MucosaTestosterone buccal systemTabletSublingual and BuccalSwabTabletsMucosalVaginalOpioidsBuprenorphineMedicationMidazolamAdultRegimensMisoprostolMifepristoneHepaticPediatricInsulinOralOpioid regimenMicronucleusDrugsMorphineRenalRoutesMumpsIncreasesRemainderConcurrentPatientsEfficacyInhibitorsDailyNicotineDurationCharacteristicsSidesNext doseEffectivenessEffectiveAdministrationCloselyApproachAvoidWithdrawal
Mucosa7
- Buccal administration is a topical route of administration by which drugs held or applied in the buccal (/ˈbʌkəl/) area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream. (wikipedia.org)
- These tablets, held within the buccal pouch, either act on the oral mucosa or are rapidly absorbed through the buccal mucosal membrane. (wikipedia.org)
- Since drugs "absorbed through the buccal mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare professionals. (wikipedia.org)
- The most common route for drug transport through the buccal mucosa is the paracellular pathway. (wikipedia.org)
- 10 , 14 Twenty-five percent of the fentanyl in this formulation is absorbed rapidly through the buccal mucosa, and the remainder is swallowed, of which another 25% of the total dose is absorbed through the gastrointestinal tract. (jnccn.org)
- Water may be used to moisten the buccal mucosa in patients with a dry mouth. (medicines.org.uk)
- la articaína mostró mayor efecto anestésico en mucosa vestibular (88,9%) y punta de lengua (55,6%), en comparación con la lidocaína. (bvsalud.org)
Testosterone buccal system11
- testosterone buccal system increases effects of cyclosporine by decreasing metabolism. (medscape.com)
- testosterone buccal system will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- testosterone buccal system and pexidartinib both increase Other (see comment). (medscape.com)
- sotorasib will decrease the level or effect of testosterone buccal system by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
- testosterone buccal system increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- testosterone buccal system increases toxicity of carbamazepine by decreasing metabolism. (medscape.com)
- testosterone buccal system increases effects of insulin degludec by pharmacodynamic synergism. (medscape.com)
- and drink alcoholic or nonalcoholic beverages while you are wearing a testosterone buccal system. (medlineplus.gov)
- If your testosterone buccal system does not stick or falls off within 8 hours after you apply it, replace it with a new system immediately and apply your next dose at the regularly scheduled time. (medlineplus.gov)
- Place your finger on the outside of your upper lip over the spot where you applied the testosterone buccal system. (medlineplus.gov)
- The testosterone buccal system should now be stuck to your gum. (medlineplus.gov)
Tablet11
- Buccal testosterone comes as a system (tablet shaped patch) to apply to the upper gum. (medlineplus.gov)
- Notable drawbacks of buccal tablets include the hazard of choking by involuntarily swallowing the tablet and irritation of the gums. (wikipedia.org)
- With recent advances on buccal tablets and in conditions where the conventional oral route (i.e. swallowing of tablet) cannot be delivered effectively, some commonly prescribed buccal tablets available in healthcare settings are listed below as examples. (wikipedia.org)
- The dose of Nitrostat is one tablet dissolved under the tongue or in the buccal ( cheek ) pouch at the first sign of an acute anginal attack. (rxlist.com)
- The past decade has seen clinical trials of transmucosal opioid formulations for breakthrough pain in cancer (BTPc), beginning with oral transmucosal fentanyl citrate (OTFC), followed by fentanyl buccal tablet and intranasal fentanyl spray, and most recently sublingual fentanyl tablet, fentanyl buccal soluble film, and fentanyl pectin nasal spray. (jnccn.org)
- According to the therapeutic response, the dose may be reduced to 7.5 mg/day (half a 15mg tablet). (medicines.org.uk)
- The recommended dose for long term treatment of rheumatoid arthritis and ankylosing spondylitis in elderly patients is 7.5 mg (half a 15 mg tablet) per day. (medicines.org.uk)
- In dialysis patients with severe renal failure, the dose should not exceed 7.5 mg (half a 15 mg tablet) per day. (medicines.org.uk)
- Cold Sores: Place 1 buccal tablet (50 mg) in your mouth between the upper cheek and gum. (buyzoviraxonline.com)
- This medication comes in buccal tablet form which is a tablet that dissolves when held between the cheek and gum. (rxwiki.com)
- 6. Before applying your next dose, be sure to clear away any remaining miconazole tablet material. (rxwiki.com)
