AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Plasma CellsMultiple MyelomaBone Marrow TransplantationBone MarrowBone Marrow CellsParaproteinemiasTransplantation, HomologousPrognosisFlow CytometryGraft vs Host DiseaseParaproteinsB-LymphocytesTransplantation ChimeraTissue DonorsBone and BonesGraft SurvivalWhole-Body IrradiationTransplantation, AutologousAmyloidosisHistocompatibility TestingTransplantation ConditioningAnemia, AplasticHistocompatibilityLeukemiaHematopoietic Stem CellsHematopoietic Stem Cell TransplantationBone Marrow DiseasesRadiation ChimeraBone Marrow PurgingMice, Inbred C57BLBone Marrow ExaminationGraft RejectionTransplantation, IsogeneicBone RemodelingLiver TransplantationGraft Enhancement, ImmunologicBone Marrow NeoplasmsTransplantation ToleranceBusulfanKidney TransplantationImmunosuppressive AgentsLeukocyte TransfusionHematopoiesisRecurrenceTime FactorsImmunosuppressionLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSkin TransplantationTreatment OutcomeHLA AntigensLymphocyte DepletionCyclophosphamideTransplantation ImmunologyPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Plasma CellT-LymphocytesChimerismBone DensityActuarial AnalysisHeart TransplantationAcute DiseaseLeukemia, Myeloid, AcuteCombined Modality TherapyBone ResorptionCell DifferentiationSurvival AnalysisColony-Forming Units AssayMice, Inbred BALB CRemission InductionChimeraHematologic NeoplasmsLeukemia, MyeloidLymphocyte Culture Test, MixedHepatic Veno-Occlusive DiseaseGraft vs Host ReactionStem Cell TransplantationCells, CulturedSpleenLymphoma, Non-HodgkinMyelodysplastic SyndromesBone NeoplasmsLymphocyte TransfusionLiving DonorsNeoplasms, Plasma CellDisease-Free SurvivalRetrospective StudiesSevere Combined ImmunodeficiencyPancytopeniaHematologic DiseasesMice, Inbred C3HBone DevelopmentLeukocyte CountBone DiseasesImmunophenotypingGranulocyte Colony-Stimulating FactorAntigens, CD34Mice, KnockoutAntineoplastic Combined Chemotherapy ProtocolsCyclosporineGranulocytes
TransplantHSCTGraft versusChemotherapyAplastic AnemiaGVHDMultiple myelomaStem cellPlateletsWorld Blood Donor DayAutologous boneTransplantsTissueAllogeneic hematopoietic-cell transplantationRecipientsHaploidenticalMalignantOrganInfusionImmuneDifferentiationMyelomaOutcomesBiopsyStromal cellImmunosuppressionClinicalEngraftmentAcuteDeficiencyMurine modelPediatricProcedureDisordersPhenotypeMononuclear cellsMesenchymal stromal cellsPatient'sTissues2023Matched unrelated donorMacrophagesPlatelet-rich plasmaAntibodiesOpportunistic infections2021EffectorPeripheral blood stem cellsTumorTransfusionExchange transfusionsAllogenicUmbilical cordSuitable donor
Transplant35
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • At the University of Chicago Medicine, our transplant team works side-by-side with the patient, family and referring physician before, during and after transplantation to ensure the best possible outcome. (uchicagomedicine.org)
  • Most patients stay in the hospital during this period to be protected from infection and monitored for side effects, though select patients may be candidates for outpatient stem cell transplant . (uchicagomedicine.org)
  • Select patients may receive outpatient stem cell transplant care in specially designed treatment rooms within the unit. (uchicagomedicine.org)
  • Our stem cell transplant physicians are members of the nationally renowned UChicago Medicine Comprehensive Cancer Center , one of only two National Cancer Institute (NCI)-designated Comprehensive Cancer Centers in Chicago. (uchicagomedicine.org)
  • Currently there are thousands of people who, in order to continue living or improve their quality of life, need a blood transfusion (in its different components) or a transplant of hematopoietic progenitors from bone marrow or umbilical cord blood. (comunidad.madrid)
  • The bone marrow transplant is the only hope of life for people with certain blood diseases such as leukemia or lymphomas. (comunidad.madrid)
  • The treatment is also referred to as a bone marrow transplant. (santaclara.com)
  • This review presents analysis of the modern state of transplant tolerance forming problem in recipient organism by using stem/ progenitory cells of bone marrow (BM) and differentiated immunoregulatory (tolerogenic) subsets of blood cells-regulatory B- and T-lymphocytes (Treg), and regulatory dendritic cells (DCreg). (genescells.ru)
  • It was given supposition that at using BM cells the forming of steady transplant tolerance state is a result of successive entering of central (thymical induction of temporary mixed chimer-ism) and peripheral tolerance mechanisms. (genescells.ru)
  • Combined application of BM cells and Treg permits to increase the terms for maintaining of donor chimerism into all cell lines (incuding Tcells) and transplant tolerance in recipient organism. (genescells.ru)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
