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  • Patients
  • Scientists from the University of Cambridge's Institute for Medical Research obtained skin cells from 10 patients-seven who had various forms of inherited liver disease, and three healthy controls. (scientificamerican.com)
  • BOSTON--A stem cell transplant (SCT) from a compatible donor early in the course of disease is the best approach for the majority of young and middle-aged adult patients with acute myeloid leukemia (AML), according to a new analysis of two dozen clinical studies. (bio-medicine.org)
  • For all AML patients other than the minority with "good-risk" disease, SCT from a compatible donor significantly improves survival, making it the preferred approach, the authors state. (bio-medicine.org)
  • Traditionally, the treatment offered to patients has largely been based on a chromosome analysis of their AML cells. (bio-medicine.org)
  • For patients with intermediate-risk disease, who account for nearly half of all adult AML patients, allogeneic transplant in first remission proved to be the most effective strategy, the investigators found. (bio-medicine.org)
  • These results indicate that HAPLO is associated with better GRFS and lower aGvHD compared to UCBT in patients with sAML and that UCBT can be a valid alternative for sAML patients who lack a matched sibling, a proper haploidentical or an unrelated donor. (nih.gov)
  • Some patients also develop antibodies to red blood cells and platelets, which then leads to anemia and thrombocytopenia. (thefreedictionary.com)
  • The good news is that this ruling should free up more funding for adult stem cell research -- which is legal, uncontroversial and already helping treat thousands of patients. (frcblog.com)
  • Italian doctors used patients' own adult stem cells to grow new corneal tissue to restore sight to people blinded by chemical burns, including one patient who had been blind for 50 years. (frcblog.com)
  • The 191 patients treated with their own bone marrow adult stem cells showed significant improvement in heart function, with decreased death and no side effects. (frcblog.com)
  • Doctors used cadaver windpipes stripped of their cells, bathed the cartilage with the patients' bone marrow stem cells and then transplanted the reconstructed windpipes. (frcblog.com)
  • The scientists said regarding adult stem cell treatments, "Patients who otherwise would have died from their disease can often now be cured. (frcblog.com)
  • Adult stem cells provide tangible results to patients today. (freerepublic.com)
  • Heart Disease - 'Four out of five seriously sick Brazilian heart-failure patients no longer needed a heart transplant after being treated with their own stem cells. (freerepublic.com)
  • Heart Disease - Patients with heart failure experienced a marked improvement after being given injections of their own stem cells, thanks to research at the University of Pittsburgh. (freerepublic.com)
  • Multiple Sclerosis (MS) Thirty-six-year old Susan Stross is one of more than 20 MS patients whose conditions have remained steady or improved after receiving an adult stem cell transplant. (freerepublic.com)
  • Speaking on the occasion Dr. Sunil Bhat said, "We have a number of patients suffering from fatal blood disorders like blood cancer and Thalassemia among others for which the last resort is blood stem cell transplant. (medindia.net)
  • vivo
  • Efforts to increase stem cell content or engraftment rate of the graft by ex vivo expansion, modulation by molecules such as fucose, prostaglandin E2 derivative, complement CD26 inhibitors, or CXCR4/CXCL12 axis have been able to accelerate engraftment speed and rate. (frontiersin.org)
  • Ex vivo adult stem cells isolated from aged donors display characteristic features of both chronological and replicative aging. (biomedcentral.com)
  • recipients
  • As per the registry protocol, the identity of donors and recipients is kept anonymous for one year. (medindia.net)
  • The donors and recipients in this study were haplo-mismatched, yet successful engraftment was achieved and graft-versus-host disease (GVHD) was avoided. (bio-medicine.org)
  • scientists
  • Some scientists are now lauding the results of a report published in April in Circulation as "undeniable evidence" against the idea that resident stem cells can give rise to new cardiomyocytes. (the-scientist.com)
  • Other scientists note that stem cells may not need to become new myocytes to help repair the injured heart. (the-scientist.com)
