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Hematopoietic Stem CellsTissue DonorsCloning, OrganismHematopoietic Stem Cell TransplantationBlood DonorsTransplantation, HomologousLiving DonorsNuclear Transfer TechniquesHematopoiesisHematopoietic SystemBone Marrow CellsTransplantation ChimeraBone Marrow TransplantationGraft vs Host DiseaseGraft SurvivalTransplantation ConditioningAntigens, CD34Cell DifferentiationMice, Inbred C57BLBone MarrowCells, CulturedHematologic NeoplasmsWhole-Body IrradiationInterleukin-3LeukemiaChimeraFlow CytometryColony-Forming Units AssayCell LineCell LineageRetroviridaeRadiation ChimeraHistocompatibility TestingCell DivisionSpleenCell TransplantationHematopoietic Cell Growth FactorsT-LymphocytesBlood CellsHistocompatibilityChimerismTransduction, GeneticConjugation, GeneticMolecular Sequence DataGraft vs Host ReactionTime FactorsGraft RejectionFetal BloodGenetic VectorsMice, KnockoutCell SeparationBase SequenceStem Cell TransplantationFetal Tissue TransplantationGreen Fluorescent ProteinsStem CellsAntigens, CDMyeloablative AgonistsStem Cell FactorEmbryo, MammalianMice, SCIDTransplantation ImmunologyGranulocytesMice, TransgenicBlastocystTransfectionMice, Inbred BALB CLeukocyte TransfusionFetusProto-Oncogene ProteinsProto-Oncogene Proteins c-mybSignal TransductionLymphocytesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphocyte TransfusionGene ExpressionCord Blood Stem Cell TransplantationBusulfanGene Transfer TechniquesCell SurvivalSkin TransplantationLeukemia, MyeloidLeukemia, Myeloid, AcuteGene Expression RegulationFibroblastsK562 CellsStromal CellsRNA, MessengerUnrelated DonorsB-LymphocytesApoptosisTransplantation TolerancePolymerase Chain ReactionFusion Proteins, bcr-ablGraft vs Tumor EffectAntigens, CD45MegakaryocytesHLA AntigensImmunosuppressive AgentsResearch Embryo Creation
MalignanciesTransplantation for Severe Aplastic AnemiaChimerismAutologousApheresisHaploidenticalPatientsHaplotypeProgenitor cellAlternative donor transplantsHSCTConditioning regimensCD34InfectionStem cells from a donorEngraftmentGraftMesenchymalBone marrow traChemotherapyAbstractPeripheral blood stem-cellOrgan donorsMyeloid cellsGVHDCytomegalovirusRecipientsProgenitorsEmbryonic and adultLymphocytesCurativeCenter of Excellence in HematologyImmuneMatched unrelatedDestroyed tissue anLymphomaAplasticTherapeuticsSickle cell diUmbilicalRecipientTumorsAntigensInfusionBloodSevereLymphocytePrecursorsAcute
Malignancies10
  • Allogeneic stem cell transplantation (allo-SCT) remains the only curative intervention for a variety of high-risk hematologic malignancies. (mhmedical.com)
  • Haploidentical stem cell transplantation (HaploSCT) from a first-degree related mismatched haplotype donor (siblings, children, parents) extends the application of this lifesaving treatment to a large proportion of patients with high-risk hematologic malignancies who otherwise do not have a suitable human leukocyte antigen (HLA)-matched donor. (mhmedical.com)
  • The CCEH Hematopoietic Cell Procurement and Processing Core maintains and gives access to a Repository of Cryopreserved Specimens consisting of large quantities of PBC components obtained from normal donors or patients with a variety of malignancies and limited quantities of normal bone marrow. (fredhutch.org)
  • Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
  • Examples of secondary immunodeficiency include HIV infection, hematopoietic malignancies, treatment with radiation, and treatment with immunosuppressive drugs. (cdc.gov)
  • Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
  • There is also a small risk of infections and malignancies from donor blood. (medscape.com)
  • Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
  • BACKGROUND: Cryopreserved hematopoietic stem cell products are widely used for certain hematologic malignancies. (lu.se)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
Transplantation for Severe Aplastic Anemia1
Chimerism3
  • We hypothesize that mixed donor engraftment as measured by chimerism at day 30 in CMV D(+) HCTs and full chimerism in CMV D(−) HCTs will be predictive of CMV reactivation. (umn.edu)
  • Dose escalation prophylactic donor lymphocyte infusion after T-cell depleted matched related donor allogeneic hematopoietic cell transplantation is feasible and results in higher donor chimerism, faster immune re-constitution, and prolonged progression-free survival. (uchicago.edu)
  • Split mixed donor chimerism has corrected the immunological defect. (frontiersin.org)
Autologous7
  • In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
  • It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
  • Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
  • Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
  • of these, 53 percent are autologous (taken from the patient) and 47 percent are allogenic (taken from a donor other than the patient). (drugdiscoverynews.com)
  • Both studies also demonstrated a favorable safety profile for Casgevy, with its side effects generally consistent with autologous stem cell transplants. (biospace.com)
  • Casgevy is an autologous gene therapy that uses a patient's own stem cells-which are harvested and genetically edited using CRISPR/Cas9-to increase their body's production of fetal hemoglobin. (biospace.com)
Apheresis3
  • T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • We therefore investigated whether Pentaisomaltose (PIM), a low-molecular-weight carbohydrate (1 kDa), can be used for cryopreservation of peripheral blood stem cells, more specifically hematopoietic progenitor cell apheresis (HPC(A)) product. (lu.se)