  • The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
  • Blood is drawn and at a later time reinfused into that patient's blood stream in a procedure known as autologous bone marrow transplant . (targetwoman.com)
  • When stem cells are obtained from a healthy person, the procedure is allogeneic bone marrow transplant. (targetwoman.com)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • Have you received a stem cell transplant? (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • Another way to manage this form of cancer developed in the bone marrow is to undergo a stem cell transplant. (healthhearty.com)
  • These cells are used for hematopoietic stem cell transplant, or shipment to manufacturers of cellular therapies such as dendritic cell vaccines and chimeric antigen receptor (CAR) T cells. (uiowa.edu)
  • Biol Blood Marrow Transplant 26(7):1247-1256, 2020. (msdmanuals.com)
  • Multiple myeloma can be treated by the bone marrow transplant process. (ghnservices.com)
  • If a patient is eligible for autologous bone marrow transplant, it becomes the recommended course of treatment. (onco.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Immune Reconstitution and Severity of COVID-19 among Hematopoietic Cell Transplant Recipients. (mdanderson.org)
  • RATIONALE: Giving an infusion of natural killer cells from a donor after a donor stem cell transplant may help kill any remaining cancer cells after the transplant. (bioseek.eu)
  • PURPOSE: This phase I/II trial is studying the side effects and best dose of donor natural killer cells when given after a donor stem cell transplant in treating patients with advanced cancer. (bioseek.eu)
  • Comparison of Haploidentical Hematopoietic Stem Cell Transplant With or Without Unrelated Cord Blood Infusion in Severe Aplastic Anemia: Outcomes of a Multicenter Study. (cdc.gov)
  • Genetic testing in severe aplastic anemia is required for optimal hematopoietic cell transplant outcomes. (cdc.gov)
HSCT15
Graft versus7
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
  • After transplantation, he suffered acute graft-versus-host disease with a systemic rash and severe diarrhea. (biomedcentral.com)
  • Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)
Chemotherapy15
  • Conditioning treatment - administration of chemotherapy and/or radiation to the patient in order to destroy all of the diseased cells in the body and to create space in the bone marrow for the transplanted stem cells to populate. (uchicagomedicine.org)
  • A qualifying patient will still need to undergo high doses of chemotherapy or radiation as a conditioning treatment, so the infused stem cells can make their way to the bone marrow to begin the production of healthy blood cells. (santaclara.com)
  • We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
  • In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
  • Chemotherapy does help to regulate the production of plasma cells. (healthhearty.com)
  • This is because chemotherapy medications cannot distinguish between healthy and cancer cells. (healthhearty.com)
  • Hence, these drugs also destroy healthy cells and so to avoid substantial reduction in the number of healthy cells, the patient is advised to undergo stem cell transplantation prior to taking chemotherapy medicines in high doses. (healthhearty.com)
  • As chemotherapy is the mainstay of treatment, healthy red blood cells are also destroyed. (healthhearty.com)
  • using cells from bone marrow, blood, or less often, umbilical cord blood cells are given after high- or moderate-dose chemotherapy and/or radiation therapy. (msdmanuals.com)
  • Chemotherapy - a drug treatment that uses powerful chemicals to kill fast growing cells in your body. (ghnservices.com)
  • The high-portion chemotherapy given before transplantation generally neglects to kill all of the plasma cells, permitting the condition to backslide after transplantation. (ghnservices.com)
  • High-portion chemotherapy is then given to kill however many plasma cells as could be expected under the circumstances, and the stem organisms are defrosted and gotten back to your body. (ghnservices.com)
  • The standard treatment includes few cycles of chemotherapy with a combination of drugs, followed by autologous transplantation, for those who are deemed fit. (onco.com)
  • No radiotherapy or chemotherapy has been carried out recently that might explain a disorder of bone marrow function ( bone marrow insufficiency ). (aa-pnh.org)
  • Chemotherapy: It involves the administration of anti-cancer drugs into the body via injection or through a pill to target cancerous cells and destroy them. (ndtv.com)
Aplastic Anemia2
  • A Japanese man who had been diagnosed with aplastic anemia underwent allogenic bone marrow transplantation from an unrelated donor at 51 years of age. (biomedcentral.com)
