NucleusNucleiVentralSerotoninAxonsPeriaqueductalProjectionsStimulatingOrganizationEndogenousBrainModulationDepressionSensoryInvolvementFiring rateEffectShowResultsNeurons in the dorsal raphe nStudied the dorsal raphe nSerotonergicNucleus accumbensSerotonin NeuronsMedianLateralLocusGABAergicForebrainOpioidRatsMicePrefrontalInputsCaudateWithdrawalRegulationBehaviorHumanActivityFoundStructuresRegionStressRootIncreaseUniversityFully
Nucleus33
- The dorsal raphe nucleus is one of the raphe nuclei. (wikipedia.org)
- The dorsal raphe is the largest serotonergic nucleus and provides a substantial proportion of the serotonin innervation to the forebrain. (wikipedia.org)
- Serotonergic neurons are found throughout the dorsal raphe nucleus and tend to be larger than other cells. (wikipedia.org)
- The dorsal raphe nucleus is rich in pre-synaptic serotonin 5-HT1A autoreceptors, and it's believed that the action of the selective serotonin reuptake inhibitors (SSRIs) in this region is responsible for the latency of their antidepressant effect. (wikipedia.org)
- The dorsal raphe nucleus has also been implicated in naloxone-induced morphine withdrawal. (wikipedia.org)
- It is known that endogenous opioid receptors exist on the dorsal raphe nucleus, and that it is a focal point as an ascending and descending regulator. (wikipedia.org)
- showed in their 2000 paper that electrical stimulation of the dorsal raphe nucleus can partially alleviate morphine withdrawal symptoms via electrical stimulation of the raphe nucleus in question. (wikipedia.org)
- studied the dorsal raphe nucleus as it pertained to narcolepsy. (wikipedia.org)
- The dorsal raphe nucleus has been known to project to the lateral hypothalamus, along with the locus coeruleus and the tuberomammillary nucleus. (wikipedia.org)
- In cats with pontine lesions, their normal atonia is not present, the dorsal raphe nucleus is fully active, as opposed to the cessation of action under normal conditions. (wikipedia.org)
- A muscle relaxant, known as Mephenesin, reduces activity of the dorsal nucleus, as well as microinjections of carbachol (which induces atonia while awake). (wikipedia.org)
- The rostral raphe nuclei, both the median raphe nucleus and particularly the dorsal raphe nucleus have long been implicated in depression. (wikipedia.org)
- citation needed] Ten percent of the axons from the dorsal raphe nucleus of the rat have been shown to project to the amygdala, while only medium cells seem to project to the caudate and putamen and olfactory bulb. (wikipedia.org)
- Since the mood-altering substances MDA, MDMA, and PCA act specifically upon 5-HT axon terminals from the dorsal raphe nucleus, DR neurons may be preferentially involved in the control of affective state. (erowid.org)
- 5-HT neurons in the dorsal raphe nucleus (DRN) often fire locked to sensory stimuli, but little is known about how 5-HT affects sensory processing, especially on this timescale. (jneurosci.org)
- In a parallel series of experiments, microdialysis probes resting on the brain slice surface provided a means to estimate 5-HT release from the dorsal raphe nucleus. (erowid.org)
- By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nucleus (DR) or optogenetic inhibition of 5-HT terminals in the anterior cingulate cortex (ACC) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. (elifesciences.org)
- Disconnectivity between Dorsal Raphe Nucleus and Posterior Cingulate Cortex in Later Life Depression. (bvsalud.org)
- The dorsal raphe nucleus (DRN) has been repeatedly implicated as having a significant relationship with depression , along with its serotoninergic innervation . (bvsalud.org)
- Although serotonin (5-HT) was proposed to be responsible for sleep regulation, whether the activity of 5-HTergic neurons in the dorsal raphe nucleus (DRN) is affected by chronic pain has been studied only infrequently. (biomedcentral.com)
- The firing rate of 5-HT-containing dorsal raphe nucleus (DRN) neurons decreases during slow wave sleep relative to that in wakefulness[ 4 ]. (biomedcentral.com)
- In our study, we evaluated the influence of their (+)- and (-) isomers on the electrical activity of serotoninergic neurones of the dorsal raphe nucleus (DRN), which bear 5-HT 1A autoreceptors, and of dopaminergic neurones of the ventral tegmental area (VTA), which possess inhibitory D 3 and D 2 receptors. (aspetjournals.org)
- Swanson, L.W. & Kuypers, H.G. The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. (nature.com)
