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  • acute
  • Transfusion-related acute lung injury (TRALI) is an uncommon syndrome that is due to the presence of leukocyte antibodies in transfused plasma. (diff.org)
  • Donor antibodies to patient WBCs can lead to transfusion-related acute lung injury (TRALI) characterized by respiratory failure, hypoxemia, hypotension, fever, and bilateral pulmonary edema. (clinicaladvisor.com)
  • endothelial
  • Histopathology in these patients is again related to endothelial injury mediated by antibodies but is less severe than that seen in hyperacute rejections. (hindawi.com)
  • For the Specular Microscopy Ancillary Study, endothelial cell counts were determined from specular images by a central reading center, and the relationship of the cell counts to donor age were assessed. (bioportfolio.com)
  • Of perhaps even greater importance, however, was the finding that irrespective of donor age, endothelial cell loss was substantial over the first five years after transplant even when the graft had been successful. (bioportfolio.com)
  • graft
  • Viable donor lymphocytes in RBC or platelet products can engraft in susceptible patients and cause fever, erythroderma, maculopapular rash, anorexia, nausea/vomiting, diarrhea, hepatitis, and pancytopenia (transfusion-associated graft-vs-host disease). (clinicaladvisor.com)
  • The CDS will continue and patients will be followed annually through 2012 in order to to determine the overall 10-year survival rate for moderate risk grafts and to determine whether the graft-failure rate is related to donor age. (bioportfolio.com)
  • TRALI
  • To reduce the risk of antibody-mediated TRALI, donors with a possibility of having HLA or HNA antibodies either because of a history of pregnancy or transfusion are not used for plasma products or apheresis platelets. (transfusion.com.au)
  • To further reduce the TRALI risk associated with apheresis platelets the Blood Service has moved to a plateletpheresis panel comprised of male donors and female donors who have never been pregnant (nulligravida). (transfusion.com.au)
  • stem
  • If the stem cell donor is not an absolutely perfect match, HLA antibodies can attack the donated stem cells and may make the patient's body reject them. (seattlecca.org)
  • In this study, stem cells that are obtained from a partially-matched donor will be highly purified using the investigational CliniMACS® stem cell selection device in an effort to achieve specific T cell target values. (clinicaltrials.gov)
  • patient's
  • If it happens that there are no close HLA matches within the patient's family, an unrelated search can be initiated in order to find an unrelated volunteer donor with the same HLA molecules as the patient. (seattlecca.org)
  • tissues
  • First of all, I wanted to find a way to detect antibodies in transplanted patients, but at that time, I had no ability to work on human tissues. (asts.org)
  • Compatibility is determined through matching of different blood group systems, the most important of which are the ABO and Rh system, and/or by directly testing for the presence of antibodies against a sample of donor tissues or blood. (laboratoryinfo.com)
  • diagnosis
  • Prior to the routine use of C4d-staining, diagnosis was often limited by lack of staining for antibody components and was often restricted to steroid-resistant cases with or without obvious histopathologic findings as described above. (hindawi.com)
  • Blood
  • Alternatively, FNHTR can be mediated by pre-formed cytokines in the donor plasma as a consequence of white blood cell breakdown. (wikipedia.org)
  • This stratagem was first introduced in 2007 and since July 2012, 100% of FFP and cryoprecipitate issued by the Blood Service has come from male donors. (transfusion.com.au)
  • This change was introduced during the 2014/15 financial year and since July 2016 100% of apheresis platelets issued by the Blood Service have been from male or nulligravida female donors. (transfusion.com.au)
  • present
  • The assigned MFI value does glean some information on the amount of antibody present and various studies show an association between MFI and outcome, albeit a generally weak association. (ajkdblog.org)
  • particular
  • In addition to measuring how much or how little PRA a patient has, we can also test if a patient has antibody to a particular HLA molecule. (seattlecca.org)