• The expression of histone genes is cell cycle controlled and coupled to DNA replication, to ensure the packaging of replicated DNA into chromatin. (elsevierpure.com)
  • The post-transcriptional control of histone gene expression is a key element in this coupling to DNA replication. (elsevierpure.com)
  • This must be supported by chromosome replication and epigenetic reprogramming, but how proliferation and cell fate acquisition are balanced in this process is not well understood. (bvsalud.org)
  • Research in our laboratory involves the molecular biology and replication of eukaryotic DNA viruses. (wisc.edu)
  • Moreover, these DNA viruses exhibit a highly controlled but complex program of transcription during replication which makes them useful and attractive models for studies on eukaryotic gene regulation. (wisc.edu)
  • The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. (frontiersin.org)
  • These ORFs were first identified as essential for oriLyt-dependent DNA replication ( Pari and Anders, 1993 ). (frontiersin.org)
  • However, this expression depends on a preliminary DNA replication that occurs normally between 21 h and 31 h following activation at 18°C. Thus, the gene for DNA-ligase I is overtly expressed at the 1-cell stage. (silverchair.com)
  • In the same cytoplasmic environment, and following egg activation and DNA replication, the gene for DNA-ligase I introduced by the male pronucleus is unable to direct any production of the corresponding enzyme. (silverchair.com)
  • In mammalian embryos, DNA methylation is initialized to maximum levels in the epiblast by the de novo DNA methyltransferases DNMT3A and DNMT3B before gastrulation diversifies it across regulatory regions. (bvsalud.org)
  • DNA methylation is known to be abnormal in all forms of cancer, but it is not really understood how this occurs and what is its role in tumorigenesis. (aacrjournals.org)
  • In this review, we take a wide view of this problem by analyzing the strategies involved in setting up normal DNA methylation patterns and understanding how this stable epigenetic mark works to prevent gene activation during development. (aacrjournals.org)
  • Aberrant DNA methylation in cancer can be generated either prior to or following cell transformation through mutations. (aacrjournals.org)
  • It is likely that this methylation contributes to the tumor state by inhibiting the plasticity of cell differentiation processes. (aacrjournals.org)
  • In this review article, we have adopted a developmental approach for understanding what DNA methylation actually does, and this suggests new concepts for the role of this modification in tumorigenesis. (aacrjournals.org)
  • The DNA methylation pattern of the entire organism is generated in a programmed manner during normal development. (aacrjournals.org)
  • Epigenetic information can be transmitted by several different molecular mechanisms, which include but are not limited to DNA methylation and histone post-translational modifications (PTMs). (plos.org)
  • It includes a zinc finger DNA-binding domain, a ligand-binding domains, and a transcriptional account activation sector. (syspro.my)
  • Embryonic stem (ES) cells possess a globally open, decondensed chromatin structure that, together with transacting factors, supports transcriptional competence of developmentally regulated genes. (huji.ac.il)
  • AlphaPoint has 3 live blockchain applications, with over 20 customers, and over $500 Million transacted on the platform. (accenture.com)
  • In some processes, chromatin modifications carry heritable regulatory information that is transmitted from mother to daughter cells, whereas in other cases, they are implicated in the execution of the information contained in the DNA sequence, or occur as a consequence of dynamic nuclear processes such as transcription. (plos.org)
  • Many processes in parasite biology involve changes at the chromatin level, including regulation of transcription along a complex life cycle, delimitation of functional elements in the genome, and antigenic variation. (plos.org)
  • Here we will describe our current knowledge of the biological processes and mechanisms that can be considered bona fide epigenetic phenomena in Plasmodium biology, and attempt to distinguish them from those unlikely to involve epigenetic flow of information, even if chromatin changes occur. (plos.org)
  • We will not judge the use of the term epigenetic in different situations, but will rather attempt to clarify the roles of chromatin-based modifications in the different processes. (plos.org)
  • Genes in a synexpression group may not be physically linked, but they are involved in the same process and they are coordinately expressed. (wikipedia.org)
  • It is expected that genes that function in the same process be regulated coordinately. (wikipedia.org)
  • Analysis of DNA microarray expression profiles has led to the discovery of a number of genes that are tightly co-regulated. (wikipedia.org)
  • Since groups of genes involved in the same biological process often share one or more common control elements, it has been suggested that the differential expression of these synexpression groups in different tissues of organisms can contribute to co-evolution tissues, organs, and appendages. (wikipedia.org)
  • To exert stimulatory or repressive effects on transcription, accessible regulatory DNA elements must be in close spatial proximity to susceptible genes. (biomedcentral.com)
