• The former functions in DNA repair, while the latter terminally adds single nucleotides to polydeoxynucleotide chains. (ebi.ac.uk)
  • Once the Artemis complex has done its job and added palindromic nucleotides (P-nucleotides) to the newly opened DNA hairpins, the stage is set for TdT to do its job. (wikipedia.org)
  • DNA carries the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the cell life cycle. (ebi.ac.uk)
  • Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. (ebi.ac.uk)
  • Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. (nih.gov)
  • To define the A light chain repertoire in humans, a single-cell PCR technique using genomic DNA obtained from individual peripheral B cells was employed. (elsevier.com)
  • Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. (creative-enzymes.com)
  • Oligonucleotides representing the G-rich strand of telomeric sequences from five different organisms specifically primed the addition of TTGGGG repeats in vitro, suggesting that primer recognition may involve a DNA structure unique to these oligonucleotides. (isharonline.org)
  • The ribonucleoprotein enzyme telomerase is a specialized type of cellular reverse transcriptase which synthesizes one strand of telomeric DNA, using as the template a sequence in the RNA moiety of telomerase. (isharonline.org)
  • The ribonucleoprotein enzyme telomerase synthesizes telomeric DNA by copying an internal RNA template sequence. (isharonline.org)
  • The latter is a gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining [ PMID: 12640116 , PMID: 17483519 ]. (ebi.ac.uk)
  • During telomeric DNA replication, the replication machinery must have access to the G-rich strand. (isharonline.org)