TransplantationGraft versusTransplantsEngraftmentProgenitor cellAutologousMalignanciesApheresisTransplantCD34ChimerismPatientsMesenchymalInfectionOrgan donorsHaploidenticalMyeloid cellsProgenitorsHSCTAplastic anemiaEmbryonic and adultLymphocytesUmbilical cordCenter of Excellence in HematologyMyeloablativeRecipientsTherapeuticsAntigensChemotherapyTissueGVHDLymphomaPrecursorsAdult donorHealthy donorSubpopulationsCytomegalovirusBlood donorsAntibodiesPBMCsRecipientEndothelial cellsTumorsCD45
Transplantation43
- Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
- Transplantation can result in granulocytopenia as well as impairment of barrier defenses, cell-mediated immunity, and humoral immunity. (medscape.com)
- In autologous transplantation, the donor and recipient is the same individual. (medscape.com)
- When the donor is someone other than the recipient, the procedure is described as allogeneic transplantation. (medscape.com)
- Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. (ca.gov)
- In utero hematopoietic cell transplantation (IUHCTx) is a promising method to induce donor-specific tolerance but the mechanisms of antigen presentation that educate host T cells and the relative importance of deletion vs. regulation in this setting are unknown. (ca.gov)
- We found that IUHCTx leads to precocious maturation of neonatal host DCs and that there is early differentiation of donor-derived DCs, even after transplantation of a stem cell source without mature APCs. (ca.gov)
- Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. (wikipedia.org)
- In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
- Recovery of cytomegalovirus (CMV)-specific immunity after hematopoietic cell transplantation (HCT) is essential in controlling CMV infection. (umn.edu)
- Association of iKIR-mismatch model and donor aKIRs with better outcome in haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia. (bvsalud.org)
- Here, we investigated the potential influence of KIR mismatch and KIR alleles on the outcome of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in acute myeloid leukemia (AML) patients . (bvsalud.org)
- PURPOSE OF REVIEW: The role of hematopoietic cell transplantation in non-malignant disorders has increased exponentially with the recognition that multiple diseases can be controlled or cured if engrafted with donor-derived cells. (wustl.edu)
- RECENT FINDINGS: Stem cell sources, novel transplant methods, and sophisticated supportive care have simultaneously made giant strides toward improving the safety and efficacy of hematopoietic cell transplantation. (wustl.edu)
- SUMMARY: This review presents the progress made in the realm of hematopoietic cell transplantation for non-malignant disorders. (wustl.edu)
- Allogeneic stem cell transplantation (allo-SCT) remains the only curative intervention for a variety of high-risk hematologic malignancies. (mhmedical.com)
- Haploidentical stem cell transplantation (HaploSCT) from a first-degree related mismatched haplotype donor (siblings, children, parents) extends the application of this lifesaving treatment to a large proportion of patients with high-risk hematologic malignancies who otherwise do not have a suitable human leukocyte antigen (HLA)-matched donor. (mhmedical.com)
- Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
- An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
- Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
- Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
- Determine the feasibility and efficacy of a reduced-intensity conditioning regimen comprising alemtuzumab, fludarabine, melphalan, and thiotepa followed by allogeneic peripheral blood stem cell transplantation (PBSCT) in patients with hematologic malignancies. (knowcancer.com)
- Allogeneic peripheral blood stem cell (PBSC) transplantation: Patients undergo allogeneic PBSC transplantation on day 0. (knowcancer.com)
- This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
- The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
- A new study published in the American Journal of Transplantation reports there is no evidence of children between 6 and 11 years of age being at a disadvantage if they are seeking deceased donor lung transplant in the current US lung allocation system. (medindia.net)
- Preferred Term is Hematopoietic stem cell transplantation. (medindia.net)
- Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
- How to perform hematopoietic stem cell transplantation. (mayoclinic.org)
- Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
- Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
- Subsequent transplantation of the cells into lethally irradiated mice results in engraftment of the animals with donor haematopoietic tissue containing the bacterial gene. (nature.com)
- Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) and potential alternative for bone marrow transplantation for patients who lack human leukocyte antigen (HLA)-matched donors. (wjgnet.com)
- Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research, said in an agency press release . (medscape.com)
- Adverse events are consistent with allogeneic hematopoietic stem cell transplantation . (medscape.com)
- The transplantation of these cells is one of the most common treatments to cure patient suffering of blood diseases. (biorxiv.org)
- Although the number of transplants each year has grown rapidly over the past two decades, the demand for transplantation using human cells, tissues and organs has also increased significantly, resulting in a continuing shortage of human material, particularly organs. (who.int)
