Dolly mammal clone cells. Medical search. Frequent questions

Dolly the Sheep, the first mammal to be cloned from an adult derived somatic cell, was born in 1996. (nottingham.ac.uk)
His research blossomed after he came to Roslin Institute where in a series of papers he put the intellectual framework into the method of mammalian cloning that ultimately led to the birth of Dolly in 1996. (nottingham.ac.uk)
It became a hot topic in 1996 when Dolly the sheep was cloned via a process called somatic cell nuclear transfer. (archstl.org)
Sir Ian Wilmut, the scientist who led the team that cloned Dolly the sheep in 1996, has died at 79. (yahoo.com)
Dolly's successful birth in 1996 marked the first time a mammal was successfully cloned from an adult cell. (yahoo.com)
Professor Sir Ian Wilmut was part of a team at the Roslin Institute at the University of Edinburgh which successfully cloned Dolly in 1996. (stv.tv)
In 1996, Dolly made headlines as the first cloned mammal from an adult cell. (inverse.com)
English embryologist who in 1996 supervised the team of scientists that produced a lamb named Dolly, the first mammal cloned from a cell from an adult. (todayinsci.com)
Wilmut, along with Keith Campbell from the animal sciences research institute in Scotland, generated news headlines and heated ethical debates in 1996 when they created Dolly, the first mammal to be cloned from an adult cell. (cyprus-mail.com)
It was these efforts which led to the births of Megan and Morag in 1995 and Dolly in 1996," the university said in a statement. (cyprus-mail.com)
Scientist Ian Wilmut, who led a team from Scotland's Roslin Institute and biotech company PPL Therapeutics plc to clone Dolly the Sheep in 1996, died on Sept. 10 at age 79. (bioworld.com)
that was until 1996 when Dolly the sheep became the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer. (grammarcheck.net)
It seemed like the prophecies of doom had come true back in 2003, when reports circulated that Dolly, the famous (and first) ewe cloned in 1996, suffered from what might be considered premature aging, in the form of osteoarthritis (OA). (blogspot.com)
The science of cloning has come a long way since the successful cloning of Dolly the sheep in Edinburgh in 1996. (blogspot.com)
It was created in a laboratory in Edinburgh in 1996 using a technique called somatic cell nuclear transfer (SCNT). (worldtimetodays.com)
Dolly the sheep (named after Dolly Parton) was actually born on July 5, 1996. (scottwintersblog.com)
She was born on 5 July 1996 and died from a progressive lung disease five months before her seventh birthday (the disease was not considered related to her being a clone) on 14 February 2003. (pooginook.com)
Although many species produce clonal offspring in this fashion, Dolly, the lamb born in 1996 at a research institute in Scotland, was the first asexually produced mammalian clone. (who.int)

