In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical reaction dolichyl phosphate D-mannose + protein ⇌ {\displaystyle \rightleftharpoons } dolichyl phosphate + O-D-mannosylprotein Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate and O-D-mannosylprotein. (wikipedia.org)
The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. (wikipedia.org)
Synthase1
UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. (unl.edu)
Enzyme that catalyzes1
An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. (lookformedical.com)
Dolichol-phosphate2
In eukaryotes, the synthesis of the oligosaccharide core is mediated by a lipid carrier called dolichol-phosphate (Dol-P) which is located in the membranes of the endoplasmic reticulum (ER, Fig. 1a ). (biomedcentral.com)
Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. (unl.edu)
Substrates1
Thus, the two substrates of this enzyme are urate D-ribonucleotide and phosphate , whereas its two products are urate and alpha-D-ribose 1-phosphate . (wikipedia.org)
Phosphorylase1
Other names in common use include UAR phosphorylase , and urate-ribonucleotide:phosphate D-ribosyltransferase . (wikipedia.org)
Catalyzes1
This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. (unl.edu)
Glucose1
For a more unknowing glutamate of the flash mannose, make the dimerization to the intracellular RNA Pol II glucose lipid well. (evakoch.com)
Fatty1
This matrix is the carnitine of the fatty proteins activating in the 4-phosphate of duplex acid and chromatin conditions. (erik-mill.de)
Acid1
The glycine directs Newly undertaken out of the 5-phosphate and into the cycle by linear( acid) taken in the cilium disease of transcripts. (evakoch.com)
Transfer2
A group of enzymes that catalyze an intramolecular transfer of a phosphate group. (lookformedical.com)
Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. (lookformedical.com)
Enzyme dolichyl-phosphate2
Deficiency of the endoplasmic reticulum enzyme dolichyl-phosphate mannose (Dol-P-Man):Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase leads to a new type of congenital disorder of glycosylation, designated type Ig. (nih.gov)
Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. (nih.gov)
Catalytic subunit1
DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. (unl.edu)
Endoplasmic reticulum3
Biosynthesis is initiated at the endoplasmic reticulum (ER) by the transfer of mannose from dolichyl phosphate-activated mannose to Ser or Thr residues of proteins that are entering the secretory pathway. (uni-heidelberg.de)
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). (nih.gov)
The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. (unl.edu)
Mannosyltransferase complex1
The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. (nih.gov)
Biosynthesis3
A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins. (nih.gov)
Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene . (wikidoc.org)
1998). "DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate" . (wikidoc.org)
Protein4
The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. (wikipedia.org)
The initial mannosyltransfer reaction is catalyzed by an essential family of Dol-P-mannose: protein O -mannosyl-transferases (PMTs) that is evolutionarily conserved from yeast to humans. (uni-heidelberg.de)
This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. (wikidoc.org)
DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. (unl.edu)
Gene2
POMT1 gene mutations that cause Walker-Warburg syndrome lead to the formation of nonfunctional POMT enzyme complexes that cannot transfer mannose to α-dystroglycan, preventing its normal glycosylation. (medlineplus.gov)
ontaining proteins 1-4 (TMTC1-4) gene products contribute to the addition of these O-linked mannoses. (xenbase.org)
DPM11
2000). "Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3" . (wikidoc.org)
Yeast1
Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. (wikipedia.org)
Cytosolic1
DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. (unl.edu)
Donor1
POMT1 and POMT2 transfer Man to the hydroxyl group of Ser or Thr of specific proteins such as alpha-dystroglycan using mannose dolicholate as a sugar donor. (acgg.asia)