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  • patient's
  • Investigators previously showed that using vessels individually created from a patient's own skin cells reduced the rate of shunt complications 2.4-fold over a 3-year period. (redorbit.com)
  • While posttransplantation relapse of disease resulting from a failure to eradicate the patient's original leukemia could occur, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome (MDS) of donor origin termed donor cell leukemia (DCL). (hindawi.com)
  • Earlier this year, Takahashi's team reported success using a patient's own iPSCs that were reprogrammed into retinal cells. (the-scientist.com)
  • Although the likelihood of HLA matching is the greatest with donors from the patient's racial and ethnic group, donors from other racial and ethnic groups may increase this likelihood. (ukessays.com)
  • patients
  • For the first time, blood vessels created in the lab from donor skin cells were successfully implanted in patients. (redorbit.com)
  • For the first time, human blood vessels grown in a laboratory from donor skin cells have been successfully implanted into patients, according to new research presented in the American Heart Association's Emerging Science Series webinar. (redorbit.com)
  • Our approach could allow hundreds of thousands of patients to be treated from one master cell line," said study lead author Todd N. McAllister, Ph.D., co-founder and chief executive officer of Cytograft Tissue Engineering Inc., of Novato, Calif. (redorbit.com)
  • The tissue-engineered blood vessels, produced from sheets of cultured skin cells rolled around temporary support structures, were used to create access shunts between arteries and veins in the arm for kidney dialysis in three patients. (redorbit.com)
  • This is the first time patients have received an infusion of WT1-specific T-cells, and thus also the first demonstration that such cells can provide a therapeutic antileukemic effect, as has been suggested from earlier vaccine trials that induce less potent responses," explained study coauthor Philip Greenberg, MD, in a statement from Fred Hutchinson Cancer Research Center in Seattle, Washington, where Greenberg heads the immunology program. (oncologynurseadvisor.com)
  • The best results were achieved when some of the patients received T-cell clones that were exposed to interleukin21 (IL-21) during the programming and growth process (the programmed cells were grown in large numbers before being infused into patients). (oncologynurseadvisor.com)
  • Of the four patients who received infusions of T cells that targeted WT1 and were generated in the presence of IL-21, one had detectable relapsed disease and went into remission shortly after the T cells were infused. (oncologynurseadvisor.com)
  • Two of the seven patients whose T cells were generated without the presence of IL-21 showed direct evidence of antileukemic activity. (oncologynurseadvisor.com)
  • Overall a 9-10/10 matched HSC donor can now be identified for 60-80% of patients of European descent. (hindawi.com)
  • Currently only 8,709 people from the Portsmouth area are registered as donors with Delete Blood Cancer UK, but many more are being sought to help find matches for the thousands of blood cancer patients needing a blood stem cell donation every year. (portsmouth.co.uk)
  • For many blood cancer patients, a blood stem cell donation is their only chance of survival and they will die if a matching donor isn't found for them. (portsmouth.co.uk)
  • However, patients may also rarely develop a secondary malignancy or myelodysplastic syndrome of donor origin termed donor cell leukemia (DCL) [ 3 ]. (hindawi.com)
  • The donors who were recruited today will offer hope and a chance of life to patients in need of a transplant for decades to come - a truly lifesaving legacy. (lboro.ac.uk)
  • Two Fire Department City of New York fire fighters will be honored with "Honor Roll of Life" for donating their bone marrow cells for saving Leukemia patients. (medindia.net)
  • The two Fire fighters John Jensen and Joe Kazlauskas donated their stem cells from bone marrow for treatment of two leukemia patients which helped to save their life. (medindia.net)
  • The fire department is very proud in helping human lives as the department offices have donated more than 72 bone marrow cells which have helped to treat patients with leukemia, Hodgkin's lymphoma and other blood disorders. (medindia.net)
  • A new study has found that the sex or pregnancy history of red blood cell donors does not influence the risk of death among patients who receive their blood. (brightsurf.com)
  • The study adds to a growing body of literature examining whether blood donor characteristics such as sex, age, and pregnancy history affect the survival of transfused patients. (brightsurf.com)
