Dose of cocaine. Medical search. Frequent questions

This register-based study sought to explore the association between prescribed methadone dose and concomitant cocaine and heroin use in the methadone population of Basel City. (biomedcentral.com)
In logistic regression analysis, cocaine use was significantly associated with heroin use (OR 4.9). (biomedcentral.com)
Cocaine use in methadone patients may be associated with heroin use, which indicates the importance of prescribing appropriate methadone dosages in order to indirectly reduce cocaine use. (biomedcentral.com)
Heroin use during the 3 months prior to interview was shown to be greatest among (1) patients maintained on methadone dosages of less than 70 mg/day (adjusted odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.3, 3.4) and (2) patients who used cocaine during treatment (adjusted OR = 5.9, 95% CI = 3.8, 9.1). (elsevierpure.com)
Cocaine users were more likely than nonusers of cocaine to use heroin at all methadone dosage levels. (elsevierpure.com)
This study confirms and extends past research showing high-dose methadone maintenance to be important to heroin abstinence. (elsevierpure.com)
Further investigation of the independent association between heroin use and cocaine use is needed. (elsevierpure.com)
Reverse transition from injecting to smoking heroin and/or crack cocaine on lower methadone dose: sub-therapeutic dosing or safer drug use? (lisbonaddictions.eu)
Heroin use in methadone treatment is common, especially for dual users of heroin and crack/cocaine or other stimulants. (lisbonaddictions.eu)
Their accounts illustrate how they adjusted their heroin and/or crack use on higher or lower methadone doses to optimize the high, suggesting that RT was easier to achieve on a low dose. (lisbonaddictions.eu)
Pumping gas is bad for your health, but feel free to do copious amounts of cocaine and heroin, folks! (wibc.com)
In November, in a near-landslide, Oregon became the first state in history to decriminalize all drugs, including hard drugs like heroin, cocaine, and meth. (activistpost.com)
Objective: To determine the efficacy of Opiate Maintenance Therapy (OMT) and adjunctive interventions for dual heroin and cocaine dependence by means of a meta-analysis. (ojp.gov)
At equivalent doses, methadone was more efficacious than buprenorphine on cocaine abstinence (RR = 1.63 [1.20, 2.22], p = .002) and also appeared to be superior on heroin abstinence (RR = 1.39 [1.00, 1.93], p = .05). (ojp.gov)
Cocaine is the most deadly drug in America…more so than heroin. (jayparkinsonmd.com)
[2] NPF is sold via illicit drug markets for its heroin-like effect and often mixed with heroin and/or cocaine as a combination product-with or without the user's knowledge-to increase its euphoric effects. (cdc.gov)

Stimulants, such as amphetamines and cocaine, speed up the nervous system. (webmd.com)
Emergency clinics and selected veterinary diagnostic laboratories have quick screening tests that can detect the most commonly abused drugs (including metabolites) in body fluids (e.g., amphetamines, barbiturates, benzodiazepines, cocaine, marijuana, and opiates). (vin.com)

The concentrations of cocaine, norcocaine, benzoylecgonine and ecgonine methyl ester were quantified by liquid chromatography/electrospray ionization tandem mass spectrometry. (unesp.br)
Plasma and liver enzymes break down cocaine into two major metabolites: benzoylecgonine and ecgonine methyl ester. (healthline.com)

Cocaine may induce miscarriage, premature labor, placental abruption, or fetal toxicity, and modifications may be necessary for acute management. (medscape.com)
Thus, there is concern primarily about use of epinephrine, lidocaine, and beta-blockers in the setting of acute cocaine toxicity. (medscape.com)
Both acute and chronic cocaine use disrupts sleep, and sleep disturbances can increase the likelihood of relapse. (sciencedaily.com)
It can take weeks for acute cocaine withdrawal to resolve. (addictionblog.org)
Moreover, people who have used cocaine for a long period of time may experience post acute withdrawal symptoms (PAWS). (addictionblog.org)
Most acute cocaine-related nontraumatic deaths are the result of tachydysrhythmias (abnormally fast heart beat). (jayparkinsonmd.com)
An acute dose of nicotine enhances cue-induced cocaine craving. (bvsalud.org)

In Todd's car, a trooper discovered dozens of grams of cocaine, more than 200 pills of fentanyl, ecstasy pills, and a stolen firearm, according to a press release. (wavy.com)
The water bottle had a false bottom and was hiding 227 fentanyl pills, 19 MDMA pills and 51 grams of cocaine. (wavy.com)
DRI seized 504 grams of cocaine ingeniously concealed in a steam press iron sent by courier from Trinidad and Tobago to Mumbai. (indiatvnews.com)