- Researchers at the Massachusetts Institute of Technology (MIT) think they've found the source of that motivation in a group of little-studied neurons in part of the brain called the dorsal raphe nucleus. (bibliotecapleyades.net)
- Involvement of different subregions of the dorsal raphe nucleus in the anti-panic. (usp.br)
- Involvement of the dorsal raphe nucleus in the mediation of panic-related defensive. (usp.br)
- The scientists focused their research on the dorsal raphe nucleus , a part of the brain that contains dorsal raphe nucleus neurons, or DRNDA neurons. (breakingmuscle.com)
- To determine the DRNDA neuron relation to sleep, they tested activity in the dorsal raphe nucleus. (breakingmuscle.com)
- However, the results of the study indicate that these neurons in the dorsal raphe nucleus do play a role in tiredness and wakefulness . (breakingmuscle.com)
- For example, patients with Lewy body dementia and multiple systems atrophy have problems with excessive daytime sleepiness due to the damage in their dorsal raphe nucleus. (breakingmuscle.com)
- The connections between two specific areas of the brain - the prefrontal cortex and the dorsal raphe nucleus - may contribute to depression. (sfn.org)
- Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction. (bvsalud.org)
- Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. (cdc.gov)
Nuclei3
- This is logical, as the raphe nuclei have been known to play a role in the sleep/wake cycle. (wikipedia.org)
- Raphe nuclei O'Hearn E, Molliver ME (December 1984). (wikipedia.org)
- Moreover, a recent anterograde transport study suggests that fine and beaded 5-HT axons arise from the dorsal raphe (DR) and median raphe (MR) nuclei, respectively. (erowid.org)
Ventral2
- It has rostral and caudal subdivisions: The rostral aspect of the dorsal raphe is further divided into interfascicular, ventral, ventrolateral and dorsal subnuclei. (wikipedia.org)
- Involvement of 5-HT1A receptor of the dorsal and ventral hippocampus on anxiety-related. (usp.br)
Serotonin5
- A substantial population of cells synthesizing substance P are found in the rostral aspects, many of these co-express serotonin and substance P. There is also a population of catecholamine synthesizing neurons in the rostral dorsal raphe, and these cells appear to be relatively large. (wikipedia.org)
- The effects of MDMA (3,4-methylenedioxymethamphetamine) on the activity of serotonin (5-HT)-containing dorsal raphe neurons were characterized using extracellular single-unit recording and microdialysis techniques in the in vitro midbrain slice preparation. (erowid.org)
- Serotonin-specific Lesions of the Dorsal Raphe alter Nursing, Reduce L" by Mary Holschbach, E. V. Vitale et al. (nova.edu)
- Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. (trinity.edu)
- We are working on the modulation of calcium current in dorsal raphe serotonergic neurons of the rat brain and have discovered a profound inhibitory modulation of this voltage-activated current by the neurotransmitter serotonin. (downstate.edu)
Axons1
- Using this method, only axons that survive PCA treatment can take up and transport the injected label back to the cell bodies of origin, thus allowing us to determine which raphe-cortical projections remain intact after PCA. (erowid.org)
Periaqueductal2
- Involvement of the benzodiazepine binding sites in the dorsal periaqueductal gray. (usp.br)
- The differences were seen in three regions in the subcallosal cingulate cortex (SCC) known to be implicated in depression ― the left frontal operculum, the left ventromedial prefrontal cortex, and the periaqueductal gray/dorsal raphe. (medscape.com)
Projections1
- The projections of the dorsal raphe have been found to vary topographically, and thus the subnuclei differ in their projections. (wikipedia.org)
Stimulating1
- Stimulating these neurons drives isolated mice to find friends, according to research ( Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation ) published earlier this year in the journal Cell . (bibliotecapleyades.net)
Organization1
- Topographic Organization and Neurochemical Identity of Dorsal Raphe Neurons that Project to the Trigeminal Somatosensory Pathway in the Rat. (drexel.edu)
Endogenous1
- Taken together, these data suggest that MDMA acts indirectly to inhibit dorsal raphe neurons through release of endogenous 5-HT. (erowid.org)
Brain1
