• Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons. (ulaval.ca)
  • Midbrain dopamine (DA) neurons are key regulators of basal ganglia functions. (ulaval.ca)
  • Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine. (nih.gov)
  • We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S + neurons of the suprachiasmatic nucleus. (nature.com)
  • These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S + inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. (nature.com)
  • Figure 5: Molecular interrogation of dopamine neurons defines a onecut-3-expressing periventricular subtype. (nature.com)
  • Figure 6: Efferent projections of periventricular onecut-3 + dopamine neurons. (nature.com)
  • Figure 7: Suprachiasmatic origin for neuromedin S inputs to onecut-3 + Nmur2 + A14 dopamine neurons. (nature.com)
  • Figure 8: Periventricular onecut-3 + dopamine neurons respond to neuromedin S produced during light periods. (nature.com)
  • Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
  • 2020 ) Dopamine D1 Receptors Regulate Spines in Striatal Direct-Pathway and Indirect-Pathway Neurons. (neurotree.org)
  • Epigenetic modification resulted in the dopamine receptor gene being silenced: neurons carried fewer dopamine receptors, and signal transmission was reduced. (neurosciencenews.com)
  • Although it is well-known that mu receptors in the midbrain regulate dopamine release and are important in mediating reward, little is known of the role of other populations that are expressed in the different neurons of the striatum, a hub of many reward pathways. (ucla.edu)
  • The transfer of information between neurons is called neurotransmission. (bloodraynebetrayal.com)
  • Sometimes signals between neurons occur in the reverse direction (called retrograde neurotransmission). (msdmanuals.com)
  • In rats working for direct, optical activation of midbrain dopamine neurons, we varied the strength and opportunity cost of the stimulation and measured time allocation, the proportion of trial time devoted to reward pursuit. (concordia.ca)
  • We show that dopamine-transporter blockade shifts the mountain along both the strength and cost axes in rats working for optical activation of midbrain dopamine neurons. (concordia.ca)
  • Dopamine neurons are an obligatory stage in the dominant model of ICSS, which positions them at a key nexus in the final common path for reward seeking. (concordia.ca)
  • Instead, we propose that midbrain dopamine neurons and neurons with non-dopaminergic, MFB axons constitute parallel limbs of brain-reward circuitry that ultimately converge on the final-common path for the evaluation and pursuit of rewards. (concordia.ca)
  • Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. (concordia.ca)
  • After re- interesting work was happening at medi- entirety, exploring their growth and con- vealing that dopamine neurons could be cal schools. (lu.se)
  • This dramatic increase coincides with the introduction of a range of new neurochemical and pharmacological tools for the study of dopamine neurons and their function in the brain, as well as the identification of the dopamine receptors, their pharmacology, and their role in mediating the antipsychotic action of neuroleptics [12,13]. (lu.se)
  • Specifically, we analyzed the maximum capacity of the nigrostriatal neurons to release dopamine (DA) in the striatum following KCl-induced depolarization of the plasma membrane and after administration of amphetamine. (lu.se)
  • Scientists in Lund have pioneered the use of fetal dopamine neurons for transplantation in Parkinson´s Disease. (lu.se)
  • We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. (nature.com)
  • We here report that Cdk5 with Tyr15 phosphorylation (Cdk5-pTyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of Tyr15-Cdk5 by acting through the D2 class dopamine receptors. (frontiersin.org)
  • Our findings indicate alteration of serotonergic and dopaminergic neurotransmission in HCV infected patients with chronic fatigue and cognitive impairment. (bmj.com)
  • In addition, both conditions are characterized by irregularities in dopaminergic neurotransmission. (additudemag.com)
  • Disruption of dopaminergic and glutamatergic neurotransmission has been proposed to be central to the pathophysiology of schizophrenia. (madinamerica.com)