Professor Campbell was instrumental in the creation of Dolly the Sheep, the first cloned mammal, a breakthrough which paved the way for the successful cloning of many other mammal species. (nottingham.ac.uk)
Professor Sir Ian Wilmut, who worked with Professor Campbell on the creation of Dolly the Sheep, said: "Always cheerful and friendly, Keith will be greatly missed by all of his friends and colleagues. (nottingham.ac.uk)
He then moved to PPLTherapeutics, the company that was spun out from Roslin Institute, where that procedure and his expertise led to the birth of cloned and genetically modified sheep, pigs and cattle. (nottingham.ac.uk)
Dolly the sheep. (nottingham.ac.uk)
Inevitably most people will remember him for Dolly the sheep although his recent work was focused on fundamental and applied stem cell research as a tool for the study of human disease. (nottingham.ac.uk)
Dolly the Sheep is known as the first mammal to be cloned from an adult cell. (learner.org)
Dolly, a Finn Dorset sheep, was introduced to the public in 1997 after scientists at the Roslin Institute at the University of Edinburgh in Scotland implanted the cell nucleus from a sheep into an egg that was subsequently fertilized to create a clone. (pewresearch.org)
A year before Dolly, he successfully cloned two lambs (Megan and Morag) whose cells were taken from sheep embryos. (yahoo.com)
Portrait of Sir Ian Wilmut, the cloner of Dolly the sheep. (yahoo.com)
Specifically, many wondered: If they're doing sheep now, how long until they clone humans? (yahoo.com)
Tributes have been paid to the scientist who led the team which cloned Dolly the sheep 27 years ago after he died at the age of 79. (stv.tv)
He was a titan of the scientific world, leading the Roslin Institute team who cloned Dolly the sheep - the first mammal to be cloned from an adult cell - which transformed scientific thinking at the time. (stv.tv)
Can Humans Be Cloned Like Sheep? (probe.org)
The difference with Dolly is that all her DNA originated in a cell from the udder of an adult sheep. (newscientist.com)
The latest experiments have also produced three lambs from the cells of a sheep fetus aborted after 26 days, and four from a nine-day-old embryo. (newscientist.com)
It's been 20 years since scientists in Scotland told the world about Dolly the sheep , the first mammal successfully cloned from an adult body cell. (wptv.com)
Dolly was an exact genetic copy of that sheep - a clone. (wptv.com)
Dolly was a perfectly normal sheep who became the mother of numerous normal lambs. (wptv.com)
She lived to six and a half years, when she was eventually put down after a contagious disease spread through her flock, infecting cloned and normally reproduced sheep alike. (wptv.com)
British scientist Ian Wilmut, whose research was central to the creation of the cloned animal, Dolly the Sheep, has died at the age of 79, the University of Edinburgh said on Monday. (cyprus-mail.com)
He led efforts to develop cloning, or nuclear transfer, techniques that could be used to make genetically modified sheep. (cyprus-mail.com)
This involved taking a sheep egg, removing its DNA and replacing it with DNA from a frozen udder cell of a sheep that died years before. (cyprus-mail.com)
Dolly was the first mammal cloned from an adult cell taken from the mammary gland of a 6-year-old Finn Dorset sheep and an egg cell from a Scottish Blackface sheep. (bioworld.com)
Then in '97 the paper by Ian Wilmut came out on the cloning of Dolly the sheep. (rupress.org)
Now, researchers in the United Kingdom are about to clear Dolly's name and show additional evidence of normal aging in the tribe of university-cloned sheep that followed her. (blogspot.com)
They show that the skeletons, stored in the collections of National Museums of Scotland in Edinburgh , display radiographic OA similar to that observed in naturally-conceived sheep and Nottingham's healthy aged clones. (blogspot.com)
Professor Corr said: "We found that the prevalence and distribution of radiographic-OA was similar to that observed in naturally-conceived sheep, and our healthy aged cloned sheep. (blogspot.com)
The Human Genome Project broadened our knowledge of our species' genetic makeup, Dolly the Sheep was the first mammal cloned from an adult somatic cell, and the FDA first approved a genetically engineered (GE) plant, the [FLAVR SAVR tomato](http://californiaagriculture.ucanr.org/landingpage.cfm?article=ca.v054n04p6), for commercial cultivation. (stanfordreview.org)
When Dolly the sheep, the first mammal to be cloned from an adult cell, was born almost a quarter century ago, it was a breakthrough. (vuzv.cz)
The inventors on the '233 application, Dr. Keith H.S. Campbell and Sir Ian Wilmut, were the first to produce a cloned mammal from an adult somatic cell -- Dolly the sheep. (patentdocs.org)
On appeal, the Roslin Institute argued that unlike the donor sheep used to create Dolly, clones like Dolly are eligible for protection because they are 'the product of human ingenuity' and 'not nature's handiwork, but [their] own. (patentdocs.org)
The Court disagreed, stating that 'Dolly herself is an exact genetic replica of another sheep and does not possess 'markedly different characteristics from any [farm animals] found in nature,'' and thus, 'Dolly's genetic identity to her donor parent renders her unpatentable. (patentdocs.org)
Dolly the sheep becomes the first mammal cloned from an adult cell. (bridgemanimages.com)
When the world learned in 1997 of Dolly the sheep, the first clone produced from an adult mammal, a broad public discussion about the ethics of human cloning ensued, largely focused on the nature, meaning, and future of human procreation. (thenewatlantis.com)
When Professor Wilmut introduced the sheep in 1997, it paved the way for potential stem cell treatments to treat conditions such as Parkinson's disease, a degenerative disease that affects more than 150,000 people in the UK. (worldtimetodays.com)
He was a giant of the scientific world and led the Roslin Institute team that cloned Dolly the sheep - the first mammal cloned from an adult cell - which changed scientific thinking at the time. (worldtimetodays.com)
How did DOLLY THE SHEEP come about? (worldtimetodays.com)
Dolly was the only surviving lamb from 277 cloning attempts and was created from a milk cell from a six-year-old Finn Dorset sheep. (worldtimetodays.com)
Dolly the sheep made history 20 years ago after being cloned at the Roslin Institute in Edinburgh. (worldtimetodays.com)
1997 - In Roslin, Scotland, Ian Wilmut and colleagues announced that an adult sheep had been successfully cloned. (scottwintersblog.com)
Quick Answer: What Year Was Dolly The Sheep Cloned? (pooginook.com)
How old was Dolly the cloned sheep when she died? (pooginook.com)
Then, at age 5 - middle age, for a sheep living the good life in a research facility - Dolly developed osteoarthritis. (pooginook.com)
Why is Dolly the sheep important? (pooginook.com)
That honour belongs to another sheep which was cloned from an embryo cell and born in 1984 in Cambridge, UK. (pooginook.com)
How much did it cost to clone Dolly the sheep? (pooginook.com)
What caused Dolly the sheep to be euthanized? (pooginook.com)
Dolly the sheep, the first mammal cloned from an adult cell, died on 14 February. (pooginook.com)
What happened to Dolly the sheep clone? (pooginook.com)
Sadly, in 2003 Dolly died prematurely at the age of 6.5 years after contracting ovine pulmonary adenocarcinoma, a form of lung cancer common in sheep that is caused by the retrovirus JSRV. (pooginook.com)
What animals have been cloned since Dolly the sheep? (pooginook.com)
Today marks the 20th anniversary of Dolly the sheep, the first mammal cloned from an adult cell. (womenofageridinghorses.com)