  • We are examining the mechanisms that control the proper turn on and turn off of viral genes during infection by focusing on the molecular interactions between cis-acting DNA regulatory sequences and virus/host transcription factors. (wisc.edu)
  • Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
  • DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. (lookformedical.com)
  • In the axolotl, DNA-ligase I (8S) is specific for embryonic stages. (silverchair.com)
  • Haploid androgenetic axolotl embryos develop devoid of the 8S DNA-ligase characteristic of control embryos ( Fig. 1A,B ). The paternal gene for DNA-ligase I is in a repressed state. (silverchair.com)
  • DNA-ligase activity in eukaryotic cells is carried out by two different molecular forms of the enzyme. (silverchair.com)
  • Developmental processes provide an example of how changes in synexpression control networks could significantly affect an organism's capacity to evolve and adapt effectively. (wikipedia.org)
  • Depending on the developmental stage and the tissue considered, types of cell are available that express exclusively either one or the other of the two DNA-ligases with a defined level of activity. (silverchair.com)
  • It involves mRNA 30 end formation by histone-specific nuclear RNA processing, which produces mRNAs lacking a poly(A) tail, translation and mRNA stability control. (elsevierpure.com)
  • Synexpression groups are determined mainly by analysis of expression profiles compiled by the use of DNA microarrays. (wikipedia.org)
  • A biological process that is crucial for gene expression in most animal life, including humans. (genomicglossaries.com)
  • To fit it into a nucleus with a diameter of ~10 μm, DNA is wrapped around histone octamers, creating strings of nucleosomes that can be further organized into higher-order levels of compaction [ 1 ]. (biomedcentral.com)
  • Here we review recent observations that now reveal that many of the factors involved are shared with processing, translation and degradation of poly(A) mRNA. (elsevierpure.com)
  • Homology phosphorylated form( HDR) through environmental particle enhancing( phagocytosis), uncertain to HDR through separate efficiency cholesterol( HRR), is individual entrepreneur of DNA crucial state degradation is( DSBs), comprised by 1-diphosphate rimantadine and concentration of the complete lacking intermediate coupled factors( IRIF) at DNA DSB members. (familie-vos.de)
  • RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
  • DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. (lookformedical.com)
  • Following fertilization, there is a step-wise process of erasure that removes most of the methyl groups derived from the gametic DNA, thus forming an epigenetic ground state. (aacrjournals.org)
  • DNA sequencing technologies and advanced analytics will enhance agricultural production, decrease reliance on fossil fuels, and extend human life expectancy. (hubinit.tech)
  • They propose a model and present supporting evidence to demonstrate the active involvement of pioneer transcription factors in this process. (huji.ac.il)
  • Instead of just processing and storing currency transactions, its nodes are supposed to collectively function as a "world computer" on which, using specialized programming languages, people can build applications that are supposed to look and feel much like the ones already on our phones-except no one is in charge of them. (technologyreview.com)
  • Often described as legacy technology, these are mission-critical applications that process daily transactions, account updates, and more. (kyndryl.com)
  • The company processed transactions for local banks, government social programs, and fuel transactions for trucking companies. (healthcarecapitalmergers.com)
  • Another strategic approach we're seeing corporates take is a 'roll-up' technique, where they acquire several companies specifically for their IT and operational digital platforms and transforming while transacting for immediate 'best of breed' technology. (deloitte.com)
  • NMD is a fine-tuned process that requires concerted action of several trans -acting factors. (nature.com)
  • Our established, industry-leading Anti-Money Laundering (AML), Know Your Customer (KYC), Counter Terrorism Financing (CTF) and Economic Trade Sanctions (ETS) processes reduce the risk for all parties in our network. (octet.com)
  • According to classic definitions, epigenetics refers to heritable differences between cells or organisms that occur without changes in DNA sequence, and do not depend on different external conditions [1] - [4] . (plos.org)
  • intermediates may dimerize on whether their hypotonia will form and what abnormal vitamin and NICD1 processes their plasma will control. (familie-vos.de)
  • People want to go away and consider it before making their decision without feeling pressured - 60% of our customers will transact online even if they have visited the store. (am-online.com)
  • By deploying the mobile app in conjunction with a desktop app, we enabled the customers to track the planting process more efficiently. (toptal.com)
  • During my Ph.D. studies at the Technical University of Munich, I wrote my dissertation: Recognition of UV-induced DNA Damage-A Molecular Dynamics Analysis. (toptal.com)
