• Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies. (nih.gov)
  • Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
  • TK is currently being investigated in patients with acute leukemia in first or subsequent complete remission and at high risk of relapse or in patients with relapsed disease who are candidates for haploidentical transplantation of hemopoietic stem cells (taken from a partially HLA-compatible family donor). (wikipedia.org)
  • TK is a cellular therapy based on the genetical engineering of donor T lymphocytes in order to express a suicide gene (thymidine kinase of the Herpes simplex virus, namely TK) Once the lymphocytes donated by partially compatible family donors (haplo-transplant) have been genetically modified, they can be infused in patients in need of hematopoietic cell transplantation. (wikipedia.org)
  • To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • Allogeneic haemopoietic stem cell transplantation offers a potentially curative treatment option for a wide range of life-threatening malignant and non-malignant disorders of the bone marrow and immune system in patients of all ages. (nih.gov)
  • We report UK consensus guidelines on the selection of umbilical cord blood units, the hierarchy of donor selection and the preferred conditioning regimens for umbilical cord blood transplantation, with a summary of rationale supporting these recommendations. (nih.gov)
  • Sica, S 2021, ' allogenic hemopoietic stem cell transplantation for myelofibrosis :2021 ', Frontiers in Immunology , pagg. (unicatt.it)
  • To understand the stem cell transplant death rate, it's crucial to have a firm grasp of what exactly stem cell transplantation involves. (medical-definitions.net)
  • There are several types of stem cell transplants, with allogeneic stem cell transplantation being one of the most common. (medical-definitions.net)
  • In a study published in the journal "Blood" in 2015, the non-relapse mortality rate at 1 year post-transplant was 15.4% for myelofibrosis patients undergoing reduced-intensity allogeneic stem cell transplantation. (medical-definitions.net)
  • Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation. (medical-definitions.net)
  • In a study published in the journal "Biology of Blood and Marrow Transplantation" in 2010, the transplant-related mortality rate was less than 5% for patients undergoing autologous stem cell transplantation. (medical-definitions.net)
  • Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS. (hoapb.com)
  • Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome. (hoapb.com)
  • The importance of identifying a back-up donor for unrelated stem cell transplantation. (focusonthedonor.nl)
  • Before coming to Columbia, Dr. Mapara was Associate Professor of Medicine (with tenure) at the University of Pittsburgh Cancer Institute and served as the Director of the Adult Hematopoietic Stem Cell Transplantation Program. (columbia.edu)
  • The research in this laboratory is primarily focused on developing new approaches to improve the outcome of patients with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation. (columbia.edu)
  • A Phase I Study of CD19 Specific Chimeric Antigen Receptor T-cells for Therapy of Persistent and Relapsed B-cell Leukaemia and Lymphoma Post Allogeneic Stem Cell Transplantation (The CARTELL Study). (westmeadinstitute.org.au)
  • Combined Infusion of Cytotoxic T-Lymphocytes and Vaccination to Enhance Infection-Specific Immune Reconstitution Post-Allogeneic Stem Cell Transplantation (CYNTAX). (westmeadinstitute.org.au)
  • Therapeutic infusion of most closely HLA-matched third party donor-derived virus- and fungus specific cytotoxic T-lymphocytes in patients with active viral reactivation or proven or probable invasive fungal infection post-allogeneic stem cell or solid organ transplantation (R3ACT). (westmeadinstitute.org.au)
  • Chemotherapy followed by infusion of partially HLA matched unrelated donor cells for patients with AML who are ineligible for stem cell transplantation (SCRAMBLE). (westmeadinstitute.org.au)
  • The technique was trialled in 16 high-risk patients who were undergoing stem-cell transplantation for primary immunodeficiencies. (zana.com)
  • We describe the successful management of Anncaliia algerae microsporidial myositis in a man with graft versus host disease after hemopoietic stem cell transplantation. (cdc.gov)
  • We document successful treatment of A. algerae infection after hemopoietic stem cell transplantation, provide an update on clinical features and management, and discuss possible routes of transmission and risk-mitigation strategies. (cdc.gov)
  • Treatment of mice with a single donor-specific transfusion plus a brief course of anti-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion of alloreactive CD8+ T cells. (palomid529.com)
  • When applied to stem cell transplantation anti-CD154 mAb treatment in combination with sublethal conditioning enables the generation of allogeneic hemopoietic chimerism and long term transplantation tolerance (11-14). (palomid529.com)
  • Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial. (utoronto.ca)
  • 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • This study compared the effects of pre-transplantation minimal residual disease (pre-MRD) on outcomes in AML patients who underwent human leukocyte antigen-matched sibling donor transplantation (MSDT) or who received unmanipulated haploidentical allografts. (biomedcentral.com)
  • This was then compared with outcome in a homogeneously treated cohort of pediatric patients undergoing high-resolution sibling or matched unrelated donor transplantation for acute lymphoblastic leukemia (ALL). (ox.ac.uk)
  • Recent medical advances in the field of regenerative medicine and tissue transplantation have highlighted the importance of umbilical cord blood (UCB) as a valuable alternative source of haematopoietic stem cells, which are potentially life-saving in a vast array of clinical applications. (sajbl.org.za)
  • IciStem is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders. (icistem.org)
  • IciStem investigates systematically the HIV reservoir in people living with HIV who either had or may get an allogeneic stem cell transplantation. (icistem.org)
  • IciStem advises systematic collection of clinical data and blood, tissue and CSF samples before and after the stem cell transplantation. (icistem.org)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • The purpose of this guideline is to maximise the safety of patients who need haemopoietic stem cell transplantation and make the best use of NHS resources, while protecting staff from infection. (bvsalud.org)
  • A review of the British Society for Histocompatibility and Immunogenetics (BSHI) "Guideline for selection and HLA matching of related, adult unrelated donors and umbilical cord units for haematopoietic progenitor cell transplantation" was undertaken by a BSHI appointed writing committee. (bvsalud.org)
  • Since many of these patients lack HLA-identical sibling donors and are older or have comorbidity, a fully ablative HSCT is not feasible and an alternative approach is required. (nih.gov)
  • Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
  • The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
  • The aim of this review is to update the current status of allogeneic hemopoietic stem cell transplants (HSCT) for patients with myelofibrosis (MF). (unicatt.it)
  • Finally we discuss monitoring the disease after HSCT with donor chimerism, driver mutations and hematologic data. (unicatt.it)
  • The presence of immune cells in UCB that are not directed against maternal foreign Ags is remarkable and may explain the reported clinical observation of improved HSCT outcome with younger sibling donors. (ashpublications.org)
  • [3] Today, patients take insulin shots and pharmaceuticals to control their diabetes, and adult stem cell transplants have shown success at ameliorating the condition. (lozierinstitute.org)
  • Contrary to popular belief, stem cell transplants have a relatively low death rate. (medical-definitions.net)
  • A Randomized Pilot Trial comparing Anti-Thymocyte Globulin (ATG) with ATG plus Post Transplant Cyclophosphamide for Prophylaxis against Acute and Chronic Graft Versus Host Disease in Matched Donor Hematopoietic Cell Transplants. (utoronto.ca)
  • With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • GVHD occurred after a matched unrelated donor, allogeneic bone marrow transplant for acute myeloid leukemia. (cdc.gov)
  • AALD scores formed a numeric continuum ranging from 0 to 1.4 (median 0.76) for sibling pairs and 0.8-2.17 (median 1.6) for high-resolution matched unrelated donor (HR-MUD) pairs. (ox.ac.uk)
  • Allogeneic hematopoietic stem cell donation: standardised assessment of donor outcome data. (focusonthedonor.nl)
  • The new treatment involves using a new method of transplanting stem cells following antibody-based minimal-intensity conditioning (MIC) rather than chemotherapy to prepare the body for donor transplant. (zana.com)
  • The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
  • We prospectively study allogeneic SCT recipients with HIV-1 infection, collecting complete information on underlying malignancy, chemotherapy, transplant procedure, donor selection, HIV-tropism, cART, and virological and immunological characteristics of a variety of samples before and after the transplant. (icistem.org)
  • Stem cell sources have been expanded from bone marrow to the use of mobilised hemopoietic progenitor cells and stem cells harvested from umbilical cord blood. (focusonthedonor.nl)
  • Results show that in redefining the architecture of blood development, the lineage potential of nearly 3,000 single cells were mapped from 33 different cell populations of stem and progenitor cells obtained from human blood samples taken at various life stages and ages. (health-innovations.org)
  • Derived from the fetal allantois, it provides a rich source of multipotent stem cells, including CD34+ and CD38- haematopoietic progenitor cells. (sajbl.org.za)
