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Amphotericin BCytosineMethylationDNA (Cytosine-5-)-Methyltransferase5-MethylcytosineDNA-Cytosine MethylasesSulfitesDNA MethylationAntifungal AgentsBase SequenceUracilMolecular Sequence DataCandida albicansCpG IslandsDNACytosine DeaminasePentoxylDinucleoside PhosphatesDeoxyribonuclease HpaIIAdenineEscherichia coliAzacitidineGuanineAmino Acid SequenceNucleic Acid ConformationSubstrate SpecificityBinding SitesPromoter Regions, GeneticKineticsMutationS-AdenosylmethionineOligodeoxyribonucleotidesMethyltransferasesNucleic Acid DenaturationEpigenesis, GeneticHydroxylaminesModels, MolecularBase CompositionDNA, BacterialCell LineTranscription, GeneticMutagenesis, Site-DirectedCloning, MolecularPolymerase Chain ReactionDNA Modification MethylasesProtein BindingDeaminationDNA-Binding ProteinsStructure-Activity RelationshipProtein Structure, TertiaryProtein ConformationGene SilencingDNA, ViralDNA Restriction EnzymesMagnetic Resonance SpectroscopyLysineCytarabineS-AdenosylhomocysteineHistonesSequence Homology, Amino AcidMethionineFlucytosineProtein MethyltransferasesProtein Structure, SecondarytRNA MethyltransferasesCrystallography, X-RayAmino Acid SubstitutionHistone-Lysine N-MethyltransferaseSequence AlignmentGenomic ImprintingRecombinant ProteinsCysteineNucleoside DeaminasesCytidineGlycine N-MethyltransferaseCatalysisEpigenomicsAmino AcidsThymineCatalytic DomainMolecular StructureCytosine NucleotidesChromatography, High Pressure LiquidSequence Analysis, DNADNA PrimersBacterial ProteinsMutagenesisHydrogen BondingPeptide FragmentsSite-Specific DNA-Methyltransferase (Adenine-Specific)Conserved SequenceHydrogen-Ion ConcentrationPeptidesArginineCell Line, TumorDrug ResiduesMass SpectrometryPlasmidsHistidineLong Interspersed Nucleotide Elements
MechanismEpigeneticHistone
Mechanism2
  • The mechanism of epigenetic regulation involves the CpG site methylation of promoter regions and the modification of DNA and histones by altering chromatin structure ( 9 - 11 ). (spandidos-publications.com)
  • Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. (ijbs.com)
Epigenetic1
  • The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. (ijbs.com)
Histone5
  • Recent advances in the field of epigenetics have enabled us to understand more clearly the role of micro RNAs, DNA methylations and histone modification in disease progression, as well as its potential role in disease prevention. (intechopen.com)
  • Histone regulation through acetylation is mediated through two enzyme systems: histone acetylases (HATs) that acetylate histone lysine residues, adding a negative charge to these residues that opens up the chromatin structure to promote transcription, and deacetylase (HDACs) that remove histone acetyl groups and decrease transcription. (flowmetric.com)
  • Histone acetylation on lysine residues is read by protein modules called bromodomains (BRD2, BRD3, BRD4) that are members of BET protein family and play an essential role in transcriptional elongation and cell-cycle regression. (flowmetric.com)
  • Histone proteins can be methylated on the side chains of arginine, lysine, and histidine residues. (flowmetric.com)
  • Histone methylation is performed by histone lysine methyltransferases (KMTs) resulting in the formation of "euchromatin" structure that is indicative of increased transcriptional activity, or demethylated by the demethylases LSD1, UTX, and JMJD-type enzymes. (flowmetric.com)