Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and is associated with Kn(a/b), McC(a), Sl(a) and Yk(a) antigens. (wikipedia.org)
The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
The protein includes a diphtheria toxin (DT) without a receptor binding domain and the C1, C2, C3 (3C) domains of Streptococcus protein G, that is DT3C. (cusabio.com)
Whether an antibody can be internalized is mainly determined by the target, and the efficiency of antibody internalization is closely related to the antigen density, antibody affinity, and antibody and antigen-binding epitopes. (cusabio.com)
Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
Complement3
Sushi domains exist in a wide variety of complement and adhesion proteins. (wikipedia.org)
Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a), Es(a), Tc(a/b/c), Wd(a), WES(a/b), IFC and UMC antigens. (wikipedia.org)
Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
Tumor1
Monoclonal antibodies (mAbs) are localized to the surface of tumor cells via the specificity and targeting of tumor cell-associated antigens. (cusabio.com)
Molecule1
The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
Autoantibodies2
Of note, various autoantibodies against ganglioside antigens have been identified and found to have significant associations with the axonal forms of GBS and Fisher syndrome. (afpm.org.my)
Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membraneantigens. (silverchair.com)
Cytoplasmic domains3
However, these isoforms are highly conserved between mouse and man, suggesting an important role for the cytoplasmic domains in CD47 function. (wikidoc.org)
The resulting close proximity between the TCR complex and CD4 (extracellular and intracellular) allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. (wikidoc.org)
Exons 1, 2 and most of exon 3 encode the N-terminal extracellular domain while the remainder of exon 3 and exon 4 encode transmembrane and cytoplasmic domains. (wikidoc.org)
Transmembrane3
All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. (iiab.me)
HER2 is found in a variety of tumours and some of these tumours carry point mutations in the sequence specifying the transmembrane domain of HER2. (iiab.me)
Substitution of a valine for a glutamic acid in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand. (iiab.me)
Epitopes1
The apoptosis inducing function of CD47 appears to be dependent on activation of specific epitopes on the extracellular domain. (wikidoc.org)
Induces1
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Extracellular1
In CD4 the interaction involves its extracellular D 1 domain. (wikidoc.org)
Recruit and activate2
Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
Phosphorylated ITAM motifs on CD3 recruit and activate SH2 domain-containing protein tyrosine kinases (PTK) such as Zap70 to further mediate downstream signalling through tyrosine phosphorylation, leading to transcription factor activation including NF-κB and consequent T cell activation. (wikidoc.org)
Protein5
Sushi domain is an evolutionarily conserved protein domain. (wikipedia.org)
Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer. (ucsf.edu)
CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease. (ucsf.edu)
The catalytic domain of DT3C leads to ADP-ribosylation of elongation factor (EF)-2, which subsequently leads to cytotoxicity by inhibiting protein translation machinery. (cusabio.com)
The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
Immune2
The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
Receptors1
Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. (iiab.me)
Membrane1
To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
Molecules1
CD4 interacts with the β 2 -domain of MHC class II molecules through its D 1 domain. (wikidoc.org)
Expression1
Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
Endothelial1
The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
Cells5
These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)
Figure 3: Characteristics of CD3/CD46-activated, sorted CD3 + CD4 + CD45RA + CD45RO + T cells. (nature.com)
Figure 4: Suppressive and proliferative properties of CD3/CD46-activated CD4 + T cells. (nature.com)
IFN-γ, TNF-α, and IL-2 by antigen experienced CD4+ T cells, and also enhanced their rate of conversion into their memory phenotypes against Leishvacc antigens. (bvsalud.org)
Upon binding to antigen, ADC-antigen complex enters cells through endocytosis (also called internalization). (cusabio.com)
Specific2
A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
Structure1
The name derives from the visual similarity of the domain to nigiri sushi when the primary structure is drawn showing the loops created by the disulfide bonds. (wikipedia.org)