- As few countries are approaching self- sufficiency in the provision of cells, tissues and organs for transplantation, new ways continue to be sought to increase the donation of human material. (who.int)
- 874 genetic polymorphisms in allogeneic hematopoietic stem cell transplantation]. (cdc.gov)
- Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation. (cdc.gov)
- The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)
- The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
- Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Graft versus6
- The greater the mismatch between donor and recipient, the higher the risk of graft versus host disease (GVHD). (medscape.com)
- Also, the incidence of patients experiencing rejection is very rare (and graft-versus-host disease impossible) due to the donor and recipient being the same individual. (wikipedia.org)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
- Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
- The main practical advantages of UCB over other HSC sources are the immediate availability, lower incidence of graft-versus-host disease, minimal risk to the donor, and lower requirement for HLA compatibility. (wjgnet.com)
- The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
Transplants11
- Donors for allogeneic transplants may be related or unrelated to the recipient. (medscape.com)
- In syngeneic transplants, the donor is the identical twin of the recipient. (medscape.com)
- Allogeneic transplants are further categorized by the degree of human leukocyte antigen (HLA) match between the donor and recipient. (medscape.com)
- Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
- At day +30, full donor engraftment was seen in 82% of myeloablative and 55% of RIC transplants. (umn.edu)
- This review provides an overview of advances made in alternative donor transplants for nonmalignant disorders. (wustl.edu)
- It advocates the consideration of alternative donor transplants in the absence of human leukocyte antigen matched siblings when indicated by disease severity. (wustl.edu)
- Younger donors, male donors, fathers rather than mothers, and first-degree to second-degree donors are preferred graft sources for recipients of haploidentical transplants. (mhmedical.com)
- GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
- Blood-forming stem cell transplants. (mayoclinic.org)
- The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
Engraftment8
- We hypothesize that mixed donor engraftment as measured by chimerism at day 30 in CMV D(+) HCTs and full chimerism in CMV D(−) HCTs will be predictive of CMV reactivation. (umn.edu)
- Source of engraftment determination included preferentially peripheral blood CD3 fraction, then myeloid cell fraction (CD15+), then bone marrow. (umn.edu)
- The cumulative incidence of CMV infection 1-year after transplant was not different in patients with full (54%, n = 276) or mixed (53%, n = 131) donor engraftment. (umn.edu)
- In multiple regression analysis, there was no significant association between donor engraftment (mixed or full) and incidence or control of CMV. (umn.edu)
- However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
- There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
- Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
- One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
Progenitor cell10
- Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
- Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
- For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
- Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
- For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
- Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
- For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
- Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
- We therefore investigated whether Pentaisomaltose (PIM), a low-molecular-weight carbohydrate (1 kDa), can be used for cryopreservation of peripheral blood stem cells, more specifically hematopoietic progenitor cell apheresis (HPC(A)) product. (lu.se)
- We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
Autologous3
- It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
- Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
- of these, 53 percent are autologous (taken from the patient) and 47 percent are allogenic (taken from a donor other than the patient). (drugdiscoverynews.com)
Malignancies5
- The CCEH Hematopoietic Cell Procurement and Processing Core maintains and gives access to a Repository of Cryopreserved Specimens consisting of large quantities of PBC components obtained from normal donors or patients with a variety of malignancies and limited quantities of normal bone marrow. (fredhutch.org)
- Examples of secondary immunodeficiency include HIV infection, hematopoietic malignancies, treatment with radiation, and treatment with immunosuppressive drugs. (cdc.gov)
- Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
- There is also a small risk of infections and malignancies from donor blood. (medscape.com)
- BACKGROUND: Cryopreserved hematopoietic stem cell products are widely used for certain hematologic malignancies. (lu.se)
Apheresis1
- T cell preparation: Patients and donors undergo apheresis to obtain peripheral blood mononuclear cells (PBMCs), which are expanded in culture. (knowcancer.com)
Transplant22
- The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