Sublingual and Buccal2
- Buprenorphine/naloxone , in a 4:1 to 7:1 ratio, is available in sublingual tablets and sublingual and buccal films under the trade names Suboxone, Zubsolv, Cassipa, and Bunavail, as well as generic products. (medscape.com)
- Buprenorphine/naloxone preparations are currently available in a range of doses and in tablets and sublingual and buccal films. (medscape.com)
Swab3
- On day 44, an underarm sweat swab sample was PCR-positive (C t value 39.6) and a buccal swab sample PCR-negative for EBOV. (cdc.gov)
- On May 1, 2015, a seventh suspected mumps case was confirmed by a positive real-time reverse transcription-polymerase chain reaction (rRT-PCR) test of a buccal swab conducted at the IDPH state laboratory. (cdc.gov)
- and viral detection in RT-PCR or culture may have low yield if the buccal swab is collected too long after parotitis onset. (cdc.gov)
Tablets6
- Objectives The aim of this randomized, crossover, controlled study was to compare efficacy and safety of fentanyl buccal tablets (FBTs) and oral morphine (OM), given in doses proportional to opioid daily doses. (univaq.it)
- Buccal tablets are a type of solid dosage form administered orally in between the gums and the inner linings of the cheek. (wikipedia.org)
- Buccal tablets serve as an alternative drug delivery in patients where compliance is a known issue, including those who are unconscious, nauseated, or having difficulty in swallowing (i.e. dysphagia). (wikipedia.org)
- Buccal tablets are typically formulated through the direct compression of drug, powder mixture, swollen polymer, and other agents that assist in processing. (wikipedia.org)
- Buccal tablets offer many advantages in terms of accessibility, ease of administration and withdrawal, and hence may improve patient compliance. (wikipedia.org)
- Examples include buccal tablets or patches that can be placed in the cheek or on the gums and fast-dissolving tablets that are placed under the tongue. (pmlive.com)
Mucosal1
- Methods: Effects of thrombin on activated-TGF-β1 levels, Smad3 phosphorylation, and connective tissue growth factor (CTGF/CCN2) synthesis in primary human buccal mucosal fibroblasts (BMFs) were assessed by enzyme-linked immunosorbent assay or Western blot analysis. (ntu.edu.tw)
Vaginal2
- 8 weeks, the specified interval between mifepristone and misoprostol was less than 24 h, the total misoprostol dose was 400 mcg (rather than higher), or the misoprostol was administered by the oral route (rather than by vaginal, buccal, or sublingual routes). (nih.gov)
- There is considerable heterogeneity with respect to the dose of mifepristone (50 mg-600 mg) or misoprostol (200 µg-800 µg) used and the route of misoprostol administration (oral, buccal, vaginal). (medscape.com)
Opioids1
- One of the most promising, called microinduction, introduces very low doses while the patient still has opioids in their system, and the dose of BUP is then escalated (see CATR November/December 2021 ). (thecarlatreport.com)
Buprenorphine1
- In 2002, the FDA approved a high-dose formulation of buprenorphine as Suboxone in 2 mg and 8 mg doses (with 0.5 mg and 2 mg naloxone, respectively) and Subutex , a buprenorphine product with no active additives, also in 2 mg and 8 mg doses for sublingual administration. (medscape.com)
Medication6
- Androgens may decrease blood glucose and, therefore, may necessitate a decrease in the dose of antidiabetic medication. (medscape.com)
- Testosterone buccal systems will soften and mold to the shape of your gum and will gradually release medication. (medlineplus.gov)
- Conclusion When used in doses proportional to the basal opioid regimen, FBT showed a clear superiority and was well tolerated when compared with OM during the first 30 minutes, which is the approximate target for a timely intervention required for a BTcP medication. (univaq.it)
- Buccal administration may provide better bioavailability of some drugs and a more rapid onset of action compared to oral administration because the medication does not pass through the digestive system and thereby avoids first pass metabolism. (wikipedia.org)
- Furthermore, most studies have found no meaningful relationship between the effective dose of transmucosal opioid and the around-the-clock scheduled medication nor the previous rescue medication. (jnccn.org)
- 1 Classically, treatment of BTPc has involved taking an extra dose of the oral opioid already being taken to relieve background chronic pain, at 5% to 20% of the total daily dose, as "rescue" medication. (jnccn.org)
Midazolam2
