• Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • To define the mechanistic basis of clonal hematopoiesis in SDS, we investigate somatic mutations acquired by patients with SDS followed longitudinally. (nature.com)
  • We use this model to investigate clonal hematopoiesis, which is a significant risk factor for hematologic cancers. (uzh.ch)
  • They also discovered that these mutated genes coincided with the abnormal expansion of the blood cells that harbor them - a phenomenon known as clonal hematopoiesis (CH) . (dana-farber.org)
  • Now, scientists are hoping to soon launch clinical trials of potential therapeutics that may be able to disrupt the inflammatory program spurred by clonal hematopoiesis of indeterminate potential (CHIP) and reduce the risk of heart disease. (dana-farber.org)
  • Of clonal mutations found in donors, 84.2% were predicted to be molecularly pathogenic and 100% engrafted in recipients. (hematologyadvisor.com)
  • Pathogenic clonal mutations in donors may lead to the proliferation of the same mutations in recipients of hematopoietic stem cell transplantation (HSCT) , according to research published in Science Translational Medicine . (hematologyadvisor.com)
  • This pilot study interrogating the prevalence of rare clonal hematopoiesis in the adolescent and young adult population and examining what happens to these clones in unrelated HSCT recipients merits a much larger study with longer follow-up to correlate post-HSCT morbidities with transfer and persistence of donor clones. (hematologyadvisor.com)
  • We predict the time taken for mutant clones to expand within a host, as well as chimerism levels that can be expected following transplantation therapy, and the probability that a preconditioned host is reconstituted by donor cells. (uzh.ch)
  • Recent advances in the understanding of immunological mechanisms of GVHD have shown that activation of donor immune cells is tightly regulated by the microenvironment tissue or digestive microbiota changes after transplantation. (pasteur.fr)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil. (cdc.gov)
  • Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
  • A Pilot Study Evaluating the Safety and Efficacy of AMD3100 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients with Advanced Hematological Malignancies. (ashpublications.org)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • HSCs were first identified by transplantation, in which recipient mice were preconditioned with ionizing radiation and reconstituted with donor bone marrow. (digs-bb.de)
  • Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation [published online January 15, 2020]. (hematologyadvisor.com)
  • The objectives of the present study were to observe the biological characteristics of MSCs from CML patients and to determine if MSCs originate in part from donors in CML patients after bone marrow transplantation (BMT). (embrapa.br)
  • We also analyse the engraftment of donor stem cells into non-conditioned and conditioned hosts, quantifying the impact of different treatment scenarios. (uzh.ch)
  • these mice carry the SIRP-alpha gene similar to humans that allows the engraftment of donor cells. (genengnews.com)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • All patients achieved initial mixed hematopoietic chimerism with two patients rejecting their graft and recovering host hematopoiesis. (aacrjournals.org)
  • Five patients had progressive disease, two patients had stable disease, and one patient experienced a partial response after receiving donor lymphocyte infusions and IFN-α. (aacrjournals.org)
  • INTRODUCTION: Despite knowledge advances on extramedullary haematopoiesis (EMH) in thalassemic patients, the real picture remains an open issue. (bvsalud.org)
  • 15% of patients with SCD have an HLA-matched sibling donor. (nih.gov)
  • 3 - 5 CXCL12 is highly expressed by MM plasma cells, 6 and circulating levels of CXCL12 are higher in the peripheral blood of MM patients than in age-matched normal donors and MGUS patients. (haematologica.org)
  • MYB is well recognized to be a key regulator of definitive hematopoiesis that plays an important role in the maintenance and multilineage differentiation of hematopoietic stem cells (HSCs). (nih.gov)
  • In the vertebrate developmental context, MYB is widely regarded dispensable for primitive hematopoiesis but critically required for the development of definitive hematopoiesis. (nih.gov)
  • Our data indicate that in contrast to its previously attributed exclusive role in definitive hematopoiesis, MYB is indispensable for primitive human hematopoiesis. (nih.gov)
  • Their results indicated that yolk sac progenitors before the onset of circulation did not have LT reconstitution potential while progenitors isolated from the AGM did, which indicates that primitive and definitive hematopoiesis may occur at distinct anatomical locations [ 10 ]. (biomedcentral.com)
  • Similar to tissue-resident macrophages, mast cells are of dual ontogeny and are generated during both fetal and adult ("definitive") hematopoiesis. (digs-bb.de)
  • Non-canonical signalling by Wnt16 is required for somitic expression of the Notch ligands deltaC (dlc) and deltaD (dld), and these ligands are, in turn, required for the establishment of definitive haematopoiesis. (ca.gov)
  • HSCs are used clinically to treat a wide array of diseases, including acute leukaemias and congenital blood disorders, but obtaining suitable numbers of cells and finding immune-compatible donors remain serious problems. (ca.gov)
  • We are investigating native hematopoiesis following mutations that either reduce genome replication fidelity or predispose to leukemia development. (digs-bb.de)
