Dopamine receptor antagonists dopamine antagonists. Medical search. Frequent questions

These agents are ergot derivatives and dopamine receptor agonists. (medscape.com)
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In summary, the present results implicate DA D1 receptors in the regulation of behavioral activation and effort-related functions, and demonstrate the utility of using tests of effort-related choice behavior for assessing the effects of D1 agonists. (nih.gov)
In monkeys trained to discriminate cocaine from vehicle, both DA antagonists attenuated and both DA agonists partially reproduced cocaine's DS effects. (umn.edu)
In studies involving reinstatement of extinguished cocaine seeking, both antagonists attenuated cocaine-induced reinstatement of responding, and both agonists induced at least partial reinstatement of cocaine seeking. (umn.edu)
Next, we assessed the effect of reversible inactivation of CeA or BLA by GABAA+GABAB receptor agonists (muscimol+baclofen, 0.03+0.3 nmol) on cue-induced methamphetamine seeking during early and late withdrawal. (nature.com)
Avoid use of amisulpride, a dopamine receptor antagonist, with dopamine agonists. (medscape.com)
Utilizing a technique for measuring the kinetics (synthesis, degradation, and half-life) of the dopamine transporter (DAT) protein in the rat striatum and nucleus accumbens, we have investigated the effects of systemic administration of dopamine receptor agonists and antagonists upon DAT kinetics in these brain regions. (aspetjournals.org)
However, the dopamine D2 receptor agonists R -(−)-propylnorapomorphine hydrochloride (NPA) and quinpirole decreased the half-life of DAT. (aspetjournals.org)
1 In addition, the United Kingdom guidelines recommend that treatment with levodopa should be delayed for as long as possible providing alternative drugs, such as dopamine agonists, can achieve adequate symptom control. (bmj.com)
Dopamine agonists exert their antiparkinsonian effects by acting directly on dopamine receptors and mimicking the endogenous neurotransmitter. (bmj.com)
11 There are two subclasses of dopamine agonists: ergoline and non-ergoline agonists. (bmj.com)
The ergoline dopamine agonists include bromocriptine, pergolide, lisuride, and cabergoline, whereas ropinirole and pramipexole are non-ergoline agonists. (bmj.com)
Apomorphine, one of the first dopamine agonists shown to improve parkinsonian symptoms, is a combined D 1 and D 2 agonist but has to be administered subcutaneously. (bmj.com)
Dopamine agonists have proved antiparkinsonian activity. (bmj.com)
Dopamine agonists have also been successfully used as monotherapy in de novo patients with the intention of delaying treatment with levodopa and consequently deferring the onset of complications. (bmj.com)
Dopamine agonists are not metabolised by oxidative pathways and so do not lead to the cytotoxic free radical formation that may be associated with metabolism of dopamine. (bmj.com)
The reason why motor complications are less often encountered with dopamine agonists than with levodopa is not fully understood. (bmj.com)
In the study, we investigated selected D2 dopaminergic receptor agonists, namely bromocriptine, cabergoline and pergolide, on hypoxia-induced neovascularization. (bvsalud.org)
The inhibitory role of D2 dopaminergic receptor agonists was investigated using confocal microscopy and qPCR. (bvsalud.org)
The present results suggest that the D2 receptor agonists can be considered as a new direction in research for antiangiogenic therapy. (bvsalud.org)
However, patients with LID receive combination therapies that often include dopamine agonists. (lu.se)

