• I'm currently have some trouble screening a ZAP II library composed of genomic DNA of my bacteria of interest. (bio.net)
  • Because the probes are not specific to a particular disease, the technology provides a genomic-based bacterial identification system that does not require a one-to-one ratio of DNA probes to pathogenic species. (phys.org)
  • More recent genomic identification methods that use polymerase chain reaction, or PCR, and genomic sequencing can be faster but require expensive equipment and training as well as a specific DNA probe for each pathogen to be tested. (phys.org)
  • From a genomic DNA library of Lactobacillus delbrueckii subsp. (asm.org)
  • As a demonstration of the usefulness of this simulation-guided design approach, we developed probes that, in combination with PCR amplification, detect low concentrations of variant alleles (1%) in human genomic DNA. (rice.edu)
  • Genomic DNA probes were made for five members of the Anopheles punctulatus complex of mosquitoes found in Papua New Guinea. (ajtmh.org)
  • farauti No. 6, by differentially screening total genomic DNA libraries of individual species and sibling species with homologous DNA against heterologous DNA labeled with 32 P. Probes ranged from 273 to 630 bp. (ajtmh.org)
  • We were able to retrieve, from published melting temperatures, several established flexibility properties such as the presence of highly flexible TATA regions of genomic DNA and support recent findings that DNA is very flexible at short length scales. (soton.ac.uk)
  • Patent No. 6,828,097, "Single Copy Genomic Hybridization Probes and Method of Generating the Same," was granted in December 2004, and patent No. 7,014,997, "Chromosomal Structural Abnormality Localization with Single Copy Probes" was granted in March 2006. (technologynetworks.com)
  • We plan to further develop this assay into a hassle-free genotyping assay to detect SNPs in real biological samples containing long genomic DNA," says Tan. (nanotech-now.com)
  • Electron microscopic DNA-DNA in situ hybridization was performed, with (a) a probe prepared from DNA extracted from the fibrillar complex of LEP cells, (b) a probe for human total genomic DNA, and (c) a probe for the transcribed part of human rDNA. (biologists.org)
  • To measure these changes in real time, the researchers anchored fluorescent-labeled DNA molecules to electrodes on the gold surface of the TUM platform, and applied an electric field to orient the fluorophores in a well-ordered manner conducive to effective detection of conformational changes. (bu.edu)
  • Pyrene binary probes for unambiguous detection of mRNA using time-resolved fluorescence spectroscopy," Nucleic Acids Research , vol. 34, no. 10, pp. 3161-3168, 2006. (hindawi.com)
  • Detection of nucleic acids in situ: novel oligonucleotide analogues for target-assembled DNA-mounted exciplexes," Organic and Biomolecular Chemistry , vol. 5, no. 7, pp. 1039-1051, 2007. (hindawi.com)
  • 1989. Detection of rotavirus by hybridization with a nonradioactive synthetic DNA probe and comparison with commercial enzyme immunoassays and silver stained Polyacrylamide gels. (springer.com)
  • Detection of enterotoxigenic Escherichia coli by dot blot hybridization with biotinylated DNA probes. (springer.com)
  • These probes, coupled with changes in the chromosome-preparation procedure that improve fluorescent signal detection, allowed the development of a FISH karyotyping method that is effective on all tested maize lines. (pnas.org)
  • With a sandwich immunoassay, one DNA-derived magnetic nanoprobe, simplified as DNA/(ZMPs-HRP-AFP Ab 2 ) n , was employed for the detection of AFP. (hindawi.com)
  • In areas where histoplasmosis is not endemic, including Taiwan, serologic tests, antigen detection reagents, and specific DNA probes for diagnosis of histoplasmosis are not universally available. (thefreedictionary.com)
  • A DNA probe for the specific detection and identification of Streptococcus oralis was isolated from HindII-digested DNA of S. oralis NCTC 11427 and cloned in Escherichia coli. (asm.org)
  • Finally, the probe complexes were reconfigured to act as AND-gates for the detection of co-localized proteins. (rice.edu)
  • A commercial DNA probe kit (Gen-probe) for the detection of rRNA from legionellae was evaluated for its accuracy in diagnosing Legionnaires' disease in 167 patients with pneumonia. (nih.gov)