  • 31C/T, -511T/C and -3954C/T Single Nucleotide Polymorphism and Their Blood Plasma Level in Acquired Aplastic Anemia. (cdc.gov)
GVHD7
  • The spleen also uniquely contributes toGraft Versus Host Disease (GVHD) complete B cell memory [11]. (fliphtml5.com)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • Using proteomics, it has been shown that plasma concentration of Suppression of Tumorigenicity 2 (ST2), accurately stratified patients according to risk of non-response to acute GvHD therapy in large retrospective sets. (cryostem.org)
  • Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
  • These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
  • Since GvT responses involve T-cell recognition of tumor-specific peptides presented by MHC molecules [ 14 ], it may be possible to identify and select donor T cells that provide beneficial GvT responses but minimal GvHD risk. (biomedcentral.com)
  • By then infusing the animals with B10.D2 T cells from only the TCR Vβ 2, 3 and 8.3 families appropriately pre-activated in vitro, we saw a vigorous GvM response without any clinical or histological signs of GvHD or disease relapse, which translated into long-term, disease-free survival. (biomedcentral.com)
Multiple myeloma18
Stem cell49
Platelets10
  • The estimated residual risk of contamination of blood products with bacterial agents is 1 in 5,000 for platelets and 1 in 30,000 for red blood cells. (medscape.com)
  • Automated blood drawing, or apheresis, is a special type of donation that allows a person to selectively donate a portion of the blood components, such as red blood cells, platelets, or plasma. (comunidad.madrid)
  • We do a processing out of the whole blood units where we prepare red blood cells, platelets, plasma and cryoprecipitate. (dailymirror.lk)
  • Red blood cells do not provide viable platelets, nor do they provide clinically significant amounts of coagulation factors. (utmb.edu)
  • Disorders can range from anemia (shortage of red blood cells) to hemophilia (bleeding disorder), thrombocytopenia (low platelets), thalassemia (abnormal and insufficient hemoglobin), and blood cancers. (santaclara.com)
  • Stem cells develop into platelets, red blood cells and white blood cells. (santaclara.com)
  • The components thus separated from the patient/donor includes, plasma, platelets or leukocytes. (targetwoman.com)
  • Stem cells are infused into the patient's blood stream in order to produce cells that eventually will mature into red blood cells, white blood cells and platelets. (targetwoman.com)
  • Erythrocytapheresis is the collection of red blood cells (RBCs) either two standard units of RBCs or one unit plus either plasma or platelets. (targetwoman.com)
  • PRP is obtained from your own blood after it has been processed to concentrate platelets and certain white blood cells that enhance healing and reduce inflammation. (jointandsports.com)
World Blood Donor Day3
  • In 2021, the traditional act of gratitude to donors could already be held on the occasion of World Blood Donor Day, although complying with the capacity restriction measures due to the COVID-19 pandemic. (comunidad.madrid)
  • In view of World Blood Donor Day (WBDD) held yesterday (June 14) the NBTS organised events to appreciate donors and organisers. (dailymirror.lk)
  • World Blood Donor Day is one of the major global events hosted by the World Health Organisation apart from other seven global days they celebrate. (dailymirror.lk)
Autologous bone1
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Transplants5
  • The court's decision may well help thousands of sick patients who need bone-marrow transplants to survive, but it also begs the question, What other body parts might next be up for sale? (time.com)
  • Flynn and the other plaintiffs said that too many such patients die waiting for transplants and argued that we should be allowed to pay people to donate their marrow as a way of ensuring a more reliable supply. (time.com)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • In transplants such as bone marrow procedures, the sick person happens to be his/her own donor. (targetwoman.com)
  • There are two types of bone marrow transplants - autologous (extracting the stem cells from a patient and giving back to them) and allogenic (the stem cells are taken from a donor who could be a blood relative). (onco.com)
Tissue16
  • The cells of this cancer have features of plasma cells as well as lymphoid tissue. (webmd.com)
  • A U.S. appeals court puts the price at about $3,000 in a ruling that now makes it legal to pay donors for their bone-marrow tissue. (time.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Mesenchymal stem cells (MSCs) support chondrogenic differentiation and are an attractive cell source for cartilage tissue engineering. (nature.com)
