• The fusion proteins formed by these translocations lack the DNA-binding domain, causing the protein to lose function. (wikipedia.org)
  • FOXP2 belongs to a family of genes that encodes transcription factors (proteins that regulate the expression of genes). (nih.gov)
  • Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. (nih.gov)
  • Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. (rcsb.org)
  • MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins, promotes FOXO nuclear translocation, and thereby induces cell death in neurons. (synergyage.info)
  • The forkhead-associated (FHA) domain [ ( PUBMED:7482699 ) ] is a phosphopeptide recognition domain found in many regulatory proteins. (embl.de)
  • The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples. (embl.de)
  • There are 73373 FHA domains in 68942 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing FHA domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with FHA domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing FHA domain in the selected taxonomic class. (embl.de)
  • FHA domains are conserved sequences of 65-100 amino acid residues found principally within eukaryotic nuclear proteins, but which also exist in certain prokaryotes. (embl.de)
  • These three phosphorylated proteins then interact with SH2 domain containing signaling proteins. (affbiotech.cn)
  • HN - 2018(1987) MH - AAA Domain UI - D000074182 MN - G2.111.570.820.709.275.500.913 MS - An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. (nih.gov)
  • HN - 2018 FX - ATPases Associated with Diverse Cellular Activities MH - AAA Proteins UI - D000074582 MN - D8.811.277.40.13 MN - D12.776.157.25 MS - A large, highly conserved and functionally diverse superfamily of NTPases and nucleotide-binding proteins that are characterized by a conserved 200 to 250 amino acid nucleotide-binding and catalytic domain, the AAA+ module. (nih.gov)
  • This protein is a transcription factor, which means that it controls the activity of other genes. (medlineplus.gov)
  • It attaches (binds) to the DNA of these genes through a region known as a forkhead domain. (medlineplus.gov)
  • Researchers suspect that the forkhead box P2 protein may regulate hundreds of genes, although only some of its targets have been identified. (medlineplus.gov)
  • Researchers are working to identify the genes regulated by forkhead box P2 that are critical for learning these skills. (medlineplus.gov)
  • Because forkhead box P2 is a transcription factor, these changes affect the activity of other genes in the developing brain. (medlineplus.gov)
  • Isolation of the underlying genetic risk factors has been hampered by complexity of the phenotype and potentially large number of contributing genes. (nih.gov)
  • Fox genes represent an evolutionary old class of transcription factor encoding genes that evolved in the last common ancestor of fungi and animals. (bvsalud.org)
  • Fox genes encode transcription factors that contain a DNA binding domain, the forkhead domain, and are known from diverse animal species. (bvsalud.org)
  • By using a combination of in situ hybridization screening, overexpression of mRNA, recombinant ligand treatments, and morpholino-based loss-of-function studies, we identified a cohort of transcription factors and signaling molecules expressed in the ventral ectoderm , dorsal ectoderm , and interposed neurogenic ("ciliary band") region in response to the known key signaling molecules Nodal and BMP2/4 and defined the epistatic relationships between the most important genes. (echinobase.org)
  • The FOXP2 gene provides instructions for making a protein called forkhead box P2. (medlineplus.gov)
  • The protein encoded by FOXP2 belongs to a divergent subgroup of forkhead-box transcription factors, with a distinctive DNA-binding domain and motifs that mediate hetero- and homodimerisation. (nih.gov)
  • The discovery of CS helped to narrow the language disorder to a specific gene, FOXP2 (forkhead box P2). (nih.gov)
  • FOXP2 contains a forkhead domain that binds to DNA. (nih.gov)
  • 2001) mapped gene responsible for language disorder as FOXP2, a fork-head domain including transcription factor protein coding gene. (anthropogeny.org)
  • 23. FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis. (nih.gov)
  • 28. The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells. (nih.gov)
  • 40. Suppression of Forkhead Box Protein O1 (FOXO1) Transcription Factor May Promote Adrenocortical Tumorigenesis. (nih.gov)
  • For example SGK phosphorylates FoxO1 at Thr24 and Ser319 (11 12 Similar to Akt SGK is activated by a variety of growth and survival factors including insulin (13 14 cAMP-dependent protein kinase (PKA) is a key regulator of many processes involved with cell growth and development. (cancer-ecosystem.com)
