Dose dexmedetomidine. Medical search. Frequent questions

Unlike opioids and other sedatives such as propofol, dexmedetomidine is able to achieve its effects without causing respiratory depression. (wikipedia.org)
One thing of note, at least in the US, is although its generic price for dexmedetomidine is still significantly higher than propofol for a mechanically ventilated patient. (emcrit.org)
Great episode, I fully agree dexmedetomidine has benefits over propofol and definitely over midazolam. (emcrit.org)
Dexmedetomidine or propofol for sedation in mechanically ventilated adults with sepsis. (thoracic.org)
Nearly ⅔ of the dexmedetomidine group received supplemental propofol to reach target sedation. (thoracic.org)
We examined whether IV lidocaine reduces the dose of propofol and the occurrence of adverse events during gastroscopy in elderly patients. (dovepress.com)
IV lidocaine reduced the total and maintenance propofol dose in Group L ( p (dovepress.com)
Conclusions: The ABM-based propofol induction dose has a high success rate in normal, overweight and obese patients. (bvsalud.org)
The aim of the study was to compare the efficacy of dexmedetomidine against propofol infusion when used for controlled hypotension during FESS. (bvsalud.org)
Patients were randomly assigned to two groups: Group A (dexmedetomidine), Group B (propofol). (bvsalud.org)

Dexmedetomidine comes as a sublingual film to place under the tongue or on the lower gum in your mouth (behind the lower lip). (medlineplus.gov)
To take dexmedetomidine sublingual film, remove the film from the foil pouch with clean dry hands and place the film under your tongue. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to dexmedetomidine, any other medications, or any of the ingredients in dexmedetomidine sublingual film. (medlineplus.gov)
Do not drive a car or operate machinery for at least 8 hours after you take dexmedetomidine sublingual film. (medlineplus.gov)
The FDA approved dexmedetomidine (Igalmi) sublingual film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder in adults. (fhea.com)
In two pivotal randomized, double-blinded, placebo-controlled, parallel-group phase 3 clinical trials of dexmedetomidine sublingual film, the medication was shown to rapidly relieve mild to moderate acute agitation in patients as soon as 20 minutes. (fhea.com)
Dexmedetomidine sublingual film is a product of BioXcel Therapeutics. (fhea.com)

Blood pressure, heart rate and oxygen levels will be monitored both continuously during the infusion of dexmedetomidine hydrochloride in 0.9% sodium chloride injection and as clinically appropriate after discontinuation. (pharmacyhq.com)
IV infusion of dexmedetomidine 1 g/kg body weight prior to SAB can be recommended to achieve better sensory blockade and adequate hemodynamic stability and sedation. (panafrican-med-journal.com)

The aim of this study was to compare the efficacy and side effect profile of dexmedetomidine as an adjunct to bupivacaine in single dose FICB for femur surgeries in two different r. (researchgate.net)

Patients received bolus doses of 2 μg·kg(-1) over 10 min for up to three doses followed by a 1 μg·kg(-1) ·h(-1) infusion (group 1) or a 1.5 μg·kg(-1) ·h(-1) infusion (group 2). (qxmd.com)
Conclusion DEX (1 μg/kg bolus, followed by 0.5 μg/kg/h infusion) and NTG is superior to NTG alone in rapid achievement of target MAP with lower HR and lower NTG doses and in reducing blood loss volume during FESS. (eg.net)
Mean + SD serum metformin concentrations over time following IV (A) and oral (B) administration of a bolus dose of metformin hydrochloride to 7 mixed-breed dogs (phase 1) in a crossover experiment (interval of 1 week between treatments). (avma.org)
Most experts recommend that intermittent IV bolus dosing of diazepam or lorazepam is the treatment of choice for drug therapy of DTs. (medscape.com)