  • It has been transposed in Estonian law mainly by the Procurement, Handling and Transplantation of Cells, Tissues and Organs Act and the regulation on Criteria for the selection of cell, tissue, and organ donors, list of precluding circumstances for the donation of cells, tissues, or organs, list of mandatory laboratory studies established for a donor, and the conditions and procedure for carrying out these studies . (eurostemcell.org)
  • Orthobiologics are natural substances such as cells, tissue, blood components and growth factors that are harnessed to aid in the treatment of orthopedic injuries or conditions. (jointandsports.com)
  • Adipose tissue or fat cells have remarkable healing and regenerative properties. (jointandsports.com)
  • These plasma cells are formed in the bone marrow, the fatty tissue located inside the hollow structure of the bones. (healthhearty.com)
  • Allogeneic transplantation - The Stem cells or bone marrow are gotten from a donor with a tissue type matching yours. (ghnservices.com)
  • There is no evidence of (new) development of connective tissue in the bone marrow ( fibrosis ) or invasion of the bone marrow by malignant cells or cells outside the bone marrow. (aa-pnh.org)
  • The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
  • Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
Allogeneic hematopoietic-cell transplantation1
  • Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
Recipients3
  • recipients who are seronegative for Herpes Simplex Virus (HSV) receiving an organ from HSV seropositive donors [2D]. (bts.org.uk)
  • Donors and recipients face a wide range of risks, depending on the type of product used. (who.int)
  • The risk-benefit ratio should be optimized at all stages, from donors to recipients, and donation incentives should not adversely affect the availability and safety of the final products. (who.int)
Haploidentical2
  • A total of 469 patients who received haploidentical transplantation were enrolled in this retrospective study. (bvsalud.org)
  • Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). (cardiff.ac.uk)
Malignant3
  • CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. (thermofisher.com)
  • for this situation, getting them from the blood is liked, on the grounds that blood undeveloped cells move to tissues all the more rapidly and are less inclined to be tainted with malignant plasma cells. (ghnservices.com)
  • To assess the clinical efficacy donor NK cell infusion, in terms of tumor response, response duration, and survival, in patients with progressive or recurrent malignant disorders. (bioseek.eu)
Organ4
  • CDC assays are used to find a suitable donor for organ or bone marrow transplantation, namely donor with matching phenotype of histocompatibility system HLA. (wikipedia.org)
  • At the core of the plaintiffs' argument was the National Organ Transplantation Act (NOTA), which since 1984 has forbid the buying and selling of human organs, including bone marrow. (time.com)
  • Now, a technique called peripheral apheresis allows doctors to extract blood stem cells directly from the blood, instead of the bone - patients first take a drug that pulls stem cells from the bone and into the blood - meaning that the marrow cells should be considered a fluid like blood, rather than an organ, the plaintiffs argued. (time.com)
  • While the decision applies only to the nine states covered by the Ninth Circuit court, and only to bone marrow obtained through apheresis, it does raise bigger questions about how we will look at organ donation in the future. (time.com)
Infusion7
  • Infusion of healthy stem cells into the patient - a painless process in which stem cells are transplanted into the patient through intravenous (IV) infusion. (uchicagomedicine.org)
  • We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
  • Repeated infusion of naïve myeloma-reactive T cell TCRVβ 2, 3 and 8.3 subfamilies was also effective. (biomedcentral.com)
  • FFP was used as replacement solution change facility was temporarily unavail- for the first 6 sessions of plasma exchange able, daily infusion of CPP was immediately and cryoprecipitate-poor plasma (CPP) for started at a dose of 15 mL/kg body weight. (who.int)
  • After discontinuation of Fifty months after the first episode she plasma exchange, CPP infusion at 15 mL/ came back with multiple bruises and a very kg body weight was given for a week. (who.int)
  • Phase I: Patients receive an infusion of donor natural killer (NK) cells on days 18 and 21. (bioseek.eu)
  • Phase II: Patients receive an infusion of donor NK cells on days 14 and 21. (bioseek.eu)
Immune16
  • A lack of white blood cells can also weaken your immune system. (webmd.com)
  • Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). (cardiff.ac.uk)
  • The results range from impairing the immune system and inflammation to disrupting or shutting down blood cell production. (santaclara.com)