  • In humans there are over 40 different Forkhead family members with diverse biological functions [ 18 ] and it is currently unclear how different Forkhead factors are recruited to specific genomic sites to regulate distinctly different transcriptional responses. (biomedcentral.com)
  • Our results (i) illustrate the utilization of just one enhancer by different tissue-specific members of the same TF family to regulate expression in different spatial domains and (ii) demonstrate a correlation between different binding motifs of the same TF family and the differential expression response of a gene. (nih.gov)
  • Transcription factors (TFs) interact with specific DNA sequences, called transcription factor binding sites (TFBSs), to regulate gene expression [ 1 , 2 ]. (biomedcentral.com)
  • This finding allows us to pursue a more comprehensive approach to understand fat biology and provides an opportunity to learn about the cascade of events that regulate KLF activation, repression and interaction with other factors in exerting its biological function at an organismal level. (ijbs.com)
  • We conclude that through its ability to regulate a specific domain of BMP activity in the vertebrate embryo , SNW1 is a critical regulator of neural plate border formation and thus neural crest specification. (xenbase.org)
  • The family of forkhead (FOX) transcription factors is composed of dozens of paralogs in mammals. (ijm.fr)
  • The forkhead domain is disrupted in CS by translocation breakpoint, and in the KE family by a point mutation. (nih.gov)
  • From NCBI Gene: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. (nih.gov)
  • Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. (nih.gov)
  • This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. (nih.gov)
  • It is a member of a large family of transcription factors which recognize DNA sequences through the conserved Forkhead (FH) domain. (ox.ac.uk)
  • FOXN1 is a member of the forkhead box (FOX) family of transcription factors, and plays an important role in thymic epithelial cell differentiation and function. (ox.ac.uk)
  • Forkhead-box protein P1 ( FOXP1 ) is part of the forkhead-box family of transcription factors that is crucial for embryonic development. (neurodlableiden.com)
  • FOXI1 is a family member of the forkhead-box (FOX) transcription factors that are characterized by the FOX ~100 amino acid monomeric DNA-binding domain [ 1 ]. (biomedcentral.com)
  • CST-1 physically interacts with RSF-1, the C. elegans homolog of the Ras-association domain family protein 1. (synergyage.info)
  • Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. (affbiotech.cn)
  • Forkhead box (FOX)p3, a member of the forkhead family, is specifically expressed in Treg cells, including CD4 + CD25 high Treg cells and CD8 + CD25 high Treg cells ( 9 ). (spandidos-publications.com)
  • Brey CW, Nelder MP, Hailemariam T, Gaugler R, Hashmi S. Krüppel-like family of transcription factors: an emerging new frontier in fat biology. (ijbs.com)
  • Work in mouse has shown that the family of Krüppel-like factors (KLFs), a conserved and important class of transcription factors, regulates adipocyte differentiation in mammals. (ijbs.com)
  • Transcription factors contain a DNA-binding domain ensuring specific recognition of DNA target sequences. (ijm.fr)
  • These results strongly support a model whereby FOXM1 is specifically recruited to chromatin through co-factor interactions by binding directly to non-canonical DNA sequences. (biomedcentral.com)
  • Conventional recruitment of transcription factors to genomic binding sites is based on a model of direct binding at high affinity consensus motif sequences in cis -regulatory regions. (biomedcentral.com)
  • In this paper, we present an efficient pentamer algorithm by splitting DNA binding sequences into overlapping fragments along with a simplified integrative energy function for transcription factor binding site prediction. (biomedcentral.com)
  • Genome-wide TFBS identification, a crucial step in deciphering transcription regulatory networks and annotating genomic sequences, remain a key challenge in post-genomics research. (biomedcentral.com)
  • One issue in structure-based TFBS prediction concerns the potential divergence of DNA structures of different sequences for a transcription factor since only one TF-DNA complex model is used for evaluating different sequences. (biomedcentral.com)
  • Our recent survey showed that the DNA structures of different cognate binding sequences of a transcription factor generally conserve well with smaller root mean squared deviations (RMSDs), suggesting that the interaction modes are conserved between the transcription factor and its specific binding sequences even though there are variations at certain positions of the binding motif [ 3 ]. (biomedcentral.com)