  • In addition, the authors state that comparing high-risk individuals against a control sample will help determine whether dopaminergic and glutaminergic factors precede the onset of "schizophrenia," which could grant or reduce legitimacy to the causal dopamine hypothesis. (madinamerica.com)
  • The transmembrane dopamine transporter (DAT) is located on the presynaptic nerve terminal and is responsible for terminating dopaminergic transmission by transporting dopamine from the synaptic cleft into the dopaminergic neuron (reuptake). (sigmaaldrich.com)
  • Changes in dopamine beta-hydroxylase (DBH) and anomalies in dopaminergic machinery have been shown in inflammatory bowel disease (IBD) patients and related animal models. (ecco-ibd.eu)
  • Experimentally induced ileitis impairs dopaminergic neurotransmission altering D1R-mediated responses. (ecco-ibd.eu)
  • Subsequent investigation of this phenomenon provided the initial link between reward-seeking behavior and dopaminergic neurotransmission. (concordia.ca)
  • They showed that resting-state functional connectivity between the frontal cortex and striatum regulated by inhibitory dopaminergic neurotransmission determines individual levels of the superiority illusion. (medicalxpress.com)
  • Research on dopaminergic neurotransmission has remained highly dynamic over the years and been extremely important in shaping our understanding of how the brain works in health and disease. (lu.se)
  • To test this hypothesis, basal extracellular concentrations of dopamine (DA) and serotonin (5-HT) in the nucleus accumbens as well as the effects of repeated ethanol pretreatment on the basal release of these transmitters were examined in alcohol-preferring (P), alcohol-nonpreferring (NP), and genetically heterogeneous Wistar rats. (aspetjournals.org)
  • The majority of these investigations have focused on brain dopamine (DA) and serotonin (5-hydroxytryptamine, or 5-HT) systems. (aspetjournals.org)
  • Patients had undergone a diagnostic programme, including clinical and psychometric examination, electroencephalogram (EEG), magnetic resonance imaging of the brain, cerebrospinal fluid analysis, and I-123-beta-CIT (2β-carbomethoxy-3-β-(4-[ 123 I]iodophenyl)tropane) single photon emission computerised tomography (SPECT) studies of serotonin and dopamine transporter binding capacity. (bmj.com)
  • Pathological dopamine transporter binding was present in 12/20 (60%) patients and pathological serotonin transporter binding in 8/19 (50%) patients. (bmj.com)
  • Interestingly, patients with both decreased serotonin and dopamine transporter binding showed significantly impaired performance in most of the tests applied. (bmj.com)
  • Prozac, for example, resulted from an intense search for a chemical that would disrupt the normal functioning of serotonin neurotransmission in the animal and human brain. (madinamerica.com)
  • It is speculated, however, that genes encoding neurotransmission such as serotonin, dopamine or GABA in the brain may participate. (databasefootball.com)
  • Also, although dopamine was the primary focus of the current study, there are other coexisting loops and different molecular systems, such as those based serotonin. (medicalxpress.com)
  • The functional effect was correlated to a recovery of dopamine, but not noradrenaline, content in the brain, suggesting that depletion of dopamine, rather than noradrenaline or serotonin, was the cause of the akinetic state in reserpine-treated animals. (lu.se)
  • Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the receptors on the dendrites of another neuron (the postsynaptic neuron) a short distance away. (wikipedia.org)
  • Neurotransmission is regulated by several different factors: the availability and rate-of-synthesis of the neurotransmitter, the release of that neurotransmitter, the baseline activity of the postsynaptic cell, the number of available postsynaptic receptors for the neurotransmitter to bind to, and the subsequent removal or deactivation of the neurotransmitter by enzymes or presynaptic reuptake. (wikipedia.org)
  • The two populations also contain different populations of dopamine receptors. (jneurosci.org)
  • Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
  • whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