- This has led to the utilization of marrow, cord, peripheral blood stem cell and haploidentical stem cell sources, and novel reduced toxicity or reduced intensity conditioning regimens to transplant non-malignant disorders such as immune dysfunctions, marrow failure syndromes, metabolic disorders and hemoglobinopathies. (wustl.edu)
- This phase II trials studies the effect of treosulfan-based versus clofarabine-based conditioning regimens before donor hematopoietic stem cell transplant in treating patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. (fredhutch.org)
- Giving chemotherapy and total-body irradiation before a donor hematopoietic stem cell transplant helps kill cancer cells in the body and helps make room in the patient`s bone marrow for new blood-forming cells (stem cells) to grow. (fredhutch.org)
- This study may help doctors determine whether treosulfan-based or clofarabine-based conditioning regimen works better before donor hematopoietic stem cell transplant in treating patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia. (fredhutch.org)
- A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
- The stem cells are frozen and stored until they are needed for a transplant. (medlineplus.gov)
- Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
- A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
- At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
- The researchers analyzed information from the Scientific Registry of Transplant Recipients, which includes data on all donors, wait-listed candidates, and transplant recipients in the United States. (medindia.net)
- Opportunities for improvement include bringing the lung donor yield in the 0-11 age group closer to the yield in adolescents, relaxing geographic allocation boundaries to ensure that pediatric lungs are offered first to children, and reserving deceased donor lobar transplant for circumstances where suitably sized donor organs are not available," they wrote. (medindia.net)
- A vaccine that stimulates CD8 T regulatory cells helps to prevent self-destructive immune reactions in autoimmune diseases and organ transplant rejection. (medindia.net)
- http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
- [ 14 ] The first successful allogeneic stem cell transplant from an HLA-identical sibling donor was reported in 1982. (medscape.com)
- Are you considering a blood stem cell transplant? (nih.gov)
- This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
- Have you received a stem cell transplant? (nih.gov)
- This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
- Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
- Both meetings agreed minimum criteria for suitability of live donors and defined the obligations of transplant professionals to treat donors as patients, including that of providing appropriate follow-up and treatment for problems caused by the donation. (who.int)
- Likewise, commercial trade in cells, tissues and organs - and even trafficking involving human beings who are kidnapped or lured into other countries where they are forced to be "donors" - continues to be a serious problem, particularly in countries with substantial transplant tourism. (who.int)
CD348
- We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)
- CD34 + cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. (hindawi.com)
- EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
- In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
- Colony Forming Cell (CFU) Assay CD34+ cells were selected from HPDSCs with a human CD34 positive selection kit and isolated using automated cell separator RoboSep (StemCell Technologies, Inc., Vancouver, Canada). (ebat2018.org)
- We maintain an inventory of millions of enriched CD34 positive cells available for projects. (fredhutch.org)
- We supply purified CD34 positive cells from healthy donors. (fredhutch.org)
- We maintain an inventory of more than 400 vials of enriched 5-10 million CD34 positive cells collected from approximately 3-4 healthy donors each month. (fredhutch.org)
Chimerism1
- Split mixed donor chimerism has corrected the immunological defect. (frontiersin.org)
Patients16
- The number and function of proangiogenic cells are impaired in patients with diabetes or cardiovascular diseases. (hindawi.com)
- Patients with RLM and the highest number of donor aKIRs had the lowest RR, lowest incidence of aGVHD and best OS. (bvsalud.org)
- The synergistic effects of RLM and donor aKIRs can provide a better donor selection strategy to improve haplo-HSCT outcome in AML patients . (bvsalud.org)
- Haploidentical grafts from a first-degree related mismatched donor extends the applicability of this lifesaving treatment to a large proportion of patients who otherwise do not have a suitable human leukocyte antigen-matched donor. (mhmedical.com)
- [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
- Determine the safety of LMB-2 immunotoxin-treated, selectively-depleted donor T cells, administered after allogeneic PBSCT, in these patients. (knowcancer.com)
- Patients' PBMCs are irradiated and mixed with donor PBMCs. (knowcancer.com)
- LMB-2 immunotoxin-treated, selectively-depleted donor T cells: Patients receive LMB-2 immunotoxin-treated, selectively-depleted donor T cells IV over 30-60 minutes on approximately day 28. (knowcancer.com)
- Cohorts of 3-6 patients receive escalating dose of LMB-2 immunotoxin-treated, selectively-depleted donor T cells until the maximum tolerated dose (MTD) is determined. (knowcancer.com)