  • According to Phillip Yang , a cardiologist at Stanford University who did not take part in the work, many scientists now agree that stem cells are not regenerating damaged cardiomyocytes. (the-scientist.com)
  • Scientists and stem cell research supporters were shocked by the ruling. (emaxhealth.com)
  • In August, University of Minnesota scientists transplanted donor adult stem cells into children with a fatal genetic skin disease and repaired the damage. (frcblog.com)
  • scientists have developed cell lines from people with different disorders, such as Parkinson's. (technologyreview.com)
  • Acute
  • Study IDs benefit of donor SCT for adults with acute myeloi. (bio-medicine.org)
  • Within a year of registering he received a call from DATRI informing him that he was a perfect match for a 6 year old suffering from an acute form of Thalassemia and required a blood stem cell transplant urgently. (medindia.net)
  • endogenous
  • Still, the concept of endogenous cardiac stem cells remained a mainstream idea until Molkentin and his colleagues published a study in 2014 reporting that c-kit cells in the adult mouse heart almost never produced new cardiomyocytes, says Bin Zhou , a cell biologist at the Chinese Academy of Sciences and a coauthor of the new study. (the-scientist.com)
  • research
  • One problem in liver research is that no one is able to grow liver cells in the lab,' says the study's lead author, Sheikh Tamir Rashid. (scientificamerican.com)
  • This research establishes that macrophages can cause disease as opposed to current dogma which asserts that the purpose of these cells is benevolent, solely to assist in fighting disease," said the study's lead investigator, Michael S. McGrath, MD, PhD, UCSF professor of laboratory medicine at UCSF's Positive Health Program at San Francisco General Hospital Medical Center (SFGHMC). (bio-medicine.org)
  • StemCellResearchFacts.org is committed to educate about adult stem cell clinical trials and treatments which are validated by published research and approved by the U.S. FDA or similar international agencies. (stemcellresearchfacts.org)
  • C ardiac stem cell research has a turbulent history. (the-scientist.com)
  • Research involving embryonic stem cells is usually conducted with four to five day old embryos created from in-vitro fertilization and ultimately discarded from fertility clinics. (emaxhealth.com)
  • The first executive branch move to block federal funding for the creation of embryos for stem cell research came in 1994 under President Bill Clinton. (emaxhealth.com)
  • This position was reinforced by President George W. Bush, who, in August 2001, strengthened the ban on federal funding by barring federal funds for research on all but a few existing embryonic stem cell lines. (emaxhealth.com)
  • Under Obama's order, the administration allowed financing of research into any embryonic stem cell lines that either were allowed by the Bush administration or had been created using embryos discarded after fertilization procedures and in which donors had given clear consent for the embryos to be used for research purposes. (emaxhealth.com)
  • Those against the use of embryonic cells for research were pleased. (emaxhealth.com)
  • MELBOURNE, April 18, 2007 (LifeSiteNews.com) - A man's vision has been restored by a corneal patch grown from adult stem cells by a team at the University of Melbourne's Centre for Eye Research Australia (CERA) and the Bernard O'Brien Institute of Microsurgery (BOBIM). (freerepublic.com)
  • Beneficiaries of any research derived from embryonic stem cells actually have more in common, morally, with Bram Stoker s Dracula, who requires the blood of unwilling victims to survive. (freerepublic.com)
  • One of the hottest debates in bioethics today surrounds research using stem cells taken from either in vitro fertilization or cloned human embryos. (freerepublic.com)
  • Fortunately, there are alternative sources of stem cells for research that do not require the destruction of human life. (freerepublic.com)
  • The Pontifical Council for Culture is organizing a conference on adult stem-cell research. (catholicculture.org)
  • Robin Smith, the chief executive of NeoStem, said that the research using adult stem cells "has the potential to alleviate human suffering by unlocking the healing power of the human body. (catholicculture.org)
  • Philadelphia, PA) Neural stem cells, transplanted into injured brains, survive, proliferate, and improve brain function in laboratory models according to research based at the University of Pennsylvania School of Medicine. (bio-medicine.org)
  • characteristic
