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  • What dose of medication is best to prevent the evolution of drug resistance? (psu.edu)
  • There is nothing in evolutionary theory that says that the dogma of hitting infections hard with high doses of medication should be the best rule of thumb to prevent drug resistance," said Andrew Read, Evan Pugh Professor of Biology and Entomology and Eberly Professor in Biotechnology at Penn State University. (psu.edu)
  • If a small number of microbes are already resistant to treatment, or if drug resistance arises by chance, high doses of medication may allow resistant microbes to survive and spread by the very act of killing off drug-sensitive microbes. (psu.edu)
  • High doses of medication can quickly eliminate this competition for resources, allowing drug-resistant microbes to thrive. (psu.edu)
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  • Medication underdosing occurs commonly when physicians write prescriptions for a dosage that is correct for a certain time, but fails to increase the dosage as the patient needs (i.e. weight based dosing in children, or increasing dosages of chemotherapy drugs if a patient's condition worsens). (wikipedia.org)
  • Low-dose naltrexone (LDN) describes the off-label use of the medication naltrexone at low doses for diseases such as multiple sclerosis . (wikipedia.org)
  • medicines
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  • vitamin
  • May 4, 2010 -- Women who take high doses of vitamin D during pregnancy have a greatly reduced risk of complications, including gestational diabetes , preterm birth, and infection, new research suggests. (webmd.com)
  • Wagner acknowledges the recommendation may be controversial because very high doses of vitamin D have long been believed to cause birth defects . (webmd.com)
  • Wagner says it took months to get permission to do a study in which pregnant women were given doses of the vitamin that were twice as high as this. (webmd.com)
  • Not surprisingly, women who took the highest doses of vitamin D were the least likely to have deficient or insufficient blood levels of the vitamin, as were their babies. (webmd.com)
  • Lawrence sees no problem with the recommendation that women take 4,000 IU of vitamin D daily during pregnancy, although she says the impact of high doses of vitamin D on pregnancy-related complications remains to be proven. (webmd.com)
  • medications
  • A new model shows that the standard practice of treating infections with the highest tolerable dose of anti-microbial medications may not be best for preventing the evolution of drug resistance in all cases. (psu.edu)
  • High doses of medications are effective at combatting the first of these evolutionary processes. (psu.edu)
  • Over-the-counter medications are typically accompanied by a set of instructions directing the patient to take a certain small dose, followed by another small dose if their symptoms don't subside. (wikipedia.org)
  • effects
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  • Even the ICRP stated that: 'The permissible doses can therefore be expected to produce effects [illnesses] that could be detectable only by statistical methods applied to large groups. (abs-cbn.com)
  • At very low doses, effects are likely to be statistically hidden by normal biological variations, yet these effects are real. (abs-cbn.com)
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  • Dose-response curves may illustrate the relationship of these metabolic effects. (wikipedia.org)
  • These apparent effects have not been seen at standard doses or in major trials. (wikipedia.org)
  • Researchers have also examined "ultra-low-doses" of naltrexone at microgram, nanogram, and picogram doses, that are co-administered with opioid analgesics with the goal of increasing pain relief and reducing side effects. (wikipedia.org)
  • Conversely, a sufficiently low dose of any compound will produce no significant effects that can be experimentally determined, no matter how sophisticated or extensive the experiment. (springer.com)
  • kilogram
  • Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's body weight to determine a safe dosage. (wikipedia.org)
  • In single dosage scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. (wikipedia.org)
  • Dose is often expressed as milligram (amount) per kilogram (a measure of body weight) per day (a measure of time) when people eat or drink contaminated water, food, or soil. (greenfacts.org)
  • lowest dose
  • Day and Read showed that the optimal approach to combatting the evolution of drug resistance will be either to use the highest dose that is safe or to use the lowest dose that is effective. (psu.edu)
  • We're extending that old rule of thumb to say that the best practice will either be the highest dose or the lowest dose of a drug," said Read. (psu.edu)