  • In the next series of experiments, coapplication of dopamine and 1 S ,3 R -ACPD, but not application of either drug alone, consistently induced LTD without tetani or even single test stimuli during drug application, suggesting that coactivation of dopamine receptors and the mGluRs is sufficient for LTD induction. (jneurosci.org)
  • Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. (jneurosci.org)
  • Our results suggest that dopamine receptors and groups I and II mGluRs cooperate to induce LTD through converging postsynaptic activation of MAP-Ks. (jneurosci.org)
  • 2023 ) Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors. (neurotree.org)
  • Striatal dopamine synthesis capacity (Ki cer ) and anterior cingulate glutamate were measured using 18F-DOPA positron emission tomography and proton magnetic resonance spectroscopy respectively, before and after at least 5 weeks' naturalistic antipsychotic treatment in people with first episode psychosis ( n = 18) and matched healthy controls ( n = 20). (nature.com)
  • Although we did not find any effect of antipsychotic treatment on absolute measures of dopamine synthesis capacity and anterior cingulate glutamate, the relationship between anterior cingluate glutamate and striatal dopamine synthesis capacity did change, suggesting that antipsychotic treatment affects the relationship between glutamate and dopamine. (nature.com)
  • Striatal dopamine synthesis capacity (Ki cer ) can be measured in-vivo using positron emission tomography, and cortical glutamate can be measured using proton magnetic resonance spectroscopy (MRS). Effects on separate components of the dopamine and glutamate systems have been examined in few in-vivo studies [ 16 ] but not together in the same population. (nature.com)
  • In microdialysis experiments this amino-acid mixture reduced basal and amphetamine-evoked striatal dopamine release, as well as amphetamine-induced hyperactivity. (ox.ac.uk)
  • Both ADHD and PTSD have common specific genetic risk factors, including polymorphisms in the dopamine transporter gene and cannabinoid receptor gene. (additudemag.com)
  • My current work focuses on the dopamine re-uptake transporter, a membrane protein that regulates neurotransmission by clearing dopamine from the synapse. (chatham.edu)
  • Research in my laboratory will capitalize on recent discoveries that certain isoforms of protein kinase C regulate dopamine transporter endocytosis, and that the transporter displays brain-region specific patterns of distribution. (chatham.edu)
  • Brain Region-Specific Trafficking of the Dopamine Transporter. (chatham.edu)
  • My research focuses on the dopamine transporter, which is a primary regulator of normal dopamine physiology as well as being the target of numerous therapeutic and addictive drugs such as cocaine, amphetamine, and some antidepressants. (chatham.edu)
  • The goal of my research program is to define the effects on dopamine transporter function of amphetamine-like stimulants, and to further probe the cellular signals and protein interactions underlying these effects. (chatham.edu)
  • Dopamine transporter endocytosis is measured using immunocytochemistry to label surface (red) and endocytosed (green) transporters. (chatham.edu)
  • Toxicity of stimulants is measured by using fluorescence microscopy to observe the dopamine transporter (blue) and functioning mitochondria (red). (chatham.edu)
  • Recognizes Dopamine transporter, N-terminus. (sigmaaldrich.com)
  • N-terminus of human dopamine transporter fused to Glutathione S-transferase. (sigmaaldrich.com)
  • This Anti-Dopamine Transporter Antibody, N-terminus, clone DAT-Nt is validated for use in IC, IH, WB for the detection of Dopamine Transporter. (sigmaaldrich.com)
  • Immunofluorescence distribution of Iba1 (a macrophage specific marker), D1R, DBH and dopamine transporter (DAT) were determined in longitudinal muscle-myenteric plexus whole-mount preparations (LMMPs) by confocal microscopy. (ecco-ibd.eu)
  • This model fails to provide a cogent account for the differential effect of dopamine transporter blockade on the reward mountain. (concordia.ca)
  • Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in the striatum. (frontiersin.org)
  • Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. (frontiersin.org)
