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Raphe NucleiSerotonergic NeuronsSerotonin8-Hydroxy-2-(di-n-propylamino)tetralinTryptophan HydroxylaseReceptor, Serotonin, 5-HT1AReceptors, Serotonin, 5-HT1Serotonin Receptor AgonistsReceptors, SerotoninAutoreceptorsSerotonin AntagonistsSerotonin 5-HT1 Receptor AgonistsHelplessness, Learned5,7-DihydroxytryptamineReceptors, Corticotropin-Releasing HormoneNeuronsLocus CoeruleusRats, Sprague-DawleySerotonin 5-HT1 Receptor AntagonistsSerotonin AgentsReceptor, Serotonin, 5-HT1BCorticotropin-Releasing HormoneReceptor, Galanin, Type 2Dominance-SubordinationHydroxyindoleacetic AcidBrain StemBehavior, AnimalSerotonin Uptake InhibitorsPiperazinesMicrodialysisMicroinjectionsSerotonin Plasma Membrane Transport ProteinsVesicular Glutamate Transport ProteinsProto-Oncogene Proteins c-fosPyridinesNeural PathwaysSerotonin 5-HT2 Receptor AgonistsFenclonine5,6-DihydroxytryptamineFluoxetineStilbamidinesAutoradiographyReceptor, Serotonin, 5-HT2CBiogenic MonoaminesMesencephalonReceptor, Galanin, Type 1Receptors, Serotonin, 5-HT2Rats, WistarReceptor, Galanin, Type 3Urocortinsp-ChloroamphetamineSeptum of BrainStress, PsychologicalAnatomy, RegionalGalaninDihydroxytryptaminesVesicular Glutamate Transport Protein 1ElectroshockAction PotentialsVesicular Glutamate Transport Protein 2WakefulnessCitalopramIontophoresisTegmentum MesencephaliGABA AgonistsImmobility Response, TonicImmunohistochemistryAllylglycineDrug Administration RoutesN,N-DimethyltryptamineEscape ReactionMedial Forebrain BundleAnxietyDose-Response Relationship, DrugAlfaxalone Alfadolone MixtureAggressionPonsBrainMedulla OblongataSynaptic TransmissionReceptor, Serotonin, 5-HT2ASleep, REMIsoindolesGABAergic NeuronsSwimmingAdrenergic Uptake InhibitorsReceptors, Neurokinin-1Rats, Long-EvansParoxetineElectric StimulationPrefrontal CortexElectrophysiologySubstantia InnominataOvariectomyGABA AntagonistsAfferent PathwaysBrain ChemistryGlutamate DecarboxylaseStress, PhysiologicalNeural Inhibition
NeuronsNucleiSerotonergicCircuitryLocus coeruleusSynapticTegmentalMechanismsPeriaqueductalUnraveled the neural circuitsLateralOptogeneticPopulationsBrainBehaviorsProgenitor cellsRewardBehavioralAcuteResponsesBehaviorRegulationSensoryRegulateCellsStructuresSocialSuitableEffectsSpecificHumanNetworksJournalCell typesRole
Neurons17
  • By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nucleus (DR) or optogenetic inhibition of 5-HT terminals in the anterior cingulate cortex (ACC) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. (elifesciences.org)
  • Finally, we found that the activation of 5-HT1A receptors in the ACC was sufficient to reverse consolation and sociability deficits induced by the chemogenetic inhibition of 5-HTergic neurons in the DR. Our study provided first direct evidence that DR-ACC 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability. (elifesciences.org)
  • 5-HT neurons in the dorsal raphe nucleus (DRN) often fire locked to sensory stimuli, but little is known about how 5-HT affects sensory processing, especially on this timescale. (jneurosci.org)
  • Researchers at the Massachusetts Institute of Technology (MIT) think they've found the source of that motivation in a group of little-studied neurons in part of the brain called the dorsal raphe nucleus. (bibliotecapleyades.net)
  • Stimulating these neurons drives isolated mice to find friends, according to research ( Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation ) published earlier this year in the journal Cell . (bibliotecapleyades.net)
  • Here we identify a hypothalamus to telencephalon neural pathway for regulating impulsivity involving communication from melanin-concentrating hormone (MCH)-expressing lateral hypothalamic neurons to the ventral hippocampus subregion (vHP). (nature.com)
  • Results from additional functional connectivity and neural pathway tracing analyses implicate the nucleus accumbens as a putative downstream target of vHP MCH1 receptor-expressing neurons. (nature.com)
  • A series of experiments where neural populations were either inhibited or activated revealed that a subset of neurons that express the protein proenkephalin (PENK) was key for green light analgesia. (sciencenewshubb.com)
  • Earlier studies determined that these neurons' axons project to the dorsal raphe nucleus (DRN), a structure in the brainstem associated with pain modulation. (sciencenewshubb.com)