  • Here, the volume-amplified magnetic nanobead detection assay (VAM-NDA) is for the first time applied for detection of rolling circle amplified (RCA) DNA molecules in a portable, commercial AC susceptometer that operates at ambient temperatures and with an analysis time of about 20 min. (diva-portal.org)
  • The findings show that the VAM-NDA holds promise for future wide-spread implementation in commercial AC susceptometer setups thus opening up for the possibility to perform magnetic bead-based DNA detection in point-of-care and outpatient settings. (diva-portal.org)
  • This thesis describes a new approach to biomolecular analysis, called the volume-amplified magnetic nanobead detection assay (VAM-DNA). (diva-portal.org)
  • Detection of plasmid-mediated beta-lactamases with DNA probes. (asm.org)
  • The limits of detection and quantification were 7 and 100 DNA copies for calibration standards and T. bryosalmonae was reliably detected down to 100 copies in tissue and eDNA samples. (usgs.gov)
  • Gene detection using immobilized DNA probes (PhD thesis). (wikipedia.org)
  • Transcription factor proteins, nucleosomes and other DNA-binding molecules may bend DNA and bring distant segments of DNA into close proximity, thereby causing genes to turn on or off. (bu.edu)
  • Since this intensity increases with height above the gold surface, the researchers could deduce any resulting height changes in segments of the DNA molecules-and thus pinpoint corresponding changes in their shape. (bu.edu)
  • When you introduce a protein in solution, the protein will bind to the DNA and change its shape, resulting in a change in the spectral signature we observe from the fluorescent molecules attached to the DNA," said Ünlü. (bu.edu)
  • In the National Science Foundation study, Spuhler introduced a protein called E. Coli Integration Host Factor (IHF) that can bend DNA molecules by as much as 180 degrees, and observed protein-induced bending upon the binding of IHF to the dsDNA probes. (bu.edu)
  • They aim to eventually use SSFM to analyze different protein-DNA interactions and to identify and characterize specific proteins that induce considerable shape changes in DNA molecules. (bu.edu)
  • Exchange-PAINT, a recently developed DNA-based multiplexing approach, in theory facilitates spectrally-unlimited multiplexing by sequentially imaging target molecules using orthogonal dye-labeled 'imager' strands. (rsc.org)
  • Nanozirconium dioxide (nano-ZrO 2 ), as a kind of Lewis acid, can be directly used to fix the antibody and enzyme through combining the carboxylic acid [ 12 , 13 ] of protein molecules with the phosphoric acid groups [ 14 ] (such as Lewis strong alkali) of DNA. (hindawi.com)
  • Lieb studies chromatin, the protein superstructure that packages DNA and controls which sections of the genome are accessible to regulatory molecules that convert the genetic code into cellular action. (unc.edu)
  • In this thesis, the structural dynamics of water molecules and counterions in the hydration shell of DNA is investigated by two-dimensional infrared (2D IR) spectroscopy and pump-probe transient spectroscopy. (hu-berlin.de)
  • Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. (healthtap.com)
  • The obvious induced circular dichroism signals in circular dichroism spectra reveal that the molecules can specifically interact with DNA. (spie.org)
  • Others mechanically disturb or modify short molecules and therefore do not obtain flexibility properties of unperturbed and pristine DNA. (soton.ac.uk)
  • The protein molecules alone are smaller in molecular size than the protein-DNA complexes, leading to a less effective steric stabilization of the nanoparticles. (nanotech-now.com)
  • The researchers next plan to combine electrical orientation of fluorescent-tagged DNA with a new optical technique developed by Unlu that uses self-interference fluorescence microscopy (SSFM) to more precisely measure the height of the fluorophores. (bu.edu)
  • In addition, the investigators conducted a set of imaging experiments in which they used a short stretch of DNA as a targeting molecule and a fluorescent dye as the imaging agent. (phys.org)
  • DNA nanotechnology has emerged as a promising technology for applications such as single molecule sensing, super-resolution imaging, and manipulating molecular components. (harvard.edu)
  • however, relative to natural biomolecular machines, the functional scope of DNA nanotechnology is limited by an inability to design dynamic mechanical behavior such as complex motion, conformational dynamics, or force generation. (harvard.edu)