  • Lymphoma originates from a type of white blood cell called lymphocytes critical to the immune system. (santaclara.com)
  • Improvements in multicolor circulation cytometry and better biological understanding of B cell maturation have led to renewed interest in detailed phenotypic analysis of B cells and T cells in immune-mediated diseases. (cgp60474.com)
  • Indications for hematopoietic cell transplantation and immune effector cell therapy: Guidelines from the American Society for Transplantation and Cellular Therapy. (msdmanuals.com)
  • In this regard, immune-transcriptome analyses of T cell receptor (TCR) Vβ CDR3-size and sequence is being used to characterize alloreactive versus tumor-specific T-cell responses. (biomedcentral.com)
  • Studies have shown that a subtype of lymphocyte in the body's own immune system attacks cells in the bone marrow, and this autoimmune process prevents the development of new blood cells. (aa-pnh.org)
  • Immunotherapy: In this treatment option, the immune system is activated to kill only specific cancer cells. (ndtv.com)
  • The Fc portion then recruits immune cells that destroy these lymphocytes. (dermnetnz.org)
  • Rituximab has a limited effect on other immune cells. (dermnetnz.org)
  • 2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)
  • Blood and blood products are essential in the treatment of blood and bone marrow disorders, as well as immune deficiency conditions. (who.int)
  • Potential y neoplastic cel s that of the effect increases with increasing tem to respond effectively to foreign arise natural y, or that have been dose or continuing exposure - and is antigens, including surface antigens transformed by carcinogens acting usually transient: immune function on tumour cells. (who.int)
  • In contrast, infection fector cells or from blockage of intra- of action associated with oncogenic with certain pathogens, such as hu- cel ular pathways essential for anti- viruses, may escape immune sur- man immunodeficiency virus type 1 gen recognition or of other elements veillance in immunosuppressed indi- (HIV-1) or malaria parasites, is per- of the immune response. (who.int)
  • The clinical presentation, cutaneous findings, and likely presence of RVC-positive granulocytes in bone marrow provide potential support to the evolving hypothesis of persistent RuV within neutrophils contributing to chronic granulomatous inflammation in a milieu of immune dysregulation. (cdc.gov)
Differentiation4
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • The mechanisms leading to the differentiation and survival of B cells to become ASCs are dictated by a variety of control mechanisms, including class switching, Edrophonium chloride homing, co-stimulation, and finally commitment to a plasma cell lineage (7). (cgp60474.com)
  • Here we document the effects of specified PEMF parameters over mesenchymal stem cells (MSC) chondrogenic differentiation. (nature.com)
  • Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
Myeloma9
  • Blood Test - In this test, it may reveal M Proteins produced by myeloma cells. (ghnservices.com)
  • This kind of transplantation conveys exceptionally high risk and isn't suggested for the vast majority with numerous myeloma. (ghnservices.com)
  • This is the ideal type of transplantation, albeit barely any individuals with different myeloma have an indistinguishable twin who can act as a donor. (ghnservices.com)
  • seldom, allogeneic transplantation fixes different myeloma. (ghnservices.com)
  • In myeloma, the normal bone marrow is replaced by the plasma cells, affecting the production of red blood cells. (onco.com)
  • Pre-stimulation ex vivo of allogeneic T cells by exposure to MOPC315.BM MM cells in the presence of IL-2, anti-CD3 and anti-CD28 resulted in expansion of the myeloma-reactive T cell TCRVβ 2, 3 and 8.3 subfamilies. (biomedcentral.com)
  • The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)
  • To test this rationale, we used the allogeneic B10.D2 → Balb/c BMT model with MOPC315.BM myeloma cells. (biomedcentral.com)
  • Myeloma is a type of cancer affecting the plasma, which is also a type of white blood cells that produce antibodies to ward off infections. (ndtv.com)
Outcomes2
  • The aim of this study was to compare the impact of TKI prophylaxis with imatinib and dasatinib on long-term outcomes after transplantation. (bvsalud.org)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Biopsy3
Stromal cell1
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Immunosuppression1
Clinical6
  • Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
  • The inferior clinical performance of CD34+-enriched and purified PBSCTs compared tounenriched PBSCTs may be explained by the omission of Hox11+ stem cells. (fliphtml5.com)
  • It is pointed out that protocols based on the using BM cells, permit to work out the tolerance state and now they are estimate at clinical kidney transplantation, during multicentre investigations. (genescells.ru)
  • Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
  • However, confirmation in clinical patient plasma samples for VNN3 is needed. (biomedcentral.com)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
Engraftment1
Acute1
  • 1.6 Consider Valganciclovir prophylaxis for at least 3 months after starting treatment for acute allograft rejection if either donor or recipient are CMV positive (D+/R-, D+/R+ or D-/R+) [2C]. (bts.org.uk)
Deficiency3
  • Presentation_1.PDF (433K) GUID:?D1661877-16B1-4938-9F24-5312CE037EC7 Figure S2: Stimulation responses of B cells, age distribution of transitional cell fractions, and B cell responses in selective IgA deficiency (IgAD) and healthy controls (HC) to T cell-dependent and T cell-independent stimuli. (cgp60474.com)
  • Bone marrow transplantation in individuals with IgAD can cure the deficiency suggesting that this defect is usually of hematopoietic origin (9). (cgp60474.com)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
Murine model2
  • Here, we attempted to identify GI aGVHD associated plasma proteins in murine model, which can help make a diagnosis of GI aGVHD. (biomedcentral.com)
  • Our results demonstrate that plasma VNN3 protein is associated with GI aGVHD in murine model. (biomedcentral.com)
Pediatric1
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
Procedure4
  • After the procedure, the patient's body gradually started producing healthy blood cells, and his symptoms improved. (zeecrunch.com)
  • The donor may feel some pain after this procedure. (uchicagomedicine.org)
  • The apheresis procedure is often employed to obtain stem cells from peripheral blood of patients suffering leukemia, a blood disease. (targetwoman.com)
  • Cartilage transplantation is a procedure to restore articular cartilage in a joint by transplanting it from another region of your body or using cartilage from a donor. (craigcapecimd.com)
Disorders1
  • Blood (hematologic) disorders can impact bone marrows, blood vessels, organs and the blood itself. (santaclara.com)
Phenotype1
  • Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)
Mononuclear cells1
Mesenchymal stromal cells2
  • Mesenchymal stromal cells in renal transplantation: opportunities and challenges. (genescells.ru)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Patient's4
  • Fortunately, the patient's cousin turned out to be a perfect match for the transplantation. (zeecrunch.com)
  • The transplantation was performed successfully, and the patient's condition gradually improved. (zeecrunch.com)
  • The transplantation was carried out successfully, and the patient's red blood cells returned to a normal shape. (zeecrunch.com)
  • After BMT, patient's peripheral white blood cells were replaced by donor's XX ones carrying a normal ALD gene confirmed by in situ hybridization using satellite DNA of the centromere of X and Y chromosomes as probes and the level of VLCFA in lymphocytes was within normal limit. (elsevierpure.com)
Tissues6
  • These abnormal cells multiply quickly throughout the bone marrow, blood and other tissues, causing anemia and a deadly risk of infections. (santaclara.com)
  • The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
  • In Estonia, the legislation covering aspects of tissues and cells being used as starting materials in a medicinal product is based on the Tissues and Cells Directive (2004/23/EC) on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells as in other European Union countries . (eurostemcell.org)
  • the use of cells, tissues and organs in scientific research if used for purposes other than medical use on human beings. (eurostemcell.org)
  • Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)
  • All tissues originate from stem cells. (bvsalud.org)
20232
  • July 27, 2023 - Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors. (nih.gov)
  • April 4, 2023 - Medication is the first to reduce bone-weakening process in patients with fibrous dysplasia. (nih.gov)
Matched unrelated donor2
  • The primary purpose of this study is to estimate and compare overall survival between the two arms: patients who are Very Likely to find a Matched Unrelated Donor (MUD) versus those who are Very Unlikely to find a MUD. (mayo.edu)
  • He received 7.16 × 10 8 nucleated bone marrow cells/kg body weight from a 9/10 human leukocyte antigen-matched unrelated donor. (cdc.gov)
Macrophages3
  • Excess accumulation of cholesterol in macrophages results in foam cell production and lesion development. (jci.org)
  • We generated mice expressing ABCA1 in macrophages and mice with selected inactivation of ABCA1 in macrophages by bone marrow transplantation in ABCA1-deficient ( ABC1 -/- ) and wild-type (WT) mice. (jci.org)
  • Comparative study of the immunoregulatory capacity of in vitro generated tolerogenic dendritic cells, suppressor macrophages, and myeloid-derived suppressor cells. (genescells.ru)
