• The fragment contained full-length ketosythase (KS) and acyl transferase (AT) domains, and the linkers that are part of the polyketide chain elongation process. (stanford.edu)
  • The distance is too large to be traversed by the long arm of a statically positioned acyl carrier protein, needed to ferry growing polyketides along the synthase backbone. (stanford.edu)
  • Acyl hydrolase (AH) domains are a common feature of trans-AT PKSs. (worktribe.com)
  • Clear preference towards short, linear acyl-ACPs is shown, with acetyl-ACP the best substrate. (worktribe.com)
  • Tries to crystallize the YchM STAS area resulted in spontaneous co-crystallization with acyl carrier proteins (ACP) liganded with malonyl coA (Babu et al. (exposed-skin-care.net)
  • The α-subunits of the oxaloacetate and methylmalonyl-CoA decarboxylases are homologous to many biotin-containing enzymes including (1) pyruvate carboxylases, (2) homocitrate synthases, (3) biotin carboxyl carrier proteins, (4) isopropylmalate synthases and (5) acyl-CoA carboxylase. (tcdb.org)
  • Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. (embl.de)
  • Background Acyl-CoA binding domain containing protein 5 (ACBD5) is a peroxisomal membrane protein with a cytosolic acyl-CoA binding domain. (bmj.com)
  • Because of its acyl-CoA binding domain, ACBD5 has been assumed to function as an intracellular carrier of acyl-CoA esters. (bmj.com)
  • Inh A, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis is one of the key enzymes involved in the mycobacterial fatty acid elongation cycle and has been considered as a promising target in antitubercular screening. (thepharmajournal.com)
  • dration of globular proteins (Baker, 1995). (lu.se)
  • In cells, some molecules can move down their concentration gradients by crossing the lipid portion of the membrane directly, while others must pass through membrane proteins in a process called facilitated diffusion. (khanacademy.org)
  • A bilayered membrane consisting of phospholipids arranged in two layers, with their heads pointing out and their tails sandwiched in the middle, is also shown. (khanacademy.org)
  • Larger charged and polar molecules, like sugars and amino acids, also need help from proteins to efficiently cross the membrane. (khanacademy.org)
  • Open up in another window Physique 2 Structural topology style of SLC26 polypeptides displaying the brief cytoplasmic N-terminal area accompanied by a transmembrane domain name with 12 putative membrane-spanning -helices, as well as the C-terminal cytoplasmic area, largely composed of the STAS domain name. (exposed-skin-care.net)
  • Fas-activated DCs increase the expression of MHC II, B7 co-stimulatory molecules, and DC-lysosome-associated membrane proteins (DC-LAMP), and secrete proinflammatory cytokines such as IL-1β and TNF-α. (biolegend.com)
  • As a test-case, the membrane protein FepA is investigated in its full environment, yielding a more precise description of the protein surface. (nature.com)
  • Membrane proteins, such as those operating transport through the membrane in a controlled way, are prone to show interesting topological properties related to their function. (nature.com)
  • Our study uses classical algorithms such as space partitions and Dijkstra paths search 9 , applied in an original and novel way by taking into account the full representation of a membrane protein including the solvent and the lipid bilayer (Fig. 1 ). (nature.com)
  • The FepA membrane protein is surrounded by a lipid bilayer separating the extracellular medium and the periplasm. (nature.com)
  • The β-subunits possess 9 transmembrane α-helical spanners (TMSs), and the protein may dip into the membrane twice between TMSs III and IV. (tcdb.org)
  • The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. (biomedcentral.com)
  • The evolutionarily conserved polarity proteins PAR-3, atypical protein kinase C (aPKC) and PAR-6 critically regulate the apical membrane development required for epithelial organ development. (silverchair.com)
  • COPI is recruited to the membrane primarily through binding to Arf GTPases, upon which it undergoes assembly to form coated transport intermediates responsible for trafficking numerous proteins, including Golgi-resident enzymes. (univ-lille.fr)
  • The 397 amino acid recombinant protein has a predicted molecular mass of approximately 44.7 kD. (biolegend.com)
  • BioLegend carrier-free recombinant proteins provided in liquid format are shipped on blue-ice. (biolegend.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • This protein family is largely expanded in land plant genomes. (frontiersin.org)
  • This fusion has not been retained in plant genomes, which solely express unfused SCP-2 domains. (slu.se)
