Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. (wikipedia.org)
As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. (wikipedia.org)
Further, TdT is the only polymerase that is known to catalyze the synthesis of 2-15nt DNA polymers from free nucleotides in solution in vivo. (wikipedia.org)
TdIF1 is another protein that interacts with TdT to inhibit its function by masking the DNA binding region of the TdT polymerase. (wikipedia.org)
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (biossusa.com)
Gene1
In humans, terminal transferase is encoded by the DNTT gene. (wikipedia.org)
Catalyzes1
In vitro, this behaviour catalyzes the general formation of DNA polymers without specific length. (wikipedia.org)
Vivo1
The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)
Addition1
Generally, TdT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. (wikipedia.org)