As such, dexmedetomidine provides less amnesia than benzodiazepines. (wikipedia.org)
For mild to moderate fear and anxiety in dogs, trazodone, clonidine, benzodiazepines (e.g. alprazolam, diazepam, lorazepam), gabapentin, imepitoin or dexmedetomidine oromucosal gel might be effective for car ride anxiety, veterinary visits and procedures. (vin.com)
GHB withdrawal can initially be treated with high doses of benzodiazepines, though anecdotally, refractory cases have responded to other sedative agents, such as pentobarbital, chloral hydrate, and baclofen. (medscape.com)
Alpha-2 agonists, mainly clonidine and dexmedetomidine, are used as adjunctive (or alternative) sedative agents alongside opioids and benzodiazepines. (lu.se)
However, compared with benzodiazepines, even at high doses, phenobarbital has a greater risk of respiratory depression and hypotension and has a lower overall safety profile. (medscape.com)
[ 13 ] Some authorities have recommended phenobarbital as a first-line agent to be given as an initial single large dose up to 10 mg/kg or preferably as repeated small doses (65, 130, or 260 mg IV per dose) for loading until the patient is calm, to be followed by use of benzodiazepines on an as-needed, symptom-triggered basis. (medscape.com)
An appropriate use for phenobarbital might be a situation in which agitation has not been controlled well with high doses of benzodiazepines. (medscape.com)

Intravenous dexmedetomidine exhibits linear pharmacokinetics with a rapid distribution half-life of approximately 6 minutes in healthy volunteers, and a longer and more variable distribution half-life in ICU patients. (wikipedia.org)
The terminal elimination half-life of intravenous dexmedetomidine ranged 2.1 to 3.1 hours in healthy adults and 2.2 to 3.7 hours in ICU patients. (wikipedia.org)
Background and Aims Perineural and intravenous dexmedetomidine as a local anaesthetic adjunct has not been compared previously in fascia iliaca compartment block (FICB). (researchgate.net)

Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. (thoracic.org)

This study is noteworthy for finding use of dexmedetomidine reduced the prevalence of delirium (54% vs 77% with midazolam) and for providing further evidence of the safety of using dexmedetomidine at higher doses and longer duration. (thoracic.org)
2020. Evaluation of subcutaneous administration of alfaxalone-midazolam and dexmedetomidine-midazolam for sedation of ball pythons (Python regius). (awionline.org)
OBJECTIVE: To evaluate SC administration of alfaxalone-midazolam and dexmedetomidine-midazolam for sedation of ball pythons (Python regius). (awionline.org)

There was no difference in all cause mortality at 90 days but bradycardia and hypotension were more common in the dexmedetomidine group. (thoracic.org)

Driving Simulator Performance After Administration of Analgesic Doses of Ketamine With Dexmedetomidine or Fentanyl. (austin.org.au)
Driving simulator performance is significantly compromised after coadministration of analgesic range doses of ketamine with dexmedetomidine but not fentanyl. (austin.org.au)
Dexmedetomidine also has analgesic effects at the spinal cord level and other supraspinal sites. (wikipedia.org)
Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics. (researchgate.net)

Pediatric use information is approved for Hospira Inc.'s PRECEDEX TM (dexmedetomidine hydrochloride) injection and PRECEDEX TM (dexmedetomidine hydrochloride) in sodium chloride injection. (nih.gov)
Dexmedetomidine, sold under the trade name Precedex among others, is a drug used in humans for sedation. (wikipedia.org)

Dexmedetomidine has also been used as an adjunct to neuroaxial anesthesia for lower limb procedures. (wikipedia.org)
The aim of this study was to compare the effect of a fixed dose of dexmedetomidine (DEX) and nitroglycerin (NTG) with NTG alone on hemodynamic parameters, NTG dose, surgeon satisfaction, and blood loss during controlled hypotensive anesthesia in FESS. (eg.net)
Adding Mg to local anesthetic mixture in peribulbar anesthesia resulted in a fast onset, long duration and better akinesia score while Dexmedetomidine supplementation offered more patient satisfaction. (longdom.org)

S clitoris, additionally, treatment involves administering high doses of antifungal medications. (njacs.org)

It is usually taken as needed as a single dose under the supervision of a healthcare professional. (medlineplus.gov)
The 200 mcg/50mL and 400 mcg/100 mL single-dose GALAXY containers do not require further dilution prior to administration. (pharmacyhq.com)
A single dose of intravenous phenobarbital given in the emergency department may decrease the subsequent ICU admission rate and decrease the total dose of benzodiazepine and decrease the use of continuous lorazepam infusions required during the hospital course, without any increased adverse effects. (medscape.com)

Dexmedetomidine induces sedation by decreasing activity of noradrenergic neurons in the locus ceruleus in the brain stem, thereby increasing the downstream activity of inhibitory gamma-aminobutyric acid (GABA) neurons in the ventrolateral preoptic nucleus. (wikipedia.org)
Conclusion and Clinical Relevance -Results suggest that IV administration of romifidine induces dose-dependent cardiovascular changes in dogs. (avma.org)

