• Here, our efforts resulted in the best 29 (LY836) with improved neuroprotective activities in primary cortical neurons from glutamate-induced damage and drug-like properties. (bvsalud.org)
  • Whereafter, co-immunoprecipitation experiment demonstrated that 29 significantly blocked PSD95-nNOS association in cultured cortical neurons. (bvsalud.org)
  • A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity (Nakano et al. (yale.edu)
  • These clusters show preferential accumulation in specific membrane compartments of different cell types, in particular, in Purkinje cell (PC) spines and granule cell (GC) presynaptic active zones. (jneurosci.org)
  • Ambient glutamate shapes AMPA receptor responses to simulated transients (Balmer et al. (yale.edu)
  • Pharmacologically, substances that enhance the components of the memory/learning circuits-dopamine, glutamate (neuronal excitation), and/or norepinephrine-stand to improve brain function in healthy individuals beyond their baseline functioning. (frontiersin.org)
  • A Method for Prediction of Receptor Activation in the Simulation of Synapses (Montes et al. (yale.edu)
  • 1997). The NEURON simulation environment. (modeldb.science)
  • Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. (yale.edu)
  • In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent memory deficits. (mdpi.com)
  • A working memory model for serial order that stores information in the intrinsic excitability properties of neurons. (modeldb.science)
  • We conclude that two cephalothoracic pathways may convey cues about antennal movement and pointing direction to thoracic motor centres via two synapses only. (bvsalud.org)
  • These neurons invaded most brain neuropils, especially the posterior slope, posterior and ventro-lateral protocerebrum, the antennal mechanosensory and motor center, but less densely the lateral accessory lobes that are targeted by central-complex outputs. (bvsalud.org)
  • Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level. (modeldb.science)
  • and cholinergic neurons of the basal forebrain, that play a significant role in in Alzheimer's disease (AD) [ 8 ]. (biomedcentral.com)