  • The location of the ORX neurons, the connected neural networks, and critical part ORX plays in arousal and wakefulness suggest that ORX may also play a role in acute and/or pathological panic states. (bioinf.org)
  • SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic occupation at serotonin neurons in the rat dorsal raphe nucleus. (wgc2010.sk)
  • The ventral striatum and dorsal striatum collectively form the striatum, which is the main component of the basal ganglia.The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium spiny neurons of the nucleus accumbens and olfactory tubercle. (cognitive-liberty.online)
  • Although serotonin (5-HT) was proposed to be responsible for sleep regulation, whether the activity of 5-HTergic neurons in the dorsal raphe nucleus (DRN) is affected by chronic pain has been studied only infrequently. (biomedcentral.com)
  • The firing rate of 5-HT-containing dorsal raphe nucleus (DRN) neurons decreases during slow wave sleep relative to that in wakefulness[ 4 ]. (biomedcentral.com)
  • NeuCELL™ is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons & glial cells. (creative-biolabs.com)
  • An immortalised cell line of human neural progenitors called NeuCELL™ CX may easily develop into neurons and glial cells. (creative-biolabs.com)
  • The researchers used electrophysiology to record the activity of GFP-labeled dopaminergic neurons in two brain areas from these mice: (1) within the well-studied VTA that houses the majority of dopaminergic neurons, and (2) in a rather underexplored brain region known as the dorsal raphe nucleus (DRN) , which contains only a few dopaminergic neurons. (knowingneurons.com)
Nuclei2
  • The neural elements of the clock are confined to the suprachiasmatic nuclei (SCN) of the anterior hypothalamus, which offers an anatomically-discrete model for studying integrative processes regulating specific aspects of circadian rhythms. (kent.edu)
  • This pathway further projects to the region containing the equivalents of the dorsal raphe, the periaqueductal gray, and the dorsal tegmental nuclei. (jnss.org)
Serotonergic1
  • These results identify a new role for serotonergic modulation in dynamically regulating the balance between different sources of neural activity in sensory systems, suggesting a possible role for 5-HT in perceptual inference. (jneurosci.org)
Circuitry6
  • While a comprehensive understanding of the neural circuitry governing both aspects of impulsivity is lacking, some evidence indicates that impulsive action and impulsive choice have both common and distinct underlying neural substrates 11 . (nature.com)
  • The team next attempted to trace the neural circuitry that transmitted the photoreceptors' signals and ultimately resulted in an analgesic effect. (sciencenewshubb.com)
  • The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation. (neurotree.org)
  • What neural circuitry urges us to spring up from the deep abyss of loneliness to a sheltered social rebound? (knowingneurons.com)
  • however, little is known about the specific neural circuitry by which maternal stress exerts its negative impacts on mental health and maternal caregiving behavior. (zoores.ac.cn)
  • Theoretically, such a circuitry should serve as an interface between the stress response system and maternal neural network, transmitting stress signals to the neural circuitry that mediates maternal behavior. (zoores.ac.cn)
Locus coeruleus1
Synaptic1
  • This obviously a very rough estimation - you don't account, for example, to membrane potential, although you can argue that discarding membrane potential while maintaining neural connectivity and synaptic strength should suffice to 'reignite' a frozen brain. (stackexchange.com)
Tegmental2
  • Anatomical and pharmacological evidence suggests that the dorsal raphe serotonin system and the ventral tegmental and substantia nigra dopamine system may act as mutual opponents. (princeton.edu)
  • I hypothesize that maternal stress acts upon the LHb and two of its major downstream targets, i.e., ventral tegmental area (VTA) and dorsal raphe nucleus (DRN), compromising the maternal care and contributing to postpartum mental disorders. (zoores.ac.cn)
Mechanisms5
  • Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. (elifesciences.org)
  • However, the neural mechanisms that contribute to these experiences remain unknown. (stanford.edu)
  • We are interested in elucidating the mechanisms by which experience modulates the responsiveness of neural and hormonal stress responses. (usd.edu)
  • A new paper has used mouse models of pain to dig into the neural mechanisms behind light-based pain relief, suggesting that activation of the brain's natural opioid receptors may play a role. (technologynetworks.com)
  • although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviours, the neural mechanisms by which social reward is encoded by the brain are largely unknown. (cognitive-liberty.online)
Periaqueductal1
Unraveled the neural circuits1
  • A new study has unraveled the neural circuits that explain how green light can relieve some cases of chronic pain. (technologynetworks.com)
Lateral2
  • We recently discovered that the dorsal and ventral Hb (dHb and vHb) of zebrafish correspond respectively to the medial and lateral regions (MHb and LHb) of mammalian Hb. (jnss.org)
  • In zebrafish, the lateral subnuclei of the dorsal habenula (dHbL) are asymmetrically connected with the dorsal and intermediate parts of the interpeduncular nucleus (d/iIPN). (jnss.org)
Optogenetic1
  • On the other hand, the recent development of optogenetic tools has provided a valuable opportunity to regulate the activity in genetically targeted neural populations with high spatial and temporal precision. (biomedcentral.com)
Populations1
  • Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator. (neurotree.org)
Brain2
  • Which focused on the negative effects of physiological stress on changes in the neural systems involved in learning and the brain and body. (nomedicalcare.com)
  • Other studies in rats showed LSD interacting with 5-HT1A serotonin receptors in a part of the brain (dorsal raphe) associated with pain perception. (gwellamushrooms.com)
Behaviors4
  • The dorsal raphe nucleus and cerebellum appear to modulate some forms of reward-related cognition (i.e., associative learning, motivational salience, and positive emotions) and behaviors as well. (wikipedia.org)
  • The fish brains are by far more similar to the mammalian brains than people used to think, and are now regarded as among the most suitable models to study the neural tmechanisms of emotional behaviors. (jnss.org)
  • Dopamine signaling contributes to key neural functions including learning and memory, movement, neuroendocrine signaling, and reward-related behaviors [ 16 ]. (nature.com)
  • Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. (cdc.gov)
Progenitor cells3
  • Neural progenitor cells (NPCs) are progenitor cells that have the ability to proliferate and differentiate into more than one cell type. (creative-biolabs.com)
  • A distinctive feature of neural progenitor cells is that they have limited proliferation capacity, do not produce non-nerve cells, and will not exhibit self-renewal. (creative-biolabs.com)
  • Creative Biolabs now offers a series of new neural lineage progenitor cells derived from control human iPSC using a non-integrated epigenetic-based differentiation method. (creative-biolabs.com)
Reward4
  • The neural mecha- of severe psychological stress has focused nisms of reward and motivation (hedonia, on stress-related psychopathology. (nomedicalcare.com)
  • The concepts of allostasis and allo- maintain neural systems regulating reward and motiva- static load link the protective and survival values of the tion in the face of an unrewarding environment? (nomedicalcare.com)
  • Our recent data showed in zebrafish that the projection from Hb to the median raphe transmits the shock-predicting negative reward expectation value to the reinforcement learning system and enables the behavioral transition from panic to adaptive active avoidance to cope with fear. (jnss.org)
  • In the field of neuroscience, years of research have unveiled the neural circuits of reward , especially from warm social interactions. (knowingneurons.com)
Behavioral1
  • Understanding the neural substrates regulating impulsivity may lead to the development of novel treatments that can improve quality of life for individuals struggling with disorders involving excessive behavioral impulsivity. (nature.com)
Acute1