  • SwissProt sequences and OMIM curated human diseases associated with missense mutations within the FHA domain. (embl.de)
  • The forkhead domain (FHD) is a segment of about 100 amino acids that binds an A-rich DNA sequence. (ijm.fr)
  • FOXM1, similar to other FKH factors, binds to a canonical FKH motif in vitro . (biomedcentral.com)
  • PKA is activated when cAMP binds to the regulatory subunit of PKA resulting in release of the catalytic subunit that then phosphorylates a variety of protein substrates including ion channels key metabolic enzymes and transcription factors (15). (cancer-ecosystem.com)
  • This gene encodes for a bHLH transcription factor, which inhibits osteogenic differentiation by transc. (uni-marburg.de)
  • atonal bHLH transcription factor 8 [Sou. (gsea-msigdb.org)
  • The transcription factor E2F1 supports HR-mediated DSB repair and protects genomic stability. (biomedcentral.com)
  • TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). (nih.gov)
  • The syndrome is due to homozygous loss-of-function missense mutations located within the forkhead domain of the FOXE1 gene (9q22), encoding thyroid transcription factor 2 (TTF-2). (cdc.gov)
  • The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. (affbiotech.cn)
  • Mutations of the transcription factor FOXL2, involved in cranio-facial and ovarian development, lead to the Blepharophimosis Syndrome. (nih.gov)
  • Here, we have systematically replaced the amino acids of the helices of the forkhead domain (FHD) of FOXL2 by glycine residues to assess the impact of such substitutions. (nih.gov)
  • In this study, we demonstrate that the FOXL2 transcription factor is also necessary for the full synergistic response between activin and progestins. (nih.gov)
  • We show that this synergy occurs in a species-specific manner and that multiple elements in the Fshb promoter that bind forkhead box L2 (FOXL2), SMA/mothers against decapentaplegic homologs (SMAD), and PR are required. (nih.gov)
  • Thus, it is likely that protein-protein interactions among FOXL2, SMAD, and PR recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents. (nih.gov)
  • Structural analyses have shown that these mutations can either disturb amino acids that are necessary for binding to DNA or interfere with the domain that mediates FOXP1 dimerization. (neurodlableiden.com)
  • In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). (rcsb.org)
  • Understanding how and where transcription factors bind at genome scale represents an essential step toward our understanding of gene regulation networks. (biomedcentral.com)
  • We also demonstrate that other FHA domains bind peptides in a phospho-dependent manner. (embl.de)
  • An in vitro fluorescence polarization assay identified point mutations in the DNA binding domain of FOXM1 that inhibit binding to a FKH consensus sequence. (biomedcentral.com)
  • The majority of the pathogenic missense and in-frame mutations are located in the DNA-binding domain of FOXP1. (neurodlableiden.com)
  • Different mutations in the human FOXI1 gene and its regulatory binding site on SLC26A4 (also known as pendrin) have been shown to compromise the transcription of this anion transporter gene in patients with Pendred Syndrome and nonsyndromic enlargement of the vestibular aqueduct [ 2 ]. (biomedcentral.com)
  • The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. (nih.gov)
  • Our results point to an unexpected and novel characteristic of the forkhead domain, the biological relevance of which remains to be explored. (ijm.fr)
  • The identification of the FOXO transcription factors as major and evolutionarily conserved targets of MST1 suggests that MST kinases play important roles in diverse biological processes including cellular responses to oxidative stress and longevity. (synergyage.info)
  • Skeletal muscle differentiation, the MG53 gene in mice ameliorates high-fat/high-sucrose diet- hypertrophy and atrophy are tightly regulated by a variety of induced insulin resistance by increasing the IRS-1 expression hormones, growth factors and cytokines. (marysfamilymedicine.org)
  • Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
  • The aim of the present study was to evaluate Tim‑3 and Gal‑9 expression and cluster of differentiation (CD)3+, CD8+ and forkhead box (FOX)p3+ T cell tumor‑infiltration in gastric cancer, as well as their impact on prognosis. (spandidos-publications.com)
  • However, unlike Th17 cells, differentiation of Tfh cells did not require transforming growth factor b (TGF-b) or Th17-specific orphan nuclear receptors RORa and RORg in vivo. (gsea-msigdb.org)
