Fentanyl. (who.int)
  • the dose administered will be: 0.5% Hyperbaric Bupivacaine according to Harten's chart + 1 ml 0.5% Hyperbaric Bupivacaine + 25 micrograms Fentanyl, will be administered intrathecally immediately after placing the standard anesthesiology monitors (blood pressure cuff for blood pressure, pulse oximeter for heart rate and oxygen saturation) and before the operation room timeout for surgery. (who.int)
  • The objective of these studies ended up being to examine and evaluate your starting point and also time period of nerve organs and also motor blockade, hemodynamic effects, duration of postoperative analgesia, along with uncomfortable side effects regarding nalbuphine as well as fentanyl provided intrathecally with hyperbaric 0.5% bupivacaine in memory foam reduce limb operations. (bisindolylmaleimideix.com)
  • Individuals had been aimlessly allocated to receive 16 mg associated with hyperbaric bupivacaine using sometimes One mg nalbuphine (team In), Twenty five μg fentanyl (class F) or even 0.9% normal saline (party Chemical) intrathecally. (bisindolylmaleimideix.com)
  • Patients that obtained intrathecal nalbuphine (group D)rthopedic methods involving lower arm or leg.Intrathecal nalbuphine in the serving of 1 mg can be an just as beneficial alternative to fentanyl inside a dose Twenty five μg any time utilized as the intrathecal adjuvant to be able to bupivacaine with regard to lower branch surgical treatments. (bisindolylmaleimideix.com)
  • Ropivacaine is a pures (-) enantiomer and is less cardiotoxic than equivalent concentrations of bupivacaine has recently introduced for its clinical use. (oaji.net)
  • The aim of this study was to evaluate the efficacy of different concentrations of ropivacaine 0.5% and 0.75% as compared to bupivacaine 0.5% in supraclavicular brachial plexus block in upper limb surgeries. (oaji.net)
  • Group I and group II received 30 ml of 0.5% and 0.75% ropivacaine respectively and group III received 0.5% bupivacaine in supraclavicular brachial plexus block. (oaji.net)
  • Conclusion: To conclude, 0.5% ropivacaine was less effective than 0.75% ropivacaine and 0.5% bupivacaine. (oaji.net)
  • Postoperatively although the duration of analgesia was comparable among all the three groups but the total dose of rescue analgesia required was significantly lesser in 0.75% ropivacaine than 0.5% ropivacaine and 0.5% bupivacaine. (oaji.net)
  • The purpose of the study was to determine the optimal dose of spinal ropivacaine for cesarean section with or without intravenous single bolus of S-ketamine and to observe the incidences of hypotension of both methods. (researchsquare.com)
  • The estimated ED90 of ropivacaine was 11.8 mg (95% CI 11.7-12.7) with and 14.7 mg (95% CI 14.6-16.0) without intravenous S-ketamine using biased coin up-down sequential dose-finding method, and the incidences of hypotension and its related symptoms were significantly lower in S-ketamine group. (researchsquare.com)
  • A spinal dose of ropivacaine 12 mg with single intravenous 0.15 mg/kg bolus dose of S-ketamine may significantly reduce the risk of hypotension and provide sedative status before delivery, thus the method could be cautiously used in parturients with high risks of hypotension or extreme nervousness. (researchsquare.com)
  • Bupivacaine hydrochloride injection contains bupivacaine hydrochloride, an amide local anesthetic indicated in adults for the production of local or regional anesthesia or analgesia for surgery, oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. (nih.gov)
  • Bupivacaine Hydrochloride Injection contains bupivacaine, an amide local anesthetic, and Bupivacaine Hydrochloride and Epinephrine Injection is a combination of bupivacaine, an amide local anesthetic, and epinephrine, an alpha and beta-adrenergic agonist. (pfizermedicalinformation.com)
  • Objective: using plain bupivacaine with dexamethasone in spinal anesthesia is a new technique in total hip replacement operation. (easpublisher.com)
  • This study was done to compare the incidence of side effects of spinal anesthesia, the duration of both sensory and motor block following administration of heavy bupivacaine alone with administration of plain bupivacaine mixed with dexamethasone. (easpublisher.com)
  • Conclusion: Dexamethasone when mixed with plain bupivacaine prolong the duration of sensory and motor block and reduce the incidence of hypotension, Breadycardia and shivering. (easpublisher.com)
  • All patients underwent regional anesthesia with plain bupivacaine (0.5%, given epidurally) or hyperbaric bupivacaine (0.5%, given spinally) without any other additives. (asahq.org)