Haploidentical8
  • Association of iKIR-mismatch model and donor aKIRs with better outcome in haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia. (bvsalud.org)
  • Here, we investigated the potential influence of KIR mismatch and KIR alleles on the outcome of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in acute myeloid leukemia (AML) patients . (bvsalud.org)
  • This has led to the utilization of marrow, cord, peripheral blood stem cell and haploidentical stem cell sources, and novel reduced toxicity or reduced intensity conditioning regimens to transplant non-malignant disorders such as immune dysfunctions, marrow failure syndromes, metabolic disorders and hemoglobinopathies. (wustl.edu)
  • Haploidentical grafts from a first-degree related mismatched donor extends the applicability of this lifesaving treatment to a large proportion of patients who otherwise do not have a suitable human leukocyte antigen-matched donor. (mhmedical.com)
  • Haploidentical use has taken precedence compared with some other alternative donor sources given its immediate availability and cost-effectiveness. (mhmedical.com)
  • Several factors are considered when choosing the best haploidentical donor. (mhmedical.com)
  • Younger donors, male donors, fathers rather than mothers, and first-degree to second-degree donors are preferred graft sources for recipients of haploidentical transplants. (mhmedical.com)
  • Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
Patients33
  • The cumulative incidence of CMV infection 1-year after transplant was not different in patients with full (54%, n = 276) or mixed (53%, n = 131) donor engraftment. (umn.edu)
  • Also, the incidence of patients experiencing rejection is very rare (and graft-versus-host disease impossible) due to the donor and recipient being the same individual. (wikipedia.org)
  • Patients with RLM and the highest number of donor aKIRs had the lowest RR, lowest incidence of aGVHD and best OS. (bvsalud.org)
  • The synergistic effects of RLM and donor aKIRs can provide a better donor selection strategy to improve haplo-HSCT outcome in AML patients . (bvsalud.org)
  • This phase II trials studies the effect of treosulfan-based versus clofarabine-based conditioning regimens before donor hematopoietic stem cell transplant in treating patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. (fredhutch.org)
  • This study may help doctors determine whether treosulfan-based or clofarabine-based conditioning regimen works better before donor hematopoietic stem cell transplant in treating patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. (fredhutch.org)
  • The number and function of proangiogenic cells are impaired in patients with diabetes or cardiovascular diseases. (hindawi.com)
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
  • Patients' PBMCs are irradiated and mixed with donor PBMCs. (knowcancer.com)
  • Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
  • LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
  • Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
  • This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
  • Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
  • The sickle cell disease (SCD) study enrolled 45 patients but only 29 provided data mature enough for the primary efficacy interim analysis. (biospace.com)
  • In transfusion-dependent beta thalassemia (TDT), data came from 42 patients, of whom 39 achieved red blood cell transfusion independence for at least 12 months after receiving Casgevy. (biospace.com)
  • TDT patients with no available HLA-matched hematopoietic stem cell donors can receive Casgevy. (biospace.com)
  • Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
  • This is a non-therapeutic study for patients at St. Jude Children's Research Hospital and Methodist Adult Comprehensive Sickle Cell Center . (stjude.org)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
  • The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
  • Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
  • The current recommendation is for BPDCN patients to be evaluated for an allo-HCT as soon as possible and to begin searching for a donor. (lls.org)
  • Both meetings agreed minimum criteria for suitability of live donors and defined the obligations of transplant professionals to treat donors as patients, including appropriate follow-up and treatment for problems caused by the donation. (who.int)
  • Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • the JAK2 mutation, the presence of the mutation has become an important diagnostic criterion for identifying patients with PV and for reducing the potential for misdiagnosis of persons with elevated red blood cell counts. (cdc.gov)
Haplotype1
Progenitor cell6
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
  • For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
Alternative donor transplants2
  • This review provides an overview of advances made in alternative donor transplants for nonmalignant disorders. (wustl.edu)
  • It advocates the consideration of alternative donor transplants in the absence of human leukocyte antigen matched siblings when indicated by disease severity. (wustl.edu)
HSCT8
Conditioning regimens1
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
CD348
  • Colony Forming Cell (CFU) Assay CD34+ cells were selected from HPDSCs with a human CD34 positive selection kit and isolated using automated cell separator RoboSep (StemCell Technologies, Inc., Vancouver, Canada). (ebat2018.org)
