ComplexesPyridineAcceptorAtomsBidentateSchiffCharacterizationDenticityNitrogenChemistryHeterocyclicMonodentateMoleculesHydrogenInteractionsNanoparticlesCopperMolecularMoleculeSpectroscopicBondsReactionsAtomStructuralRolesFunctionalMetalWeakSuitableMurinePatientsFormCellCellsComplexStructureUniqueSurfaceIRONData
Complexes13
- The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties. (tsijournals.com)
- The antimicrobial data reveals that the metal complexes act as more active antibacterial agents than the uncomplexed ligand from which they are derived. (tsijournals.com)
- Trimethylphosphine is a highly basic ligand that forms complexes with most metals. (wikipedia.org)
- The ligand N -acetyl-4-(4-X-phenylsulfonyl)benzohydrazide (I), X=H, Cl, Br, forms complexes [Cu(L-H) 2 ] and [Cu(L-H) 2 (NH 3 ) 2 ] which have been characterized by elemental analyses, magnetic moments, molar conductance, electronic, ESR and IR spectral measurements. (upt.ro)
- The dioxygen complexes of Cu(II) were generated in situ by stirring copper salts and bidentates ligands derivated from benzoxazole. (imist.ma)
- The tridentate N-donor ligand 2,6-di(2-oxazolyl)pyridine (L) reacts with AgClO 4 and AgPF 6 to yield two new complexes, {[Ag 5 (L) 5 ](ClO 4 ) 5 } n ( 1 ) and {[Ag 5 (L) 5 ](PF 6 ) 5 } n ( 2 ), which have been characterized by single-crystal and powder X-ray diffractions, IR spectroscopy, and elemental and thermogravimetric analyses. (degruyter.com)
- A series of ONO-tridentate Schiff base ligands derived from chiral and achiral amino alcohols and amino acids were synthesized and reacted with AlEt 3 to provide dimeric aluminum complexes. (acs.org)
- In this project, our efforts were directed to the synthesis and characterization of nickel(II) and zinc(II) complexes with tetradentate N 2 O 2 -Schiff base ligands based on diaminomaleonitrile and various aldehydes such as 2-hydroxybenzaldehyde, 3-methoxy-2-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde. (springer.com)
- The metallated carbon of the 4 electron donor anionic bridging ligands has some carbene character, reminiscent of the situation in N-metallated protic NHC complexes. (rsc.org)
- Displacement of cod ligands from 3 H-H and 3 H-T afforded the tetracarbonyl complexes [Ir(CO) 2 {μ-C 3 H 2 N 2 (Mes)-κC2,κN3}] 2 4 H-H and 4 H-T , respectively. (rsc.org)
- In the design of supramolecular complexes, a well known and effective strategy is the matching of suitable hydrogen bond donors and acceptors (Wuest, 2005). (iucr.org)
- A new generation of octahedral iron(ii)-N-heterocyclic carbene (NHC) complexes, employing different tridentate C^N^C ligands, has been designed and synthesized as earth-abundant photosensitizers for dye sensitized solar cells (DSSCs) and related solar energy conversion applications. (lu.se)
- Denticity in the Unexpected Formation of an All-Carbon Donor-Atom Ligand in Rh III (Cp*)(Anthracenyl-NHC) Complexes. (bvsalud.org)
Pyridine3
- abstract = "Three new ligands have been prepared in which two terdentate chelating pyrazolyl‐bipyridine units are connected by a central aromatic spacer via methylene "hinges": the spacers are o‐phenylene (LPh), 2,6‐pyridine‐diyl (LPy) and 2,3‐naphthalenediyl (Lnaph). (hud.ac.uk)
- This work explores the effects of types of nitrogen donors (pyridine vs . triazole) and ligand coordination modes (tridentate vs . bidentate) on average sizes and catalytic oxidation activities of the corresponding Pd nanoparticles. (mahidol.ac.th)
- each Cu atom is coordinated with two water molecules and two nitrogens of the pyridine- propionic acid ligand, and the remaining carboxylate groups of the ligands are connected in monodentate fashion to the next Cu to form three-dimensional (3D) networks (Fig. 2). (elsevierpure.com)
Acceptor5
- An overview of the bonding and reactivity of metal carbon σ,π donor/π acceptor ligands will be given. (bath.ac.uk)
- Both structure- and ligand-based pharmacophore mapping proposed that acceptor and donor features of the molecule are essential for receptor-ligand interactions. (unboundmedicine.com)
- PyMOL will not properly recognize donor and acceptor atoms if molecular valences are not specified in the input file. (pymol.org)
- The team cross-linked a donor-acceptor polymer with iron (Fe)-ligand mechanophores. (stanford.edu)
- Metal aqua-ions may act as excellent, readily available hydrogen bond donors with limited acceptor properties. (iucr.org)
Atoms3
- Bill's research interests are in synthetic inorganic chemistry and include the design and coordination of neutral bi- and multi-dentate ligands containing heavy group 15 and 16 donor atoms (P, As, Sb, Bi, Se and Te), transition metal coordination chemistry, especially in high oxidation states, and metal halide and oxo-halide chemistry. (southampton.ac.uk)
- Schiff base ligands with a variety of donor atoms including nitrogen, oxygen and sulfur can be coordinated with transition metal atoms. (springer.com)
- Four carboxylate O atoms, derived from two bidentate malonate ligands, build the equatorial plane, whereas two water molecules occupy the axial sites. (iucr.org)
Bidentate2
- He remained there to study for a Ph.D developing the coordination chemistry of bidentate antimony containing ligands, graduating in 1975. (southampton.ac.uk)