0.001 for the cocaine 40 mg dose at both modafinil levels). (erowid.org)

Her cause of death was "cocaine toxicity. (caribbeanfever.com)
Patients with cocaine toxicity may be combative, aggressive, and disoriented, and have delusions of persecution or hallucinations. (medscape.com)
Patients with cocaine toxicity should receive initial evaluation and stabilization, including attention to ABCs, oxygen, intravenous access, and cardiac and pulse oximetry monitoring. (medscape.com)
Perform routine pregnancy testing for appropriate patients as physiologic changes in pregnancy may increase cocaine toxicity. (medscape.com)
[ 45 ] The American College of Cardiology Foundation/American Heart Association (ACCF/AHA) 2014 recommendations for treatment of patients with cocaine toxicity are based on class C evidence (ie, consensus opinion of experts, case studies, or standard of care). (medscape.com)
Vasopressin offers considerable theoretical advantage over epinephrine in cardiac arrest due to cocaine toxicity. (medscape.com)
The rise of cocaethylene and cocaine increases heart and liver toxicity. (healthline.com)
Toxicity may be medically indistinguishable from cocaine. (vin.com)

Fifteen subjects dependent on both opioids and cocaine completed an ascending and tapering schedule of buprenorphine dosing, with maintenance for 21 days at each dose of buprenorphine (4, 8, 12, 16 mg sublingual daily) during both ascending and tapering phases. (umassmed.edu)
Based on research presented in this document, the authors suggest that dependence on both opioids and cocaine can be effectively treated with Opiate Maintenance Therapy in combination with adjunctive interventions. (ojp.gov)

Edward Judie was arrested the night of July 1st, following an interview with investigators where they questioned him about the suspicious death of Joyce Fox Judie in late November of 2019, who was found to have a lethal dose of cocaine in her system- it was also found that Edward had purchased cocaine the same night. (caribbeanfever.com)
Autopsy results showed Judie's wife had "many times the lethal dose" of cocaine in her system when she died on Nov 29, 2019, per the report. (caribbeanfever.com)
15, 2019 Scientists have revealed neuronal mechanisms underlying the formation and retrieval of cocaine use-associated memories. (sciencedaily.com)
Jan. 16, 2019 A study finds a surprising response to cocaine in a novel strain of mutant mice -- they failed to show hyperactivity seen in normal mice when given cocaine and didn't run around. (sciencedaily.com)

The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [ 11 C]WIN-35,428 ([ 11 C]2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced DAT loss in living primates. (jneurosci.org)
PET-derived binding potential values, used to index striatal DAT density, were significantly decreased after methamphetamine, with larger decreases occurring after higher methamphetamine doses. (jneurosci.org)
These results indicate that methamphetamine, at doses used by some humans, produces long-term reductions in brain DA axonal markers in baboons, and that it is possible to detect methamphetamine-induced DAT loss in living nonhuman primates by means of PET. (jneurosci.org)

In the setting of abuse, high-dose bupropion is ground up for snorting and creates a euphoric high similar to cocaine. (medpagetoday.com)
1 Also known as "coke," "snow," and "blow," cocaine is a white, crystal-like powder that provides a euphoric high. (drugabuse.com)

While MMT has been demonstrated to be an effective treatment for opioid dependence, its impact on the treatment outcome of cocaine abuse is not as clear. (biomedcentral.com)
To determine if modafinil, a putative treatment for cocaine dependence, influences the pharmacokinetics of intravenous cocaine in otherwise healthy cocaine-dependent volunteers. (erowid.org)
0001). Conclusions: Dual opioid and cocaine dependence can be effectively treated with OMT in combination with adjunctive interventions. (ojp.gov)

In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. (wikipedia.org)
LD50 i.v." The related quantities LD50/30 or LD50/60 are used to refer to a dose that without treatment will be lethal to 50% of the population within (respectively) 30 or 60 days. (wikipedia.org)
As reported by Law and Crime, Edward Judie, 67, was indicted by Macon-Bibb County grand jurors on charges of felony murder after allegedly killing his wife with a lethal amount of cocaine. (caribbeanfever.com)
A Columbus, Ohio doctor and the Mount Carmel Health System are being sued for allegedly intentionally administering a lethal dose of fentanyl to a woman in late 2017. (wfla.com)
In fact, mixing cocaine and alcohol can have lethal results. (healthline.com)
the oral lethal dose is generally 2 to 4 times higher. (vin.com)