  • We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)
  • CD34 + cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. (hindawi.com)
  • EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
  • In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
  • We maintain an inventory of millions of enriched CD34 positive cells available for projects. (fredhutch.org)
  • We supply purified CD34 positive cells from healthy donors. (fredhutch.org)
  • We maintain an inventory of more than 400 vials of enriched 5-10 million CD34 positive cells collected from approximately 3-4 healthy donors each month. (fredhutch.org)
Infection9
  • Recovery of cytomegalovirus (CMV)-specific immunity after hematopoietic cell transplantation (HCT) is essential in controlling CMV infection. (umn.edu)
  • For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
  • In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
  • NK cells are now accepted to play an important role in both the adaptive and innate immune responses that govern infection, autoimmunity, and tumor immunosurveillance ( 2 , 3 ). (frontiersin.org)
  • With this, why is transfusion transmissible infection (TTI) such as Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
  • Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research, said in an agency press release . (medscape.com)
  • The donor had returned from her trip 3 days before the start of G-CSF-injections without any signs of infection. (cdc.gov)
  • After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Stem cells from a donor2
Engraftment8
  • Source of engraftment determination included preferentially peripheral blood CD3 fraction, then myeloid cell fraction (CD15+), then bone marrow. (umn.edu)
  • At day +30, full donor engraftment was seen in 82% of myeloablative and 55% of RIC transplants. (umn.edu)
  • In multiple regression analysis, there was no significant association between donor engraftment (mixed or full) and incidence or control of CMV. (umn.edu)
  • The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment. (notifylibrary.org)
  • However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
  • Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
  • One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
Graft11
  • The greater the mismatch between donor and recipient, the higher the risk of graft versus host disease (GVHD). (medscape.com)
  • However, T-cell depletion is associated with higher rates of graft rejection and increased vulnerability to viral and fungal infections while the T-cell population is diminished. (medscape.com)
  • Fully matched related donors remain the preferred graft source for allo-SCT. (mhmedical.com)
  • The donor-specific antibodies remain one of the most important factors to consider because the presence of antibodies is associated with a high risk of graft failure. (mhmedical.com)
  • White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
  • African Americans and Caucasians were matched for age, donor-recipient HLA match, graft type and transplantation year. (aamds.org)
  • It primarily concentrates on finding a safe biotechnology of allogeneic stem cell graft preparation to minimize its unwanted alloreactivity leading often to lethal graft-versus-host reaction, and at the same time to preserve and potentiate its anti-tumor reactivity. (muni.cz)
  • Lack of donors and the risk of graft-versus-host disease or graft failure limits this option for many people. (aacn.org)
Mesenchymal3
  • Among the remaining cells, several different cell types are recognized, including hematopoietic stem cells, mesenchymal stem cells (MSCs), megakaryocytic precursors, and endothelial progenitors. (ebat2018.org)
  • PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Bone marrow tra1
Chemotherapy8
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • Chemotherapy drugs, such as treosulfan, fludarabine, and clofarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (fredhutch.org)
  • Giving chemotherapy and total-body irradiation before a donor hematopoietic stem cell transplant helps kill cancer cells in the body and helps make room in the patient`s bone marrow for new blood-forming cells (stem cells) to grow. (fredhutch.org)
  • Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
Abstract1
  • abstract = "PURPOSE OF REVIEW: The role of hematopoietic cell transplantation in non-malignant disorders has increased exponentially with the recognition that multiple diseases can be controlled or cured if engrafted with donor-derived cells. (wustl.edu)
Peripheral blood stem-cell3
  • In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
  • This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
  • Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
Organ donors1
  • Karnataka is to follow Tamil Nadu's organ donation policy to respect organ donors and their families and to encourage the admirable cause of organ donation. (medindia.net)
Myeloid cells1
GVHD4
Cytomegalovirus2
  • Why is Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
  • As stated in the journal article, Cytomegalovirus donor seroprevalence ranges from 40-100% across the globe. (researchgate.net)
Recipients2
  • The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
  • Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
Progenitors2
  • Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
  • 02:14 progenitors that make red blood cells. (yale.edu)