- The octa-hedral O 6 coordination geometry is defined by two bidentate malonate ligands and two water mol-ecules, with the latter in a trans configuration. (iucr.org)
Schiff1
- The condensation of DAMN with different aromatic aldehydes can form 1:1 and/or 1:2 Schiff base ligands [ 14 ]. (springer.com)
Characterization1
- However, UV-Vis absorption, photoluminescence, X-ray diffraction, energy dispersive X-ray and FTIR spectroscopy techniques are used for characterization of the ligand coated ZnO nanoparticles. (csio.res.in)
Denticity1
- A variety of stretchable polymers with different mechanical features can be created by varying the type and oxidation state of the metal center, and the class and denticity, i.e., number of donor groups in a single ligand that bind to a central atom in a coordination complex, of the coordinating ligands. (stanford.edu)
Nitrogen1
- This work introduces a linearly aligned push-pull design principle that reaches from the ligand having nitrogen-based electron donors, over the Fe(ii) centre, to the ligand having an electron withdrawing carboxylic acid anchor group. (lu.se)
Chemistry3
- The compound is a common ligand in coordination chemistry. (wikipedia.org)
- The new triazole-based ligands reported in this project were used in our subsequent project, which has recently been accepted for publication in New Journal of Chemistry (2020). (mahidol.ac.th)
- The development of ligand-field theory in quantum chemistry has provided useful tools for exploring the metal-ligand cooperativity in coordination compounds as well as the related redox processes 5 , 6 , 7 . (nature.com)
Heterocyclic1
- However, by introducing heterocyclic spaces such as the Py ligand, the crystallinity and size of the rigid crystallites can be tailored to modify mechanical properties. (stanford.edu)
Monodentate1
- Of these six benzoates, four act as a bridging ligand between two coppers and the remaining two benzoates are coordinated in monodentate fashion. (elsevierpure.com)
Molecules3
- Therefore, the ion centers act as active sites of the metallo-gallate complex that can donate electrons from the gallate ligands to ambient free oxygen molecules for the oxygen reduction and reactive oxygen species (ROS) generation 3 , after which the ligand field around iron center attenuates due to the electron loss from gallate 12 . (nature.com)
- Frankfurt am Main, Germany about half of the crystallographically visible water molecules appear to be expelled by the ligand, we find that ligand binding actually increases the number of water molecules within the cavity. (lu.se)
- At 300 K, the water mol- ecules in the cavity exchange positions on a time-scale of about 1 ns and exchange with external water on longer time-scales (0.01 -1 ms). Exchange of water molecules among hydration sites within the cavity should be strongly coupled to ligand motion. (lu.se)
Hydrogen1
- The nanocomplex with a highly reductive ligand field can promote oxygen reduction reactions generating hydrogen peroxide. (nature.com)
Interactions1
- Another theory is that interactions between Fas (a cell-surface receptor that induces apoptosis) and its ligand, particularly a soluble form of Fas ligand released from mononuclear cells, lead to cell death and blister formation. (msdmanuals.com)
Nanoparticles3
- The optical properties of mixed donor ligand directed semiconductor ZnO nanoparticles are evaluated and imine linked receptor is used as capping agents. (csio.res.in)
- The capping with ligand resulted in the successful amendment of the surface of ZnO nanoparticles, as it particularly reduced the defects related visible emission known as green luminescence and hence resulted in improvement in the UV luminescence. (csio.res.in)
- The UV-Vis absorption spectra also showed blue shift in the UV region for the ligand based ZnO nanoparticles due to the effect of quantum confinement. (csio.res.in)
Copper1
Molecular2
- Low molecular weight (LMW) allosteric FSHR ligands were developed for use in assisted reproductive technology yet could also provide novel pharmacological tools to study FSHR. (frontiersin.org)
- We discovered that the molecular ordering of semiconducting polymers can be effectively manipulated by the dynamic of metal-ligand coordination bonds, leading polymer semiconductors to be highly stretchable without sacrificing charge transporting," says Wu. (stanford.edu)
Molecule2
- For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided. (guidetopharmacology.org)
- We screened a ChemBridge small molecule library and identified 10-chloro-7H-benzimidazo[2,1-a]benzo[de]Iso-quinolin-7-one (10-Cl-BBQ) as a potent AhR ligand that was rapidly metabolized and not cytotoxic to proliferating T cells. (oregonstate.edu)
Spectroscopic1
- The formation of ligand is confirmed with spectroscopic methods including NMR and mass spectroscopy. (csio.res.in)
Bonds1
- Mechanophores are dynamic areas in a polymer network that contain either adaptive covalent or weak non-covalent bonds, such as metal-ligand coordination bonds, that can dissipate mechanical stress under strain by breaking and reforming. (stanford.edu)
Reactions3