  • The mechanical properties of DNA fundamentally constrain and enable the storage and transmission of genetic information and its use in DNA nanotechnology. (uni-muenchen.de)
  • By merging two powerful sequencing-based assays with a machine learning-based tool, a research team led by Xinchen Wang and associate members Melina Claussnitzer and Manolis Kellis in the Broad's Metabolism and Epigenomics programs, respectively, have engineered a powerful new approach for measuring individual noncoding DNA segments' ability to control gene expression, and doing so at both massive scale and high resolution. (broadinstitute.org)
  • On my medical records, it says that a test that was taken was performed using the bd probetec chlamydia trachomatis and neisseria gonorrhoeoae amplified DNA assays, does that indicate that it was a DNA probe test? (healthtap.com)
  • Burgeoning Molecular Diagnostics Market Propels the Global DNA Probes-Based Diagnostics Market, According to New Report by Global Industry Analysts, Inc. (prweb.com)
  • GIA announces the release of a comprehensive global report on DNA Probe-Based Diagnostics markets. (prweb.com)
  • The global market for DNA Probe-Based Diagnostics is forecast to reach US$30 billion by the year 2017, driven by the rapidly expanding molecular diagnostics market. (prweb.com)
  • Growth in the marketplace is also expected to stem from affluent population and widening health insurance as well as medical reimbursements, which are making expensive cutting edge diagnostic tools such as DNA-based diagnostics increasingly affordable. (prweb.com)
  • And given the need to rapidly and inexpensively determine the relevant DNA sequence information in a given organism, the potential of DNA probes-based diagnostics is huge. (prweb.com)
  • Also, the boom in the molecular diagnostics market is beginning to echo downstream into the DNA-probe based diagnostics segment. (prweb.com)
  • Further, affluent population and widening health insurance and medical reimbursements are additionally making expensive cutting edge diagnostic tools, such as DNA-based diagnostics, increasingly affordable. (prweb.com)
  • The US represents the largest regional market for DNA Probe-Based Diagnostics market worldwide, as stated by the new market research report on DNA Probes-Based Diagnostics . (prweb.com)
  • In the US, the rapid growth of DNA-based diagnostics is leading to the development of new tests for the treatment of non-contagious diseases, such as diseases related to aging or chronic diseases. (prweb.com)
  • Infectious Diseases represents the key end-use market for DNA probes-based diagnostics worldwide. (prweb.com)
  • The research report titled "DNA Probes-Based Diagnostics: A Global Strategic Business Report" announced by Global Industry Analysts Inc., provides a comprehensive review of the DNA probe-based diagnostics markets, current market trends, key growth drivers, recent product introductions, recent industry activity, and profiles of major/niche global as well as regional market participants. (prweb.com)
  • The report provides annual sales estimates and projections for DNA Probe-Based Diagnostics market for the years 2009 through 2017 for the following geographic markets - US, Canada, Japan, Europe, Asia-Pacific and Latin America. (prweb.com)
  • This econometric study covers the world outlook for DNA probes-based diagnostics across more than 200 countries. (marketresearch.com)
  • This study gives, however, my estimates for the worldwide latent demand, or the P.I.E. for DNA probes-based diagnostics. (marketresearch.com)
  • Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent. (bio-medicine.org)
  • In order to successfully capitalize on the opportunities presented by the molecular diagnostics market, many companies are already exploiting new DNA probe and biochip technologies as corporate strategic assets, managed in support of business and marketing strategies. (bio-medicine.org)
  • As they reported in Nature Communications , the team applied HiDRA to a blood cell line to test about seven million noncoding DNA fragments for ones that regulate gene expression, ultimately identifying 65,000. (broadinstitute.org)
  • Fragments that bind to this pocket were shown to inhibit the ATPase activity as well as the DNA topological transition activity of DNA gyrase in vitro . (rsc.org)
  • An X-ray plate has been superimposed onto the grid, showing some DNA fragments tagged with a radioactive marker (dark spots). (sciencephoto.com)
  • Using primers that are 9-mer and longer and exonuclease-free enzyme results in higher labeling efficiency and longer probes. (clontech.com)