  • The results are reassuring in that the survival of patients who got transfused with red blood cells does not appear to be associated with whether the blood they received was donated by a man, by a woman who had been pregnant--or by one who had not. (brightsurf.com)
  • Together, the three cohorts made available data on more than 1 million patients who had received red blood cell transfusions from 2003 to 2016. (brightsurf.com)
  • Even in the case of female donors who gave birth for the first time during the study period and continued to donate blood--a group analyzed in detail in the SCANDAT cohort--researchers found no effect on the risk of death among patients transfused with their blood. (brightsurf.com)
  • Previously, this same group of scientists, led by the Riken Center for Developmental Biology's Masayo Takahashi, tested an iPSC-based therapy for macular degeneration using the patients' own cells. (the-scientist.com)
  • Nikkei Asian Review reported that about five patients will enter the donor-cell trial, which is slated to begin in the first half of 2017. (the-scientist.com)
  • Giving patients stem cells from someone else may help to cure many patients with certain immune diseases. (clinicaltrials.gov)
  • Patients who have a brother or sister that have stem cells that match the patient. (clinicaltrials.gov)
  • Patients who do not have a matched sibling donor but have a donor that matches in the National Marrow Donor Program. (clinicaltrials.gov)
  • To prevent the body from getting rid of the donated cells, patients are given sirolimus. (clinicaltrials.gov)
  • On the day before the BMT, patients in the matched unrelated donor group also receive a low-dose of whole-body radiation. (clinicaltrials.gov)
  • This will further improve the chances that the patients body will accept the donor cells. (clinicaltrials.gov)
  • Patients will get the donor stem cells through an intravenous (IV) line that goes into a vein in their body. (clinicaltrials.gov)
  • Based on the existing donor numbers, the largest MP increases in addition of 500,000 same-population donors were observed for patients from Greece (+0.21) while only small MP increases occurred for European Americans (+0.004) and Germans (+0.01). (ukessays.com)
  • According to the calculations, the likelihood of finding an available 8/8 HLA matched donor is 75% for white patients of European descent but only 46% for White patients of Middle Eastern or North African descent . (ukessays.com)
  • Since patients are in urgent need by the time a transplant is recommended for them, it is important for donors to already be registered so they can be found quickly. (giftoflife.org)
  • facing a stem cell trans
  • Sponsored by Be The Match Foundation , the Unity College Conservation Law Club, and Maine Warden Service Relief Association, the drive is seeking to find potential donors for Maine Warden Service Major Gregory Sanborn , who is facing a stem cell transplant in May. (unity.edu)
  • recipient
  • The research, which used three large donor-recipient databases for its analyses, was funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. (brightsurf.com)
  • In the KPNC cohort, 9% of the transfusions were from previously pregnant female donors, 39% from never-pregnant female donors, and 44% from donors of the opposite sex of the recipient. (brightsurf.com)
  • embryos
  • Effect of Donor Cell Type on Nuclear Remodelling in Rabbit Somatic Cell Nuclear Transfer Embryos. (biomedsearch.com)
  • As reported previously, NT embryos reconstructed with fresh cumulus cells (CC-embryos) have better developmental potential than those reconstructed with foetal fibroblasts (FF-embryos) in vivo and in vitro. (biomedsearch.com)
  • Anti-5-methylcytosine immunofluorescence of in vivo-fertilized and cloned rabbit embryos revealed that there was no detectable active demethylation in rabbit zygotes or NT-embryos derived from either fibroblasts or CC. In the process of nuclear remodelling, however, the proportion of nuclei with abnormal appearance in FF-embryos was significantly higher than that in CC-embryos during the first cell cycle. (biomedsearch.com)
  • survival
  • Akt is a major cell survival and angiogenic mediator downstream of angiopoietin-1 (Ang-1)/Tie-2 signaling pathway. (ahajournals.org)
  • This improvement was attributed to the activation of various protein factors downstream of Akt cell survival signaling pathway. (ahajournals.org)
  • The rationale behind our present study was to ensure maximum cell survival and enhanced angiogenesis by the delivery of Ang-1 and Akt genes for cardiac repair. (ahajournals.org)
  • Indeed, there is an emerging role for Ang-1, an agonist of Tie-2 receptor, in angiogenesis and a central role for Akt, a member of the class of serine or threonine protein kinases downstream of Ang-1, in cell survival signaling. (ahajournals.org)
