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  • Antiemetics
  • Based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron , the concomitant use of apomorphine with drugs of the 5HT3 antagonist class including antiemetics (for example, ondansetron, granisetron, dolasetron, palonosetron) and alosetron are contraindicated [see CONTRAINDICATIONS ]. (rxlist.com)
  • striatum
  • Dopamine D 2 receptor antagonists modulate gene transcription in the striatum. (frontiersin.org)
  • Here we used the expression of Nur77 , a transcription factor of the orphan nuclear receptor family, as readout to explore the role of dopamine, glutamate, and adenosine receptors in the effect of a dopamine D 2 antagonist in the striatum. (frontiersin.org)
  • A combination of a metabotropic glutamate type 5 (mGlu5) and adenosine A 2A receptor antagonists abolished eticlopride-induced upregulation of Nur77 mRNA levels in the striatum. (frontiersin.org)
  • Removal of the dopamine input protected the denervated striatum from the neurotoxic effects of systemic 3-NP but did not prevent the formation of lesions in the intact striatum. (jneurosci.org)
  • Although there are a large number of neuroactive substances in the striatum that might be involved in 3-NP toxicity, one of the best candidates is dopamine. (jneurosci.org)
  • The precise mechanism of action of pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum. (nih.gov)
  • glutamate
  • Thus, these results uncover an unappreciated role of presynaptic D 2 heteroreceptors and support a prominent role of glutamate in the effect of D 2 antagonists. (frontiersin.org)
  • By contrast, infusion of the glutamate antagonist kynurenic acid in the accumbens shell inhibits the release of dopamine and reduces the time that females spend investigating male-soiled bedding. (frontiersin.org)
  • exert
  • The integration of findings from these approaches will provide significant information related to the structure of the DAT active site and how antagonists exert effects on transport. (grantome.com)
  • Reversal
  • Pathological gambling has been associated with dopamine transmission abnormalities, in particular dopamine D2-receptor deficiency, and reversal learning deficits. (springer.com)
  • However, there is no empirical evidence for a direct link between dopamine, reversal learning and pathological gambling. (springer.com)
  • The aim of the present study is to triangulate dopamine, reversal learning, and pathological gambling. (springer.com)
  • Here, we assess the hypothesis that pathological gambling is accompanied by dopamine-related problems with learning from reward and punishment by investigating effects of the dopamine D2-receptor antagonist sulpiride (400 mg) on reward- and punishment-based reversal learning in 18 pathological gamblers and 22 healthy controls, using a placebo-controlled, double-blind, counter-balanced design. (springer.com)
  • These data demonstrate that pathological gambling is associated with a dopamine-related anomaly in reversal learning from reward and punishment. (springer.com)
  • By contrast to substance addiction, there appears to be no empirical evidence for a direct link between dopamine, reversal learning and pathological gambling. (springer.com)
  • Objective To establish the reversal potential of D1, D2 and 5-HT receptor antagonists acutely, and D1 and D2 receptor antagonists chronically, on d-amphetamine-induced disruption of a conditional discrimination task that depends on the ability to use task-setting cues to direct goal directed performance. (cardiffmet.ac.uk)
  • compounds
  • This project will investigate how drug compounds interact with dopamine transporter (DAT) utilizing an integrated approach combining biochemical and computational methodologies. (grantome.com)
  • The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. (patentsencyclopedia.com)
  • doses
  • It can be taken any time of the day but in higher doses its dopaminergic agonism probably becomes stronger so if taking more than 4mg in a single dose I would take in the morning as is the recommendation for other dopamine agonists. (raypeatforum.com)
  • rats
  • These data are in agreement with previous reports in male rats showing that exposure to opposite-sex odors elicits dopamine release in the accumbens, and with data in female mice showing that the behavioral preference for male chemosignals is not affected by opioidergic antagonists. (frontiersin.org)
  • evaluate
  • The results obtained from biochemical and computational analyses will lead to hypotheses that will be experimentally tested using site-directed mutagenesis, cysteine-scanning accessibility, and a library of DAT antagonist analogs to evaluate the molecular predictions. (grantome.com)