  • beta-Lactamase identification by colony hybridization with 32P-labeled DNA probes for TEM-1, SHV-1, OXA-1, OXA-2, PSE-1, PSE-2, and PSE-4 was compared with isoelectric focusing in 122 clinical isolates making a variety of enzyme types. (asm.org)
  • All strains producing a probe-type enzyme gave a positive hybridization reaction. (asm.org)
  • The report on "Global DNA Probe-based Diagnostic Market" is a professional report which provides thorough knowledge along with complete information pertaining to the DNA Probe-based Diagnostic industry a propos classifications, definitions, applications , industry chain summary, industry policies in addition to plans, product specifications, manufacturing processes, cost structures, etc. (openpr.com)
  • The Global DNA Probe-based Diagnostic Market Research Report renders deep perception of the key regional market status of the DNA Probe-based Diagnostic Industry on a global level that primarily aims the core regions which comprises of continents like Europe, North America, and Asia and the key countries such as United States, Germany, China and Japan. (openpr.com)
  • It is a methodical research depending on the market and examines the competitive framework of the global DNA Probe-based Diagnostic Market industry. (openpr.com)
  • Research at Western Carolina University on DNA sequencing used in crime labs has gotten a $718,000 grant from the National Institute of Justice. (smokymountainnews.com)
  • Mark Wilson, director of the Forensic Science Program at WCU, has been evaluating new DNA sequencing instrumentation for use in crime laboratories. (smokymountainnews.com)
  • The grant will not only support the research but also provides scholarships for three graduate students working on related projects to help with the work, which builds on previous DNA sequencing done at WCU. (smokymountainnews.com)
  • Dynamic DNA complexes are able to undergo multiple hybridization and dissociation events through a process called strand displacement. (rice.edu)
  • Given the ability to visualize large numbers of cellular markers using dynamic DNA probe complexes, high-content proteomic analyses can be performed on a single sample, enhancing the power of fluorescence imaging techniques. (rice.edu)
  • Furthermore, dynamic DNA complexes offer new avenues to incorporate DNA-based computations and logic for in situ molecular imaging and analyses. (rice.edu)
  • Tan and co-workers discovered that when single-stranded DNA and its binding protein were both present in the solution, coupled with a salt that stimulates nanoparticle aggregation, the DNA remained red in color, indicating that the DNA-protein complexes had bound with the nanoparticles through electrosteric stabilization forces. (nanotech-now.com)
  • The greatest challenge in this work was to determine the optimum conditions for single-stranded DNA to bind with its binding protein to form complexes that confer the highest stability to gold nanoparticles from salt-induced aggregation," says Tan. (nanotech-now.com)
  • The researchers attribute binding of the nanoparticles and the DNA-protein complexes to the presence of sulphur-containing groups in the protein, which are known to create strong bonds with gold. (nanotech-now.com)
  • The binding protein can thus attach to the dissociated single-stranded DNA to form protein-DNA complexes, offering sites to which gold nanoparticles can adhere. (nanotech-now.com)
  • Photoactivated DNA cleavage may be coupled to this conformation-specific binding by taking advantage of the photophysical properties of ruthenium(II) complexes. (caltech.edu)
  • Osmium tetroxide complexes have been widely used as probes of the DNA structure (1). (jbsdonline.com)
  • Now researchers at Boston University's College of Engineering, the Technical University of Munich (TUM) and Nanyang Technological University in Singapore have demonstrated a new strategy to more efficiently measure protein-induced DNA shape, or conformational changes in real-time. (bu.edu)
  • The piece of DNA that the researchers chose recognizes and binds to the BRCA1 tumor suppressor gene, mutations in which increases susceptibility to developing breast cancer. (phys.org)
  • To really understand the functional geography of the noncoding genome, however, researchers need a way to isolate and characterize thousands to millions of regulatory DNA elements within it simultaneously, rapidly, and at high resolution. (broadinstitute.org)