Polly, born in 1997, was the first genetically modified cloned mammal. (yahoo.com)
Viable Offspring Derived from Petal and Adult Mammalian Cells', Nature (1997), 385 , 810. (todayinsci.com)
After years of experiments …cloning hit the big time in February 1997. (exposingsatanism.org)
General Assembly the following year,3 and the World Medical Association's Resolution on Cloning, endorsed in 1997, have confronted the issue but lack binding legal force. (who.int)

Wilmut moved to the University of Edinburgh the following decade, focusing on using cloning to make stem cells for regenerative medicine. (yahoo.com)
Prof Wilmut hoped cloning would mean no species became extinct - but Dolly also helped to pioneer stem cell research. (stv.tv)
A year ago, we showed that you could do it with cells from embryos," says Wilmut. (newscientist.com)
Wilmut and his colleagues fuse the empty oocyte with the donor cell by bringing them together and subjecting them to an electric current. (newscientist.com)
They fuse as one cell," says Wilmut. (newscientist.com)
Wilmut says there were so many failures because it is difficult to ensure that the empty oocyst and the donor cell are at the same stage of the cell division cycle. (newscientist.com)
20 Years Since 'Dolly' Dolly with Professor Sir Ian Wilmut, who led the research which produced her. (pooginook.com)

At the same time, labs in a variety of countries have successfully cloned human embryos for the purpose of producing stem cells that can be used in medical therapies. (pewresearch.org)
More than 10 different cell types have been used successfully as "parents" for cloning. (wptv.com)
They used adult cells, but it was possible that the cells that gave rise to successfully cloned animals were derived from rare adult stem cells. (rupress.org)
á belongs to a small group of world´s leading scientists who have successfully cloned mice. (vuzv.cz)
But cloning research continued, and American scientists announced in 2013 that they had for the first time successfully obtained stem cells from cloned human embryos. (thenewatlantis.com)
Dolly was the first successfully created clone from an adult mammalian cell. (worldtimetodays.com)
She was the first mammal to have been successfully cloned from an adult cell. (scottwintersblog.com)
It was reported that 29 embryos were successfully created, and subsequently implanted into 13 surrogate mothers, but Dolly was the only pregnancy that went to full term. (pooginook.com)
In 1998, scientists in South Korea claimed to have successfully cloned a human embryo, but said the experiment was interrupted very early when the clone was just a group of four cells. (pooginook.com)
Then, histological and SEM evaluations indicated that the cells could successfully penetrate the bone and cartilage lacunas in implanted grafts. (bvsalud.org)