  • In other words, LD50 means the lowest dose at which a material kills half of the test subjects. (scienceblogs.com)
  • average dose
  • The 5 rem per 30 years was set as the average dose to a population, with a maximum of 0.5 rem (5 msV) per year for any individual member of the public. (abs-cbn.com)
  • Under-dosing is a common problem in pharmacy, as predicting an average dose that is effective for all individuals is extremely challenging because body weight and size impacts how the dose acts within the body. (wikipedia.org)
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  • decrease
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  • Decrease your basal dose (see chart below). (nationwidechildrens.org)
  • If your blood glucose is below target range at 3:00 a.m., then decrease your basal dose. (nationwidechildrens.org)
  • viagra
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  • Bowling noted that safety of low-dose naltrexone treatment for multiple sclerosis has not been assessed, and that patients who chose to undergo the treatment should be fully informed of the limited research backing its use. (wikipedia.org)
  • The UK National Health Service concluded that small pilot studies indicate low-dose naltrexone can improve symptoms in multiple sclerosis patients, but that more thorough studies are needed to determine its efficacy and safety. (wikipedia.org)
  • One small pilot study found a reduction in fibromyalgia symptoms in patients treated with low-dose naltrexone. (wikipedia.org)
  • According to current international guidelines, it is assumed that even the smallest radiation dose poses a risk to patients. (news-medical.net)
  • reaction
  • The correct dosage for a patient is dependent on their individual reaction to both chemicals, and therefore the dosing must be continually adjusted once treatment is initiated to find the right balance. (wikipedia.org)
  • periods
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  • Some substances are meant to be taken in small doses over large periods of time to maintain a constant level in the body, while others are meant to have a large impact once and be expelled from the body after its work is done. (wikipedia.org)
  • erectile
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  • treatment
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  • In drugs where multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up into intervals for the most effective treatment for the patient. (wikipedia.org)
  • Organizations promoting low-dose naltrexone have advocated it as a treatment for a variety of medical conditions. (wikipedia.org)
  • Dose-response relationships have received a generic treatment in all general textbooks of toxicology, such as those by Loomis (1974), Doull et al . (springer.com)
  • side
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  • efficacy
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  • Some proponents of low-dose naltrexone have brought forth claim about its efficacy in treating a wide range of diseases, including cancer and HIV/AIDS . (wikipedia.org)
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  • smallest
  • This rather limited concept, while useful for estimating risks from exposure to certain toxicants in particular situations, does not apply for toxic substances (like radioactive materials) which do not have any 'tolerance' level, meaning, even the smallest possible dose can produce a toxic effect. (abs-cbn.com)
  • Therefore, as a general rule, the amount of exposure during a nuclear medicine procedure is kept "As Low As Reasonably Practicable" (ALARP), meaning that the smallest dose of radiation possible is used that will still achieve accurate results. (news-medical.net)
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  • High
  • Personal testimonials describing low-dose naltrexone as a cure for multiple sclerosis are not supported by high quality evidence in large randomised , double-blind , placebo-controlled clinical trials. (wikipedia.org)
  • practitioners
  • Drugwatch educates practitioners about the recommended cipro dose trial people and prescriptions of someone' antacids and instinctive concentrations. (jtelsen.com)
  • Low-dose naltrexone may relieve certain symptoms in people with multiple sclerosis, although medical practitioners often advise against using it as a substitute to proven therapies, and the evidence supporting its use in MS is not robust, as different studies have come to conflicting conclusions. (wikipedia.org)
  • units
  • The radiation dose from a nuclear medicine procedure is measured in units of sieverts (usually in millisieverts, mSv). (news-medical.net)
  • clinical
  • However, currently no peer-reviewed studies that would justify clinical use of low-dose naltrexone in treating Multiple Sclerosis (MS) have been published. (wikipedia.org)
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