Embryonic and adult1
  • Although transcriptional similarities have been found between embryonic and adult endothelial cells, we found some key differences in term of transcription factors expression. (biorxiv.org)
Lymphocytes3
Curative1
Center of Excellence in Hematology1
  • As a lab within the Cooperative Center of Excellence in Hematology (CCEH) at Fred Hutch, Hematopoietic Cell Procurement and Processing is recognized as a leader in the field of acquisition, analysis, and enrichment of normal hematopoietic cells, this facility provides well defined and highly purified populations of cells to support the research of both internal and external investigators. (fredhutch.org)
Immune10
  • A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
  • Severe combined immune deficiency (SCID) is a life-threatening primary immunodeficiency (PI), with a combined absence of T cell and B cell function. (primaryimmune.org)
  • In the early phases of cancer immune surveillance, NK cells directly identify and lyse cancer cells. (frontiersin.org)
  • Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
  • instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)
  • However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
  • An important class of innate immune cells that play a critical role in mediating the antitumor immune response is the natural killer (NK) cell. (frontiersin.org)
  • The polymorphisms of T cell-specific TBX21 gene may contribute to the susceptibility of chronic immune thrombocytopenia in Chinese population. (cdc.gov)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
  • This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)
Matched unrelated1
  • 1 fully matched unrelated female donor was identified in the German National Registry. (cdc.gov)
Destroyed tissue an1
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)
Lymphoma5
  • Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
  • No HLA-matched (10/10 or 9/10) sibling donor or unrelated donor available NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. (knowcancer.com)
  • This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic Leukemia. (uchicagomedicine.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) was previously known as natural killer (NK) cell leukemia/lymphoma. (lls.org)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
Aplastic1
Therapeutics3
  • Efforts at using NK cells as antitumor agents began over two decades ago, but recent advances in elucidating NK cell biology have accelerated the development of NK cell-targeting therapeutics. (frontiersin.org)
  • The U.K.'s Medicines and Healthcare products Regulatory Agency on Thursday granted Vertex Pharmaceuticals and CRISPR Therapeutics conditional marketing authorization for their CRISPR/Cas9 gene-edited therapy exagamglogene autotemcel, now to carry the brand name Casgevy, for the treatment of sickle cell disease and transfusion-dependent beta thalassemia. (biospace.com)
  • Although challenges remain, investment in the field has started to bear fruit, with a number of gene and cell therapeutics reaching the market in the past decade. (bvsalud.org)
Sickle cell di1
  • This is what life is often like every day for more than 6 million people worldwide who live with sickle cell disease (SCD). (aacn.org)
Umbilical5
  • The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
  • In 407 CMV R+ subjects, 77% (n = 313) were CMV D(−) cells from umbilical cord blood (n = 209), peripheral blood (n = 58) or marrow (n = 46). (umn.edu)
  • Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
  • Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
  • Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
Recipient9
  • When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
  • Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
  • In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
  • Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
  • The harvested stem cells are processed before infusion into the recipient. (medscape.com)
  • The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
  • In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
  • However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
  • AHTR usually results from recipient plasma antibodies to donor RBC antigens. (msdmanuals.com)
Tumors3
  • There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
  • However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
  • The antitumor effect provided by natural killing has been observed in tumors of hematopoietic and non-hematopoietic origins and reported in diverse in vivo models and clinical series ( 8 ). (frontiersin.org)
Antigens3
  • The Rh system consists of over 50 red cell antigens. (medscape.com)
  • There are 5 main Rh red cell antigens-D, C, c, E, and e-that involve most clinically significant transfusion complications. (medscape.com)
  • The RhD protein has 2 clinically significant variations, "partial D"" and "weak D." Because the D antigen comprises multiple epitopes, red cells that lack components of the D antigens are often described as "partial D." Molecular studies have identified that many partial D phenotypes result from amino acid substitutions or protein segment switch on the extracellular portion of the RhD protein. (medscape.com)
Infusion1
  • She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
Blood42
  • All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. (notifylibrary.org)