  • The extracellular region of FAS possesses three cystein-rich domains characteristic of the TNF superfamily, and the intracellular region which includes a death domain (DD). (biolegend.com)
  • In fluorescence resonance energy transfer (FRET) experiments in live cells we show that Vpu oligomerizes in what appears to be either the Golgi region or intracellular vesicles, but not in the ER. (biomedcentral.com)
  • Sterol carrier protein-2 ( SCP-2) is an intracellular, small, basic protein domain that in vitro enhances the transfer of lipids between membranes. (slu.se)
  • The intracellular protein extracts of a fungal strain Pycnoporus sanguineus was used as reducing and stabilizing agents to synthesize AuNPs with various shapes and dimensions, which present good catalyzing ability on the degradation of 4-nitroaniline [ 11 ]. (springer.com)
  • In a paper in Extracellular Vesicle , the researchers demonstrated that lung-derived nanoparticles were more effective at delivering mRNA and protein cargo to bronchioles and deep lung tissue than synthetic liposome particles. (ncsu.edu)
  • Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu, where it mostly occurs as insoluble Fe 3+ . (biomedcentral.com)
  • cDNA analysis showed that the deleterious effect of the latter mutation was skirted by deleting the premature termination codon containing exon 30. (nih.gov)
  • Results We identified a homozygous deleterious indel mutation in ACBD5 , leading to complete loss of ACBD5 protein in the patient. (bmj.com)
  • A TH domain missense mutation has also been described in BTK. (medscape.com)
  • [ 1 ] A database of BTK mutations ( BTKbase: Mutation registry for X-linked agammaglobulinemia ) lists 544 mutation entries from 471 unrelated families showing 341 unique molecular events. (medscape.com)
  • This is thought to be due to a mutation in the protein, rather than a complete absence. (medscape.com)
  • BLMbase ( http://structure.bmc.lu.se/idbase/BLMbase/ ) (3) lists 33 mutation entries from 32 unrelated families showing 23 unique molecular events. (lu.se)
  • The carrier frequency to this mutation is about 1/104 in the Ashkenazi Jewish population. (lu.se)
  • Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)
  • While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. (nature.com)
  • Inside the cell, these proteins operate much like a shuttle bus, binding and exchanging energy-carrying molecules known as ATP and ADP. (inje.ac.kr)
  • The NMRD data show that all water molecules associated with the duplex, except the ®ve molecules in the spine, have residence times signi®cantly shorter than 1 ns at 4C. (lu.se)
  • Usually, the NOE and NMRD in B-DNA is expected to be less ``integral'' than methods can only provide bounds on the residence water molecules buried inside proteins. (lu.se)
  • These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
  • an oxygenase-like protein with a Rieske electron carrier domain, from the silkworm Bombyx mori and the fruitfly Drosophila melanogaster. (biologists.com)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
  • In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)
  • Certainly, STAS domain-encoding SulP genes have already been found as the different parts of antibiotic operons, like the BLM bleomycin biosynthesis operon of (Du et al. (exposed-skin-care.net)
  • In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)
  • The induction cascades of early morphogenesis involve numerous growth factors, homeobox genes, and paired domain genes. (medscape.com)
  • Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. (nih.gov)
  • The 2.7- resolution image showed that the active site residues of the KS and AT domains, Cys199 and Ser642, respectively, were more than 80 apart. (stanford.edu)
  • Conserved nucleotides are indicated by an asterisk and identical amino acid residues are shown in bold font. (xenbase.org)
  • These mutations affect critical residues in the cytoplasmic BTK protein and are highly variable and uniformly dispersed throughout the molecule. (medscape.com)
  • FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. (biolegend.com)
  • Smith UM, Consugar M, Tee LJ, McKee BM, Maina EN, Whelan S. The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. (medscape.com)
  • deletion of an exon encoding the transmembrane domain results in a soluble FAS molecule that blocks apoptosis. (biolegend.com)
  • Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ASC (apoptosis-associated speck-like protein containing a CARD). (nih.gov)
  • These unusual ORFs are maternally inherited, and effectively translated into novel mitochondrial proteins, with the resulting failure to produce functional pollen as the sole observed phenotype ( Chen and Liu, 2014 ). (frontiersin.org)