  • epithelial
  • We investigated a potential of human amniotic epithelial (HAE) cells as a donor for neural progenitor cells. (arvojournals.org)
  • In September, Takahashi and her colleagues reported that iPSC-derived retinal pigment epithelial (RPE) cells from monkeys implanted in immune-matched monkeys' eyes were not rejected. (the-scientist.com)
  • leukemia
  • However, T-cell depletion often results in an increased incidence of graft rejection and an increased frequency of leukemia relapse. (bloodjournal.org)
  • Brooke Williams 27 years was suffering from acute leukemia and also had a remission of the disease and after stem cell therapy with bone stem cells transferred from Jensen she recovered. (medindia.net)
  • progenitor cells
  • Neural stem/progenitor cells are regarded as promising tools for regenerative medicine in the retina. (arvojournals.org)
  • Neural progenitor cells were obtained from human amniotic membrane. (arvojournals.org)
  • It is suggested that human amniotic membrane may be usable as a source of neural progenitor cells for regenerative medicine in the central nervous system, including the retina. (arvojournals.org)
  • organ
  • Legal Terms Organ Donors Should Know Anyone who receives a state issued drivers license will have the opportunity to become an organ donor prior to receiving the license. (viceteam.org)
  • cardiac
  • The conduction time (CT) between two 638um spaced recording sites was measured in pure cardiac strands (control) and across inserts populated with different donor cell types. (ahajournals.org)
  • Majority of GFP + cells were noted in the middle of cardiac myocyte. (frontiersin.org)
  • potential
  • Major Sanborn does not have a donor at this time and a world-wide search for a potential match is currently underway. (unity.edu)
  • 2016
  • The procedure was expensive and time-consuming, costing about 100 million yen ($930,000) to cultivate and test the iPS cells and about 11 months for the transplant to take place," The Asahi Shinbum reported in June 2016. (the-scientist.com)
  • National Marrow
  • Jessup, now 27, was a little girl when Scott decided to join the National Marrow Donor Program at a drive at his base. (ocregister.com)
  • Asian Americans are represented in greater numbers in the National Marrow Donor Program than the overall population percentage. (wordpress.com)
  • However this must be coordinated through the US agency NMDP (National Marrow Donor Program) and I have heard of a couple of people whose doctors did not make the specific request. (wordpress.com)
  • The National Marrow Donor Program also has a cooperative agreement with the Chinese Marrow Donor Program, which was approved a couple of years ago. (wordpress.com)
  • laboratory
  • But they typically don't know there's also a huge demand for blood cells to fuel a growing field of laboratory research and other studies. (fredhutch.org)
  • find
  • An ex-police officer who struggled to find a stem cell donor match is campaigning to get more Asians to register. (itv.com)
  • But first, they have to find donors. (fredhutch.org)
  • We looked at three donor groups, and after careful adjustment for the number of transfusions, we didn't find any evidence of an association," said Nareg Roubinian, M.D., M.P.H., senior study author and clinical investigator at the Kaiser Permanente Division of Research, Vitalant Research Institute, and the University of California, San Francisco. (brightsurf.com)
  • After they shared a warm hug, David said, "I only had about a year left on medication, and my doctor said, 'We're going to see if we can find a transplant donor for you. (giftoflife.org)
  • however
  • However, very few cases of donor-derived multiple myeloma (MM) exist. (hindawi.com)
  • However, to our knowledge only one case of donor-derived multiple myeloma following HSCT for refractory sideroblastic anemia has been published [ 8 ]. (hindawi.com)
  • In humans, however, such cells are accompanied with significant problems concerning ethics, supply in quantity, and immunological rejection. (arvojournals.org)
  • However, donor dendritic cells (dDC) are the most potent antigen-presenting cells and have proven to be major regulators in determining the fate of the alloimmune response. (frontiersin.org)
  • search
  • The diversity of the HLA system at the allelic and haplotypic level and the heterogeneity of HLA typing data of the registered donors render the search process a complex task. (hindawi.com)
  • This paper summarizes our experience with a search algorithm that includes at the start of the search a probability estimate (high/intermediate/low) to identify a HLA-A, B, C, DRB1, DQB1-compatible donor (a 10/10 match). (hindawi.com)