The National Institute on Drug Abuse reports that in 2017, approximately 2.2 million people said they had used cocaine in the past. (santecenter.com)

Xi was looking for a compound that would have the same effect on cocaine users. (discovermagazine.com)
0001) but had no effect on cocaine abstinence. (ojp.gov)

If you have anything at all wrong with your heart, even a tiny amount of cocaine can kill you. (jayparkinsonmd.com)

Self-reported days, times, and quantity of cocaine used per week showed a similar pattern of intermediate reductions at the 12-mg and 16-mg dose during the ascending phase and significantly reduced values during the descending schedule. (umassmed.edu)
Investigations till now have revealed that this syndicate had cleared multiple consignments of cocaine in the past and the total quantity of cocaine smuggled by the same modus operandi was over 3.3 Kgs since August 2020 itself, having a market value of over Rs. (indiatvnews.com)

Morris reagent consists of two liquids, bottle A and bottle B. When A and B are combined onto a small drug sample and stirred, Morris produces a unique blue color in the presence of cocaine, like the Jolly Rancher hard candy. (dancesafe.org)
It turns yellow in the presence of cocaine, but will turn a rusty red color if the cocaine is cut with either levamisole or lidocaine. (dancesafe.org)
DRI first intercepted the consignment and ascertained the presence of cocaine. (indiatvnews.com)

In fact, this stimulant manifests withdrawal symptoms that usually start just a couple of hours after stopping cocaine use. (addictionblog.org)
Cocaine is a Schedule II illegal stimulant drug that is highly addictive. (drugabuse.com)
Cocaine is a stimulant drug with highly addictive properties that is derived from the coca plant. (drugabuse.com)
Cocaine is a stimulant drug and has been around for thousands of years in one form or another. (santecenter.com)
Research also suggests that cocaine elevates people's stress levels, making sense since it's a stimulant. (santecenter.com)

The maximum admissible concentration for cocaine and/or metabolites in the urine of horses is difficult to establish unequivocally because of the substantial individual variation in the drug elimination pattern observed in horses, which can be inferred by the large standard error of the means obtained. (unesp.br)

Cocaine overdose can be a serious concern for anyone who uses cocaine. (drugabuse.com)
When a person uses cocaine, this chemical is activated and enhanced, thereby triggering a strong sense of euphoria. (santecenter.com)

Although recommended for achieving abstinence, many people reject high doses of methadone. (lisbonaddictions.eu)
OMT can be enhanced with indirect dopaminergic drugs and with CM focusing on cocaine abstinence. (ojp.gov)

A few years ago, Xi was studying this phenomenon in mice, hoping to find a pill to treat addiction to dopamine-boosting drugs such as cocaine. (discovermagazine.com)
Meanwhile, when he and his team tested JWH-133 on mice without CB2 receptors, the rodents kept going for the cocaine, and their dopamine levels were higher. (discovermagazine.com)
Both cocaine and cocaethylene raise levels of the brain chemicals dopamine and serotonin and block their reuptake. (healthline.com)
Cocaine affects the dopamine part of the brain. (santecenter.com)

Finally, enter the pack-donkey of the fragile (a whole nother paper on this perhaps to come) Columbian economy, that which is derived from the leaves of the coca plant native to said nation: Cocaine. (erowid.org)
Cocaine is extracted from the coca plant, Erythroxylum coca. (santecenter.com)

Cocaine is one of the most widespread illegal stimulants utilized by the human population throughout the world. (unesp.br)

Higher doses of buprenorphine led to greater reductions in opioid use: 64.7% of subjects were opioid abstinent for 3 weeks at the 16-mg dose compared to 27.3% at the 4-mg ascending dose. (umassmed.edu)
This study indicates that buprenorphine dose has a significant and substantial impact on opioid use and a significant but less robust impact on cocaine use, with higher doses and longer time on buprenorphine leading to attenuated cocaine use. (umassmed.edu)

25% for opiates, 10% cocaine. (natap.org)