  • With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. (nih.gov)
  • HLA-identical sibling stem cells are used for the treatment of patients suffering from various hematologic malignant and nonmalignant diseases. (ashpublications.org)
  • Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type. (medical-definitions.net)
  • Currently, only stem cell transplant utilizing cells from a donor-called an allogeneic transplant-can consistently cure patients with MDS. (hoapb.com)
  • The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent. (focusonthedonor.nl)
  • A clinical trial of donor-derived WT1 specific T cells for prevention of relapse in combination with multiple pathogen specific T cells for prevention of infection in patients undergoing allogeneic haemopoietic stem cell transplant (INTACT-WT1). (westmeadinstitute.org.au)
  • We studied quantitative and functional parameters of bone marrow stem cells and mature lymphocyte population under conditions of impaired innervation in patients with injuries to the cervical and thoracic portions of the spinal cord.Our findings indicated the absence of deficiency of quantitative and proliferative potentials of stem cells and demonstrated intact subpopulation structure of mature lymphocytes and T-cell proliferative activity similar to that in donors. (staminafoundation.org)
  • The content of CD34+ cells in patients did not differ from that in donors.The percentage of CD34+CD38- hemopoietic stem cells was elevated in patients, presumably due to increased proliferative activity of hemopoietic stem cells. (staminafoundation.org)
  • Both HIV patients now in remission were diagnosed with leukemia, and the destruction of their immune systems provided the opportunity for renewal through stem cell transplant, a risky procedure. (mlsucsd.com)
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • if confirmed, it has the potential to improve donor selection for patients with multiple prospective donors. (ox.ac.uk)
  • These data are very encouraging for patients who have limited, if any, treatment options, especially for those who have failed prior CD19 directed CAR T-cell therapy and allogeneic stem cell transplant" said Mark Frattini, M.D., Ph.D., Chief Medical Officer at Cellectis. (ricentral.com)
  • Cellectis utilizes an allogeneic approach for CAR-T immunotherapies in oncology, pioneering the concept of off-the-shelf and ready-to-use gene-edited CAR T-cells to treat cancer patients, and a platform to make therapeutic gene editing in hemopoietic stem cells for various diseases. (ricentral.com)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • Bone marrow mononuclear cells (BMMNCs) consist of hemopoietic stem cells and mesenchymal stem cells together with progenitors of endothelial cells or somatic cells [ 1 , 2 ]. (biomedcentral.com)
  • Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
  • The choice of a transplant platform including the conditioning regimen, the stem cell source and GvHD prophylaxis, are crucial for a successful program in MF, and will be outlined. (unicatt.it)
  • Alloreactive donor T cells are important mediators of both relapse control by graft- versus -leukemia (GvL) effects, and of GvHD. (haematologica.org)
  • 1 In unrelated donor (UD)-HCT, frequent human leukocyte antigen (HLA)-DPB1 disparity is the target of T-cell alloreactivity, contributing to both leukemia control and GvHD. (haematologica.org)
  • Alloreactive donor T cells recognizing patient-specific genetic polymorphisms, including mismatched HLA allotypes, play a major role in both beneficial GvL and severe GvHD after UD-HCT. (haematologica.org)
  • The outcomes the researchers were studying were the rate of non-engraftment (where the donor stem cells do not successfully establish themselves in the bone marrow), rejection (where the hosts body rejects the donor cells), frequency of graft-versus-host disease (GvHD, where the donor cells attack the body of the host), and the rate of illness and death caused by conditioning. (zana.com)
  • Donor-derived T-cells are transduced using a lentiviral vector to express the anti-CD22 chimeric antigen receptor (CAR) and are further modified using Cellectis' TALENĀ® technology to disrupt the T-cell receptor alpha constant (TRAC) and CD52 genes to minimize risk of graft-vs-host disease (GvHD) and allow use of an anti-CD52 antibody for lymphodepletion (LD). (ricentral.com)
  • Managing a dual role - experiences and coping strategies of parents donating haplo-identical G-CSF mobilised peripheral blood stem cells to their children. (focusonthedonor.nl)
  • Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells We carried out a Section I scientific trial of donor derived CD19-specific chimeric antigen receptor T-cells (CAR T-cells) for B-cell malignancy that relapsed or persevered after matched associated allogeneic hemopoietic stem cell transplant. (medmk.com)
  • Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells We carried out a Part I scientific trial of donor derived CD19-specific chimeric antigen receptor T-cells (CAR T-cells) for B-cell malignancy that relapsed or endured after matched associated allogeneic hemopoietic stem cell transplant. (ultrasonic-scientific.com)
  • Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
  • Researchers have developed a new technique to prevent the body rejecting bone marrow cells from a donor. (zana.com)
  • A 53-year-old man in Germany has become at least the third person with HIV to be declared cleared of the virus after a procedure that replaced his bone marrow cells with HIV-resistant stem cells from a donor. (icistem.org)
  • a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
  • The presence of TK allows for retention of immune protection and anti-leukaemic effects of donor T lymphocytes and at the same time to control and annul possible harmful reactions between these lymphocytes and healthy tissues of the patient, reaction known as graft-versus-host disease. (wikipedia.org)
  • A new suicide system based on gene transfer of FAS into donor lymphocytes for controlled GVL. (unisr.it)
  • A pilot study of HSV-TK gene transfer into donor peripheral blood lymphocytes for controlled GVL after allo-BMT. (unisr.it)
  • Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. (nih.gov)
  • [5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
  • Although less controversial than the use of embryonic stem cells obtained from fetal tissue, the practice of UCB biobanking presents several ethical and regulatory challenges surrounding its procurement and use, especially in developing countries like South Africa, where the majority of the population is vulnerable and prone to exploitation. (sajbl.org.za)
  • As a source of non-embryonic stem cells, UCB has found potential uses as a therapeutic modality in more than 80 clinical applications, both haematological and non-haematological. (sajbl.org.za)
  • UCB's advantages over other sources of stem cells such as adult bone marrow and embryonic stem cells include easy procurement, minimal risk to the donor, excellent proliferation and differentiation, immediate availability, and autologous use. (sajbl.org.za)
  • In view of the fact that UCB has become a valuable, non-invasive source of stem cells for regenerative therapy, establishment of a public cord blood bank (CBB) in South Africa would vastly improve the availability of haematopoietic stem cells for research and therapeutic uses, and increase the tissue genetic diversity that currently impedes the South African bone marrow registry. (sajbl.org.za)
  • Combined therapy consisting of anti-CD154 mAb plus a L-Thyroxine solitary donor-specific transfusion (DST)5 in mice is definitely even more effective than anti-CD154 mAb monotherapy in prolonging the survival of islet pores and skin and heart allografts (5 6 15 The mechanism by which DST enhances graft survival appears in part to involve the deletion of recipient CD8+ alloreactive T cells (15). (palomid529.com)
  • However, for family donors long term follow up studies were mainly performed in retrospect, and cohorts are often small. (focusonthedonor.nl)
  • The lack of well-documented pre-donation conditions for donors has demonstrated the need for stricter guidelines for care management of family donors. (focusonthedonor.nl)
  • Correlation between microsatellite discrepancy scores and transplant outcome after haemopoietic SCT for pediatric ALL. (ox.ac.uk)
  • As unknown ancestral differences could potentially have an impact on transplant outcome, we developed an average allele length discrepancy (AALD) score to assess allele length discrepancy between donor/recipient (D/R) using microsatellites analysed routinely in post-transplant chimeric assessment. (ox.ac.uk)
  • A bone marrow transplant is the only cure for this condition, where haemopoietic stem cells (cells that can develop into any type of blood cell) from a healthy donor are transplanted into the child. (zana.com)
  • UCART22 is a genetically modified allogeneic T-cell product manufactured from healthy donor cells. (ricentral.com)
  • Namely, recipients sharing one or more HLA Ags with their cord blood donor inherited paternal Ags had reduced relapse rates compared with those who did not. (ashpublications.org)
  • To test this hypothesis more directly and to analyze L-Thyroxine the underlying mechanisms in detail we established a new analytical system based on allo-TCR transgenic hemopoietic chimeric graft recipients. (palomid529.com)
  • When lymphoma proves especially difficult to treat, doctors may perform a bone marrow transplant , either from the patient or from a donor. (lymphomainfo.net)
  • Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. (biomedcentral.com)
  • FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
  • For a more in-depth analysis of this procedure, you can check out this Allogeneic Stem Cell Transplant Procedure guide. (medical-definitions.net)