Dolly was the first successful cloning of a mammal from an adult somatic cell, demonstrating the viability of somatic cell nuclear transfer (SCNT). (yahoo.com)
In contrast, Dolly was produced by what's called somatic cell nuclear transfer. (wptv.com)
By my calculations, Dolly was the single success from 277 tries at somatic cell nuclear transfer. (wptv.com)
Sometimes the process of cloning by somatic cell nuclear transfer still produces abnormal embryos, most of which die. (wptv.com)
Dolly, named after country singer Dolly Parton, was the first mammal to be cloned from an adult cell, using a process called somatic cell nuclear transfer (SCNT). (cyprus-mail.com)
Somatic cell nuclear transfer (SCNT) is a type of cloning that has to be done in a lab. (bartleby.com)
In SCNT they take the nucleolus out of an egg cell, replace it with the nucleolus of a somatic cell (body cell with two complete sets of chromosomes), and make the egg cell divide into a blastocyst ("What Is Cloning? (bartleby.com)
Dr. Campbell and Sir Ian obtained U.S. Patent No. 7,514,258 for the method they used to produce Dolly: somatic cell nuclear transfer, which involves removing the nucleus of a somatic cell that has been arrested in the quiescent phase of the cell cycle and implanting that nucleus into an enucleated oocyte. (patentdocs.org)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)

They produced idential lambs called Megan and Morag, which originated from different cells of the same embryo. (newscientist.com)
Last week, they published further evidence, in the form of a radiographic assessment of the skeletons of Dolly herself, Bonnie (her naturally conceived daughter) and Megan and Morag (the first two animals to be cloned from differentiated cells). (blogspot.com)

That's why Father Pacholczyk, director of education at the National Catholic Bioethics Center in Philadelphia, said that the efforts to help people understand the immorality of embryo reserch, including human cloning, must focus on humanizing the issue and appreciating our own embryonic origins, not just on the desired results of embryonic or other types of stem-cell research. (archstl.org)
After growing and dividing for a week or so in a laboratory culture dish, the fused cell forms an early embryo called a blastocyst, which Wilmut's team implants into a surrogate mother. (newscientist.com)
Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. (todayinsci.com)
The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. (todayinsci.com)
Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. (todayinsci.com)
When the one-cell embryo duplicates its genetic material, both cells of the now two-cell embryo are genetically identical. (wptv.com)
But there was no way to easily know all the characteristics of the animal that would result from a cloned embryo or fetus. (wptv.com)
Other policy options, such as supposed compromises that would prohibit "reproductive cloning" but permit "therapeutic cloning" by prohibiting not the act of creating a cloned embryo but the act of transferring a cloned embryo to a woman's uterus, would inherently mandate the wide-scale destruction of human embryos. (thenewatlantis.com)
An electric shock was used to stimulate the hybrid cell to divide and create an embryo, which was then implanted into the uterus of a surrogate mother. (worldtimetodays.com)
It would involve introducing Neanderthal DNA into a human stem cell, before finding a human surrogate mother to carry the Neanderthal-esque embryo. (pooginook.com)

There he continued his research on the cloning and genetic modification of livestock. (nottingham.ac.uk)
Part of the reason is that cloning can introduce profound genetic errors , which can result in early and painful death. (pewresearch.org)
Next, the researchers take cells containing donor genetic material. (newscientist.com)
The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. (todayinsci.com)
These germ cells are the only ones in the body that have their genetic material all jumbled up and in half the quantity of every other kind of cell. (wptv.com)
From that moment forward, nearly all cells in that body have the same genetic makeup. (wptv.com)
When they in turn duplicate their genetic material, each cell at the four-cell stage is genetically identical. (wptv.com)
In this process, researchers remove the genetic material from an egg and replace it with the nucleus of some other body cell. (wptv.com)
instead of half the genetic material coming from a sperm and half from an egg, it all comes from a single cell. (wptv.com)
Dolly's creation triggered fears of human reproductive cloning, or producing genetic copies of living or dead people, but mainstream scientists have ruled this out as far too dangerous. (cyprus-mail.com)
Since then, further research has made genetic human cloning a very real prospect, prompting huge debate over whether man is going too far in trying to play God. (grammarcheck.net)
The Y-chromosome is one of a pair of chromosomes that determine the genetic sex of individuals in mammals, some insects, and some plants. (asu.edu)
A third view says that cloning will provide for the possibility of improvement by giving birth to children who are free of birth defects, because when any two people create a child through sex there is the possibility for genetic defects. (bartleby.com)
However, since clones are the exact replicas of someone already alive, their genetic dispositions will have already surfaced. (bartleby.com)
This form of genetic engineering would deny the children it produces an open future, burdening them with the expectation that they will be like the individuals from whom they were cloned. (thenewatlantis.com)
And cloning could make possible still more dramatic forms of genetic engineering. (thenewatlantis.com)
Most natural cloning occurs in those species that produce their descendants asexually, that is, without combining the male and female genetic material. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
[ 1 ] Three biovars (with minor genetic variations) have been identified within the Y pestis clone-Antiqua, Medievalis, and Orientalis. (medscape.com)