  • After reddish blood cell depletion using Hetastarch and volume reduction, the cells were cryopreserved in a solution containing 5% human albumin and 10% dimethyl sulfoxide with a controlled rate freezer prior to final storage in the gas phase of a liquid nitrogen tank. (ebat2018.org)
  • Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
  • However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
  • The bone marrow produces blood cells. (medlineplus.gov)
  • Stem cells in the bone marrow give rise to all of your different blood cells. (medlineplus.gov)
  • Due to the smaller number of stem cells, blood counts take much longer to recover. (medlineplus.gov)
  • The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • During leukapheresis, blood is removed from the donor through an IV line. (medlineplus.gov)
  • The red blood cells are returned to the donor. (medlineplus.gov)
  • We provide mobilized or non-mobilized peripheral blood cells (PBC) and bone marrow (BM) products. (fredhutch.org)
  • Accurate white blood cell, red blood cell and platelet counts. (fredhutch.org)
  • Comprehensive assessment of red blood cell, white blood cell and platelet indices. (fredhutch.org)
  • Also available are freshly donated peripheral blood mononuclear cells (PBMC) and/or G-CSF mobilized peripheral blood cells (PBC), which are acquired through our healthy adult donor volunteer recruitment program. (fredhutch.org)
  • Blood-forming stem cell transplants. (mayoclinic.org)
  • Babies born with SCID lack white blood cells called T cells. (primaryimmune.org)
  • T cells not only directly attack cells infected with viruses, bacteria, or other microorganisms, but they also cause B cells, another type of white blood cell, to produce antibodies. (primaryimmune.org)
  • The newborn screening blood test can show if a baby has a low number of T cells, a sign that a baby may have SCID. (primaryimmune.org)
  • If a child's newborn screening blood test shows low T cells, try to stay calm and remember that you are not alone. (primaryimmune.org)
  • Additionally, a 11-year prospective cohort study of Japanese inhabitants linked low peripheral-blood NK cell cytotoxicity with increased cancer risk ( 12 ). (frontiersin.org)
  • The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
  • Transfusion of washed, leukocyte-poor red blood cells (RBCs) at approximately 8-15 mL RBCs per kilogram (kg) of body weight over 1-2 hours is recommended. (medscape.com)
  • 02:47 and red blood cells in vitro. (yale.edu)
  • Are you considering a blood stem cell transplant? (nih.gov)
  • Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
  • To participate in this study, you must have a disorder that compromises your body's ability to make blood cells. (nih.gov)
  • Ensure that regulatory agencies and blood transfusion services have clear guidelines and standards for donor screening, testing, and quality control. (researchgate.net)
  • Hematopoietic stem cells are crucial for the continuous production of blood cells during life. (biorxiv.org)
  • The transplantation of these cells is one of the most common treatments to cure patient suffering of blood diseases. (biorxiv.org)
  • Hematopoietic stem cells emerge from endothelial cells in blood vessels during embryogenesis through the endothelial to hematopoietic transition. (biorxiv.org)
  • However, BPDCN usually progresses with bone marrow involvement and a decrease in red blood cell, white blood cell and platelet counts. (lls.org)
  • Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
  • Individuals with the D antigen present on their red blood cells are labeled as "Rh (D)-positive. (medscape.com)
  • CONCLUSION: Our findings demonstrate that PIM cryopreservation of HPC(A) products provides recovery of CD34+ cells, CD34+ subpopulations, and CFCs similar to that of DMSO cryopreservation and therefore may have the potential to be used for cryopreservation of peripheral blood stem cells. (lu.se)
  • Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (msdmanuals.com)
  • Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (msdmanuals.com)
  • Polycythemia vera (PV) is a rare blood disease in which the bone marrow makes too many red blood cells. (cdc.gov)
  • The extra red blood cells make the blood thicker than normal. (cdc.gov)
  • This is accomplished by removal of blood through periodic phlebotomy and drug treatment to suppress red blood cell production by the bone marrow. (cdc.gov)
  • Polycythemia vera is a myeloproliferative neoplasm characterized by increased production of red blood cells and often other blood cell lines. (cdc.gov)
  • In 2005, researchers discovered a mutation in the Janus Tyrosine Kinase 2 gene (JAK2 (V617F)), which plays a pivotal role in the regulation of blood cell production (Levine et al. (cdc.gov)
Severe3
  • NK) cells (T-B-NK-SCID) and severe lymphopenia. (researchgate.net)
  • Sickle cell anemia, the most severe form of SCD, occurs when both sickle cell genes (hemoglobin S or Hb S ) are inherited from each parent. (aacn.org)
  • Hemolysis is most common and most severe when incompatible donor RBCs are hemolyzed by antibodies in the recipient's plasma. (msdmanuals.com)
Lymphocyte1
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
Precursors2
  • Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
  • Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
Acute2
  • While pain can be acute, such as in a sickle cell crisis, people with SCD can also have chronic pain. (aacn.org)
  • Hydroxyurea can help reduce an acute sickle cell episode, but it has many adverse effects that may limit its use. (aacn.org)