Studies suggest dexmedetomidine for sedation in mechanically ventilated adults may reduce time to extubation and ICU stay. (wikipedia.org)

The daily sedation interruption group received higher doses of sedatives and opiates, and required greater nursing care based on a visual analog scale. (thoracic.org)
This study used higher doses of dexmed for longer durations than what the product labeling advises. (medicalevidenceblog.com)

Administer dexmedetomidine injection by continuous infusion not to exceed 24 hours. (nih.gov)
Administer dexmedetomidine injection using a controlled infusion device. (nih.gov)
Administer dexmedetomidine hydrochloride in 0.9% sodium chloride injection using a controlled infusion device. (pharmacyhq.com)
Then, one could administer a small dose of phenobarbital and repeat every 30 minutes until sedation occurs. (medscape.com)

however, performance after coadministration with the adjuvant sedating agents dexmedetomidine or fentanyl is unclear. (austin.org.au)

Dexmedetomidine, an alpha 2 agonist, has been used to manage symptoms of delirium in pediatric patients and is gaining popularity in treatment for pediatric patients with severe anticholinergic toxidrome [ 5 , 6 ]. (hindawi.com)
Monitoring: Continuously monitor patients while receiving dexmedetomidine HCl. (nih.gov)
One third of the patients had at least 1 dose reduction of docetaxel due to toxicity. (unav.edu)
Conclusions: Pharmacokinetically-guided dose adjustment of standard chemotherapy treatments might improve survival outcomes in patients with pancreatic ductal adenocarcinoma. (unav.edu)
[ 12-14 ] Whether perioperative dexmedetomidine could reduce the risk for AKI in adult patients undergoing cardiac surgery remains unclear. (medscape.com)
Early sedation with dexmedetomidine in critically ill patients. (thoracic.org)
RCT of 4000 patients undergoing ventilation in the ICU for less than 12 hours to receive dexmedetomidine as sole or primary agent vs usual care with target RASS score of -2 to +1. (thoracic.org)
This study randomized 566 patients with acute respiratory failure or shock and hypoactive (89%) or hyperactive delirium (11%) to receive intravenous boluses of haloperidol (maximum dose, 20 mg daily), ziprasidone (maximum dose, 40 mg daily), or placebo. (thoracic.org)
When dexmedetomidine hydrochloride in 0.9% sodium chloride injection is infused for more than 6 hours, patients should be informed to report nervousness, agitation, and headaches that may occur for up to 48 hours. (pharmacyhq.com)
Additionally, patients should be informed to report symptoms that may occur within 48 hours after the administration of dexmedetomidine hydrochloride in 0.9% sodium chloride injection such as: weakness, confusion, excessive sweating, weight loss, abdominal pain, salt cravings, diarrhea, constipation, dizziness or light-headedness. (pharmacyhq.com)
Monitoring: Continuously monitor patients while receiving dexmedetomidine hydrochloride in 0.9% sodium chloride injection. (pharmacyhq.com)
Sixty American Society of Anaesthesiologists (ASA) grade 1 pediatric patients undergoing laproscopic orchidopexy under general anaesthesia were ra ndomized into two groups (GroupLD and Group LT). Group LD recieved ultrasound guided bilateral TAP block with 0.3 ml/kg 0.25% levobupivacaine with 1μg/ kg of dexmedetomidine on both sides and Group LT recieved TAP block with 0.3 ml/kg 0.25% levobupivacaine with 1mg/ kg of tramadol. (magiran.com)
Both doses of the film (120 mcg and 180 mcg) showed a high response rate in patients. (fhea.com)
My very small experience with this drug so far at the labelled doses is that it is difficult to use in that it does not achieve adequate sedation in the most agitated patients - those receiveing the highest doses of benzos and narcotics, in whom lightenting of sedationl is assigned the highest priority. (medicalevidenceblog.com)
Scaling drug doses to obese patients by total body mass (TBM) results in overdose. (bvsalud.org)

Dexmedetomidine is a highly selective α2-adrenergic agonist. (wikipedia.org)

2. lorazepam was titrated upwards without boluses between dose increases. (medicalevidenceblog.com)