  • What al- acute response to stress to the adverse consequences that terations in neural systems regulating fear conditioning result if the acute response persists (3). (nomedicalcare.com)
Responses5
  • Our laboratory focuses on the impact of social and environmental stressors on molecular, neural and endocrine responses to influence adaptive behavior and activities like learning, coping, developing social rank relationships, biological rhythms, reproduction, and social interaction. (usd.edu)
  • The investigations include the connection between molecular, neural and endocrine responses and variability in the magnitude and way in which individuals respond to and cope with stress behaviorally. (usd.edu)
  • Korzan, Wayne W., Summers, Tangi T., and Summers, Cliff C.. Neural and endocrine responses to social stress differ during actual and virtual aggressive interactions or physiolgical sign stimuli, 1-10. (usd.edu)
  • Background: Neural interfaces often elicit inflammatory responses and neuronal loss in the surrounding tissue which adversely affect the function and longevity of the implanted device. (lu.se)
  • This MPOAGal-specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. (bvsalud.org)
Behavior3
  • Collectively, these data reveal a specific neural circuit that regulates impulsivity and provide evidence of a novel function for MCH on behavior. (nature.com)
  • Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. (uba.ar)
  • How can neural sys- such changes on human psychological resilience on one tems regulating social behavior respond to persistent hand, and vulnerability to psychopathology on the other. (nomedicalcare.com)
Regulation2
  • In recent years, with emerging studies on neural regulation technology, we observed that it has a certain effect on various neurological diseases, and its treatment of TBI has also become a possibility. (aging-us.com)
  • This work established the release of serotonin from dendrites in the dorsal raphe nucleus and described its regulation. (virginia.edu)
Sensory1
  • The cell bodies of the sensory nerves are located in the dorsal root ganglia. (medscape.com)
Regulate1
  • Ocular and neural genes jointly regulate the visuospatial working memory in ADHD children. (cdc.gov)
Cells2
  • Overnight, the neural connections onto a certain set of cells had grown stronger, regardless of whether the animals were given drugs or not. (bibliotecapleyades.net)
  • In addition, we also provide optimized media and kits for your in-house work on expanding and differentiating NPCs into high-quality neural lineage cells. (creative-biolabs.com)
Structures1
  • Each dorsal root contains the input from all the structures within the distribution of its corresponding body segment (ie, somite). (medscape.com)
Social2
  • Padilla-Coreano N , Tye KM , Zelikowsky M. Dynamic influences on the neural encoding of social valence. (neurotree.org)
  • Dwortz MF, Curley JP, Tye KM , Padilla-Coreano N . Neural systems that facilitate the representation of social rank. (neurotree.org)
Suitable1
  • Results: MC-NPs were successfully incorporated into gelatin-coatings of neural implants by an absorption method suitable for thermosensitive drug-loads. (lu.se)
Effects2
  • Since sleep problems are linked to the development of of alcoholism, it is important to understand the neural processes that contribute to ethanol-associated effects in the circadian clock. (kent.edu)
  • Therefore, gamma signaling may provide a biomarker (or neural readout) of the therapeutic effects of all classes of antidepressants. (mpeg3.org)
Specific1
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
Human1
  • Thank you for your interest in NeuCELL™ Human Neural Progenitor Cell Line, Immortalized . (creative-biolabs.com)
Networks2
Journal1
  • Journal of Neural Engineering. (lu.se)
Cell types1
  • Tenascin-R mRNA was expressed by distinct neural cell types in the unlesioned olivocerebellar system. (researchgate.net)
Role2
  • Specifically, she has developed highly-sensitive optical sensors for protein kinase C (PKC) isozymes in order to understand the role of PKC in the neural correlates of learning and memory. (virginia.edu)
  • The tectum is the term given to the midbrain's dorsal side, and it plays a role in reflex actions responding to auditory or visual stimuli. (databasefootball.com)