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D 1 -like receptor antagonist with K i s of 0.2 nM and 0.3 nM for the D 1 and D 5 receptor , respectively. (medchemexpress.com)
The highly selective D1 antagonist ecopipam was studied for its effects on effort-related choice behavior using the concurrent fixed ratio (FR) 5/chow feeding choice and T-maze barrier choice procedures. (nih.gov)
The goal of this project is to synthesize a highly selective D4 antagonist with high binding affinity for PET tracing and useful in vivo properties to test in animal models. (vanderbilt.edu)
Although these results strongly implicate dopamine release in the long-term neurochemical effects of MDMA, protection was also provided by selective 5-HT 2 antagonists indicating that the neurotoxicity is dependent upon the release of both dopamine and 5-HT. (erowid.org)
Selective effects of an essential sulfhydryl group on the activation of dopamine- and guanine nucleotide-sensitive adenylate cyclase. (nih.gov)
The active ingredient of ZOFRAN Injection is ondansetron hydrochloride, a selective blocking agent of the serotonin 5-HT3 receptor type. (globalrph.com)
Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D(3) receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. (exeter.ac.uk)
METHODS: Twenty healthy human subjects were scanned twice, once after placebo and once after sulpiride 400 mg, a selective DA D2 receptor antagonist, while performing a verbal working memory task requiring different levels of manipulation. (exeter.ac.uk)
In particular, compounds modulating D1 receptor signaling had a stronger effect in the L-dopa-only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L-dopa-ropinirole cotreated animals. (lu.se)

On the need for convergence in animal and human studies on the role of dopamine in diet-induced obesity. (mpg.de)

The second generation, or atypical antipsychotics, are dopamine antagonists that block serotonin receptors and affect serotonin levels. (medicalnewstoday.com)
SCH 23390 and SK&F 83566 are antagonists at vascular DA and serotonin receptors. (rndsystems.com)
Iloperidone acts on both dopamine and serotonin receptors, making it a favorable choice against competing drugs clozapine and olanzapine. (bionity.com)
It was found to block the sites of noradrenaline, dopamine, and serotonin receptors. (bionity.com)

For example, cocaine administration leads to altered responsiveness of striatal medium spiny neurons to dopamine ( Henry and White, 1991 ). (jneurosci.org)
Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ 8 tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. (jneurosci.org)
Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. (jneurosci.org)
CB1 receptors have been identified on both subpopulations of medium spiny neurons ( Mailleux and Vanderhaeghen, 1992 ). (jneurosci.org)
Some of these receptors dampen the signals sent by neurons when the body is injured. (discovermagazine.com)
Opioids block pain by fitting into specialized receptors on the surface of neurons. (discovermagazine.com)
When a neurotransmitter binds to a receptor, an extracellular signal is transduced into an intracellular one, causing a functional change inside target neurons. (psychiatrictimes.com)
2 Levodopa enters dopaminergic neurons where it is metabolised to dopamine, replacing the depleted endogenous neurotransmitter. (bmj.com)
By suppressing endogenous dopamine release it is also conceivable that they may protect dopaminergic neurons from injury, a theoretical concern if high concentrations of exogenous dopamine are present. (bmj.com)
This dramatic increase coincides with the introduction of a range of new neurochemical and pharmacological tools for the study of dopamine neurons and their function in the brain, as well as the identification of the dopamine receptors, their pharmacology, and their role in mediating the antipsychotic action of neuroleptics [12,13]. (lu.se)

The first generation, or typical antipsychotics, are dopamine receptor blockers that work by blocking dopamine receptors in the brain. (medicalnewstoday.com)

LSD as an agonist and antagonist at central dopamine receptors. (erowid.org)
Evidence for essential thiol groups and disulfide bonds in agonist and antagonist binding to the dopamine receptor. (nih.gov)
Iloperidone was tested for both agonist and antagonist activity, and was shown to only display antagonistic properties. (bionity.com)

In the current study, we use dopamine receptor-specific pharmacology and multivoxel pattern-based functional magnetic resonance imaging to test the hypothesis that blocking D2-receptor activation enhances prefrontal representations. (cam.ac.uk)
For clinicians to make effective use of the new drugs that will emerge from this active research area, they will need to understand how dopamine affects behavior and keep abreast of the developments in dopamine pharmacology. (psychiatrictimes.com)
Dopamine as an independent neurotransmitter in the nervous system was discovered in Lund by the pharmacologist Arvid Carlsson in 1957, working at the Department of Pharmacology at Sölvegatan 10 in Lund (the current Geocentrum building). (lu.se)