  • Immunoblot analysis showed expression of the 180-kDa bullous pemphigoid antigen (BP180) with a slightly higher SDS-PAGE mobility, in line with the deletion of 12 amino acids from the COL15 domain. (nih.gov)
  • BLM protein comprises of 1417 amino acids. (lu.se)
  • C. cassiicola showed pathogenic and genetic variation among isolates sampled in different host plants, proving that the intraspecific strains of C. cassiicola showed high host specialization [ 2 , 7 ]. (biomedcentral.com)
  • Using Vpu proteins from a primary subtype C and the pNL4-3 subtype B isolates of HIV-1, we show oligomerization of the full-length protein as well as its transmembrane (TM) domain by genetic, biochemical and biophysical methods. (biomedcentral.com)
  • 2010). The mammalian and bacterial STAS domains reported to day have already been monomeric in answer. (exposed-skin-care.net)
  • A small amount of bacterial SulP transporters absence a C-terminal STAS domain name, but have in its place an enzymatically energetic (Nishimori et al. (exposed-skin-care.net)
  • Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)
  • Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
  • Indeed, the protein-to-RNA ratio per sample of the bacterial populations matched previous calculations for the existing example from axenically cultured E. coli 2 . (nature.com)
  • This study shows the natural occurrence of serratiochelins, photobactin, enterobactin, and aerobactin in a single bacterial species and illuminates the interplay between siderophore biosynthetic pathways and polyamine production, indicating routes of molecular diversification. (biomedcentral.com)
  • In the present research work the docking studies was performed on the human pathogenic bacterial enzyme InhA from its parent domain Mycobacterium Tuberculosis . (thepharmajournal.com)
  • HSD17B4 which encodes a D-bifunctional protein ( DBP) with domains for D-3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and SCP-2 are found in animals from insects to mammals and also in fungi. (slu.se)
  • This method ( 10 ) mea- chemical-induced skin sensitization is the ability of a chemical, sured the depletion of the peptides after treatment with excess either as such or after ex/in cutaneo activation, to covalently electrophile for 24 h and adopted the percent depletion (dp) as react with a carrier protein or peptide ( 6 ), resulting in an the reactivity index of a given chemical. (cdc.gov)
  • HSD17B4, SCPX, HSDL2, and STOML1 encode fusion proteins with SCP-2 downstream of another protein domain, whereas C20orf79 encodes an unfused SCP-2. (slu.se)
  • Moreover, high-performance liquid chromatography studies showed that the dltX mutant was devoid of D -alanine, and electrophoretic mobility measurements indicated that the cells carried a higher negative surface charge. (frontiersin.org)
  • The role of Albumin in Metabolic ActivitySerum albumin is a single-chain protein synthesized in and secreted from liver cells. (artscolumbia.org)
  • Procaspase-8 localised to ASC inflammasome 'specks' in cells, and bound directly to the pyrin domain of ASC. (nih.gov)
  • It is the fourth in a family of proteins that perform transfer processes to help cells make and use energy. (inje.ac.kr)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • The figure below shows the proposed biosynthesis of psymberin based on analysis of the gene clusters. (wikipedia.org)
  • Gene knockdown showed caspase-8 to be the apical caspase in the AIM2- and NLRP3-dependent apoptotic pathways, with little or no requirement for caspase-9. (nih.gov)
  • The gene is 160 kilobases in length and has 15 exons and 14 introns with specific structural and functional domains. (medscape.com)
  • Bloom syndrome (BS) is a rare human autosomal recessive disorder cased by mutations in the gene (BLM) coding for Bloom syndrome protein. (lu.se)
  • Open up in another window Physique 1 Phylogenetic romantic relationship of BIIE 0246 supplier human being SLC26 polypeptides generated with Jalview (http://www.jalview.org) using NCBI proteins sequences listed in Desk 1. (exposed-skin-care.net)
  • Intronic sequences are shown in lower case. (xenbase.org)
  • DmCpGs within Ras Association (RalGDS/AF-6), Pleckstrin Homology Domains 1 (RAPH1), Musashi RNA-Binding Protein 2 (MSI2), and solute carrier family 25 member 10 (SLC25A10) are associated with both BMI and WC. (edu.au)
  • Loss of GORAB causes impairment of COPI-mediated retrieval of trans-Golgi enzymes, resulting in a deficit in glycosylation of secretory cargo proteins. (univ-lille.fr)
  • Phosphopantetheine is attached to a serine residue in these proteins. (embl.de)
  • c TEL bound within the NPET with the surrounding nucleotides of the 25S rRNA (gray) and His133 residue of uL22 protein (purple). (ciisb.org)