  • By building on these approaches, HiDRA lets researchers create massive libraries of regulatory DNA and study their influence over gene expression at nucleotide-level resolution. (broadinstitute.org)
  • In addition, the team used HiDRA to examine how disease risk DNA variants in regulatory elements affect gene expression compared to variants that do not raise risk - a boon for researchers seeking to study how minute sequence variations in promoters and enhancers can impact human traits and disease states. (broadinstitute.org)
  • Rice University researchers (clockwise from left) Richard Baraniuk, Amirali Aghazadeh and Rebekah Drezek have invented a technology that could potentially identify hundreds of bacterial pathogens simply, quickly and at low cost using a single set of random DNA probes. (phys.org)
  • Writing in the Nov. 18 Proceedings of the National Academy of Sciences (PNAS), Stanford researchers described how newly created circles of synthetic DNA - called "nanocircles" - could help researchers learn more about the aging process in cells. (innovations-report.com)
  • As in many other sensing schemes, the researchers attach DNA probes to the material's surface. (thefreedictionary.com)
  • MIT researchers, led by toxicology graduate student Yelena Margolin of the Biological Engineering Division, have discovered that the DNA damage produced by one of these inflammatory chemicals, nitrosoperoxycarbonate, occurs at unexpected locations along the DNA helix. (wordpress.com)
  • For years researchers have studied how the chemicals associated with the body's response to infection can damage DNA. (wordpress.com)
  • By using comprehensive chemical screening and analysis of the frequency of DNA damage, the researchers found that a chemical produced during inflammation, nitrosoperoxycarbonate, actually caused oxidative damage at guanines that were supposed to be the least easily oxidized. (wordpress.com)
  • The researchers used the optical properties of gold nanoparticles to probe the mechanism of protein-DNA binding. (nanotech-now.com)
  • 3. A synthetic DNA hybridization probe as defined by claim which comprises a single sequence at least 12 nucleotides long. (google.com.au)
  • 4. A locus specific synthetic DNA probe which hybridizes at high criteria to form 100% matched duplexes with a nucleotide sequence as described by claim 1. (google.com.au)
  • a labeled segment of DNA or RNA used to find a specific sequence of nucleotides in a DNA molecule. (thefreedictionary.com)
  • Tan and co-workers showed that there was a minimum length of DNA sequence under which the binding protein-DNA adhesion mechanism could operate. (nanotech-now.com)
  • They found that the binding protein had a preference for binding to specific chemical units (bases) which make up DNA, and were able to spot DNA sequence variations, called single nucleotide polymorphisms (SNPs), even at the extreme ends of the molecule which are difficult to identify. (nanotech-now.com)
  • The license agreement grants Ikonisys a worldwide license under Abbott patents for the manufacture and sale of DNA probes in conjunction with Chromotest(TM), a revolutionary test for the prenatal diagnosis of chromosomal abnormalities using fetal cells from the maternal circulation. (thefreedictionary.com)
  • The results indicate that the examination of respiratory tract secretions by the Gen-probe kit is a suitable screening test for the diagnosis of Legionnaires' disease. (nih.gov)
  • These probes allow us to now drill down to the DNA level and see that the cause of the disease may actually be slightly different between patients with the same diagnosis. (technologynetworks.com)
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/733335/all/DNA_probe. (tabers.com)
  • DNA Probe-based Diagnostic Market 2017-2022, has been prepared based on an in-depth market analysis with inputs from industry experts. (openpr.com)
  • But it is likely to stir up discussions in the DNA damage and mutagenesis fields that could help us better understand the consequences of inflammation. (wordpress.com)
  • Mini-Tn5 transposon derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative eubacteria. (asm.org)
  • J. D. Hall and D. W. Mount, Mechanism of DNA replication and mutagenesis in ultraviolet-irradiated bacteria and mammalian cells, Prog. (springer.com)
  • Rice University scientists have invented a technology that could potentially identify hundreds of bacterial pathogens simply, quickly and at low cost using a single set of random DNA probes. (phys.org)