A high-dose continuous infusion of IV dexmedetomidine was administered, and his violent behavior and delirium significantly improved. (hindawi.com)
He had persistent hyperactive delirium and was managed in the ICU with continuous dexmedetomidine infusion for 24 hours before his symptoms improved. (hindawi.com)
Continuous low-dose morphine or dexmedetomidine may be considered for preterm or term neonates exhibiting signs of stress during mechanical ventilation and therapeutic hypothermia, respectively. (iasp-pain.org)

Reduction in dosage of dexmedetomidine hydrochloride or the concomitant medication may be required. (nih.gov)
Dexmedetomidine hydrochloride in 0.9% sodium chloride injection is indicated for short-term intravenous sedation. (pharmacyhq.com)
These highlights do not include all the information needed to use DEXMEDETOMIDINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE INJECTION safely and effectively. (pharmacyhq.com)
DEXMEDETOMIDINE HYDROCHLORIDE in 0.9% sodium chloride injection, for intravenous use. (pharmacyhq.com)
Dexmedetomidine hydrochloride in 0.9% sodium chloride injection 200 mcg/50 mL (4 mcg/mL) in a 50 mL GALAXY container. (pharmacyhq.com)
Dexmedetomidine hydrochloride in 0.9% sodium chloride injection 400 mcg/100 mL (4 mcg/mL) in a 100 mL GALAXY container. (pharmacyhq.com)

High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness. (qxmd.com)
The University of North Carolina's (UNC) Pediatric Sedation Service adopted a noninvasive procedural sedation protocol that uses dexmedetomidine in children based on review of literature that reported fast recovery times and low morbidity. (qxmd.com)
Dexmedetomidine can also be used for procedural sedation such as during colonoscopy. (wikipedia.org)
Dexmedetomidine is also used for procedural sedation in children. (wikipedia.org)

to evaluate the effects of intravenous (IV) dexmedetomidine as a pre-medication on clinical profile of bupivacaine spinal anaesthesia in lower abdominal surgeries. (panafrican-med-journal.com)
These data claim that 2 tablets of lopinavir-ritonavir BD may be insufficient when dosed with NNRTIs in Ugandan adults, and the medication dosage should be elevated with the addition of yet another adult tablet or a half-dose tablet (100/25 mg), where obtainable. (woofahs.com)

If you are still agitated after you receive your first dose, you may be given up to 2 more additional doses, given at least 2 hours apart. (medlineplus.gov)

Therefore, we conducted a meta-analysis to evaluate the effect of perioperative dexmedetomidine (compared to placebo or other drugs) on the risk for AKI and mortality. (medscape.com)

In addition, there has been no systematic review that comprehensively focuses on the potential renal effect of dexmedetomidine in adult cardiac surgery. (medscape.com)

The VAS score and the need of supplemental dose were much higher in the control group. (longdom.org)

The following parameters were also recorded: duration of surgical interference (time from the beginning to the end of surgical intervention), blood loss volume, surgeon satisfaction, time to achievement of the target MAP, time to reversibility of MAP to baseline, and the highest dose of NTG needed to reach target MAP. (eg.net)
As there is extensive individual variability, drugs should be assessed in advance of the fear-evoking situation, to determine effect, side effects, dose, onset to peak effect, duration, frequency and combination use. (vin.com)
Depending on the duration of effect, it might be advisable to combine drugs, give an additional dose 8-12 hours in advance or to begin one or more of the medications two to three days in advance. (vin.com)
RCT found daily interruption of sedation in a MICU population resulted in shorter duration of mechanical ventilation and ICU stay, less total dose of sedation, and less use of diagnostic tests to work-up impaired mental status compared to the control group. (thoracic.org)
Duration of mechanical ventilation was shorter with dexmedetomidine but length of ICU stay was similar. (thoracic.org)
Sedative-hypnotic withdrawal is treated by substituting drugs that have a long duration of action, either a benzodiazepine or phenobarbital, in a maintenance dose for a few days followed by a gradually decreasing dose over 2-3 weeks. (medscape.com)
Tolerance depends on the dose, duration, and frequency of use and is the result of pharmacokinetic (metabolic) or pharmacodynamic (cellular or functional) adaptation. (medscape.com)

Selection criteria: We searched for randomized controlled trials, quasi-randomized controlled trials, and cluster trials comparing clonidine versus placebo, no treatment, or dexmedetomidine administered to term and preterm newborns receiving mechanical ventilation via an endotracheal tube. (lu.se)

Dexmedetomidine is in a class of medications called alpha 2 receptor agonists. (medlineplus.gov)