- This is a single arm, open-label, multi-center, Phase 1 study to determine the safety and tolerability of an experimental therapy called NKX019 (allogeneic CAR NK cells targeting CD19) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL), chronic lymphocytic. (uchicagomedicine.org)
- Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
- This is a non-therapeutic study for patients at St. Jude Children's Research Hospital and Methodist Adult Comprehensive Sickle Cell Center . (stjude.org)
- The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
- Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
- Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
- the JAK2 mutation, the presence of the mutation has become an important diagnostic criterion for identifying patients with PV and for reducing the potential for misdiagnosis of persons with elevated red blood cell counts. (cdc.gov)
Mesenchymal3
- Among the remaining cells, several different cell types are recognized, including hematopoietic stem cells, mesenchymal stem cells (MSCs), megakaryocytic precursors, and endothelial progenitors. (ebat2018.org)
- PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
- Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Infection5
- For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
- In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
- NK cells are now accepted to play an important role in both the adaptive and innate immune responses that govern infection, autoimmunity, and tumor immunosurveillance ( 2 , 3 ). (frontiersin.org)
- With this, why is transfusion transmissible infection (TTI) such as Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
- genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Organ donors1
- Karnataka is to follow Tamil Nadu's organ donation policy to respect organ donors and their families and to encourage the admirable cause of organ donation. (medindia.net)
Haploidentical2
- Haploidentical use has taken precedence compared with some other alternative donor sources given its immediate availability and cost-effectiveness. (mhmedical.com)
- Several factors are considered when choosing the best haploidentical donor. (mhmedical.com)
Myeloid cells1
- In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
Progenitors2
- Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
- 02:14 progenitors that make red blood cells. (yale.edu)
HSCT2
- Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
- Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
Aplastic anemia1
- Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
Embryonic and adult1
- Although transcriptional similarities have been found between embryonic and adult endothelial cells, we found some key differences in term of transcription factors expression. (biorxiv.org)
Lymphocytes3
- In both cell sources, greater than 80% of the cells are lymphocytes, monocytes, or granulocytes. (ebat2018.org)
- First described in 1975, NK cells were initially identified as a distinct sub-population of lymphocytes by their capacity to spontaneously lyse tumor cells ( 1 ). (frontiersin.org)
- B and T lymphocytes, CD4+ B lymphocytes versus CD8+ T lymphocytes), and tests that measure T-cell proliferation or function in response to specific or nonspecific stimuli (e.g., lymphocyte proliferation assays) ( 4,5 ). (cdc.gov)
Umbilical cord3
- The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
- In 407 CMV R+ subjects, 77% (n = 313) were CMV D(−) cells from umbilical cord blood (n = 209), peripheral blood (n = 58) or marrow (n = 46). (umn.edu)
- Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
Center of Excellence in Hematology1
- As a lab within the Cooperative Center of Excellence in Hematology (CCEH) at Fred Hutch, Hematopoietic Cell Procurement and Processing is recognized as a leader in the field of acquisition, analysis, and enrichment of normal hematopoietic cells, this facility provides well defined and highly purified populations of cells to support the research of both internal and external investigators. (fredhutch.org)
Myeloablative1
- Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
Recipients1
- Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
Therapeutics2
- Efforts at using NK cells as antitumor agents began over two decades ago, but recent advances in elucidating NK cell biology have accelerated the development of NK cell-targeting therapeutics. (frontiersin.org)
- Although challenges remain, investment in the field has started to bear fruit, with a number of gene and cell therapeutics reaching the market in the past decade. (bvsalud.org)
Antigens4
- The Rh system consists of over 50 red cell antigens. (medscape.com)
- There are 5 main Rh red cell antigens-D, C, c, E, and e-that involve most clinically significant transfusion complications. (medscape.com)
- The RhD protein has 2 clinically significant variations, "partial D"" and "weak D." Because the D antigen comprises multiple epitopes, red cells that lack components of the D antigens are often described as "partial D." Molecular studies have identified that many partial D phenotypes result from amino acid substitutions or protein segment switch on the extracellular portion of the RhD protein. (medscape.com)
- AHTR usually results from recipient plasma antibodies to donor RBC antigens. (msdmanuals.com)
Chemotherapy4
- The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
- Chemotherapy drugs, such as treosulfan, fludarabine, and clofarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (fredhutch.org)
- Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
- After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
Tissue7