Scientists estimate that the average human body contains 37.2 trillion cells. (learner.org)
1 No one has ever cloned a human being , though scientists have cloned animals other than Dolly , including dogs, pigs, cows, horses and cats. (pewresearch.org)
Scientists named Dolly after singer Dolly Parton, because she was cloned using a cell from the mammary gland of a six-year-old Dorset Finn ewe, and she was kept a secret for the first months of her life. (stv.tv)
But scientists have not managed to isolate such cells from farm animals, and must rely instead on injecting genes randomly into early embryos. (newscientist.com)
Dolly was an important milestone, inspiring scientists to continue improving cloning technology as well as to pursue new concepts in stem cell research. (wptv.com)
Today, cloning is used to produce police dogs, racehorses and, more recently, even pets, although it is a very controversial topic and many scientists clearly reject cloning. (vuzv.cz)
However, following the successful derivation of human embryonic stem cells in 1998, the debate over human cloning largely shifted to the question of whether it is acceptable for scientists to create human embryos only to destroy them. (thenewatlantis.com)
Mice Used as Sperm Factories for Pigs, Goats - Hillary Mayell, for National Geographic News August 14, 2002″For the first time scientists have been able to produce viable sperm from the tissue of sexually immature mammals-and at the same time produce sperm of one species in the body of another species. (exposingsatanism.org)
That month, scientists reported the first successful attempt to reproduce a large, adult mammal through cloning. (exposingsatanism.org)

It's a rather fatuous use of the technology," said Dr Harry Griffin, director of the Roslin Institute in Edinburgh, which produced Dolly. (pooginook.com)

She is the first mammal ever created from the non-reproductive tissue of an adult animal. (newscientist.com)
Last year they used the same reproductive technology to create the world's first cloned lambs (Nature, vol 380, p 64). (newscientist.com)
Dolly was the first mammal to be cloned through nuclear transfer from a somatic (non-reproductive) cell. (hosfeltgallery.com)
A second argument for cloning starts with the idea of reproductive rights. (bartleby.com)
Cloning-to-produce-children could also be used to attempt to control the physical and even psychological traits of children, extending the eugenic logic of those who would use reproductive biotechnology to have the perfect child. (thenewatlantis.com)
Under the AHR Act, it is illegal to knowingly create a human clone, regardless of the purpose, including therapeutic and reproductive cloning. (pooginook.com)
Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)
Elaboration of an international convention against reproductive cloning of human beings has been under consideration in the United Nations since December 2001 when the subject was included in the agenda of the fifty- sixth session as a supplementary agenda item at the request of France and Germany. (who.int)

Known as the four "Nottingham Dollies," they were the only survivors of a group of 10 Dolly clones that were born in 2007. (hosfeltgallery.com)
Teams at the University of Nottingham in England and the University of Glasgow in Scotland published research last year showing that a group of eight-year-old Nottingham 'Dollies' had aged normally. (blogspot.com)
The four Nottingham 'Dollies' - Debbie, Denise, Dianna and Daisy - were derived from the cell line that gave rise to Dolly. (blogspot.com)
The researchers concluded that the Nottingham Dollies had aged normally with no clinical signs of OA. (blogspot.com)

Although the latest scientific work related to cloning has been focused on potential medical applications, much of that research is relevant to the creation of cloned children. (thenewatlantis.com)

The Threat of Human Cloning concludes by calling for laws prohibiting both human cloning and the creation of embryos for research. (thenewatlantis.com)

Although the simple use of the word 'clone' may have negative connotations, many people have resigned themselves to the idea of cloning cows that produce more milk or using a cloned mouse for use in controlled experimentation. (bartleby.com)
Researchers at the Brasilia Zoo have previously produced over 100 living clones of cows and horses but the process for wild animals is different and the next stage is to get those researchers trained. (blogspot.com)

Twenty years ago today, the world's first clone made from the cells of an adult mammal made her public debut. (pewresearch.org)
Dolly, the world's first cloned mammal from an adult cell, is on display at the National Museums of Scotland in Edinburgh. (blogspot.com)

On Dec. 27, 2002, Brigitte Boisselier held a press conference in Florida, announcing the birth of the first human clone, called Eve. (pooginook.com)