Dexmedetomidine dose range is 0.001 to 0.0075 mg/kg. (vasg.org)

Compared with other sedatives, some studies suggest dexmedetomidine may be associated with less delirium. (wikipedia.org)
At the very least, when aggregating many study results together, use of dexmedetomidine appears to be associated with less neurocognitive dysfunction compared to other sedatives. (wikipedia.org)
Dexmedetomidine may enhance the effects of other sedatives and anesthetics when co-administered. (wikipedia.org)

Unlike dexmedetomidine, none of the new compounds caused sedation, even at doses significantly higher than those required for pain relief. (iric.ca)

Pediatric outpatients (6 months-18 years) who received dexmedetomidine per protocol for a noninvasive procedure or study from January 2011 through April 2012 were included in this retrospective chart review. (qxmd.com)

Dexmedetomidine may be useful for the treatment of the negative cardiovascular effects of acute amphetamines and cocaine intoxication and overdose. (wikipedia.org)
Objective -To characterize the cardiovascular effects of romifidine at doses ranging from 5 to 100 µg/kg of body weight, IV. (avma.org)
However, the 2 lowest doses (5 and 10 µg/kg) induced less cardiovascular depression, and doses ≥ 25 µg/kg induced similar cardiovascular changes, suggesting that there may be a ceiling on the cardiovascular effects of romifidine. (avma.org)

Toxic doses may cause first-degree or second-degree atrioventricular block. (wikipedia.org)
There are also many other features such as toxic dose calculators for chocolate and rodenticides, glucose monitoring features, fluid rate calculators, and a feature to help grade kidney disease amongst other things. (apple.com)

Spinal anaesthesia is advantageous in that it uses a small dose of anaesthesia, simple to perform and offer a rapid onset of action, reliable surgical analgesia and good muscle relaxation. (panafrican-med-journal.com)

Similarly, drugs that lower blood pressure and heart rate, such as beta blockers, may also have enhanced effects when co-administered with dexmedetomidine. (wikipedia.org)
These molecules preferentially and selectively activated Gi, Go and Gz protein subtypes, in contrast to known drugs (such as dexmedetomidine) that activate a much broader set of G proteins. (iric.ca)

Your doctor may need to change the doses of your medications or monitor you carefully for side effects. (medlineplus.gov)
Dexmedetomidine may cause side effects. (medlineplus.gov)
Thus, adverse effects may be reduced by omitting a loading dose. (wikipedia.org)
Pharmacokinetic-guided (PKG) dosing has demonstrated beneficial effects in other tumors, but scarce data is available in pancreatic cancer. (unav.edu)
Therapeutic molecules (dexmedetomidine) target this type of receptor but have side effects (such as sedation) that limit its use to hospitals. (iric.ca)
To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)

Individualize and titrate dexmedetomidine injection dosing to desired clinical effect. (nih.gov)

From an economic perspective, dexmedetomidine is associated with lower ICU costs, largely due to a shorter time to extubation. (wikipedia.org)

Group-1 (control group) received normal saline and group-2 (study group) received IV dexmedetomidine 1 g/kg over 10 min as premedication. (panafrican-med-journal.com)
At 1 h before operation, 5.0 μg/kg dexmedetomidine and 5.0 μg/kg Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway agonist SC-39100 were intraperitoneally injected into experimental and control groups, respectively, while the same dose of normal saline was injected into sham and model groups. (ijpsonline.com)

Dexmedetomidine, magnesium sulphateand rocuronium bromidehave been added to local anesthetics to achieve such goal. (longdom.org)

A Complicated Course: Severe Alcohol Withdrawal with Dexmedetomidine Infusion. (ahrq.gov)

For medications to be effective, they must be administered before the fearful event and at a dose and frequency to achieve optimal effect. (vin.com)

Food was withheld from each dog for 16 hours before and 6 hours after either dose administration. (avma.org)

There is currently a paucity of information on using dexmedetomidine for levetiracetam-induced acute psychosis. (hindawi.com)

Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)

In dogs given romifidine at a dose of 25, 50, or 100 µg/kg, an initial increase followed by a prolonged decrease in arterial pressure was observed. (avma.org)

This study aimed to compare dexmedetomidine discharge readiness times observed at UNC with those previously published with a hypothesis that the discharge times at UNC are longer than those previously published. (qxmd.com)

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Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology4

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Propofol10

Sublingual film7

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Benzodiazepines7

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