Molecular imaging of central dopamine in obesity: A qualitative review across substrates and radiotracers. (mpg.de)
In comparisons of ill and well GW veterans, magnetic resonance spectroscopy found metabolite abnormalities in basal ganglia associated with increased central dopamine turnover, and cholinergic challenge with physostigmine caused abnormal cholinergic response in caudate, putamen and globus pallidus. (cdc.gov)

N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. (uams.edu)
Fast receptor systems, such as the GABAA receptor and the nicotinic receptor at the neuromuscular junction, involve the direct binding of a neurotransmitter to a ligand-gated channel, which opens or closes the channel. (psychiatrictimes.com)
They also looked at use of bupropion (Wellbutrin), an atypical antidepressant that acts as a norepinephrine-dopamine reuptake inhibitor and a nicotinic receptor antagonist, and also investigated mirtazapine, nefazodone, and trazodone. (medscape.com)

Dopamine acting in the striatum is necessary for normal movement and motivation. (jneurosci.org)
Dopamine acts in the striatum through the D 1 and D 2 subfamilies of G-protein-coupled receptors. (jneurosci.org)
CONCLUSIONS: These results support models of dopamine function that posit a 'gating' function for dopamine D2 receptors in the striatum, which enables the flexible updating and manipulation of information in working memory. (exeter.ac.uk)
Also at this time researchers discovered that dopamine depletion in the striatum played a role in Parkinson's disease. (psychiatrictimes.com)
In the striatum, the dopamine D1 receptor agonist SKF38393 and the dopamine D1 receptor antagonist SCH23390 were without effect. (aspetjournals.org)
The results of the present study suggest that, through dopamine receptors, dopamine indirectly influences DAT protein turnover in the striatum and in the nucleus accumbens, but in different ways. (aspetjournals.org)

Opposing effects of metoclopramide and the interacting drug on dopamine. (medscape.com)

In 1963, Carlsson first postulated that the effects of neuroleptics were secondary to dopamine receptor blockade. (psychiatrictimes.com)

Mimic dopamine action of inhibition of prolactin release. (medscape.com)
Theorized that action may be related to mediation through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that decreases uptake of monoamines (eg, dopamine, serotonin, norepinephrine, histamine) into synaptic vesicles and depletes monoamine stores from nerve terminals. (medscape.com)

If intracellular Ca2+ is increased, such as after activation of the glutamate NMDA receptor, calcineurin activity increases and the phosphates will be removed. (ecu.edu)
This balance of phosphorylation control suggests that a D1 receptor agonist and a NMDA glutamate receptor antagonist should have additive or synergistic actions to increase activated DARPP-32 and consequent behavioral effects. (ecu.edu)
Findings indicate that dopamine and glutamate dysfunction occurs in schizophrenia but raise the question of whether it predates the onset of the disorder. (madinamerica.com)
The meta-analysis aims to examine whether "greater variability of dopamine and glutamate measures exists in high-risk individuals compared to controls. (madinamerica.com)
In the present paper, we meta-analyzed neuroimaging studies of the dopamine and glutamate systems in individuals at high clinical or genetic risk for psychosis to provide the best estimate of the magnitude and variability of group differences across samples and settings. (madinamerica.com)
Only forty-eight of these met the inclusion criteria, which included the above-mentioned risk factors as well as several targets of neuroimaging, such as striatal presynaptic dopamine function, striatal D2/D3 receptor availability, and glutamate or Glx (glutamine-glutamate) concentrations. (madinamerica.com)
Catatonia is caused by neurochemical abnormalities including low GABA activity in the frontal cortex, low dopamine (D2) activity in the basal ganglia, high glutamate-N-methyl-D-aspartate (NMDA)-activity in the parietal cortex, or a combination of these. (mhaus.org)

