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  • lymphocyte
  • Graft-host tolerance was broken by the delayed infusion of donor cells, as indicated by the persistence of antihost-reactive donor T cells in these chimeras in T-cell receptor cross-linking and mixed lymphocyte reaction assays. (bloodjournal.org)
  • HSCT
  • HLA-C locus mismatches (MMs) are the most frequent class I disparities in unrelated hematopoietic stem cell transplantation (HSCT) and have a detrimental impact on clinical outcome. (frontiersin.org)
  • Because of the high rate of HLA-DPB1 incompatibilities in HLA-A-, B-, C-, DRB1-, and DQB1-matched unrelated HSCT patient/donor pairs, the impact of HLA-DPB1 mismatching, a potential bystander of CD4 + T cell activation, was also considered. (frontiersin.org)
  • Cancer
  • A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer. (nih.gov)
  • Tumor cell fusion with motile bone marrow-derived cells (BMDCs) has long been posited as a mechanism for cancer metastasis. (nih.gov)
  • While there is much support for this from cell culture and animal studies, it has yet to be confirmed in human cancer, as tumor and marrow-derived cells from the same patient cannot be easily distinguished genetically. (nih.gov)
  • RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill cancer cells. (clinicaltrials.gov)
  • Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by chromosomal fragility, progressive marrow failure, and cancer predisposition. (bloodjournal.org)
  • induce
  • Although delayed infusion of normal donor cells did not induce GVHD, spleen cells from donors previously sensitized to host alloantigens induced GVHD when infused 21 days after BMT. (bloodjournal.org)
  • reactivity
  • However, the anti-donor response was completely undetectable by Day 24, while third-party reactivity persisted. (harvard.edu)
  • blood
  • The eligibility criteria for a stem cell donor are essentially the same as for blood donation. (medscape.com)
  • cells
  • GVHD can be eliminated by depleting mature donor T cells from the BM inoculum, thereby facilitating the development of graft-host tolerance. (bloodjournal.org)
  • When sufficient numbers of donor spleen cells, as a source of T-cells, were added to the BM graft, AKR hosts developed severe and lethal GVHD. (bloodjournal.org)
  • Antihost reactive donor T cells persisted in chimeras undergoing GVHD, indicating that graft-host tolerance did not develop. (bloodjournal.org)
  • Multiple infusions of immunocompetent donor cells could be administered without increasing the risk for GVHD if delayed until 21 days post-BMT. (bloodjournal.org)
  • Delayed infusions of donor spleen cells also resulted in a long-term antileukemic effect in the absence of GVHD in an MHC-haplotype-mismatched model of BMT (SJL into [SJL x AKR]F1). (bloodjournal.org)
  • All alleles in the donor and patient pre-BMT lymphocytes were found in tumor cells. (nih.gov)
  • Expression and function of phosphoinositide 3-kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow. (annals.org)
  • expertise
  • A liver pathologist and a member of the transplantation center with expertise in hepatopathology graded the specimens by using the Ishak staging and grading systems. (annals.org)
  • diseases
  • Now, treatment of a number of diseases is possible through stem cell transplantation. (medscape.com)
  • Donors are screened for transmittable diseases such as HIV , hepatitis, West Nile virus , syphilis , and human T-lymphotropic virus (HTLV). (medscape.com)
  • However, certain donors with these diseases may still be considered for donation on a case-to-case basis. (medscape.com)
  • patient
  • We carried out genotyping of a metastatic melanoma to the brain that arose following allogeneic bone-marrow transplantation (BMT), using forensic short tandem repeat (STR) length-polymorphisms to distinguish donor and patient genomes. (nih.gov)
  • Forensic STR analyses of the MH3 melanoma along with donor and patient pre-BMT lymphocytes. (nih.gov)
  • Shown are "informative" loci exhibiting donor and patient specific alleles in pre-BMT lymphocytes. (nih.gov)
  • Tumor loci are listed in order of relative abundance of the donor-specific alleles (red asterisk) compared to patient-specific (blue asterisk) and shared alleles (black asterisk). (nih.gov)
  • 0.001), male sex of the patient ( P = 0.05), and female sex of the donor ( P = 0.002). (annals.org)
  • family
  • 2 - 4 The lead author (L.F.R.) replied that these objections mischaracterize the role of the advocate, who should be considered an "ally" of the donor and family. (aappublications.org)
  • studies
  • 13 - 15 Across these studies, both positive and negative psychosocial consequences of typing and donation are reported, including sibling donors' lack of choice, lack of appropriate information, and need for greater support. (aappublications.org)