  • An epidural catheter was inserted for postoperative analgesia, and spinal anesthesia was performed with 7.5 mg of intrathecal hyperbaric bupivacaine at the L3/L4 interspace. (ispub.com)
  • Symptomatic GI disturbances occur in 2-10% of healthy individuals receiving normal doses of aspirin-containing products for analgesia or fever and 30-90% of patients with preexisting peptic ulcer gastritis or duodenitis. (wellrx.com)
  • However, total doses of rescue analgesia required was least in group II (1.86 ± 7.86) as compared to group I (3.60 ±8.83) and group III (3.26 ± 8.06) (p (oaji.net)
  • Spinal anaesthesia is advantageous in that it uses a small dose of anaesthesia, simple to perform and offer a rapid onset of action, reliable surgical analgesia and good muscle relaxation. (panafrican-med-journal.com)
  • 100-250 mcg) are associated with a prolonged time until first analgesia request (by 4.5 hours) with a higher risk of opioid related side-effects such as pruritus and postoperative nausea and vomiting (PONV) when compared with lower doses (50-100 mcg). (asra.com)
  • Therefore a balance between analgesia and side-effects must be considered for each patient when deciding individual neuraxial morphine dosing strategies. (asra.com)
  • Doses of ≤50 mg bupivacaine equivalents (20 ml 0.25% bupivacaine on each side, for example) are recommended on each side to balance analgesia efficacy with risk of local anesthetic systemic toxicity (LAST). (asra.com)
  • 21 The role of liposomal bupivacaine, which provides longer duration of analgesia, shows some promise in the CD setting. (asra.com)
  • Postoperative pain was assessed for 48 hours by a visual analog scale of pain at rest and during cough and by patient-controlled cumulative morphine doses. (bmj.com)
  • 7 An analgesic ceiling effect and dose related side-effects with the use of neuraxial morphine have previously been described. (asra.com)
  • There have been reports of cardiac arrest and death during the use of bupivacaine for intravenous regional anesthesia (Bier Block). (nih.gov)
  • Conclusion: Intraoperative administration of dexmedetomidine at a conventional dose does not appear to significantly reduce the increase in postoperative plasma NfL concentration in elderly patients undergoing thoracoscopic surgery. (bvsalud.org)
  • Intravenous versus intrathecal dexmedetomidine as an additive to hyperbaric bupivacaine in spinal anesthesia for hip arthroplasty. (ekja.org)
  • The study series incorporated intravenous tranexamic acid (TXA) infusion in 2 doses of 10-15 mg/kg, 15 minutes before tourniquet release and 3 hours later. (openorthopaedicsjournal.com)
  • to evaluate the effects of intravenous (IV) dexmedetomidine as a pre-medication on clinical profile of bupivacaine spinal anaesthesia in lower abdominal surgeries. (panafrican-med-journal.com)
  • Methods such as intrathecal adjuvant opioid use to reduce the total dose of anaesthetics delivered, 8 prophylactic use of vasopressors, 4,9 and the use of intravenous (IV) pre-load colloid liquid 10 have been proposed to reduce the incidence or extent of maternal hypotension after spinal anesthesia during cesarean delivery. (researchsquare.com)
  • He injected hyperbaric bupivacaine 0.5% and the cesarean delivery was carried out uneventfully. (ahrq.gov)
  • Because of the technical challenges of readily identifying the epidural space and the toxicity associated with the large doses of local anesthetics needed for epidural anesthesia, spinal anesthesia was the dominant form of neuraxial anesthesia well into the 20th century. (medscape.com)
  • This case represents a "near miss," in that a pregnant woman received neuraxial anesthesia only four hours after her last dose of prophylactic low molecular weight heparin (LMWH). (ahrq.gov)
  • The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. (silverchair.com)
  • After lumbar epidural catheter placement, 20 ml bupivacaine (n = 35) or bupivacaine with epinephrine 1:300,000 (n = 35) was administered. (silverchair.com)
  • The lowest maternal blood pressure was significantly lower in the bupivacaine-epinephrine group (P = 0.03). (silverchair.com)
  • There were statistically significant reductions in fetal heart rate (P = 0.011) in the bupivacaine-epinephrine group that were not clinically significant. (silverchair.com)
  • The addition of epidural epinephrine 1:300,000 (66 microg) resulted in a significant 29% reduction in the MLAC of bupivacaine. (silverchair.com)
  • Three mL of Bupivacaine Hydrochloride and Epinephrine Injection without antimicrobial preservative (0.5% bupivacaine with 1:200,000 epinephrine) is recommended for use as a test dose prior to caudal and lumbar epidural blocks when clinical conditions permit. (pfizermedicalinformation.com)