A new meta-analysis of data from individuals at high risk for schizophrenia finds no evidence for the dopamine hypothesis. (madinamerica.com)
The authors found no significant differences between high-risk populations and control groups when analyzing neuroimaging studies from 1960 to 2020, putting the dopamine hypothesis of the cause of "schizophrenia" in question. (madinamerica.com)
Although there has long been criticism of the dopamine hypothesis of "schizophrenia" as the cause of the condition, including a previous meta-analysis that found no support for the hypothesis after analyzing relevant neurochemical processes, the hypothesis continues to maintain prominent status in psychiatry. (madinamerica.com)
In addition, the authors state that comparing high-risk individuals against a control sample will help determine whether dopaminergic and glutaminergic factors precede the onset of "schizophrenia," which could grant or reduce legitimacy to the causal dopamine hypothesis. (madinamerica.com)
OBJECTIVE: the present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for the manipulation of information in working memory. (exeter.ac.uk)
the dopamine hypersensitivity hypothesis and the serotonin-dopamine antagonist hypothesis. (who.int)
The neuroleptic-induced TD with those who did serotonin-dopamine antagonist hypothesis not develop it under comparatively similar maintains that drugs which have a high conditions. (who.int)

Amisulpride is in a class of medications called dopamine receptor antagonists. (medlineplus.gov)
Human subjects performed a simple reward prediction task after double-blind and placebo controlled administration of the D2-receptor antagonist amisulpride. (cam.ac.uk)

Depletes neurotransmitter stores of dopamine, serotonin, and noradrenaline within nerve cells in the brain, thereby altering transmission of electric signals from the brain that control movement by reversibly inhibiting vesicular monoamine transporter 2 (VMAT2). (medscape.com)
The discovery of dopamine as a neurotransmitter in the brain was one of the seminal events in the development of modern neuroscience. (lu.se)

Vehicle, the D1 agonist SKF 38393, the non-competitive NMDA receptor antagonist memantine, or their combination were injected 2 h before and after lights out. (ecu.edu)
The combination of SKF 38393 with (+)-MK-801, another NMDA receptor antagonist, also failed to show an additive effect. (ecu.edu)

Others activate the release of dopamine, causing euphoria as well as cravings for more dopamine. (discovermagazine.com)

The dopamine receptor antagonist haloperidol was also effective in this regard. (erowid.org)

Mechanisms of dysregulation of dopamine neurotransmission by cholinesterase-inhibitors: implications for Gulf War Illness. (cdc.gov)
From these findings, we hypothesized that Gulf War Illness (GWI) involves dysregulation of dopamine neurotransmission in the mesocorticolimbic reward and motor circuitry of the basal ganglia, which contributes emotional and visceral nervous system processing. (cdc.gov)
Conclusion: Repetitive exposure to AChE-inhibitors causes dopamine neurotransmission abnormalities, possibly contributing to brain dysfunction in GWI. (cdc.gov)

A new D4 antagonist was created using organic synthesis, or production of a complex chemical compound from more simple compounds. (vanderbilt.edu)
Similar results were achieved by selectively inhibiting dopamine synthesis with a-methyl-p-tyrosine or through bilateral lesions of the substantia nigra with 6-hydroxydopamine. (erowid.org)
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. (rndsystems.com)
Increased striatal dopamine synthesis capacity in gambling addiction. (mpg.de)
Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation. (mpg.de)
The amine 3-hydroxytyramine (`dopamine') had earlier been identified as an intermediary in the synthesis of noradrenaline and adrenaline from tyrosine. (lu.se)
Lindqvist, Tor Magnusson and Bertil Waldeck, made the seminal observations that during the subsequent years would lead to the unravelling of dopamine as a transmitter in the central nervous system, independent of its role as a precursor in noradrenaline and adrenaline synthesis. (lu.se)