  • When the team compared three of the disease-specific cultures with the cells generated from the healthy controls, they discovered that the diseased cells had many of the key molecular defects characteristic of the original donors' liver disorder. (scientificamerican.com)
  • therapy
  • MEDS ) announced today peer-reviewed publication of its data on what is believed to be the first "combination therapy" adult stem cell protocol for spinal cord injury. (marketwired.com)
  • The patient was injected with a combination universal donor stem cell therapy in November of 2008, and January and July of 2009. (marketwired.com)
  • The findings, published in the October edition of the journal Neurosurgery, suggest that stem cells could provide the first clinical therapy to treat traumatic brain injuries. (bio-medicine.org)
  • destroy embryos
  • Although the administration claims the rules abided by the Dickey-Wicker Amendment because the federal money would only be used once the stem cells were created and would not finance the process to destroy embryos, Judge Lamberth disagreed. (emaxhealth.com)
  • The same fatal process to collect human embryonic stem cells is also used to destroy embryos formed by in vitro fertilization. (freerepublic.com)
  • human
  • This proof-of-principle study shows 'for the first time…that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,' the authors wrote in their paper , published online in The Journal of Clinical Investigation August 25. (scientificamerican.com)
  • Nonparenchymal epithelial (NPE) cells were isolated from samples of human liver resections located at a distance from the lesion that motivated the operation and were cultured and characterized. (wiley.com)
  • Speculation regarding the scientific promise of human embryonic stem cells leads some to dismiss the ethical questions raised by the embryo's destruction. (freerepublic.com)
  • However, embryonic stem cells (human or animal) have not cured or treated a single human patient. (freerepublic.com)
  • study
  • The study, published Aug. 5 in Cell Stem Cell, showed for the first time that adult blood stem cells can be regulated to overcome an immune response that leads to transplant rejection. (technologynetworks.com)
  • It also opens up further studies in stem cell immunology, said Dr. Chengcheng "Alec" Zhang, assistant professor of physiology and developmental biology at UT Southwestern and senior author of the study. (technologynetworks.com)
  • Brain stem cells in people with the most severe form of multiple sclerosis look much older than they really are, according to a new study. (technologynetworks.com)
  • My wife, Karen, she, when I proposed the idea of me doing this stem cell study, she was really kind of concerned. (stemcellresearchfacts.org)
  • For years people have wondered why we have mast cells when they seem to do nothing but cause misery for people with allergy and asthma," said microbiologist Soman Abraham, lead investigator of the study. (bio-medicine.org)
  • Findings from this study will contribute to the understanding of how cholesterol/CAV-1/caveolae regulates aspects of the cell membrane important to cell adhesion, substrate sensing, and microenvironment interaction. (springer.com)
  • This study also provides further support for our belief that purified stem cells may make it possible to use un-matched donors, such as a parent or non-identical sibling, for a variety of HSC treatment procedures. (bio-medicine.org)
  • progenitors
  • For example, they noted that the method, which involved tagging c-kit-expressing cells and their progeny with a fluorescent marker, compromised the gene required to express the c-kit protein, impairing the progenitors' regenerative abilities. (the-scientist.com)
  • vitro
  • SKPs have the potential to produce in vitro cell types normally not found in the skin, such as neuronal cells. (rupress.org)
  • liver
  • The new liver cells created from this patient also lacked the proper machinery to take up LDL. (scientificamerican.com)
  • Cultures representing two other hereditary liver diseases, alpha 1-antitrypsin deficiency (a protein-folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder-specific abnormalities. (scientificamerican.com)
  • markers
  • Outcomes of individuals with CLL are complicated by the absence or presence of a variety of cell markers, such as IGHV, CD38, and ZAP70, as well as specific gene changes. (healthline.com)
  • These cells were tested for their surface markers and multilineage differentiation capability. (pubmedcentralcanada.ca)