  • To explore the effect of transcription factor Foxp1 on angiogenesis after myocardial infarction from two levels of in vivo and in vitro experiments. (researchsquare.com)
  • The aim of this study is to investigate the possible association between antenatal steroid and fetal Forkhead box M1(Foxm1) expression. (medsci.org)
  • Using qRT-PCR and Western blot, mRNA transcription and protein expression of surfactant protein (SP) A, B, C, and Foxm1 were compared between the pups of those four groups. (medsci.org)
  • Significantly lower Foxm1 mRNA transcription and protein expression were observed in group 3 or 4 compared with group 1 or 2. (medsci.org)
  • In addition, some studies regarding embryonal development of pulmonary tissue reported the importance of the expression of Forkhead box M1 (Foxm1). (medsci.org)
  • The Forkhead (FKH) transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in most types of cancer. (biomedcentral.com)
  • This shows that interaction of the FOXM1 DNA binding domain with target DNA is essential for recruitment. (biomedcentral.com)
  • A functional DNA binding domain is essential for FOXM1 chromatin recruitment. (biomedcentral.com)
  • studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. (nih.gov)
  • Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. (rcsb.org)
  • Here, we show that the two highly divergent FHA domains of Saccharomyces cerevisiae Rad53p, a protein kinase involved in cell cycle checkpoint control, possess phosphopeptide-binding specificity. (embl.de)
  • A DNA binding sequence is split into overlapping pentamers (5 base pairs) for calculating transcription factor-pentamer interaction energy. (biomedcentral.com)
  • FOXN1 recognizes a DNA sequence that is different from the common consensus binding sequence of FH domains, although key binding residues are identical. (ox.ac.uk)
  • In silico, the truncated FOXN1 protein was predicted to lack the activation domain and critical parts of the forkhead DNA binding domain, both involved in the interaction between FOXN1 and its targets, a mandatory step to promote normal hair and thymic epithelial development. (plos.org)
  • Furthermore, IGF signaling-mediated cell-cell interaction between the cellular domains highlights the pivotal role of autonomous regulation of the dental mesenchyme. (nature.com)
  • These findings indicate that the FHA domain is a phospho-specific protein-protein interaction motif and have important implications for mechanisms of intracellular signaling in both eukaryotes and prokaryotes. (embl.de)
  • Its expression regulation is critically modulated by multiple physiopathological factors such as inflammation, stress, Epstein-Barr virus infection and sex hormones. (medscape.com)
  • 25. The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis). (nih.gov)
  • 35. Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. (nih.gov)
  • We know that forkhead domain transcription factors have many important roles in the regulation of the development of embryos. (nih.gov)
  • A common theme in developmental biology is the repeated utilization of the same gene in diverse spatial and temporal domains, a process which generally involves transcriptional regulation mediated through multiple distinct enhancers, each with its own arrangement of transcription factor (TF) binding sites and associated activities. (nih.gov)
  • We also find that like growth factor-1 (IGF-1) has a key role in the regulation of MG53 protein level is not upregulated in the muscle samples skeletal muscle size. (marysfamilymedicine.org)
  • The T‑cell immunoglobulin and mucin domain‑containing protein 3 (Tim‑3)/galectin 9 (Gal‑9) pathway, which serves a pivotal role in immune regulation, is similar to the programmed death (PD)‑1/PD‑ligand 1 pathway. (spandidos-publications.com)
  • It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. (thermofisher.com)
  • Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene. (wikipedia.org)
  • We hypothesized that a FOXN1 ( forkhead box N1 ) loss-of-function allele, associated with the nude phenotype in humans, mice and rats, may account for the syndrome observed in Birman cats. (plos.org)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • Tim‑3 expression and CD8+ T cell density were revealed to be independent prognostic factors for patients with gastric cancer. (spandidos-publications.com)
  • FOXO transcription factors have been shown to be the down downstream effector molecules of insulin-like growth factor (IGF) signaling pathway. (wikipedia.org)
  • Notably, the administration of simvastatin inhibited activating transcription factor‑6‑mediated extracellular signal‑regulated kinase/AKT serine/threonine kinase (ERK/AKT) signaling pathway in hippocampal cells. (nih.gov)