- We study the regulation of central serotonergic (5-HT) neurotransmission and neuropharmacology using electrophysiological patch clamp techniques to record isolated ion currents from acutely isolated, adult rat brain, serotonergic dorsal raphe (dr) neurons. (downstate.edu)
Modulation1
- We have gathered evidence recently suggesting that the action of PMA in decreasing the effectiveness of Ca current modulation, appears to be exerted on the G-protein in raphe cells rather than on the Ca channel. (downstate.edu)
Depression1
- Some studies have suggested that the dorsal raphe may be decreased in size in people with depression and, paradoxically, an increased cell density in those who die by suicide. (wikipedia.org)
Sensory1
- The cell bodies of the sensory nerves are located in the dorsal root ganglia. (medscape.com)
Involvement2
- Involvement of CRF-mediated neurotransmission in the lateral wings of the dorsal. (usp.br)
- Involvement of 5-HT2C receptors of the dorsal hippocampus on anxiety-related defensive. (usp.br)
Firing rate1
- MDMA (100 microM) caused the release of measureable quantities of 5-HT with a time course which corresponded to the change in dorsal raphe cell firing rate. (erowid.org)
Effect1
- Pretreatment with the selective 5-HT uptake inhibitor fluoxetine, at a concentration which had no effect on baseline firing (20 microM), blocked the inhibitory effect of (+)-MDMA and PCA on dorsal raphe neurons. (erowid.org)
Show1
- Charts based on injection of local anesthetics into single dorsal root ganglia show bands of hypalgesia to be continuous longitudinally from the periphery to the spine. (medscape.com)
Results1
- Knowing that the spread of charge across such a short area is very plausible, as is an alternate connection to the raphe magnus, these results could be called into question. (wikipedia.org)
Neurons in the dorsal raphe n3
- A unique subdivision of serotonergic neurons in the dorsal raphe nucleus projects to the basolateral amygdala complex to enhance fear-conditioned behaviors. (atsbio.com)
- Electrical activity of serotonergic neurons in the dorsal raphe nucleus was similarly suppressed, an action likewise blocked by idazoxan, which did not, itself, influence firing. (aspetjournals.org)
- 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. (nih.gov)
Studied the dorsal raphe n1
- studied the dorsal raphe nucleus as it pertained to narcolepsy. (wikipedia.org)
Serotonergic12
- The dorsal raphe is the largest serotonergic nucleus and provides a substantial proportion of the serotonin innervation to the forebrain. (wikipedia.org)
- Serotonergic neurons are found throughout the dorsal raphe nucleus and tend to be larger than other cells. (wikipedia.org)
- The dorsal raphe contains diverse neurons, including serotonergic, glutamatergic and GABAergic neurons, important for regulation of mood and motivation. (helsinki.fi)
- In particular, we are interested in the mechanisms by which transcription factors expressed in the post-mitotic neurons drive differentiation of molecularly, anatomically and functionally distinct subsets of dorsal raphe serotonergic neurons. (helsinki.fi)
- Haugas M, Tikker L, Achim K, Salminen M, Partanen J. Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. (helsinki.fi)
- To determine whether the response profile of serotonergic neurons in the midbrain is similar to that observed in the medulla, the single-unit activity of serotonergic dorsal raphe nucleus cells was studied during three specific motor activities: treadmill-induced locomotion, hypercarbia-induced ventilatory response and spontaneous feeding. (erowid.org)
- In contrast to the results obtained for medullary raphe cells, none of the serotonergic dorsal raphe cells studied (n=26) demonstrated increased firing during treadmill-induced locomotion. (erowid.org)
- A subset of serotonergic dorsal raphe cells (8/36) responded to the hypercarbic ventilatory challenge with increased firing rates that were directly related to the fraction of inspired carbon dioxide, and a non-overlapping subset of cells (6/31) was activated during feeding. (erowid.org)
- Although the proportions of serotonergic cells activated by hypercarbia or feeding in the dorsal raphe nucleus were similar to those found in the medullary raphe, there were several major distinctions in the response characteristics for the two cell groups. (erowid.org)
- In contrast to the medullary serotonergic neurons, only a minority of dorsal raphe nucleus serotonergic neurons responded to a motor challenge. (erowid.org)
- The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates diverse functions and brain states, including mood, anxiety, and sensory and motor functions. (nih.gov)
