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  • Viral
  • Localization of DNA to the cytosol is associated with tumorigenesis or viral infection. (wikipedia.org)
  • After recognizing viral DNA, DNA sensors initiate the downstream signaling pathways by activating STING-mediated interferon response. (wikipedia.org)
  • genetics
  • in molecular genetics) an enzyme that catalyzes the assembly of deoxyribonucleoside triphosphates into deoxyribonucleic acid, with single-stranded DNA serving as the template. (thefreedictionary.com)
  • cytosolic
  • The cGAS-STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes. (wikipedia.org)
  • The cGAS - STING pathway acts to detect cytosolic DNA and induce an immune response. (wikipedia.org)
  • Upon directly binding cytosolic DNA, cGAS forms dimers to catalyze production of 2'3'-cGAMP from ATP and GTP. (wikipedia.org)
  • This activity is dependent on cytosolic DNA. (wikipedia.org)
  • Perforation of the phagosome membrane mediated by ESX1 secretion system allows extracellular mycobacterial DNA to access host cytosolic DNA sensors, thus inducing the production of type I interferon in macrophages. (wikipedia.org)
  • viruses
  • This is in contrast to previously characterized minimal DNA ligases from viruses, which use flexible loop regions for DNA interaction. (iucr.org)
  • STING mediates the type I interferon production in response to intracellular DNA and a variety of intracellular pathogens, including viruses, intracellular bacteria and intracellular parasites. (wikipedia.org)
  • Cells
  • Purified DNA from sorted subpopulations of B cells from wild-type Balb/c mice was subjected to LMPCR to detect CBE associated with Jκ1, Jκ2, and Jκ5 and most Vκ segments. (nih.gov)
  • duplex
  • It does not require any cofactors for its activity EC 3.1.26.4: RNase H is a ribonuclease that cleaves the RNA in a DNA/RNA duplex to produce ssDNA. (wikipedia.org)
  • Reaction
  • This function is carried out by DNA ligases in a three-step reaction in which the enzyme first self-adenylates, followed by DNA binding and transfer of AMP to the 5′-phosphate terminus of the DNA nick, which is then activated for nucleophilic attack by the apposing 3′-OH group. (iucr.org)