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  • antigens
  • Limiting dilution analysis was used to assess helper-T-lymphocyte reactivity to donor antigens. (harvard.edu)
  • MHC-Restricted cytotoxic T-Cell: studies on the biological role of polymorphic major transplantation antigens determining t-cell restriction specificity, function, and responsiveness. (springer.com)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • HLA-identical siblings or HLA-identical unrelated donors often have genetically different proteins (called minor histocompatibility antigens) that can be presented by Major histocompatibility complex (MHC) molecules to the donor's T-cells, which see these antigens as foreign and so mount an immune response. (wikipedia.org)
  • body's
  • While StemRad is forthcoming about the fact that its product does not protect all of the body's bone marrow and that some radiation may enter the shielded region, it is claimed that the product can save the life of an individual even at very high doses of gamma radiation based on the unique regenerative potential of marrow tissue. (wikipedia.org)
  • cord blood
  • To facilitate the exchange of information and improve business relations, the WMDA provides access to contact data of organisations that are listing donors or cord blood products in the global database of Bone Marrow Donors Worldwide. (wikipedia.org)
  • Search & Match tool: The BMDW provides a fast preliminary search tool to find the best matched stem cell donor or cord blood unit for a patient in need of a transplant. (wikipedia.org)
  • tissue
  • Distribution of lipid formulations of amphotericin B into bone marrow and fat tissue in rabbits. (semanticscholar.org)
  • Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected. (wikipedia.org)
  • The human tissue endowed with the most regenerative potential is bone marrow. (wikipedia.org)
  • It is well documented that upon human exposure to gamma radiation doses of up to 10 Gy (median lethal dose= 4 Gy), the life-limiting factor is damage sustained by the bone marrow tissue. (wikipedia.org)
  • clinical
  • A number of clinical trials have proved the superiority of this method over collection from the bone marrow. (medscape.com)
  • John Raymond Hobbs MRCS, FRCP, FRCPath, FRCPaed (17 April 1929 - 13 July 2008) was a professor who was at the forefront of the techniques of clinical immunology, protein biochemistry and bone marrow transplantation, specifically in child health. (wikipedia.org)
  • adults
  • As for the children who were treated by Professor Hobbs's bone marrow team at the Westminster hospital, most of these children now enjoy full lives as adults. (wikipedia.org)
  • Bone marrow failure in both children and adults can be either inherited or acquired. (wikipedia.org)
  • Inherited bone marrow failure is often the cause in young children, while older children and adults may acquire the disease later in life. (wikipedia.org)
  • inborn
  • However, in situations where the recipient is immunocompromised (inborn immunodeficiency, acquired immunodeficiency, malignancy), or when the donor is homozygous and the recipient is heterozygous for an HLA haplotype (as can occur in directed donations from first-degree relatives), the recipient's immune system is not able to destroy the donor lymphocytes. (wikipedia.org)