- In 2005 Abrams and colleagues determined that there were robust BLC projections that originate from the midline dorsal (DRD) and ventral (DRV) subdivisions of the dorsal raphe nucleus (DRN), but it was not determined that they were serotonergic. (atsbio.com)
Nucleus accumbens1
- Effects of nicotine and dimethylphenylpiperazinium on extracellular 5-HT in the dorsal raphe and nucleus accumbens of freely behaving rats. (fau.edu)
Serotonin Neurons1
Median1
- Using whole-cell patch-clamp recording and immunohistochemistry, we tested whether serotonin circuitry in the dorsal and median raphe was functionally mature during the first 3 postnatal weeks in mice. (jneurosci.org)
Lateral3
- The dorsal raphe nucleus has been known to project to the lateral hypothalamus, along with the locus coeruleus and the tuberomammillary nucleus. (wikipedia.org)
- An increased number of cells in the lateral aspects of the dorsal raphe is characteristic of primates (including humans). (wikipedia.org)
- UCMS exposure also increased Fos-ir and the number of double-labeled neurons in the mid-rostral subdivision of the dorsal part of the DR and in the mid-caudal region of the lateral wings. (unesp.br)
Locus1
- One project is assaying substantia nigra, locus coeruleus, and dorsal raphe from human opioid/cocaine users with and without HIV. (nih.gov)
GABAergic1
Forebrain1
- In the study, serotonin-producing neurons were optogenetically stimulated in a part of the brain called the dorsal raphe nucleus (DRN), which output widely to the forebrain. (sciencedaily.com)
Opioid1
- It is known that endogenous opioid receptors exist on the dorsal raphe nucleus, and that it is a focal point as an ascending and descending regulator. (wikipedia.org)
Rats2
Mice1
- Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus. (cdc.gov)
Prefrontal1
- Recently we demonstrated that infusions of CRF into the rat dorsal raphe nucleus result in a delayed increase in serotonin release within the medial prefrontal cortex that coincided with a reduction in fear behavior. (keyopinionleaders.com)
Inputs1
Caudate1
- citation needed] Ten percent of the axons from the dorsal raphe nucleus of the rat have been shown to project to the amygdala, while only medium cells seem to project to the caudate and putamen and olfactory bulb. (wikipedia.org)
Withdrawal2
- The dorsal raphe nucleus has also been implicated in naloxone-induced morphine withdrawal. (wikipedia.org)
- showed in their 2000 paper that electrical stimulation of the dorsal raphe nucleus can partially alleviate morphine withdrawal symptoms via electrical stimulation of the raphe nucleus in question. (wikipedia.org)
Regulation1
- The role of serotonin in emotional regulation is well established, but little is known about the postnatal development of the raphe where serotonin is made. (jneurosci.org)
Behavior1
- Erowid.org: Erowid Reference 2964 : Discrimintaive Control of Behavior by Electrical Stimulation of the Dorsal Raphe Nucleus: Generalization to Lysergic Acid Diethylamide (LSD). (erowid.org)
Human1
Activity1
- A muscle relaxant, known as Mephenesin, reduces activity of the dorsal nucleus, as well as microinjections of carbachol (which induces atonia while awake). (wikipedia.org)
Found1
- A substantial population of cells synthesizing substance P are found in the rostral aspects, many of these co-express serotonin and substance P. There is also a population of catecholamine synthesizing neurons in the rostral dorsal raphe, and these cells appear to be relatively large. (wikipedia.org)
Structures1
- Each dorsal root contains the input from all the structures within the distribution of its corresponding body segment (ie, somite). (medscape.com)
Region1
- The dorsal rami of C1-4 are located in the suboccipital region. (medscape.com)
Stress1
- Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addiction. (bvsalud.org)
Root2
- The cell bodies of the sensory nerves are located in the dorsal root ganglia. (medscape.com)
- Charts based on injection of local anesthetics into single dorsal root ganglia show bands of hypalgesia to be continuous longitudinally from the periphery to the spine. (medscape.com)
Increase1
University1
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Fully1
- In cats with pontine lesions, their normal atonia is not present, the dorsal raphe nucleus is fully active, as opposed to the cessation of action under normal conditions. (wikipedia.org)