  • Instead, the UMD system measures how well the disease DNA binds with each of the random probes and creates a specific binding profile for the test organism. (phys.org)
  • Comparative mapping of cleavage sites on a linear pBR322 fragment for tris(phenanthroline)ruthenium(II), which binds to B-DNA and cleaves also by sensitization of singlet oxygen, and for Ru(TMP)2/3+ shows the selective binding of ARu(TMP)2/3+ to conformationally distinct sites along the fragment. (caltech.edu)
  • The photoinduced DNA strand scission is likely to be mediated by singlet oxygen, which leads to a preferential cleavage of guanine residues. (caltech.edu)
  • Consequently, almost half of the identifications made so far have been solely on the basis of genetic testing--682 of the 1,411 named--and DNA analysis helped in the identification of 343. (latimes.com)
  • The probes are species-specific and with the use of 32 P labeling sensitive enough so that a squash blot of only a small segment of the mosquito is required for identification. (ajtmh.org)
  • Problems in the Connecticut state police crime lab delayed for at least four years the identification of a woman investigators think was killed by suspected serial killer William Devin Howell and hindered their ability to match several different samples of DNA found in Howell's van, The Courant has learned. (courant.com)
  • Construction of a DNA probe for the specific identification of Streptococcus oralis. (asm.org)
  • Wells, Robert J. 1996-12-01 00:00:00 The random amplified polymorphic DNA (RAPD) method was investigated as a potential fish species identification method. (deepdyve.com)
  • Microarrays can be used as multigenic predictors of patient response, but probe selection remains problematic. (biomedcentral.com)
  • DNA-based diagnostic testing is rapidly entering the cancer setting as well. (prweb.com)
  • Rice's "universal microbial diagnostic," or UMD, uses pieces of randomly assembled DNA and mathematical techniques that were originally pioneered for signal processors inside digital phones and cameras. (phys.org)
  • With universal microbial diagnostic, we won't need new probes or to change any other parts of the sensing hardware," he said. (phys.org)
  • The diagnostic performance of the DNA probe assay in this study was superior to that of the DFA test. (nih.gov)
  • QY Research Groups has released a most recent report in view of industry research on DNA Probe-based Diagnostic market . (openpr.com)
  • The report cloaks the market analysis and projection of "DNA Probe-based Diagnostic Market" on a regional as well as global level. (openpr.com)
  • Distinguishing the increasing predominance of DNA Probe-based Diagnostic Market, this market research report demonstrates to be a key source of management and thorough data on the market across the globe. (openpr.com)
  • DNA Probe-based Diagnostic Market report helps to increase business/sales activities by understanding competitor's businesses better, company's strategic, business and operational performance, recognize potential partnerships and suppliers. (sbwire.com)
  • New York, NY -- ( SBWIRE ) -- 04/16/2018 -- The latest market intelligence study on DNA Probe-based Diagnostic market relies on statistics derived from the application of both primary and secondary research to present insights pertaining to the operational model, opportunities and competitive landscape of DNA Probe-based Diagnostic market for the forecast period, 2018 - 2025. (sbwire.com)
  • In addition, the research on the DNA Probe-based Diagnostic market concentrates on extracting valuable data on swelling investment pockets, significant growth opportunities and major market vendors to help understand business owners what their competitors are doing best to stay ahead in the competition. (sbwire.com)
  • The research also segments the DNA Probe-based Diagnostic market on the basis of the end-user, product type, application and demography for the forecast period 2018 - 2025. (sbwire.com)
  • For more clarity on the real potential of the DNA Probe-based Diagnostic market for the forecast period of 2018 - 2025 the study provides vital intelligence on the major opportunities, threats and challenges posed by the industry. (sbwire.com)
  • There are 14 Chapters to deeply display the global DNA Probe-based Diagnostic Profiler market. (sbwire.com)
  • What is estimated growth rate and market size of the DNA Probe-based Diagnostic industry for the forecast period 2018 - 2025? (sbwire.com)