And Jonathan Slack, an embryologist at the University of Bath, says that it is dangerous to base big ideas on a single case of a lamb raised from an adult ewe cell. (newscientist.com)

This pioneering study has helped pave the way for others to develop gene and stem-cell based strategies for therapeutic purposes. (nottingham.ac.uk)
At just 31 years old, Hochedlinger has already worked on therapeutic cloning in a mouse model ( 2 ), reprogramming cancer nuclei ( 3 ), and the molecular mechanisms controlling stem cell pluripotency ( 4 ). (rupress.org)

4 The public is divided about the prospect of using cloning to bring back to life species of animals that are currently extinct , such as the carrier pigeon or even the woolly mammoth. (pewresearch.org)
In a 2013 Pew Research Center poll , half of all adults surveyed (50%) said that by 2050 researchers will be able to use cloning to bring back extinct species, with 48% predicting such a development won't occur. (pewresearch.org)
I've been working with mammalian embryos for over 40 years, with some work in my lab specifically focusing on various methods of cloning cattle and other livestock species. (wptv.com)
it's highly variable, though, depending on the cell type used and the species. (wptv.com)
Includes all families of mammals, birds, reptiles and amphibians together with several of the more important genera and species, most of the families of fishes and a selection of families and genera of molluscs and insects. (grimshaworigin.org)
However, it can also be used to build the populations of still-existing species, as Endangered Animal Cloning explains. (blogspot.com)
The 8 species the Brasilia Zoo will attempt to clone include the maned wolf, brush dog, grey brocket deer, bison, jaguar, black lion tamarin monkey, Collared Anteater, and the Brazilian Aardvark. (blogspot.com)
Though, the zoo has said that they would only release the cloned animals into the wild if the species was nearing total extinction. (blogspot.com)
Guide to African Mammals (13) and the taxonomy described tion has so far been documented in 26 primate species, and 20 by Colin Groves (14). (cdc.gov)

Father Tad Pacholczyk is convinced that embryonic stem cells will someday cure diseases. (archstl.org)
At present, this is only possible with mice, using so-called embryonic stem cells. (newscientist.com)
The new technique means they will not need embryonic stem cells. (newscientist.com)

Dolly was the only lamb born from 277 fusions of oocytes with udder cells. (newscientist.com)
To give you an idea how hard this was, Dolly (initially identified as 6LL3) was the only lamb born alive from 277 attempts! (pooginook.com)

However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells. (todayinsci.com)
164. The clone of any of claims 155-159, wherein the donor mammal is non-foetal. (patentdocs.org)
Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)

The researchers wanted to see whether "mature" cells that have differentiated to fulfil a specialised role (such as that of an udder cell or a fetal cell) could be returned to a primitive state from which they could grow into entire organisms. (newscientist.com)
For each clone, the Roslin researchers combine material from two sources. (newscientist.com)
Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
The researchers travelled to Edinburgh and, with special permission from Dr Andrew Kitchener, Principal Curator of Vertebrates at National Museums Scotland, undertook radiographic examinations of the skeletons of Dolly and her contemporary clones. (blogspot.com)
Carlos Frederico Martins, one of the head researchers, would not say how long it could take to produce the first clone but he did say it would likely be a maned wolf. (blogspot.com)

Czech scientist Helena Fulková is one of those who are looking for a deeper sense of cloning „, says Iveta Toušlová, the author and presenter of the show Geyser. (vuzv.cz)

Nuclear transfer is one of the most sophisticated, fickle, and challenging techniques in cell biology. (rupress.org)
Before that, nuclear reprogramming hadn't been shown in mammals. (rupress.org)

It was thought that mammalian cells might be refractory to cloning. (rupress.org)

DOLLY may look like other lambs, but she is the most remarkable animal ever born. (newscientist.com)

While Dolly proved that cells could be used to create a copy of the animal they came from, Wilmut's next experiment proved that they could also be altered. (yahoo.com)
The book is separated into three chapters covering biotechnology, animal cloning and human cloning. (progress.org.uk)
The first cloned animal was created in 1885. (medicaldaily.com)
if a desirable animal was produced, they could thaw the frozen cells and make more copies. (wptv.com)
Thus, one could know the characteristics of the animal being cloned. (wptv.com)
I asked whether a terminally differentiated cell is still amenable to reprogramming and able to give rise to a cloned animal. (rupress.org)
Reports in 2003 that Dolly, the first animal cloned from adult cells, was suffering from osteoarthritis at the age of 5½ led to considerable scientific concern and media debate over the possibility of early-onset age-related diseases in cloned animals. (blogspot.com)
Her birth proved that specialised cells could be used to create an exact copy of the animal they came from. (pooginook.com)
Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)