  • Contributed by Saitou Naruya, domain leader of Genetics section. (anthropogeny.org)
  • May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. (nih.gov)
  • Galectins are characterized by their β-galactoside-binding affinity, and have an evolutionarily conserved carbohydrate recognition domain (CRD) ( 7 ). (spandidos-publications.com)
  • Both PI3K and AKT modify FOXO4 and prevent it from translocating to the nucleus, effectively preventing the transcription of the downstream FOXO targets. (wikipedia.org)
  • For gma miR160 in the cotyledon degradome library, we have identified five targets annotated as Auxin Response Factors. (vegfr-1inhibitor.com)
  • Indeed, when the side chains of the amino acids involved in the helices of the forkhead are supposed to point towards the hydrophobic core formed by the three main helices, a loss of function was observed. (nih.gov)
  • FOXJ3 is a transcription factor which regulates sperm function. (nih.gov)
  • By exploiting a combination of immunostaining for phosphorylated Smad1 in Xenopus embryos and a BMP-dependent reporter transgenic zebrafish line, we show that SNW1 regulates a specific domain of BMP activity in the dorsal ectoderm at the neural plate border at post- gastrula stages. (xenbase.org)
  • The FHA domain is a modular phosphopeptide recognition motif. (embl.de)
  • SAYSVFN motif domain containing 1 [Sour. (gsea-msigdb.org)
  • FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. (nih.gov)
  • No significant associations were observed between rs4442975 and traditional progression factors such as tumor size, nodal status, distant metastasis, or TNM staging. (oncotarget.com)
  • We reveal the landscape of transcriptional heterogeneity and define the specific cellular domains during the progression of cranial neural crest cell-derived dental lineage diversification, and find that each domain makes a specific contribution to distinct molar mesenchymal tissues. (nature.com)
  • They found that multiple regulatory layers including cis regulatory elements and transcription factors govern the neural crest ontogeny. (nature.com)
  • Bone morphogenetic protein (BMP) gradients provide positional information to direct cell fate specification, such as patterning of the vertebrate ectoderm into neural, neural crest , and epidermal tissues, with precise borders segregating these domains. (xenbase.org)
  • We use double in situ hybridizations and immunofluorescence to show how this domain of BMP activity is spatially positioned relative to the neural crest domain and that of SNW1 expression. (xenbase.org)
  • Muscle samples derived from human diabetic patients and mice with insulin resistance show normal expression of MG53, indicating that altered MG53 expression does not serve as a causative factor for the development of metabolic disorders. (marysfamilymedicine.org)
  • suggesting that MG53 upregulation is not a causative factor In vivo injection of IGF-1 in skeletal muscle or skeletal muscle- for the development of insulin resistance. (marysfamilymedicine.org)
  • The human FOXI1 gene codes for a transcription factor involved in the physiology of the inner ear, testis, and kidney. (biomedcentral.com)
  • A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. (nih.gov)
  • A forkhead-domain gene is mutated in a severe speech and language disorder. (medlineplus.gov)
  • pcDNA3 expression vectors for HA-tagged PKA were kindly provided by Dr. Susan S. Taylor (University of California San Diego CA). These included constructs containing the full-length open reading frame of the wild-type PKA-catalytic domain (PKA-cat-WT) and a mutant with a kinase-dead PKA-catalytic domain. (cancer-ecosystem.com)
  • Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. (synergyage.info)
  • Inactivation of this domain abolished DNA damage-dependent Rad53 phosphorylation, G2/M cell cycle phase arrest, and increase of RNR3 transcription but did not affect replication inhibition-dependent Rad53 phosphorylation. (embl.de)
  • The T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3)/galectin 9 (Gal-9) pathway, which is yet to be entirely characterized, may be a potential site of immune checkpoint blockade in immunotherapy, which could be used to overcome drug resistance ( 3 ). (spandidos-publications.com)
  • Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3. (gsea-msigdb.org)
  • The forkhead box P2 protein appears to be essential for the normal development of speech and language. (medlineplus.gov)
  • The forkhead box P2 protein is active in several tissues, including the brain, both before and after birth. (medlineplus.gov)