There's a myth out there about using cocaine and alcohol together. (healthline.com)
Keep reading to learn how cocaine and alcohol affect the body and what happens when you mix the two. (healthline.com)
Using cocaine with alcohol creates new elements. (healthline.com)
This product is stronger than either cocaine or alcohol alone. (healthline.com)
Sudden stroke is possible when using both cocaine and alcohol. (healthline.com)
Research finds that alcohol can increase cravings for cocaine. (healthline.com)
People who use cocaine and alcohol are also more likely to have injuries or adverse reactions and visit emergency rooms more often. (healthline.com)
How long does cocaine and alcohol stay in your system? (healthline.com)
When people mix cocaine and alcohol, cocaethylene can stay around for days to even weeks in the body. (healthline.com)
Studies show alcohol and cocaine use during pregnancy have negative effects on both mother and fetus. (healthline.com)
In 74% of cocaine-related fatalities in the United States, another drug, usually alcohol, had been co-ingested. (jayparkinsonmd.com)
The addition of alcohol to cocaine increases the risk of sudden death 25-fold. (jayparkinsonmd.com)
A Multiple Dose Study in Participants with Severe Alcohol-Associated Hepatitis to Assess the Safety and the Way the Body Absorbs, Distributes, and Eliminates the drug SZN-043. (who.int)

A physician-administrator called the family and informed them of the fentanyl dose, according to the lawsuit. (wfla.com)

When this occurs, a cocaine addiction treatment center provides the best option for successful withdrawal. (santecenter.com)
During cocaine withdrawal, addiction treatment programs provide a nurturing environment in which to safely detox. (santecenter.com)

The shortage of pediatric medication in Canada last year led to a spike of dosing errors in children in Ontario, new research shows. (cp24.com)
Jansen said if the additional pediatric testing is successful, 'we would have a consistent three-dose vaccine approach for all ages. (fox10phoenix.com)

Anxiety, confusion and depression are only few cocaine withdrawal symptoms. (addictionblog.org)
But, how long do cocaine withdrawal symptoms last …over the long term? (addictionblog.org)
Here's a list of detailed cocaine withdrawal symptoms BY TIME PERIOD to easily guide you on what to expect. (addictionblog.org)
When cocaine is regularly used for a length of time, you can expect to endure cocaine withdrawal symptoms upon stopping. (santecenter.com)
You don't need to go through the cocaine withdrawal symptoms alone. (santecenter.com)

There were no significant buprenorphine dose effects on cocaine euphoria. (umassmed.edu)

Higher OMT doses are preferable to lower ones and methadone to buprenorphine. (ojp.gov)

The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. (wikipedia.org)

The aim of this study was to establish the highest no-effect dose (HNED) of cocaine on the spontaneous locomotor activity (SLA) of horses in a behavior chamber, and thereby to determine the maximal acceptable threshold of the urinary drug concentration in horses. (unesp.br)
It was concluded that the HNED of cocaine for horses in a behavior chamber is 0.02 mg kg(-1). (unesp.br)
In December 2008, however, because of crack cocaine use and belligerent behavior, she lost housing privileges. (cdc.gov)

some may be killed by much less, while others survive doses far higher than the LD50. (wikipedia.org)
We found that at higher doses it produced a decrease," Xi says. (discovermagazine.com)
Rather than trying a higher-dose shot for the preschoolers, Pfizer decided to expand the study to evaluate three of the very low-dose shots in all the study participants - from 6 months up to age 5. (fox10phoenix.com)
People try to "exacerbate" the hallucinogenic effect by taking the drug more often or at higher doses. (medpagetoday.com)
In Colorado, doctors noticed that some trauma patients needed a higher dose of painkillers . (listverse.com)
While NPF-related overdoses can be reversed with naloxone, a higher dose or multiple number of doses per overdose event may be required to revive a patient due to the high potency of NPF. (cdc.gov)

Crack cocaine is the cheaper street form. (vin.com)

La présente note d'orientation a pour objectif de passer en revue les interventions disponibles pour la prise en charge des troubles liés à la consommation de substances psychoactives, d'examiner les bases factuelles pour ces interventions dont le guide d'intervention du Programme d'action de l'OMS : Combler les lacunes en santé mentale (mhGAP), et d'effectuer des recommandations concernant le traitement de ces troubles. (who.int)

Details of antihypertensive drug therapy and compliance, intake of over-the-counter (OTC) preparations such as sympathomimetic agents, and use of illicit drugs such as cocaine are important elements of the medication history. (medscape.com)
Drugs like cocaine have reputations for being extremely addictive, but still many people will want to try them "just once. (drugabuse.com)

During the five years he worked here, this doctor ordered significantly excessive and potentially fatal doses of pain medication for at least 27 patients who were near death. (wfla.com)
In contrast, long-term administration of modafinil significantly decreased systemic exposure to cocaine during the first 180 minutes following intravenous cocaine administration. (erowid.org)

Cocaine overdose. (drugabuse.com)
This article will help you understand what a cocaine overdose is, cocaine overdose effects, and potential risk factors for cocaine overdose. (drugabuse.com)