  • In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
  • Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GPCR150. (antibodies-online.cn)
  • This reactivity of chemicals to cutaneous the peptide reactivity assay ( 10 ), quantitative LC-MS was proteins is the basis for most, if not all, current nonanimal- exploited by Natsch et al. (cdc.gov)
  • Next, the researchers created and tested an inhalable, protein-based, virus-like particle (VLP) vaccine by decorating the exterior of LSC-Exo with a portion of the spike protein - known as the receptor binding domain, or RBD - from the SARS-CoV-2 virus. (ncsu.edu)
  • Zinc has "mimetic" activity where it is involved in a range of functions including insulin receptor signal transduction, insulin storage, secretion and tissues/organelle distribution, and inhibition of protein tyrosine phosphatases [ 5 - 8 ]. (hindawi.com)
  • Because neuropeptide Y is a natural substrate of FAP and the cleavage product has been shown to be proangiogenic, FAP is considered to be involved in tumor angiogenesis, as has been substantiated by studies showing a correlation between FAP expression and microvessel density in tumors ( 10 , 11 ). (snmjournals.org)
  • X-ray crystallography was used to investigate this complex enzymatic process, which showed Orf1 has two substrate-binding sites that sit 13.5 Å apart unlike canonical FAD-dependent oxidoreductases. (hokudai.ac.jp)
  • The results showed that TEO increased the oxidative stability of the emulsion and reduced the emulsion droplet size. (magiran.com)
  • Our comparison testing data indicates that when handled and stored as recommended, the liquid format has equal or better stability and shelf-life compared to commercially available lyophilized proteins after reconstitution. (biolegend.com)
  • Compared with the previously published ligand, FAPI-02, FAPI-04 showed excellent stability in human serum, higher affinity for FAP as opposed to CD26, and slower excretion in vitro. (snmjournals.org)
  • One of these proteins is the fibroblast activation protein (FAP), a type II transmembrane serine protease with both dipeptidyl peptidase activity and endopeptidase activity ( 2 - 4 ). (snmjournals.org)
  • It consists of seven distinct structural domains, which are from the N-terminus, poly-aspartate domain (PD1), poly-serine domain (PS), poly-aspartate domain (PD2), DEAH helicase domain (DEAH), RecQ helicase C-terminal domain (RecQCt), helicase and RNase D C-terminal domain (HRDC). (lu.se)
  • DctA and DcuB exert regulatory functions and link transport to metabolic control through interaction with regulatory proteins. (bvsalud.org)
  • No InterPro domain matches or not analyzed. (cornell.edu)
  • Structure of a phospholipid, showing hydrophobic fatty acid tails and hydrophilic hea. (khanacademy.org)
  • Our studies showed that ACBD5 deficiency leads to accumulation of very long-chain fatty acids (VLCFAs) due to impaired peroxisomal β-oxidation. (bmj.com)
  • 2010). NMR answer structures have already been resolved for the STAS BIIE 0246 supplier domain name of putative sulfate transporter Rv1739c from (Sharma et al. (exposed-skin-care.net)
  • The CusB protein is part of the CusCBA periplasmic Cu(I) efflux system in Gram-negative bacteria, and it was recently reported to play a key role in the functioning of the whole CusCBA system, in which conformational changes as well as the assembly/disassembly process control the opening of the transporter. (biorxiv.org)
  • Immunofluorescence of skin sections showed diminished, but correctly localised expression of BP180, and this, in concert with the mild clinical phenotype, suggests that this COL15 mutated BP180 is still partly functional. (nih.gov)
  • Whether Vpu is a viral pathogenesis factor remains to be established, but compared to HIV-1, closely related retroviruses such as HIV-2 and SIV that lack expression of a fully functional Vpu protein also cause less severe disease outcomes. (biomedcentral.com)
  • COPI is a key mediator of protein trafficking within the secretory pathway. (univ-lille.fr)
  • First, the researchers looked at whether LSC-Exo was able to deliver protein or mRNA "cargos" throughout the lungs. (ncsu.edu)
  • For example, mRNA vaccines deliver a script to your cell that instructs it to produce antibodies to the spike protein. (ncsu.edu)
  • Thus, the proteins that transport zinc likely facilitate cell signaling processes that contribute to glycemic control in peripheral tissues by modulating cytosolic zinc concentrations. (hindawi.com)
  • For example, when Escherichia coli is grown axenically in steady state, we can expect that each RNA molecule corresponds to 10 2 -10 4 of the matching protein (absolute protein-to-RNA ratio, hereafter referred protein-to-RNA ratio) and the variation in the level of cellular RNA explains ~29% of the variation in the amount of detectable protein 2 . (nature.com)