  • Bupivacaine Hydrochloride Injection, USP and Bupivacaine Hydrochloride and Epinephrine Injection, USP are available in multiple concentrations. (pfizermedicalinformation.com)
  • Bupivacaine Hydrochloride and Epinephrine Injection contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. (pfizermedicalinformation.com)
  • There have been reports of cardiac arrest with difficult resuscitation or death during use of bupivacaine hydrochloride for epidural anesthesia in obstetrical patients. (nih.gov)
  • The 0.75% (7.5 mg/mL) concentration of bupivacaine hydrochloride is not recommended for obstetrical anesthesia and should be reserved for surgical procedures where a high degree of muscle relaxation and prolonged effect are necessary ( 5.1 ). (nih.gov)
  • It is widely used in obstetrical anesthesia because of its short time to action peak (about 5 minutes), the rapid termination of its effect after a single dose, and the occurrence of relative cardiovascular stability. (wikipedia.org)
  • Patients and Methods: Patients aged ≥60 years undergoing general anesthesia for thoracoscopic surgery were randomly assigned to receive dexmedetomidine (group D) or not receive dexmedetomidine (group C). Patients in group D received a loading dose of dexmedetomidine 0.5 µg/kg before anesthesia induction and a continuous infusion at 0.5 µg·kg-1·h-1 until the end of the surgery. (bvsalud.org)
  • This finding suggests that the neuroprotective effect of dexmedetomidine at a conventional dose was not obvious during general anesthesia. (bvsalud.org)
  • Methods Sixty women scheduled for lower abdominal surgery were randomly assigned to two groups of 30 patients each to receive spinal anesthesia (SA) or general anesthesia (GA). In the SA group, 3 mL of hyperbaric 0.5% bupivacaine was injected into the subarachnoid space through the third or fourth lumbar interspace. (bmj.com)
  • The researchers conducted a randomized clinical trial protocol to assess autonomic function at motor recovery in patients receiving spinal anesthesia with isobaric bupivacaine alone or clonidine-associated isobaric bupivacaine. (bvsalud.org)
  • therefore, delivery in a hyperbaric chamber is necessary to use as a sole agent for complete anesthesia. (medilib.ir)
  • this prospective randomized double blind study was done on 60 patients with ASA grade I/II undergoing lower abdominal surgeries under bupivacaine spinal anaesthesia. (panafrican-med-journal.com)
  • Intra-articular infusions of local anesthetics including bupivacaine hydrochloride following arthroscopic and other surgical procedures is an unapproved use, and there have been post-marketing reports of chondrolysis in patients receiving such infusions. (nih.gov)
  • RCT: a Comparison between a fixed intrathecal dose of 0.5% Hyperbaric Bupivacaine, and tailored intrathecal dose of 0.5% Hyperbaric Bupivacaine based on a modified Harten's Chart in non pregnant patients. (who.int)
  • Acetaminophen can cause acute renal tubular necrosis and chronic analgesic nephropathy, which is characterized by interstitial nephritis and renal papillary necrosis, in patients receiving high doses (e.g., 2.5-10 g/day) chronically or after acute overdose. (wellrx.com)
  • a review on overcoming the problem of patients who do not have an overnight carer, a report on outcomes and satisfaction with semi-elective day case hand trauma surgery and a randomised controlled trial studying the efficacy and recovery profile of low doses of hyperbaric bupivacaine for spinal anaesthesia. (daysurgeryuk.net)
  • Large doses of local anesthetics should not be used in patients with heartblock. (themeditary.com)
  • debilitated, elderly patients or acutely ill patients should be given reduced doses commensurate with their weight, age, and physical status. (themeditary.com)
  • Reduced doses are also indicated for obstetric patients and those with increased intra-abdominal pressure. (themeditary.com)
  • Patients were divided into two groups: one group received Bupivacaine with clonidine, and the other group received only bupivacaine at a dose of 15 mg. (bvsalud.org)
  • These highlights do not include all the information needed to use BUPIVACAINE HYDROCHLORIDE INJECTION safely and effectively. (nih.gov)
  • Recommended concentrations and dosages of bupivacaine hydrochloride injection according to type of block. (nih.gov)
  • Bupivacaine hydrochloride injection is available in multiple concentrations. (nih.gov)
  • Known hypersensitivity to bupivacaine or to any local anesthetic agent of the amide-type or to other components of bupivacaine hydrochloride injection. (nih.gov)
  • Monitor cardiovascular and respiratory vital signs and patient's state of consciousness after injection of bupivacaine hydrochloride. (nih.gov)