  • There has been some suggestion that these post-treatment issues are linked to clones of pathogenic mutations present in donor clones. (hematologyadvisor.com)
  • For this study, researchers evaluated whether adolescent and young adult donors carry hematopoietic clones with pathogenic mutations that may be undetectable using standard next-generation sequencing, as well as how often any such clones are transferred to HSCT recipients and any effects on the clones thereafter. (hematologyadvisor.com)
  • Allogeneic hematopoietic stem cell (HSC) is a curative treatment used for many hematologic malignancies and congenital or acquired anomalies of hematopoiesis. (pasteur.fr)
  • Members of the Hematopoiesis and Hematologic Malignancies research program at IU Simon Comprehensive Cancer Center are leading remarkable laboratory and clinical studies that reduce the burden of cancer. (iu.edu)
  • This development is also often referred to as fetal hematopoiesis, and was demonstrated by the production of embryonic erythrocytes that still possess a nucleus, express fetal hemoglobin, and lack any lymphoid potential [ 5 ]. (biomedcentral.com)
  • These models display a robust and broad-spectrum human hematopoiesis, are suitable for large cohort generation, and are thoroughly standardized for reconstitution kinetics. (genengnews.com)
  • Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor hematopoiesis reconstitution in vivo still exist, mainly attributing to the lack of solid, reproduced, or pursued differentiation system. (biomedcentral.com)
  • The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. (lidsen.com)
  • Error-corrected sequencing, which has a detection limit of at least 0.0001, was performed on 125 blood and marrow samples from 25 matched unrelated donors and their recipients. (hematologyadvisor.com)
  • Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
  • We are evaluating whether allogeneic HSCT can reconstitute normal hematopoiesis in MonoMAC and reverse the hematological abnormalities in MDS, if MDS is present at the time of transplant. (nih.gov)
  • Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
  • Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
  • Eight of the nine donors mobilized following AMD3100 collected at least 2.0x 10e6 CD34+ cells/kg recipient weight following 1 (n=5) or 2 (n=4) LP procedures. (ashpublications.org)
  • An antigenic mismatch between donor and recipient blood. (bvsalud.org)
  • To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
  • Loss of Tada2b or Taf5l inhibited hematopoiesis in vivo and was associated with upregulation of interferon response gene expression. (biorxiv.org)
  • We are also evaluating whether we achieve sufficient donor chimerism to reverse the MDS. (nih.gov)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • We inactivated the human MYB gene by biallelic integration of reporter donor cassette through TALENs-supported genetic engineering. (nih.gov)
  • Antibodies present in the recipient's serum may be directed against antigens in the donor product. (bvsalud.org)
  • The restoration of hematopoiesis together with the donor's immune system can lead to a major immune reaction, graft- versus -host disease (GvHD). (gvhdhub.com)
  • Serum/plasma samples from all donors were screened for HIV antibodies by ELISA and the results confirmed by Western blot analysis. (embrapa.br)
  • A sub-fraction of myelofibrosis megakaryocyte progenitors (MkPs) are transcriptionally similar to healthy-donor MkPs, but the majority are disease specific, with distinct populations expressing fibrosis- and proliferation-associated genes. (ox.ac.uk)
  • B19 was discovered in England in 1975 in serum specimens from healthy blood donors (1). (cdc.gov)
  • Using our fate mapping and proliferation reporter mouse models, we recently investigated how native hematopoiesis responds to systemic inflammation or blood loss (Munz et al. (digs-bb.de)
  • Mouse models for fate mapping and proliferation tracking allow investigating the contribution of HSC to native hematopoiesis. (digs-bb.de)
  • after this and several subsequent unsuccessful attempts to use primates as organ donors and the development of a working cadaver organ procuring program, interest in xenotransplantation for kidney failure dissipated. (wikipedia.org)
  • Our goal is to understand how blood formation proceeds in mammals, which factors govern and control this and how dysregulation of hematopoiesis leads to disease. (digs-bb.de)
  • The present study reports the molecular and epidemiological characterization of 31 HIV-1 isolates from blood donors from the State of Amazonas who donated blood between April 2006 and March 2007. (embrapa.br)
  • Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (bvsalud.org)
  • Utilizing biochemical, molecular and cellular approaches to study normal and malignant haematopoiesis. (nottingham.ac.uk)
  • Clinical data overview of NK-LGLL sufferers and normal healthful donor examples. (synanet2020.com)
  • The PAI-1 inhibitor not only accelerated the expansion of the donor HSCs during the early-stage of regeneration, but also supported long-term hematopoiesis. (cusabio.com)
  • Examples were acquired from sufferers or healthy donors not on immunosuppressant treatment currently. (synanet2020.com)
  • The individual or healthy donor age may be the age at the proper time the sample was collected. (synanet2020.com)
  • We also reflect on one of the earliest realizations made in this area of study: that hematopoiesis is evolutionarily conserved, and as a consequence we reflect on the impacts of early and current discoveries and their clinical implications. (biomedcentral.com)
  • AMD3100 was well tolerated and no donors experienced any greater than grade 1 toxicity. (ashpublications.org)