Platelet-rich plasma1
  • A meta-analysis of 22 studies of bacterial contamination rate estimates for apheresis (AP), platelet-rich plasma (PRP), and buffy coat (BC) collection methods found an overall mean contamination rate of 0.51 per 1000 components (95% confidence index [CI], 0.38-0.67). (medscape.com)
Antibodies10
  • When they are bound to surface antigen on target cell (e.g. bacterial or viral infected cell), the classical complement pathway is triggered by bonding protein C1q to these antibodies, resulting in formation of a membrane attack complex (MAC) and target cell lysis. (wikipedia.org)
  • Development of antitumor therapeutic antibodies involves in vitro analysis of their effector functions including ability to trigger CDC to kill target cells. (wikipedia.org)
  • Classical approach is to incubate antibodies with target cells and source of complement (serum). (wikipedia.org)
  • Measuring of the metabolic activity of live cells (live cells staining): after incubation of target cells with antibodies and complement, plasma membrane-permeable dye is added (e.g. calcein-AM or resazurin). (wikipedia.org)
  • When potentially suitable couple is found, crossmatch test is done to exclude that patient produces donor-specific anti-HLA antibodies, which could cause graft rejection. (wikipedia.org)
  • There are modifications available to increase test sensitivity including extension of minimal incubation time, adding antihuman globulin (AHG), removing unbound antibodies before adding complement, separation of T cell and B cell subset. (wikipedia.org)
  • A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. (webmd.com)
  • This plasma has antibodies against the virus which may be beneficial to patients who have active disease. (uiowa.edu)
  • Other symptoms are associated with the disruption of the normal function of plasma cells, which is to produce antibodies and fight infections. (onco.com)
  • High Levels of Common Cold Coronavirus Antibodies in Convalescent Plasma Are Associated With Improved Survival in COVID-19 Patients. (mdanderson.org)
Opportunistic infections2
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • T cell immunodeficiencies and severe combined immunodeficiencies (SCIDs) are marked with opportunistic infections caused by common environmental microorganisms. (lu.se)
20211
  • In 2021 until August 31, another 2.955 new donors have been incorporated, which represents 52% of the objective set for the year 2021. (comunidad.madrid)
Effector2
  • Upon bacterial stimulation, MAIT cells display immediate effector activity, namely production of pro-inflammatory cytokines (TNFα, IFNγ, IL-17) and cytotoxicity. (cryostem.org)
  • The collection shows a linear regression for transitional B cell fractions compared to age, no correlation is seen, as well as induced T effector cells and T regulatory cells were comparable to healthy controls. (cgp60474.com)
Peripheral blood stem cells1
  • for the procurement of bone marrow and peripheral blood stem cells, the blood sample for carrying out laboratory studies has to be collected within 30 days before the procurement ( § 8 (4) of the regulation ). (eurostemcell.org)
Tumor2
  • McDonald's group used several proteins to predict severe GI aGVHD and non-relapse mortality, such as T-cell immunoglobulin and mucin-domain containing-3, soluble tumor necrosis factor-alpha, interleukin 1 receptor-like 1 and interleukin −6 [ 8 ]. (biomedcentral.com)
  • Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
Transfusion3
  • In addition, as it comes from a single donor, a higher quality and transfusion safety is guaranteed. (comunidad.madrid)
  • On September 18, the Transfusion Center held an act of gratitude to the donors on the occasion of the World Bone Marrow Donor Day and Umbilical Cord Blood. (comunidad.madrid)
  • Reducing viral risks through nents and products originated from several expansion of donor history screening, im- hundred donors, she did not contract any provements in testing for infectious disease transfusion-transmitted disease. (who.int)
Exchange transfusions1
  • After 18 sessions of plasma exchange transfusions given were washed red cell over a period of 20 days without improve- preparations. (who.int)
Allogenic3
Umbilical cord2
  • The transplantation of hematopoietic progenitors incorporated the umbilical cord blood of newborns a few years ago as one of the sources from which these progenitors could be extracted. (comunidad.madrid)
  • It's a single intravenous (IV) dose of human allogeneic stem cells from umbilical cord blood. (santaclara.com)
Suitable donor2
  • The family found a suitable donor in their extended family. (zeecrunch.com)
  • Finding a matching donor was challenging, but a suitable donor was identified after extensive testing. (zeecrunch.com)