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  • antigens
  • Limiting dilution analysis was used to assess helper-T-lymphocyte reactivity to donor antigens. (harvard.edu)
  • MHC-Restricted cytotoxic T-Cell: studies on the biological role of polymorphic major transplantation antigens determining t-cell restriction specificity, function, and responsiveness. (springer.com)
  • HLA-identical siblings or HLA-identical unrelated donors often have genetically different proteins (called minor histocompatibility antigens) that can be presented by Major histocompatibility complex (MHC) molecules to the donor's T-cells, which see these antigens as foreign and so mount an immune response. (wikipedia.org)
  • donation
  • The eligibility criteria for a stem cell donor are essentially the same as for blood donation. (medscape.com)
  • However, certain donors with these diseases may still be considered for donation on a case-to-case basis. (medscape.com)
  • Accordingly, all donors should be evaluated for the possibility of general anesthesia during the donation process. (medscape.com)
  • 56% of donors stated they benefited from donation. (aappublications.org)
  • 13 - 15 Across these studies, both positive and negative psychosocial consequences of typing and donation are reported, including sibling donors' lack of choice, lack of appropriate information, and need for greater support. (aappublications.org)
  • Before donation, a drug is injected into the donor, which increases the number of stem cells into their body. (wikipedia.org)
  • cells
  • For Subject 2, a pre-transplant limiting dilution assay revealed T helper cells recognizing both donor and third-party PBMCs. (harvard.edu)
  • RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill cancer cells. (clinicaltrials.gov)
  • There, he conducted one of the first human gene therapy studies when he transduced bone marrow stem cells with a retroviral vector with the intention of marking them to study their survival and fate. (wikipedia.org)
  • This seminal study demonstrated that engrafted bone marrow stem cells contribute to long-term hematopoiesis and also that contaminating tumor cells in autografts can cause relapse. (wikipedia.org)
  • After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the host, attack the tissues of the transplant recipient after perceiving host tissues as antigenically foreign. (wikipedia.org)
  • Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation. (wikipedia.org)
  • In allogeneic cell therapy the donor is a different person to the recipient of the cells. (wikipedia.org)
  • A peripheral stem cell donor must have the same blood type as the patient receiving the blood cells. (wikipedia.org)
  • clinical
  • A number of clinical trials have proved the superiority of this method over collection from the bone marrow. (medscape.com)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • adults
  • As for the children who were treated by Professor Hobbs's bone marrow team at the Westminster hospital, most of these children now enjoy full lives as adults. (wikipedia.org)
  • Bone marrow failure in both children and adults can be either inherited or acquired. (wikipedia.org)
  • siblings
  • We recommend education for all siblings before typing, comprehensive education for the donor by a health care provider pretransplant, and systematic donor follow-up after transplantation. (aappublications.org)
  • One barrier to determining appropriate stringency for a donor protection policy is the relative lack of empirical data regarding the experience of families and specifically siblings who are typed and/or serve as donors. (aappublications.org)
  • Research
  • In 1990, he left the UK to work in St. Jude Children's Research Hospital in Memphis as the director of the Bone Marrow Transplant Division. (wikipedia.org)
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • murine bone
  • Tolerogenic DCs have been generated in the presence of 1,25(OH) 2 D 3 , the active form of vitamin D 3 , and of vitamin D 3 analogues from both human blood monocytes and murine bone marrow and shown to induce Treg ( 8 , 9 , 10 ). (jimmunol.org)
  • tissues
  • Volumetric analyses over large areas reveal that spectrally coded HSPC-derived cells can be detected non-invasively in various intact tissues, including the bone marrow (BM), for extensive periods of time following transplantation. (jove.com)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Some organs and tissues can be donated by living donors, such as a kidney or part of the liver, part of the pancreas, part of the lungs or part of the intestines, but most donations occur after the donor has died. (wikipedia.org)
  • transfusion
  • hosting the UK NEQAS external quality assessment scheme for Histocompatibility and Immunogenetics and the Welsh Assessment of Serological Proficiency scheme (WASPS), contribution to the maintenance of quality standards in the transfusion and transplantation community. (wikipedia.org)
  • fetal
  • In mammalian embryology, the first definitive HSCs are detected in the AGM (aorta-gonad-mesonephros), and then massively expanded in the fetal liver prior to colonising the bone marrow before birth. (wikipedia.org)
  • vitro
  • In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the development of bone marrow-derived tolerogenic DCs in vitro and in vivo. (jimmunol.org)
  • organ
  • Shapiro RI, Cerra FB (1978) A model for reimplantation and transplantation of a complex organ: the rat hind limb. (springer.com)
  • Organ donation is when a person allows an organ of theirs to be removed, legally, either by consent while the donor is alive or after death with the assent of the next of kin. (wikipedia.org)
  • While views of organ donation are positive there is a large gap between the numbers of registered donors compared to those awaiting organ donations on a global level. (wikipedia.org)
  • citation needed] Organ donors are usually dead at the time of donation, but may be living. (wikipedia.org)
  • For living donors, organ donation typically involves extensive testing before the donation, including psychological evaluation to determine whether the would-be donor understands and consents to the donation. (wikipedia.org)
  • The lead surgeon, Joseph Murray, won the Nobel Prize in Physiology or Medicine in 1990 for advances in organ transplantation. (wikipedia.org)
  • The youngest organ donor was a baby with anencephaly, born in 2015, who lived for only 100 minutes and donated his kidneys to an adult with renal failure. (wikipedia.org)
  • The oldest known organ donor for an internal organ was a 92-year-old Texas man, whose family chose to donate his liver after he died of a brain hemorrhage. (wikipedia.org)
  • Globally, pioneering experimental studies in the surgical technique of human organ transplantation were made in the early 1900s by the French surgeon Alexis Carrel, and successful transplants starting spreading worldwide after the Second World War. (wikipedia.org)
  • 2017
  • a short A BBB video appeal was published in early 2017 The laws of different countries allow potential donors to permit or refuse donation, or give this choice to relatives. (wikipedia.org)
  • therapy
  • Until now insulin replacement is still the major therapy, because islet transplantation has been limited by donor availability and by the need for long-term immunosuppression. (jove.com)
  • organs
  • For dead donors, the process begins with verifying that the person is hopelessly dead, determining whether any organs could be donated, and obtaining consent for the donation of any usable organs. (wikipedia.org)
  • After the surgeons remove the organs, they are transported as quickly as possible to the recipient, for immediate transplantation. (wikipedia.org)
  • In the case of a dead donor, after the organs are removed, the body is normally restored to as normal an appearance as possible, so that the family can proceed with funeral rites and either cremation or burial. (wikipedia.org)
  • In 2007, China issued regulations banning the commercial trading of organs, and the Chinese Medical Association agreed that the organs of prisoners should not be used for transplantation, except for members of the immediate family of the deceased. (wikipedia.org)
  • Genetic
  • From 60 matching donors, they selected a [CCRΔ32 homozygous individual with two genetic copies of a rare variant of a cell surface receptor. (wikipedia.org)
  • human
  • In 2007, a patent application was filed on methods for creating human female sperm using artificial or natural Y chromosomes and testicular transplantation. (wikipedia.org)
  • include
  • Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair and lethargy. (wikipedia.org)
  • produce
  • Since the late 1980s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. (wikipedia.org)
  • time
  • The first is spin speed and bowl diameter, the second is "sit time" in centrifuge, the third is solutes added, and the fourth is not as easily controllable: plasma volume and cellular content of the donor. (wikipedia.org)