- The ligand substitution reactions of hydrophobic vitamin B12 derivatives. (scielo.org.za)
- In addition IMACS-CD4+ but not IMACS/FACS-CD4+ reactions were upregulated from the TLR-4 ligand lipopolysaccharide (LPS). (mingsheng88.org)
- Altogether these results indicate that small variations in cell purity can significantly alter T cell reactions to TLR ligands. (mingsheng88.org)
Atom2
Structural2
- In the present study, structure-based pharmacophore and ligand-based 3D QSAR, HQSAR and pharmacophore mapping studies have been emphasized to explore the possible structural requirement of this potential kinase inhibitors using a structurally diverse set of compounds. (unboundmedicine.com)
- TY - JOUR T1 - Exploring Structural and Physicochemical Profiles of Potential GSK-3β Inhibitors Using Structure- and Ligand-Based Modeling Studies. (unboundmedicine.com)
Roles1
- The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. (oregonstate.edu)
Functional3
- The composite (ZnO-ligands) stability is confirmed theoretically with Density Functional Theory. (csio.res.in)
- In a recent paper published in Advanced Functional Materials , a team of researchers led by Professor Zhenan Bao and Dr. Hung-Chin Wu in the Department of Chemical Engineering at Stanford University made use of metal-ligand based mechanophores to improve the mechanical and electrical performance of their PSCs commonly found in wearable electronics. (stanford.edu)
- In X-linked hyper-IgM syndrome, T cells lack functional CD40 ligand and cannot signal B cells to switch. (msdmanuals.com)
Metal4
- This angle is an indication of the amount of steric protection that this ligand provides to the metal that to which it is bound. (wikipedia.org)
- The strong metal-ligand exchange coupling between Fe center and gallate ligands results in a strong electronic delocalization throughout the whole polymer, which not only significantly enhances light absorption to show deep black color of the iron gall ink, but also makes the spin densities of ion centers closer to the values of high-spin iron(II) 11 . (nature.com)
- Amongst them, metal-ligand coordination is particularly useful. (stanford.edu)
- Wu and colleagues made use of iron metal-ligand based mechanophores to improve the mechanical robustness and charge transport performance of PSCs ( Figure 1 ). (stanford.edu)
Weak1
- and a weak σ-donor ligand. (sigmaaldrich.com)
Suitable1
- An important barrier to HSCT has been the inability to secure a suitable donors. (medscape.com)
Murine1
- Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. (oregonstate.edu)
Patients1
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Form1
- Next, the authors added FeX2 (X = Cl, B(Ph4)) to these ligands to form Wolf type-II metallopolymers before characterizing their mechanical properties. (stanford.edu)
Cell4
- Programmed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses. (diabetesjournals.org)
- Like TCDD,10-Cl-BBQ altered donor CD4(+) T cell differentiation during the early stages of a graft versus host (GVH) response resulting in expression of high levels of CD25, CTLA-4 and ICOS, as well as several genes associated with Treg function. (oregonstate.edu)
- Direct regulation of T cell function by microbial ligands through Toll-like receptors (TLR) is an emerging part of T cell biology. (mingsheng88.org)
- This study stresses the importance of a stringent purification method when investigating the part of microbial ligands in T cell function. (mingsheng88.org)
Cells10
- T cells within a certain range of high avidity for their cognate ligand are believed to be most effective. (mdc-berlin.de)
- therefore, determination of koff rates could guide selection of the most effective donor cells. (mdc-berlin.de)
- The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. (oregonstate.edu)
- The Treg phenotype required AhR expression in the donor CD4(+) T cells. (oregonstate.edu)
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
- Most cases are X-linked and caused by mutations in a gene on the X chromosome that encodes a protein (CD154, or CD40 ligand) on the surfaces of activated helper T cells. (msdmanuals.com)
- In the presence of cytokines, normal CD40 ligand interacts with B cells and thus signals them to switch from producing IgM to producing IgA, IgG, or IgE. (msdmanuals.com)
- Lymphoid tissue is very small because deficient CD 40 ligand signaling does not activate B cells. (msdmanuals.com)
- This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
- The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
Complex1
Structure1
- Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. (guidetopharmacology.org)
Unique1
- These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. (guidetopharmacology.org)
Surface1
- AZ8838 is a PAR2 antagonist that binds to PAR2 in a fully occluded pocket near the extracellular surface and competes with the tethered ligand. (guidetopharmacology.org)
IRON1
- Figure 1 Schematic showing iron-ligand coordination-based mechanophores in polymer semiconductors. (stanford.edu)
Data1
- For the analysis of data from multiple donors, the data underwent logarithmic transformation due to the non-normal distribution of ideals. (mingsheng88.org)