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  • metabolites
  • Finlay JM, Jakubovic A, Fu DS, Fibiger HC (1987) Tolerance to haloperidol-induced increases in dopamine metabolites: fact or artifact? (springer.com)
  • vivo
  • An in vivo animal model, along with the technique of in vivo electrochemistry was used to demonstrate, in real time, the characteristics of dopamine release and clearance. (ohiolink.edu)
  • The possibility to use the new ligand 3 H-domperidone to identify some dopamine binding sites at the ultrastructural level was assessed in the neostriatum after in vivo administration and high-resolution radioautography. (springer.com)
  • prefrontal
  • Long-term memory in the prefrontal cortex is a necessary component of adaptive executive control and is strongly modulated by dopamine. (jneurosci.org)
  • In vitro experimental results on dopamine-dependent shaping of prefrontal long-term plasticity often appear inconsistent and, altogether, draw a complicated picture. (jneurosci.org)
  • This study presents a unified view of the functional role of dopamine in the prefrontal cortex by framing it within the Bienenstock-Cooper-Munro theory of cortical plasticity. (jneurosci.org)
  • It also suggests that dopamine may constitute a new player in metaplastic and homeostatic processes in the prefrontal cortex. (jneurosci.org)
  • decreases
  • Carbidopa reduces the amount of levodopa required to produce a given response by about 75% and, when administered with levodopa, increases both plasma levels and the plasma half-life of levodopa, and decreases plasma and urinary dopamine and homovanillic acid. (drugs.com)
  • carbidopa
  • In clinical pharmacologic studies, simultaneous administration of separate tablets of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine when compared to the two drugs administered at separate times. (drugs.com)
  • forebrain
  • These treatments were applied to the rat forebrain and measurement of the ensuing dopamine release were monitored using the IVEC-10 system and software capable of measuring neurochemical substances such as dopamine. (ohiolink.edu)
  • effect
  • For this reason, large doses of levodopa are required for adequate therapeutic effect and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues. (drugs.com)