  • In 2002 we have introduced at the very start of the search an estimation of the probability to identify a perfectly matched donor, that is, compatible for the HLA-A, B, C, DRB1/B3/B5, and DQB1 loci. (hindawi.com)
  • clinical
  • Researchers in Japan who have been developing a cell therapy for macular degeneration received support from health authorities this week (February 1) to begin a clinical trial using donor-derived induced pluripotent stem cells (IPSCs) converted to retinal cells. (the-scientist.com)
  • blood stem cells
  • Scott flew to Washington, D.C., where he underwent a five-day process culminating in the extraction of his white blood stem cells while he rested in a hospital bed. (ocregister.com)
  • It's an occupational hazard for the Fred Hutchinson Cancer Research Center project manager, who spends half of her time at the Heimfeld Lab trying to track down people willing to donate their peripheral blood stem cells, or PBSC - all in the name of science. (fredhutch.org)
  • vitro
  • We designed a reproducible, well-controlled in vitro assay for comparing the efficacy of different donor cell types to electrically couple with cardiomyocytes and propagate action potentials. (ahajournals.org)
  • Cytoprotective effects of transgene overexpression in vitro were assessed by exposure of cells to 8 hours of anoxia. (ahajournals.org)
  • made
  • The study was commissioned by Cytograft Tissue Engineering Inc. of Novato, California, and made use of donor skin cells to grow the blood vessels. (medindia.net)
  • And in a second paper published simultaneously, they demonstrated that human-donor RPE cells made from iPSCs did not spark an immune response from lymphocytes in culture. (the-scientist.com)
  • match
  • Thousands of students from both De Monfort University and the University of Leicester have also signed up to the stem cell register through numerous events held on their campuses - and a handful have been a successful match for people with blood cancer. (lboro.ac.uk)
  • They believed they had found her ideal match, but the prospective donor was temporarily unavailable. (ocregister.com)
  • Any Korean without a blood relative match has a 50% chance of a perfect match, 80% chance of a match good enough to proceed with a marrow transplant, from the Korean marrow donor banks. (wordpress.com)
  • As it was reported that adult-donor availability differs according to racial and ethnic background , models including this variable have substantially lower match likelihoods than those which did not take into this account. (ukessays.com)
  • patient
  • The deleterious impact of single HLA disparities between patient and donor has been largely documented [ 1 - 3 ]. (hindawi.com)
  • Darren Young donated his stem cells earlier this month in a bid to save the life of a patient in desperate need of a stem cell transplant. (stornowaygazette.co.uk)
  • Researchers found no significant associations between patient mortality and red blood cell transfusions from either the parous, previously pregnant, and never-pregnant female donors or the donors of the opposite sex. (brightsurf.com)
  • Roubinian said the study adds to our understanding of blood safety in current transfusion practice, in parallel with work studying how donors are selected, how blood is processed, and how those factors may affect patient outcomes. (brightsurf.com)
  • The authors described a general framework for MP estimations of specific and mixed patient populations under consideration of international stem cell donor exchange. (ukessays.com)
  • time
  • This will be the first trial in which the team's physicians administer donor cells, an approach expected to lower costs and preparation time. (the-scientist.com)
  • But with the use of the iPS cell stock [from donors], the time frame could be reduced to as short as a month and costs could be significantly reduced. (the-scientist.com)
  • She is his lifesaving stem cell donor, and they were about to meet each other for the first time. (giftoflife.org)
  • Tissue
  • A number of studies have demonstrated the role of CX3CR1 in regulating the migration of monocytes into peripheral tissue and their transformation into dendritic cell (DC). (frontiersin.org)
  • Chemokines have also been increasingly recognized for their role in regulating migration of circulating monocytes and their transformation to tissue dendritic cells (DCs). (frontiersin.org)
  • researchers
  • It takes about eight donors a month, or nearly 100 a year, to supply the hundreds of billions of stem cells used by Fred Hutch researchers - and others nationwide. (fredhutch.org)
  • Fred Hutch provides the cells at cost to the researchers, offering a steep discount over commercially available products. (fredhutch.org)
  • The Hutch is one of very few sites that supplies cells to outside researchers, Heimfeld said. (fredhutch.org)