- and nicotine as a smoking cessation aid were commercially available in buccal forms, as was midazolam, an anticonvulsant, used to treat acute epileptic seizures. (wikipedia.org)
- Sedative Doses of Midazolam Depress Hypoxic Ventilatory Responses in Humans. (benzo.org.uk)
Adult2
- Testosterone buccal systems are used to treat symptoms of low testosterone in adult men who have hypogonadism (a condition in which the body does not produce enough natural testosterone). (medlineplus.gov)
- Background Most indications and doses of medicines used in paediatric palliative medicine are derived from anecdotal evidence and involve scaled down adult doses. (bmj.com)
Regimens3
- Our aim was to summarize extant data on the effectiveness and safety of regimens using the widely recommended lower mifepristone dose, 200 mg, followed by misoprostol in early pregnancy and to explore potential correlates of abortion failure. (nih.gov)
- We show that current dosing regimens are preventing severe deficiency but are not effective at maintaining sufficient vitamin D levels within the Duchenne population. (vitamindwiki.com)
- To better understand INSTI distribution and inform dosing selection we compared the pharmacology of two-dose boosted elvitegravir and unboosted bictegravir regimens in MSM. (cdc.gov)
Misoprostol1
- and changing the dose of mifepristone (600 mg to 200 mg) and misoprostol (400 mcg to 800 mcg). (nationalrighttolifenews.org)
Mifepristone1
- The dose of mifepristone approved by most government agencies for medical abortion is 600 mg. (nih.gov)
Hepatic1
- No dose reduction is required in patients with mild to moderate hepatic impairment (for patients with severely impaired liver function, see section 4.3). (medicines.org.uk)
Pediatric1
- This study aims to evaluate the genotoxicity of dental materials used in pediatric treatment through micronucleus (MN) test of exfoliated buccal cells. (bvsalud.org)
Insulin1
- Insulin dosed using this system to rats had a bioavailability of around nine per cent, suggesting that, at least in principle, this approach could provide an oral alternative to insulin injections for treating diabetes. (pmlive.com)
Oral4
- Oral dose = 2/3 effectiveness of IV route when converting. (globalrph.com)
- 1 Two of the studies assessed effective dosing of OTFC, 11 , 12 another tested OTFC against placebo, 13 whereas the last study compared OTFC with oral immediate-release morphine sulfate. (jnccn.org)
- Patients were randomly allocated to a single oral dose of BXCL501: 120 mcg, 180 mcg, or placebo. (medscape.com)
- Specimens were collected up to 96 h after two oral doses of tenofovir alafenamide and emtricitabine with elvitegravir boosted by cobicistat or unboosted bictegravir given 24 h apart. (cdc.gov)
Opioid regimen2
Micronucleus1
- A 12-fold increase in micronucleus frequency was noted for epithelial cells from the buccal area of the mouth during the study period. (cdc.gov)
Drugs1
- Antiretroviral drugs were measured by LC-MS. RESULTS: Mean bictegravir plasma concentrations remained above the 95% protein-adjusted effective concentration 96 h after dosing [273 (95% CI: 164-456) ng/mL] whereas elvitegravir plasma concentrations became undetectable 48 h after the second dose. (cdc.gov)
Morphine1
Renal1
- No dose reduction is required in patients with mild to moderate renal impairment (i.e. patients with a creatinine clearance of greater than 25 ml/min). (medicines.org.uk)
Routes1
- Various doses, combinations, and routes of administration are in use. (medscape.com)
Mumps8
- Mumps outbreaks can occur in close-contact settings like universities, despite high 2-dose MMR vaccination coverage. (cdc.gov)
- A third dose of MMR vaccine has been used in previous mumps outbreaks, but its effectiveness is not established. (cdc.gov)
- 89% of patients with mumps had received at least 2 doses of measles-mumps-rubella (MMR) vaccine, and a third dose was recommended as a control measure. (cdc.gov)
- Additional studies are needed to determine the effectiveness of a third MMR dose as a mumps outbreak control measure in certain populations. (cdc.gov)
- Because of sustained transmission in a population with high 2-dose coverage with measles-mumps-rubella (MMR) vaccine, a third MMR dose was recommended by IDPH, C-UPHD, and the university's McKinley Health Center. (cdc.gov)
- However, CDC has provided guidelines for use of a third dose as a control measure during mumps outbreaks in settings in which persons are in close contact with one another, where transmission is sustained despite high 2-dose MMR coverage, and when traditional control measures fail to slow transmission ( 2 ). (cdc.gov)