  • Our results suggest a functional link of Cdk5-pTyr15 with postsynaptic dopamine and glutamate signals through the c-Abl kinase activity in the striatum. (frontiersin.org)
  • In the striatum, Cdk5 plays a regulatory role in the dopamine and glutamate transmissions that are integrated by DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) ( Greengard, 2001 ). (frontiersin.org)
  • Glutamate inputs activate Cdk5, which inhibits postsynaptic dopamine D1 receptor (D1R)-mediated signaling by phosphorylating DARPP-32 at Thr75 (Thr75-DARPP-32) in the striatum, since DARPP-32 with Thr75 phosphorylation (DARPP-32-pThr75) functions as an inhibitor of cAMP-dependent protein kinase A (PKA). (frontiersin.org)
  • however, it is not fully understood how Cdk5 interacts with dopamine signaling in the striatum. (frontiersin.org)
  • This strategic localization of Cdk5-pTyr15 suggests a possible role of the c-Abl/Cdk5 signaling in modulation of postsynaptic dopamine and glutamate transmissions in the striatum. (frontiersin.org)
  • Here, we show that in the mouse striatum, dopamine receptor stimulation negatively regulates phosphorylation of Tyr15-Cdk5 most likely through a D2R-mediated mechanism. (frontiersin.org)
  • Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum. (cdc.gov)
  • A second challenge, Yamada continues, was determining the neuromolecular basis for the superiority illusion by demonstrating an interrelationship between dopamine neurotransmission and resting-state functional connectivity between the frontal cortex and striatum. (medicalxpress.com)
  • Here, we tested the hypothesis that Nrxns regulate DA neuron neurotransmission. (ulaval.ca)
  • The dopamine hypothesis [ 13 ] is arguably the most well-known and well-supported neurochemical model of schizophrenia, but has been unable to explain the occurrence of treatment-resistant schizophrenia. (biomedcentral.com)
  • Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments. (nel.edu)
  • Li W, Ling S, Yang Y, Hu Z, Davies H, Fang M. Systematic hypothesis for post-stroke depression caused inflammation and neurotransmission and resultant on possible treatments. (nel.edu)
  • A new meta-analysis of data from individuals at high risk for schizophrenia finds no evidence for the dopamine hypothesis. (madinamerica.com)
  • The authors found no significant differences between high-risk populations and control groups when analyzing neuroimaging studies from 1960 to 2020, putting the dopamine hypothesis of the cause of "schizophrenia" in question. (madinamerica.com)
  • Although there has long been criticism of the dopamine hypothesis of "schizophrenia" as the cause of the condition, including a previous meta-analysis that found no support for the hypothesis after analyzing relevant neurochemical processes, the hypothesis continues to maintain prominent status in psychiatry. (madinamerica.com)
  • Only forty-eight of these met the inclusion criteria, which included the above-mentioned risk factors as well as several targets of neuroimaging, such as striatal presynaptic dopamine function, striatal D2/D3 receptor availability, and glutamate or Glx (glutamine-glutamate) concentrations. (madinamerica.com)
  • Changes in ileal muscle tension were isometrically recorded following 30 μM dopamine or 30 μM SKF38393 (a dopamine receptor 1 (D1R) agonist) or 30 μM bromocriptine (a D2R agonist). (ecco-ibd.eu)
  • Open access research for "Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? (neurosciencenews.com)
  • Glycogen synthase kinase 3ß (GSK3ß) activity is regulated by dopamine D2 receptor signaling and can be inhibited by psychoactive drugs in a D2 receptor-dependent manner. (bvsalud.org)
  • The VTA is important for its role in the dopamine neurotransmission involved in reward-directed behavior. (bioquicknews.com)
  • The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. (nature.com)
  • Dopamine as an independent neurotransmitter in the nervous system was discovered in Lund by the pharmacologist Arvid Carlsson in 1957, working at the Department of Pharmacology at Sölvegatan 10 in Lund (the current Geocentrum building). (lu.se)
  • The discovery of dopamine as a neurotransmitter in the brain was one of the seminal events in the development of modern neuroscience. (lu.se)