- The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood-cell production. (wikipedia.org)
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
- The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
- An infectious retrovirus vector has been used to transfer a bacterial gene encoding resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells present in explanted murine bone marrow tissue. (nature.com)
- NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
- Thymus tissue is obtained from donors less than or equal to 9 months of age undergoing cardiac surgery. (rxlist.com)
- The manufacturing process preserves the thymic epithelial cells and tissue structure and depletes most of the donor thymocytes from the tissue. (rxlist.com)
GVHD2
- In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
- GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
Lymphoma3
- No HLA-matched (10/10 or 9/10) sibling donor or unrelated donor available NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. (knowcancer.com)
- This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic Leukemia. (uchicagomedicine.org)
- Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
Precursors3
- Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
- Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
- Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
Adult donor1
- Also available are freshly donated peripheral blood mononuclear cells (PBMC) and/or G-CSF mobilized peripheral blood cells (PBC), which are acquired through our healthy adult donor volunteer recruitment program. (fredhutch.org)
Healthy donor1
- After collecting a blood sample from a healthy donor, researchers treat the red blood cells with a B vitamin called biotin and then store the sample. (nih.gov)
Subpopulations4
- We collect and enrich subpopulations of hematopoietic cells. (fredhutch.org)
- STUDY DESIGN AND METHODS: We cryopreserved patient or donor HPC(A) products using 10% DMSO or 16% PIM and quantified the recovery of CD34+ cells and CD34+ subpopulations by multicolor flow cytometry. (lu.se)
- The distribution of CD34+ cell subpopulations was similar when comparing DMSO or PIM as CPA. (lu.se)
- CONCLUSION: Our findings demonstrate that PIM cryopreservation of HPC(A) products provides recovery of CD34+ cells, CD34+ subpopulations, and CFCs similar to that of DMSO cryopreservation and therefore may have the potential to be used for cryopreservation of peripheral blood stem cells. (lu.se)
Cytomegalovirus2
- Why is Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
- As stated in the journal article, Cytomegalovirus donor seroprevalence ranges from 40-100% across the globe. (researchgate.net)
Blood donors1
- This study is evaluating how blood donors affect the stability of stored red blood cells. (nih.gov)
Antibodies4
- The donor-specific antibodies remain one of the most important factors to consider because the presence of antibodies is associated with a high risk of graft failure. (mhmedical.com)
- T cells not only directly attack cells infected with viruses, bacteria, or other microorganisms, but they also cause B cells, another type of white blood cell, to produce antibodies. (primaryimmune.org)
- Hemolysis is most common and most severe when incompatible donor RBCs are hemolyzed by antibodies in the recipient's plasma. (msdmanuals.com)
- Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (msdmanuals.com)
PBMCs1
- LMB-2 immunotoxin is added to the PBMCs in order to selectively deplete T cells from the donor PBMCs. (knowcancer.com)
Recipient3
- The harvested stem cells are processed before infusion into the recipient. (medscape.com)
- The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
- In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. (medindia.net)
Endothelial cells7
- Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
- Neither AT alone in control media nor conditioned media nor AT-stimulated cells affected numbers of endothelial cells in the plug or plug's vascularization. (hindawi.com)
- The process of neovascularization can be influenced not only by the residual endothelial cells but also by the circulating cells. (hindawi.com)
- Hematopoietic stem cells emerge from endothelial cells in blood vessels during embryogenesis through the endothelial to hematopoietic transition. (biorxiv.org)
- Here, we used single-cell transcriptomics analysis to compare embryonic and post-natal endothelial cells to investigate the potential of adult vasculature to be reprogrammed in hematopoietic stem cells. (biorxiv.org)
- There is a deficit of expression of Runx1, Tal1, Lyl1 and Cbfb in adult endothelial cells compared to their embryonic counterparts. (biorxiv.org)
- Using a combination of gene expression profiling and gene regulatory network analysis, we found that endothelial cells from the pancreas, brain, kidney and liver appear to be the most suitable targets for cellular reprogramming into hematopoietic stem cells. (biorxiv.org)
Tumors4
- There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
- However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
- However, a class of important immune-modulators is conspicuously absent: agents that utilize the power of innate immune cells to eradicate tumors. (frontiersin.org)
- The antitumor effect provided by natural killing has been observed in tumors of hematopoietic and non-hematopoietic origins and reported in diverse in vivo models and clinical series ( 8 ). (frontiersin.org)
CD451
- Specifically, a subpopulation of cells with a phenotype of CD34+/CD45? (ebat2018.org)