  • What are major driving factors impacting the DNA Probe-based Diagnostic market worldwide? (sbwire.com)
  • Which market trends from the yesteryears and the future are likely to keep the prospect of the DNA Probe-based Diagnostic market high for the forecast period 2018 - 2025? (sbwire.com)
  • Mercury electrodes were not suitable for studies the DNA - Os, L reaction mixtures without purification due to strong binding of Os, L to the mercury surface. (jbsdonline.com)
  • In a paper online this week in Science Advances, Rice's research team used lab tests to verify that UMD could identify 11 known strains of bacteria using the same five random DNA probes. (phys.org)
  • The new study includes several computer simulations, including one that shows how a random selection of five probes can identify 40 different strains of bacteria, and another that demonstrates how the system can accurately differentiate between 24 different species of Staphylococcus. (phys.org)
  • No P1 lysogens of indigenous soil bacteria were detected with the DNA probe. (asm.org)
  • In an effort that rivals the Human Genome Project, Shaler has marshaled a national network that includes the New York State Police, the FBI, six biotechnology companies, a score of DNA consultants, computer software developers and an advisory committee of 30 forensic experts that has met every eight weeks to thrash out technical issues. (latimes.com)
  • Approximately 98 percent of the human genome is made up of noncoding DNA, including enhancers, promoters, and other elements that regulate gene activity. (broadinstitute.org)
  • The need is great, as more than 90 percent of variants identified in genome-wide association studies of traits and disease are located in noncoding DNA. (broadinstitute.org)
  • The paper, titled "Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project," was authored by Lieb and other members of the model organism ENCyclopedia Of DNA Elements ( modENCODE ) Consortium, which is funded by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. (unc.edu)
  • It turns out that particularly important stretches of DNA in the genome are "conserved," or retained throughout evolutionary history. (unc.edu)
  • That observation overturns the prevailing theory for predicting the location of DNA damage in the genome and complicates our understanding of the basis for diseases arising from chronic inflammation," said Dedon. (wordpress.com)
  • He will discuss their fundamental work to design and characterize nanostructures with controllable dynamic behavior and two applications that focus on implementing dynamic DNA devices to probe the structural dynamics of nucleosomes and to measure depletion forces due to molecular crowding. (harvard.edu)
  • The sensitivity of the method was tested by using an α- 32 P-labeled DNA probe. (asm.org)
  • Our method defined three types of probe sets: 71% were mono-informative probe sets (59% predicted only NoPCR, and 12% predicted only PCR), 25% were bi-informative, and 4% were non-informative. (biomedcentral.com)
  • Based on DLDA and the nearest centroid method, bi-informative probes proved more successful predictors than probes selected using a t test. (biomedcentral.com)
  • Such events are not detectable using conventional tension probes. (pnas.org)
  • These results demonstrate the utility of ethidium and related compounds forthe probing of non-conventional DNA structures and reveal an interesting fundamentalthermodynamic linkage in DNA aptamers. (mdpi.com)
  • In conclusion, probes developed to yeast-like pathogens were found to be highly specific and should prove to be useful in differentiating these organisms in the clinical setting. (asm.org)
  • To investigate the influence of the putative "warhead" and the prodrug strategy on genotoxicity, a series of photolabile colibactin probes were prepared that upon irradiation induced a pks(+) like phenotype in HeLa cells. (diva-portal.org)
  • M. D. Ford and M. F. Lavin, Ataxia telangiectasia: an anomaly in DNA replication after irradiation, Nucleic Acids Res. (springer.com)
  • B. S. Rosenstein and R. B. Setlow, DNA repair after ultraviolet irradiation of ICR 2A frog cells, Biophys. (springer.com)
  • S. N. Buhl, R. B. Setlow, and J. D. Regan, Steps in DNA chain elongation and joining after ultraviolet-irradiation of human cells, Int. J. Radiat. (springer.com)
  • S. N. Buhl, R. B. Setlow, and J. D. Regan, Recovery of the ability to synthesize DNA in segments of normal size at long times after ultraviolet irradiation of human cells, Biophys. (springer.com)