- All patients with suspected mumps had documentation of receipt of 2 doses of MMR vaccine. (cdc.gov)
- Investigators identified contacts of mumps patients to verify receipt of 2 doses of MMR vaccine and recommended vaccination of susceptible close contacts if they were not fully vaccinated. (cdc.gov)
Increases1
- In the 22 men, a dose response relationship was noted between cumulative exposure to formaldehyde and increases in buccal micronuclei. (cdc.gov)
Remainder1
- 61% prescribers would start wherever a dose range (eg, 200-300 mg/kg/dose) seemed most appropriate, the remainder at the lowest dose. (bmj.com)
Concurrent1
Patients3
- patients with prior opiate exposure may require higher initial doses. (globalrph.com)
- Researchers therefore sought to create a reliable microinduction protocol for patients hospitalized on medical floors utilizing intravenous BUP (IV-BUP), which is inexpensive and easy to dose in small increments (see "Intravenous Microinduction Strategies Utilized" table). (thecarlatreport.com)
- This is a small study, but you can consider this approach for medically hospitalized patients if small sublingual or transdermal doses are unavailable. (thecarlatreport.com)
Efficacy1
- In several controlled studies, the value of treatment with nicotine only has been proved, 2 - 4 but recent studies assessing the efficacy of treatment with nicotine by high dose nicotine patches gave different results. (bmj.com)
Inhibitors1
- If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. (medscape.com)
Daily1
- Buccal administration of vaccines has been studied, but there are challenges to this approach due to immune tolerance mechanisms that prevent the body from overreacting to immunogens encountered in the course of daily life. (wikipedia.org)
Nicotine4
- The best dose for you is the dose that decreases the urge to smoke without side effects from too much nicotine. (webmd.com)
- Start to lower your dose after 6 weeks or as directed by your doctor until you are no longer smoking and no longer need nicotine replacement. (webmd.com)
- Withdrawal is more likely if you have used nicotine for a long time or in high doses. (webmd.com)
- 7. Smoke no more than 8 cigarettes, pipes, cigars, e-cigarettes or equivalent per month, including nicotine products, from 3 months prior to Screening and is willing to abstain from smoking/using nicotine products for 24 hours before VLS-01 administration and during the entire dosing Visit. (who.int)
Duration3
- Single I.M. doses have a duration of 1-2 hours, single I.V. doses last 0.5-1 hour. (globalrph.com)
- 5 - 7 In the Collaborative European Antismoking Evaluation study, evidence in favour of dose-response relations was found, but increasing the duration of patch use did not improve abstinence rates. (bmj.com)
- Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms (see section 4.4). (medicines.org.uk)
Characteristics1
- The rationale for the recommendation of a third MMR dose included a consideration of seasonal trends and characteristics of the at-risk population. (cdc.gov)
Sides1
- Alternate sides at every dose so that you never apply a system to the same side two doses in a row. (medlineplus.gov)
Next dose1
- The replacement system will take the place of your next dose. (medlineplus.gov)
Effectiveness1
- These were weighed against potential drawbacks, which included the potential for vaccine-related side effects, associated costs, and the lack of evidence of the effectiveness of a third MMR dose. (cdc.gov)
Effective2
- Within this shift, the necessity of easy-to-use and effective self-dosing medications is underscored and at this juncture, these buzzwords are seen as imperative solutions. (drug-dev.com)
- Effective dose (ED) 50 and ED95 values were calculated by probit statistic software. (who.int)
Administration1
- Weight loss may also lead to decreased dose or frequency of drug administration. (vin.com)
Closely2
- Monitor closely, especially upon initiation or following a dose increase. (drugs.com)
- After immediate implant site preparation, the socket is filled with Bio-Oss collagen and trimmed in a cone form to closely adapt to the buccal wall. (allenpress.com)
Approach1
- The aim of this article is to present a novel approach to preserve the buccal wall when performing immediate implants. (allenpress.com)
Avoid1
- Also, to prevent this buccal wall modeling/remodeling, the implant should be placed more palatally to avoid pressure against the buccal plate and to facilitate bone-grafting outcomes, since a gap is always left between the implant and the buccal bone. (allenpress.com)
Withdrawal1
- To help prevent withdrawal, your doctor may lower your dose slowly. (webmd.com)