  • 2020 ) Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse. (neurotree.org)
  • 2020 ) Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice. (neurotree.org)
  • The goal of this project was to study how genetic polymorphisms of genes involved in dopamine transmission and various hormonal differences modulate the reward system in humans. (europa.eu)
  • The study focused on testing genes that are important in dopamine-based signal transmission (dopamine neurotransmission). (neurosciencenews.com)
  • According to a new study, listening to classical music enhanced the activity of genes involved in dopamine secretion and transport, synaptic neurotransmission, learning and memory, and down-regulated the genes mediating neurodegeneration. (sciencedaily.com)
  • Listening to music enhanced the activity of genes involved in dopamine secretion and transport, synaptic function, learning and memory. (sciencedaily.com)
  • Pre-clinical models show interactions between the dopamine and glutamate systems which could contribute to the actions of antipsychotics [ 12 ]. (nature.com)
  • In the present paper, we meta-analyzed neuroimaging studies of the dopamine and glutamate systems in individuals at high clinical or genetic risk for psychosis to provide the best estimate of the magnitude and variability of group differences across samples and settings. (madinamerica.com)
  • Dopamine inhibits excitatory neurotransmission in basolateral amygdala during development via pre-synaptic mechanism. (nel.edu)
  • Wang P, Fang M, Zha Y, Lai J, Li Z. Dopamine inhibits excitatory neurotransmission in basolateral amygdala during development via pre-synaptic mechanism. (nel.edu)
  • Knowledge gained from this research contributes to an overall understanding of dopamine physiology and pharmacology, and lends insights toward new therapeutic avenues for substance use and other neurological disorders. (chatham.edu)
  • Moreover, drug challenge studies have demonstrated targeting one system may have reciprocal effects, for example, acute ketamine increasing cortical, striatal and nucleus accumbens dopamine in-vivo [ 15 ]. (nature.com)
  • Moreover, the data suggest that ethanol exposure can alter basal DA and 5-HT in the nucleus accumbens and that vulnerability to ethanol-induced changes in monoamine neurotransmission may be a factor in genetically determined ethanol preference. (aspetjournals.org)
  • An emerging literature suggests that neuroligins, trans-synaptic cell adhesion molecules, regulate both DA neuron connectivity and neurotransmission. (ulaval.ca)
  • The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak dopamine antagonism. (biomedcentral.com)
  • Similarly, it is not a coincidence that all "antipsychotic" drugs disrupt dopamine neurotransmission in the animal and human brain. (madinamerica.com)
  • Tetanic stimuli to layer I-II afferents in rat prefrontal cortex induced long-term depression (LTD) of layer I-II to layer V pyramidal neuron glutamatergic synapses when tetani were coupled to bath application of dopamine. (jneurosci.org)
  • Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson's Disease OPEN ACCESS eNeuro. (lu.se)
  • Dysregulation of dopamine physiology is involved with disorders such as Parkinson's Disease, depression, ADHD, and substance use disorder. (chatham.edu)
  • Such genetically and hormonally driven variations in dopamine function and consequent reactivity of the reward system have important implications for clinical manifestations of diseases involving disordered catecholamine regulation, and therefore clarify biological mechanisms underlying individual and/or gender differences in neuropsychiatric disorders affecting the reward system. (europa.eu)
  • We first tested subjects presenting genetic polymorphisms of the catechol-O-methyltransferase (COMT), an enzyme that catabolises released dopamine in order to investigate how these polymorphisms of the COMT could influence brain activation related to reward signals in humans. (europa.eu)
  • Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight. (cdc.gov)
  • The amine 3-hydroxytyramine (`dopamine') had earlier been identified as an intermediary in the synthesis of noradrenaline and adrenaline from tyrosine. (lu.se)