Medications commonly administered to treat pathophysiologic effects of cocaine may worsen other adverse effects of cocaine. (medscape.com)

In my head, I originally intended to smoke weed, carefully experiment in moderate doses with ecstasy and acid, and never touch anything else. (erowid.org)

Early diagnosis and correction of sex-steroid level abnormalities and excess oxidative stress could attenuate risk for developing AD/ADRD in supraphysiologic-dose AAS users, in people with other substance use disorders, and in people with low sex-steroid levels or excess oxidative stress associated with aging. (nih.gov)
Cocaine is the most frequently reported substance associated with drug abuse or misuse deaths. (jayparkinsonmd.com)

Those in good health were mainly on lower methadone doses and switched to smoking without using high-risk sites. (lisbonaddictions.eu)
Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. (nih.gov)
suggesting that they may be permanent, at least in rhesus monkeys given repeated high doses. (jneurosci.org)
Therefore, if epinephrine is used, the AHA Textbook of Advanced Cardiac Life Support for the Experienced Provider recommends that high-dose epinephrine be avoided and that the interval for its administration be increased (q5-10 min). (medscape.com)
Without the high, he theorized, cocaine might lose its appeal. (discovermagazine.com)
People believe taking both can boost the cocaine high and help avoid withdrawal. (healthline.com)
The authors summarized and I agree: grazoprevir / elbasvir Fixed Dose Combination for 12 Weeks demonstrated high efficacy and high medication adherence. (natap.org)

The length of this period depended on the period that cocaine was used, which will also determine the severity of cocaine withdrawal period. (addictionblog.org)

This study explores reverse transition (RT) and discusses possible advantages of lower methadone doses for safer drug use and better health. (lisbonaddictions.eu)
Lower methadone doses could be a harm reduction option for those who choose to continue drug use. (lisbonaddictions.eu)
Children weren't coming into hospital more often for these drug dosing errors, but that doesn't mean no harm was done,' Zipursky said. (cp24.com)
In the 1900s, the purified version of the drug, cocaine hydrochloride, was added to some drinks and tonics. (santecenter.com)
Cocaine is reported in 39% of such drug deaths, ranging from 8-70% in various areas. (jayparkinsonmd.com)

When people use cocaine for an extended time, they can expect to experience symptoms of cocaine withdrawal. (santecenter.com)

Cocaine stimulates your body's nervous system making the heart race and increasing the body temperature. (santecenter.com)

Twelve English thoroughbred mares received 0.02, 0.03, 0.04, 0.08 or 0.12 mg kg(-1) cocaine i.v. or saline solution (control). (unesp.br)

Concomitant cocaine use is a major problem in clinical practice in methadone maintenance treatment (MMT) and may interfere with successful treatment. (biomedcentral.com)
Let's verify your coverage for Cocaine treatment at an American Addiction Centers location. (addictionblog.org)
Treatment options for cocaine addiction . (drugabuse.com)

Their experiment involved isolating a small segment of the bee population, and dosing them regularly with cocaine. (cracked.com)

Other causes of sudden death associated with cocaine use include stroke, subarachnoid hemorrhage, hyperthermia, and the consequences of agitated delirium. (jayparkinsonmd.com)

Large doses of ephedrine might cause or make anxiety worse. (webmd.com)

After injection of this dose in five horses, urine samples were collected at predetermined intervals through vesical catheterization. (unesp.br)

Anatomy5

Organisms5

Diseases7

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology20

Phenomena and Processes10

Health Care6

Heroin16

Amphetamines2

Benzoylecgonine and ecgonine methyl ester2

Acute7

Grams of cocaine3

0.0011

Toxicity8

Opioids and cocaine2

20194

Methamphetamine3

Euphoric high2

Dependence3

Lethal6

20171

Effect on cocaine2

Amount of cocaine1

Quantity of cocaine2

Presence of cocaine3

Stimulant5

Metabolites1

Uses cocaine2

Abstinence2

Dopamine4

Coca plant2

Stimulants1

Opioid2

Opiates1

Alcohol13

Fentanyl1

Addiction Treatment2

Pediatric2

Withdrawal Symptoms5

Euphoria1

Buprenorphine1

Duration1

Behavior3

Higher6

Crack1

Interventions1

Drugs2

Significantly2

Overdose2

Adverse effects1

Ecstasy1

Substance2

High7

Determine1

Drug5

Symptoms1

Body temperature1

Saline1

Treatment3

Regularly1

Sudden death1

Anxiety1

Urine1