  • The large portion of injection doses is excreted in the urine as inactivated compounds. (drugs-library.com)
  • Respiratory depression after intrathecal injection of tramadol with hyperbaric bupivacaine]. (pneumotox.com)
  • Five minutes after premedication, subarachnoid block (SAB) was given with 3 ml of 0.5% hyperbaric bupivacaine following which sensory and motor blockade, hemodynamic changes, sedation, and complications of the surgery were recorded and this data was analyzed statistically using χ 2 test, corrected χ 2 test, Fisher´s exact test, and test of proportion (Z-test). (panafrican-med-journal.com)
  • If the upper sensory level of the patient reached T6 and the visual analogue scale (VAS) scores continuously below 3 before delivery, the next patient had a 1/9th chance of receiving a lower dose or an 8/9th chance of receiving the same of previous dose. (researchsquare.com)
  • The sensorimotor block produced requires smaller doses of local anesthetics (hence, local anesthetic toxicity is rarely a concern) and is often more dense in character. (medscape.com)
  • Characterizing the Toxicity and Dose-Effect Profile of Tramadol Ingestions in Children. (pneumotox.com)
  • Allergy to local anesthetics may also be a contraindication, but true allergies are usually found with ester-based local anesthetics (eg, tetracaine), not the amide-based local anesthetics (eg, bupivacaine), so finding a suitable local anesthetic is not challenging. (medscape.com)
  • Aft er negative aspiration and a nega tive test dose, a total of 15-25 mL of local anesthetic is injected slowly in 5-mL increments in order to minimize the risk of systemic local anesthetic toxic-ity. (brainkart.com)
  • At high doses, the drug may act on the fetus to cause postnatal respiratory distress. (wikipedia.org)
  • Low dose and the conventional dose of 0.5% hyperbaric bupivacaine produce comparable outcomes in the lower segment caesarean section. (manipal.edu)
  • The amount of local anaesthesia administered to the patient during spinal anaesthesia prior to caesarean section was considered the dose used. (bvsalud.org)
  • Conclusion: There were appropriate uses of the local anaesthesia with respect to the choice and doses for caesarean deliveries but there were wastages often ignored as infinitesimal. (bvsalud.org)
  • To reduce the risk of psychomimetic reactions, S-ketamine administration was limited to an ultra-low single dose in the present study. (researchsquare.com)
  • Although this patient did not experience an adverse event attributable to the short interval, placement of a spinal needle was contraindicated given recent dosing of LMWH. (ahrq.gov)
  • Spinal anaesthesia was performed at the L3-L4 inter space with a 25 gauge spinal needle and 3 ml (15 mg) of 0.5% hyperbaric bupivacaine. (scholars.direct)
  • The concentration of bupivacaine was determined by the response of the previous patient in that group to a higher or lower concentration using up-down sequential allocation. (silverchair.com)
  • Continuous low dose noradrenaline (0.1 μg/kg/min) infusion was required for the first 2 hours. (scholars.direct)
  • After the start of landiolol administration at a dose of 6 µg?kg -1 ?min -1 , HR decreased to 75 bpm and ST segment depression improved to -0.05 mV. (ispub.com)
  • Bupivacaine is most widely used local anaesthetic in regional anaesthesia, but its cardiotoxicity has led to the development of a new and safer local anaesthetic agent. (oaji.net)
  • Fifteen minutes after the start of landiolol administration at a dose of 5 µg?kg -1 ?min -1 , HR had improved to 80 bpm with improvement of ST segment depression. (ispub.com)
  • 9 For epidural administration, a 1-3 mg dose is recommended by SOAP. (asra.com)
  • The wastage was found more during the use of hyperbaric bupivacaine as the cost of its wastage formed the bulk (N75,000.00/ $210.10) of the estimated total cost of wasted local anaesthetic agents during the study period which was N88, 100.00 ($246.77). (bvsalud.org)
  • After securing informed consent, each patient will be allocated to either group: Arm 1 (Controls group with fixed dose of 0.5% Hyperbaric Bupivacaine (FD Group)), and Arm2: (Cases group with modified dose of 0.5% Hyperbaric Bupivacaine (MD Group)), using the two sides of a coin, where Head is for Arm1 and Tails for Arm2. (who.int)
  • During first 14 days, G-1 and G-2 (control group and Iso-control group) animals got 1ml normal saline, while G-3, G-4 and G-5 animals got citric acid at the dose of 250 mg/kg, 500 mg/kg and 750 mg/kg body weight respectively. (edu.pk)
  • Aspirate for blood or cerebrospinal fluid (where applicable) prior to each dose. (nih.gov)