Almost 20 years ago, skeptics and opponents of the cloning of horses and other livestock forecast musculoskeletal calamities and weaknesses. (blogspot.com)

The subject of human cloning has been around for much of the 20th century and beyond. (archstl.org)
A decade later, cloning came to the forefront in Missouri with the narrow passage of Amendment 2, a ballot initiative in 2006 that constitutionally protects embryonic stem-cell research and human cloning. (archstl.org)
The Catholic Church has always held that stem-cell research and therapies are morally acceptable, as long as they don't involve the creation and destruction of human embryos. (archstl.org)
Dolly's debut set off a firestorm about both the practical value and ethics of cloning, including the possibility of human cloning. (pewresearch.org)
Currently, more than 40 countries - including the UK, France, Germany and Japan - formally ban human cloning. (pewresearch.org)
2 Eight-in-ten American adults (81%) say cloning a human being is not morally acceptable, according to a May 2016 Gallup poll . (pewresearch.org)
There has been overwhelming opposition to human cloning since 2001. (pewresearch.org)
In a 2010 Pew Research Center survey , 48% of adults said that a human being would definitely or probably be cloned by 2050, compared with 49% who said such an event would not happen. (pewresearch.org)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour). (progress.org.uk)
While it is banned in Britain, however, human cloning is legal elsewhere, including the US. (newscientist.com)
Should Human Cloning Be Pursued? (bartleby.com)
The Threat of Human Cloning begins by laying out the scientific and policy background of the cloning debates. (thenewatlantis.com)
Not only would cloning-to-produce-children be a dangerous experimental procedure, one that cannot be consented to by its subjects (the children created by it), it is also a profound distortion of the moral meaning of human procreation. (thenewatlantis.com)
Cloning-for-biomedical-research is also profoundly unethical, as it turns human reproduction into a manufacturing process in the most literal sense: human embryos are created to serve as raw materials for the production of biomedical research supplies. (thenewatlantis.com)
This kind of cloning is today being performed at several scientific labs in the United States, despite the availability of alternative techniques that produce cells of nearly the same scientific and medical value but that require neither the creation nor destruction of human embryos. (thenewatlantis.com)
If research cloning is not stopped now, we face the prospect of the mass farming of human embryos and fetuses, and the transformation of the noble enterprise of biomedical research into a grotesque system of exploitation and death. (thenewatlantis.com)
The United States government can, and must, outlaw human cloning. (thenewatlantis.com)
When was the first human cloned? (pooginook.com)
There currently is no solid scientific evidence that anyone has cloned human embryos. (pooginook.com)
To date, some 35 countries have adopted laws forbidding human cloning. (who.int)
Human umbilical vein endothelial cells were used to assess the effects of miRNA mimics or inhibitors on regulation of candidate proteins. (cdc.gov)

Their results, published July last year in the academic journal Nature Communications , were in apparent stark contrast to Dolly the Sheep's diagnosis of early onset OA which led to scientific concern and media debate over the possibility of early-onset, age-related diseases in cloned animals. (blogspot.com)

Dolly's DNA came from a cell in the udder of a six-year-old Finn Dorset ewe. (newscientist.com)

Before the decades of experiments that led to Dolly, it was thought that normal animals could be produced only by fertilization of an egg by a sperm. (wptv.com)
Dolly was the culmination of hundreds of cloning experiments that, for example, showed diploid embryonic and fetal cells could be parents of offspring. (wptv.com)
I got interested in cloning during my undergraduate course, when I learned about John Gurdon's classic frog cloning experiments. (rupress.org)
What were the limitations of experiments such as Dolly? (rupress.org)
In in vitro experiments, mimics of miR-1287-5p and miR-197-5p and inhibitors of miR-339-5p and miR328-3p upregulated concentrations of EPHA2 in either cell lysate, supernatant, or both. (cdc.gov)

Perform scientific experimentation and observation to understand structures of cells and their relation to living things. (learner.org)

Kevin Sinclair, Professor of Developmental Biology, in the School of Biosciences at the University of Nottingham, said: "No formal, comprehensive assessment of osteoarthritis in Dolly was ever undertaken. (blogspot.com)

Even while clones are genetically identical, their phenotypes - the characteristics they express - will be different. (wptv.com)