  • The PPR protein family is consequently divided in subfamilies depending on the number and type of repeats present in their sequence as well as optional C-terminal domains. (frontiersin.org)
  • Moreover, speci®c hy- found in narrow minor groove regions in a variety dration patterns seem to play a role in nucleotide sequence recognition by proteins (Otwinowski of oligonucleotide duplexes (Prive et al. (lu.se)
  • The structural consequences of mutations in DEAH domain have been studied based on computer-aided molecular modeling. (lu.se)
  • Rong, S. B., Väliaho, J. and Vihinen, M. (2000) Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain. (lu.se)
  • 0.22 µm filtered protein solution is in 10 mM NaHPO 4 , 0.3 M NaCl, pH 7.2. (biolegend.com)
  • The didomain structure also revealed a novel protein fold for the KS-to-AT linker. (stanford.edu)
  • b Isolated cryo-EM density for TEL (gray mesh) with fitted molecular model for TEL. The similarly-oriented chemical structure of TEL is shown for reference. (ciisb.org)
  • Pathogenic GORAB mutations perturb Scyl1 binding or GORAB assembly into domains, indicating the importance of these interactions. (univ-lille.fr)
  • Mutations in each of the 5 domains of BTK can lead to disease. (medscape.com)
  • All missense mutations are in the highly conserved DEAH or RecQ C-terminal helicase domains. (lu.se)
  • The STAS domain name of Rv1739c binds and adjustments conformation in response to guanine nucleotides (Sharma et al. (exposed-skin-care.net)
  • The N-terminal domain binds the glutaconyl-CoA, and the C-terminal domain binds the biotinyl lysine moiety. (tcdb.org)
  • No function offers however been reported for the IVS, and its own deletion was necessary for production from the 1st STAS domain name crystals diffracting to high res (Pasqualetto et al. (exposed-skin-care.net)
  • Roman numerals represent which clade each Ketosynthase domain belongs. (wikipedia.org)
  • Subtle differences are detected between two forms of FepA, ligand-free and complexed with its natural iron carrier, the enterobactin. (nature.com)
  • N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. (hokudai.ac.jp)
  • All the derivatives were considered and docked as well as bound to ligand binding domain EAcCPR. (thepharmajournal.com)
  • The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
  • The aim of this study was to establish whether this protein is involved in the D -alanylation process in Bacillus thuringiensis . (frontiersin.org)
  • SIGNIFICANCE: The trajectory analysis showed different patterns of urinary OPE metabolite concentrations, suggesting the need to collect multiple samples to adequately reflect OPE exposure. (cdc.gov)
  • In this context, the exploration of temporal interplay between populations with different lifestyles (comprising metabolism, motility, sporulation, etc.) becomes of primary importance to interpret the changes in fundamental quantities in a microbial community, such as the protein-to-RNA ratio that ultimately impacts the overarching community phenotype(s). (nature.com)
  • In order to perform studies of such design and test if previously defined quantitative data about the functioning of microorganisms (i.e., protein-to-RNA ratio) is applicable to real world consortia, we must first sample microbial communities across transition events and employ quantification techniques that are absolute. (nature.com)
  • Psymberin was found to be highly bioactive as it showed LC50s at nanomolar concentrations against various types of tumors. (wikipedia.org)
  • Given the low plasma concentration of zinc and its importance in cellular signaling, it is essential that the availability and distribution of "free" zinc (free zinc is used to differentiate zinc involved in cell signaling from zinc that tightly bound to protein and therefore thermodynamically unavailable) are tightly controlled [ 6 ]. (hindawi.com)
  • These results imply a more targeted housekeeping role for PedC: namely the removal of unwanted acetyl groups from ACP domains caused by erroneous transfer of acetyl-CoA, or possibly by decarboxylation of malonyl-ACP. (worktribe.com)
  • Our results therefore identify GORAB as a COPI scaffolding factor, and support the view that defective protein glycosylation is a major disease mechanism in gerodermia osteodysplastica. (univ-lille.fr)
  • These results show that LMP1 , mour viruses classified by IARC in EBV-specific T-cell response. (who.int)
  • [ 6 ] B9d1 and B9d2 are essential components of a B9 protein complex and, when this is disrupted, Meckel syndrome results. (medscape.com)