These findings are in line with a dual-state model of prefrontal dopamine, and provide new insights into the potential mechanism of action of dopaminergic drugs. (cam.ac.uk)
It is likely that a significant proportion of the 4-15% of de novo patients recruited for recent clinical trials with antiparkinsonian drugs who have no evidence of nigrostriatal dopamine denervation on functional imaging (subjects without evidence of dopaminergic deficit (SWEDDs)) have tremulous syndromes other than PD. (bmj.com)
This is supported by long term follow-up showing minimal clinical deterioration, no response to dopaminergic therapy and in some cases no evidence on repeat functional imaging of dopamine denervation. (bmj.com)
Slower G-protein-linked receptor systems, as seen in the dopaminergic system, work through second-messenger systems, such as cyclic adenosine monophosphate (cAMP), and have a longer duration of action. (psychiatrictimes.com)

In their 1957 and 1958 papers [1.2], (Carlsson et al 1957) (Carlsson et al 1958) Carlsson and co-workers made the intriguing observation that the akinetic effects of reserpine could be reversed by an intravenous injection of the dopamine (and noradrenaline) precursor, 3,4- dihydroxyphenylalanine (DOPA). (lu.se)
The functional effect was correlated to a recovery of dopamine, but not noradrenaline, content in the brain, suggesting that depletion of dopamine, rather than noradrenaline or serotonin, was the cause of the akinetic state in reserpine-treated animals. (lu.se)

SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. (medchemexpress.com)
Symptoms of Parkinson's disease may be caused by low levels dopamine in the brain. (rxlist.com)
These receptors have been found to be involved in the pathogenesis of a variety of diseases including Attention Deficit Hyperactivity Disorder (ADHD), schizophrenia, Alzheimer's, Parkinson's, and substance addiction [2, 3, 4]. (vanderbilt.edu)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)

A receptor antagonist is a compound that inhibits the function of an agonist, which would normally create a biological response when bound to a receptor. (vanderbilt.edu)

Using indirect methods, it has been shown that the D4 receptor is expressed in the frontal cortex, hippocampus, hypothalamus, retina, and amygdala regions of the brain [1, 3]. (vanderbilt.edu)
These results suggest that D2-receptor blockade enhances content-specific representations in frontal cortex, presumably by a dopamine-mediated increase in pattern separation. (cam.ac.uk)

Although much is known about the characteristics of DA D2 receptor antagonism on effort-related choice behavior, less is known about the effects of D1 antagonism, and agonist/antagonist interactions. (nih.gov)
Studies have shown that antagonism of dopamine receptor 4 is a possible treatment for substance addiction [1]. (vanderbilt.edu)

Stimulation of the dopamine D1 receptor is reported to cause the phosphorylation of DARPP-32 at the thre34 position and activates the protein. (ecu.edu)
Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)

Bupropion is a dopamine and norepinephrine reuptake inhibitor with nicotine receptor antagonist properties. (cdc.gov)

Dopa-decarboxylase inhibitor + dopamine precursor + COMT inhibitor. (renalandurologynews.com)

Its affinity for these particular receptors indicates that it has the potential to be a broad spectrum antipsychotic, against positive, negative, depressive and cognitive symptoms of schizophrenia. (bionity.com)
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase. (diabetesjournals.org)

Dopamine is a hormone that affects movement and feelings of reward and pleasure. (medicalnewstoday.com)
Using a whole-brain searchlight decoding approach we show that D2-receptor blockade enhances decoding of reward signals in the medial orbitofrontal cortex. (cam.ac.uk)
Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers. (mpg.de)

Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)

The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)

Preliminary evidence for an association between intake of high‐fat high‐sugar diet, variations in peripheral dopamine precursor availability and dopamine‐dependent cognition in humans. (mpg.de)

SCH-23390 maleate also binds with high affinity to the 5-HT 2 and 5-HT 1C receptors . (medchemexpress.com)
Buspirone binds to D3 and D4 receptors with a high affinity [1]. (vanderbilt.edu)
Binds to dopamine D2 receptors where it is a receptor antagonist. (herts.ac.uk)

Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. (umn.edu)
Two subtypes of cannabinoid receptors have been identified. (jneurosci.org)
However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. (exeter.ac.uk)