The taxidermy remains of the first mammal ever cloned from an adult cell are on display in Edinburgh. (atlasobscura.com)
The University of Edinburgh announced that he had died five years after he revealed he had been diagnosed with Parkinson's - the disease for which Dolly offered hope of a cure. (worldtimetodays.com)

3 Americans are divided as to whether humans will be cloned in the near future. (pewresearch.org)
5 Fewer Americans are concerned with cloning animals than with the prospect of cloning humans , according to the same 2016 Gallup survey . (pewresearch.org)
If the same could be achieved in humans, it would mean that each of us could have clones of ourselves made from our own tissue. (newscientist.com)
The Ethical Debate Concerning Cloning In the year that has elapsed since the announcement of Dolly's birth, there has been much discussion of the ethical implications of cloning humans. (bartleby.com)
However, the idea of cloning humans is a highly charged topic. (bartleby.com)
Can humans clone? (pooginook.com)

Just 13% of adults in 2016 say cloning is morally acceptable. (pewresearch.org)
Still, a majority of adults (60%) say cloning animals like Dolly is morally wrong, compared with 34% who say it's morally acceptable. (pewresearch.org)

The breakthrough technique involved transferring the nucleus of an adult cell into an unfertilized egg whose own nucleus had been removed. (worldtimetodays.com)

A type of cloning that occurs naturally is when identical twins are born ("What Is Cloning? (bartleby.com)

Their article, Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis , has been published in the online Nature Research Open Access journal Scientific Reports . (blogspot.com)

Professor Campbell was a cell biologist/embryologist with a research career spanning more than 30 years, the majority of which was in the field of cell growth and differentiation. (nottingham.ac.uk)
His pioneering studies into cell-cycle control and cellular differentiation led to the programme of work at Roslin that gave birth to the first mammal to be cloned from adult cells - ie. (nottingham.ac.uk)
Transferring a terminally differentiated cell nucleus into an egg cell that has had its own nucleus removed wipes away the epigenetic marks of differentiation and allows the nucleus once again to code for any cell type. (rupress.org)
The cell penetration, differentiation to bone and cartilage, viability, and cell proliferation in vitro and in vivo were evaluated by qPCR, histological staining, MTT assay, and immunohistochemistry. (bvsalud.org)

In most of the 100 trillion cells of our body are 46 chromosomes. (probe.org)

The scientifically groundbreaking announcement also set off a media firestorm as experts and casual observers wrestled with lab-made mammals' ethical implications. (yahoo.com)
Several authors have attempted to outline some of the ethical objections to cloning while at the same time minimizing the role religion plays in this debate. (bartleby.com)
The report offers an ethical and policy analysis, articulating what makes cloning morally repugnant and calling for the practice to be definitively prohibited in the United States. (thenewatlantis.com)

and stem cell research, written about by the Irish Council for Bioethics and the Telegraph among others. (progress.org.uk)
In addition, Dolly's DNA may have come from a stem cell that had not yet matured into an udder cell. (newscientist.com)
The reason I then was drawn into epigenetics and stem cell biology was a lecture at the IMP by Rudolf Jaenisch. (rupress.org)
Novel treatment strategies, such as stem-cell-based therapy and their derivatives can be used to relieve inflammation in these cases. (bvsalud.org)

What was special about Dolly is that her "parents" were actually a single cell originating from mammary tissue of an adult ewe. (wptv.com)

Dolly's creation showed that genes in the nucleus of a mature cell are still capable of reverting to an embryonic totipotent state - that is, the cell can divide to produce all of an animal's differential cells. (worldtimetodays.com)

Anatomy3

Organisms11

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes21

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

199618

Sheep52

19974

Wilmut7

Successfully10

Somatic cell12

Megan and M2

Embryo10

Genetic19

Scientists9

Roslin Institute in Edinburgh1

Reproductive8

Nottingham Dollies4

Creation of cloned1

Embryos for research1

Cows2

World's2

20021

Raised from an adult1

Therapeutic2

Species9

Embryonic stem3

Lamb2

Donor4

Researchers5

Scientist1

Nuclear2

Mammalian Cells1

Lambs1

Animal9

Horses1

Human22

Sheep's1

Finn Dorset1

Experiments5

Experimentation1

Developmental biology1

Genetically identical1

Edinburgh2

Humans6

Morally acceptable2

Breakthrough1

Naturally1

Osteoarthritis1

Differentiation4

Trillion cells1

Ethical3

Stem-cell4

Adult ewe1

Dolly's1