  • Lindqvist, Tor Magnusson and Bertil Waldeck, made the seminal observations that during the subsequent years would lead to the unravelling of dopamine as a transmitter in the central nervous system, independent of its role as a precursor in noradrenaline and adrenaline synthesis. (lu.se)
  • In their 1957 and 1958 papers [1.2], (Carlsson et al 1957) (Carlsson et al 1958) Carlsson and co-workers made the intriguing observation that the akinetic effects of reserpine could be reversed by an intravenous injection of the dopamine (and noradrenaline) precursor, 3,4- dihydroxyphenylalanine (DOPA). (lu.se)
  • Dopamine plays an important role in the brain's reward system and is crucial in modulating a person's drive and motivation. (neurosciencenews.com)
  • What is the process of neurotransmission of neurotransmitters? (bloodraynebetrayal.com)
  • Number of publications per year from 1945 to 2006 on the topics of Dopamine and of related classical neurotransmitters. (lu.se)
  • Illicit dopamine transients: reconciling actions of abused drugs. (nih.gov)
  • LTD by dopamine + 1 S ,3 R -ACPD coapplication was also blocked by postsynaptic injection of synthetic MAP-K substrate peptide. (jneurosci.org)
  • The biochemical aim of all psychiatric drugs is disruption of normal neurotransmission in the brain. (madinamerica.com)
  • Effect of acute tyrosine depletion in using a branched chain amino-acid mixture on dopamine neurotransmission in the rat brain. (ox.ac.uk)
  • Central dopamine function is reduced by decreasing the availability of the catecholamine precursor, tyrosine, using a tyrosine-free amino acid mixture containing multiple large neutral as well as branched chain amino-acids, which compete with tyrosine for uptake into the brain. (ox.ac.uk)
  • Here, we investigate whether individual or limited amino-acid combinations could reduce brain tyrosine levels and hence dopamine function. (ox.ac.uk)
  • In conclusion, the present study identified a small combination of amino acids that reduces brain tyrosine and dopamine function in a manner similar to mixtures of multiple amino acids. (ox.ac.uk)
  • Background: While it has recently been shown that dopamine release stimulates conscious self-monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such oscillations, interaction of the two transmitter systems has not been demonstrated in human. (researchgate.net)
  • Studies that included individuals with comorbid substance dependence were excluded because substance use can affect the dopamine system. (madinamerica.com)
  • This observation indicates alteration of serotonergic neurotransmission in HCV infected patients with chronic fatigue. (bmj.com)
  • Consistently, LTD by dopamine + 1 S ,3 R -ACPD coapplication, as well as the two other forms of LTD (LTD by dopamine + tetani and LTD by 1S,3R-ACPD + tetani), was blocked by bath application of MAP-K kinase inhibitor PD98059. (jneurosci.org)
  • The synchronization of these oscillations is modulated by dopamine release. (researchgate.net)
  • It was hypothesized that dopamine release in the striatal system induced by pleasure songs are involved in the cardiac autonomic regulation. (bvsalud.org)
  • Commenting on the results of the study, Dr. Kaminski explains: "We have previously been able to observe links between stress and cognitive performance, particularly in relation to the activity of the dopamine-controlled reward system. (neurosciencenews.com)
  • In addition, dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. (lu.se)
  • Although these findings strongly implicate dysfunctions in forebrain DA and 5-HT neurotransmission as a factor in ethanol preference, several issues remain unresolved. (aspetjournals.org)
  • Considering the indirect findings for the superiority illusion reported in the literature separately by PET and fMRI studies, we speculated an interrelationship between dopamine neurotransmission and frontal lobe function might be the key to identifying the neurobiological mechanisms underlying this cognitive bias. (medicalxpress.com)
  • on the other hand, the salt of sibutramine monohydrate, which has a pharmacological mechanism of action similar in these systems of central neurotransmission, have not had their use tested in a model of ADHD. (usp.br)
  • The mechanism is unclear but may involve abnormalities in dopamine neurotransmission in the central nervous system (CNS). (merckmanuals.com)