  • The heavy molecular form of the enzyme, referred to as DNA-ligase I, is generally present in proliferating tissues. (silverchair.com)
  • Coordinate and own the renewal process workflow for successful, timely execution. (susaventures.com)
  • Relax in the certainty that we've extensively verified all members transacting on our platform. (octet.com)
  • It's in our DNA, that sensitivity to our members' needs, that drive to respond,' says Missy Agee, CommunityAmerica's Director of Performance Tracking. (gallup.com)
  • Suddenly a whole world has opened up and restaurant leaders are seeing that the old ways of kitchen operations had a lot of inaccuracies," says Rich Lopez, manager of customer success engineering and restaurant solutions at TransAct Technologies. (qsrmagazine.com)
  • Lopez says many restaurant leaders reach out to TransAct Technologies because they are looking for food safety solutions. (qsrmagazine.com)
  • T-REX - a platform that provides tools for sophisticated risk analysis and valuation of assets to make the finance process more efficient and transparent, shortening the transaction time from up to six months to less than one week. (accenture.com)
  • But we increasingly recommend companies tackle both at once to 'transform while transacting', with a flexible cloud-based solution across front, middle, and back office. (deloitte.com)
  • It is awarded by B Lab to leading companies in their social and environmental commitment after passing a rigorous assessment process through which companies must provide evidence of good practice and incorporate their legal commitment to social purpose into their charter. (scrapad.com)
  • With the phrase "other biological attributes", the text technically leaves the door open for the collection of DNA data, contrary to the court's directive. (aljazeera.com)
  • It's part of our business' DNA, because keeping both you and your data safe is paramount. (octet.com)
  • The new core systems introduced less costly N-tier architectures that supported real-time processing and allowed for separating front-end business logic from the mid-tier business logic and the data access logic. (kyndryl.com)
  • The purpose of collecting your data is to be able to deal with your request for information, without transferring them to third parties, Samoving SL being responsible for the processing. (scrapad.com)
  • The tool has a lot of promise within the financial industry, where it could allow users to transact anonymously. (a2d-consulting.com)
  • There is a tangible entrepreneurial spirit and a DNA consisting of wealth, mobility and innovation.How can people begin to invest in assets and goods such as fine art for the first time?With Idoneus, acquiring assets and goods, such as fine art, is simple and secure. (gulf-times.com)
  • Streamlined, secure contracting and transacting will propel commercial use. (hubinit.tech)
  • This position is responsible for coordinating the internal service process for assigned commercial property and casualty clients in a new, industry-changing brokerage. (susaventures.com)
  • PCD or apoptosis is a built-in, signal-induced process by which a cell self-destructs. (wisc.edu)
  • Back-of-house operations have been slowest to switch to digital and cloud-based platforms, but thanks to front-of-house advancements technology has begun seeping into the DNA of the modern kitchen. (qsrmagazine.com)
  • Genetic engineering technology will expand with faster computer processing speeds. (hubinit.tech)
  • Zero-Carbon Natural Gas - a company in Houston is testing a technology that generates power from natural gas while also capturing all the carbon dioxide that the process releases resulting in cheap (as cheap as current natural gas plants), carbon-free energy. (a2d-consulting.com)
  • Their microservice-driven architecture decouples business capabilities such as customer and account management, transaction processing, statements, and reporting. (kyndryl.com)
  • People don't want to haggle, they want a simple, transparent process as that's what it's like when we buy other things. (am-online.com)
  • Sandra Montes Pérez, COO and founder of ScrapAd, adds that "respect for the environment and people are in our company's DNA. (scrapad.com)
  • If images are taken in a specific order, the process can also be automated. (toptal.com)
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
  • We are particularly interested in the baculoviruses, a group of large DNA viruses that are pathogenic to invertebrates. (wisc.edu)
  • Rubicon took part in the re-capitalisation of Fletcher Challenge Forests that occurred last year - again, as part of the restructuring of the Fletcher Challenge Group, where Rubicon acted as a facilitator of the FCL separation process. (sharechat.co.nz)
  • During the second half of the 20th century, barley ( Hordeum vulgare ) has been widely used as a model organism for studying biological processes such as photosynthesis and chloroplast development. (mdpi.com)
  • Below, we share the highlights from our theme, Transform while transacting. (deloitte.com)
  • The disposal process has of course been a great value-success for shareholders - we sold the Brisbane and Challenge businesses for NZ$73 million, which compares with a combined acquisition cost of only $20 million - i.e. a value-gain of some $53 million, or 15 cents per Rubicon share. (sharechat.co.nz)