They act on postsynaptic dopamine receptors while causing no effect on other anterior pituitary functions. (medscape.com)
The dopamine cells of the hypothalamus project via the tuberoinfundibular tract to the infundibulum and anterior pituitary. (psychiatrictimes.com)

Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in behavioral activation and effort-related processes. (nih.gov)
Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)
Dopamine has long been suggested to play a key role in the integrity of such representations, with D2-receptor activation rendering them flexible but weak. (cam.ac.uk)
However, it is currently unknown whether and how D2-receptor activation affects prefrontal representations in humans. (cam.ac.uk)
Activation of the D1 dopamine receptor/cAMP/PKA cascade is regulated by the neuronal protein kinase, Cdk5. (cdc.gov)
Synergistic activation of estrogen receptor with combinations of environmental chemicals. (cdc.gov)

It works by blocking the action of dopamine, a natural substance that may cause nausea and vomiting. (medlineplus.gov)
Studies that included individuals with comorbid substance dependence were excluded because substance use can affect the dopamine system. (madinamerica.com)

Effects of DA D 1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats. (rndsystems.com)
FELICIO, L. F. Effects of dopamine receptor antagonists on ongoing maternal behavior in rats. (bvsalud.org)

Known D4 antagonists have properties that can be significantly improved upon, such as binding affinity, potency, metabolic rate, and selectivity [2]. (vanderbilt.edu)
One promising D4 antagonist is a benzimidazole compound, which displayed many sought after attributes, such as potency, but lacks the desired binding affinity to be effective in vivo [2]. (vanderbilt.edu)
A second project goal was to create a library of compounds that will be tested for affinity, potency, and other aforementioned biological properties in the hopes that they will perform better than previous D4 antagonists. (vanderbilt.edu)
1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O 2 conditions [5] . (medchemexpress.com)

The treatment is based on administration of the dopamine agonist pergolide. (bvsalud.org)

Interactions Between Lysergic Acid Diethylamide And Dopamine-sensitive. (erowid.org)
signaling interactions between these receptors have not been investigated extensively. (jneurosci.org)

Cocaine increases synaptic levels of dopamine, which is perceived as a positive feeling, reinforcing its effects, potentially resulting in addiction [1, 2]. (vanderbilt.edu)

SCH-23390 maleate is a potent and high efficacy human 5-HT 2C receptor agonist with a K i of 9.3 nM. (medchemexpress.com)

Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D 1 receptors in rodents, nonhuman primates, and humans [1] . (medchemexpress.com)
Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. (cam.ac.uk)

There are opioid receptors in many parts of the brain and spinal cord. (discovermagazine.com)
Scientists were already familiar with this mechanism and had found opioid receptors distributed throughout the brain and central nervous system. (discovermagazine.com)

Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)

RATIONALE: Dopamine (DA) plays an important role in working memory. (exeter.ac.uk)

Anatomy23

Organisms10

Diseases8

Chemicals and Drugs178

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology9

Phenomena and Processes16

Disciplines and Occupations1

Health Care1

Agonists23

Selective9

Role of dopamine1

Serotonin receptors4

Neurons11

Blocking dopamine receptors in the brain1

Agonist and antagonist3

Pharmacology3

Central dopamine2

Nicotinic receptor3

Striatum6

Metoclopramide1

Neuroleptics1

Inhibition2

Glutamate7

Hypothesis7

Amisulpride2

Neurotransmitter2

NMDA2

Release of dopamine1

Haloperidol1

Neurotransmission3

Synthesis7

Dopaminergic4

Noradrenaline2

Parkinson's4

Inhibits1

Frontal cortex2

Antagonism2

Stimulation2

Norepinephrine1

Inhibitor1

Antipsychotic2

Reward3

Adenylate cyclase4

Tardive dyskinesia1

Precursor1

Binds3

Subtypes3

Anterior pituitary2

Activation7

Substance2

Rats2

Affinity4

Augments1

Pergolide1

Interactions2

Increases1

Potent1

Humans2

Opioid2

19911

RATIONALE1