• ROS are involved in inflammation-induced oxidative damage to cellular components including regulatory proteins and DNA. (hindawi.com)
  • These depletion syndromes are caused by anomalous mtDNA or nuclear DNA encoding for mitochondrial proteins resulting in a quantitative reduction in mtDNA and abnormal oxidative phosphorylation. (stanford.edu)
  • Malignant neoplasms are also simply known as cancers and are the focus of oncology . (wikipedia.org)
  • Thermo Fisher Scientific's Ion Torrent Oncomine Myeloid Research Assay interrogates DNA mutations, RNA fusion transcripts and gene expression levels associated with myeloid cancers in a single run, yielding results in 2-3 days. (medindia.net)
  • DNA methylation, a covalent chemical modification resulting in addition of a methyl group at the carbon 5 position of the cytosine ring in CpG dinucleotides, is one of the most consistent and best known epigenetic events in human cancers. (frontiersin.org)
  • Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies. (springer.com)
  • In addition to these 11 families already diagnosed with HNPCC, 3 new families with germ line mutations of hMSH2 gene and hMLH1 gene were found through analysis of DNA from patients who had multiple cancers with alteration in microsatellite DNA. (springer.com)
  • In families in which germ line mutations were identified presymptomatic examination was then carried out using polymerase chain reaction single-strand conformation polymorphism analysis of DNA from peripheral blood, and the result was the detection of family members predisposed to HNPCC who did not yet show signs of cancer. (springer.com)
  • Detecting somatic mutations from plasma DNA in advanced cancer patients may be potentially preferable when repeated tumor biopsies are not feasible and genomic analysis of archival tumor is deemed insufficient [ 9 ]. (mdpi.com)
  • The neoplasms are positive for platelet-derived growth factor α (PDGFα) mutations. (dovepress.com)
  • Scientists at Johns Hopkins have surveyed the DNA in four common types of pancreatic cysts and have determined that each type bears a distinct pattern of gene mutations. (jhu.edu)
  • One way would be to harvest fluid and cells from cysts during an ultrasound endoscopy of the pancreas-a relatively inexpensive and safe outpatient procedure-and check the DNA in the sample for mutations that are characteristic of the cyst type. (jhu.edu)
  • This defect is caused by mutations in the (pol)eta polymerase, which initiates translesion synthesis of UV-damaged DNA in an error-free manner. (medscape.com)
  • This list is not comprehensive for all myeloid neoplasms and will evolve as insights into effects of combinations of relevant biomarkers on specific clinicopathologic characteristics of CMNs accumulate. (cdc.gov)
  • DNA, Neoplasm" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Cooper GS, Markowitz SD, Chen Z, Tuck M, Willis JE, Berger BM, Brenner DE, Li L. Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. (harvard.edu)
  • Using NGS, we identify distinct mechanisms for development of metachronous or synchronous neoplasms in patients with IPMN. (ovid.com)
  • Patients with a primary IPMN with HGD or with positive family history are at an increased risk to develop subsequent high-risk neoplasms in the remnant pancreas. (ovid.com)
  • Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. (mdpi.com)
  • These results indicate the value of DNA analysis in the screening and diagnosis of HNPCC patients and families. (springer.com)
  • DNA Vaccine Coding for the Rhesus Prostate Specific Antigen (rhPSA) and Electroporation in Patients With Relapsed Prostate Cancer. (knowcancer.com)
  • Assess the feasibility and safety of escalating doses of pVAXrcPSAv53l DNA vaccine, administered intradermally in combination with electroporation in patients with relapse of prostate cancer. (knowcancer.com)
  • In early case-control studies ( APT 2013;37:546, Gastroenterology 2016;150:S48), stool DNA testing targeting a panel of informative methylated gene markers detected 90-100% of CRC and high grade dysplasia in IBD patients using colonoscopy and surgery as reference standards. (aacrjournals.org)
  • This study aimed to investigate both methylcytosine (mCyt) and hydroxymethylcytosine (hmCyt) status in the DNA of individual patients from colon cancer tissue, synchronous liver metastases, and in cancer-free colon and liver tissues and leukocytes. (frontiersin.org)
  • Fibroblasts from different patients with xeroderma pigmentosum were fused, and DNA repair after UV exposure was assayed. (medscape.com)
  • Cruz SHA, De Souza CRS (2014) High-Risk HPV DNA Test for Screening Anal Lesions in HIV-Positive and Negative Patients. (omicsonline.org)
  • All of the patients underwent the high-risk HPV DNA test, anal Pap smear protocol and highresolution anoscopy. (omicsonline.org)
  • 28 HIV-positive patients were positive for the high-risk HPV DNA test and 29 patients were positive for the high-risk HPV DNA test and had anal dysplasia. (omicsonline.org)
  • Additional cell free DNA species, such as cell-free mitochondrial DNA (mtDNA) are also under evaluation for clinical relevance [ 5 ]. (mdpi.com)
  • Syndromes caused by depletion of mitochondrial DNA (mtDNA) are exceptionally rare, but can often cause devastating outcomes. (stanford.edu)
  • Recognition of the clinical signs and symptoms of mitochondrial DNA depletion coupled with the histologic and ultrastructural features can result in early diagnosis and optimal treatment. (stanford.edu)
  • It has been proposed that the numerous mitochondria seen in Hurthle cells may be secondary to defects in mitochondrial DNA resulting in mitochondrial dysfunction. (redorbit.com)
  • 12-14 Maximo et al13,14 have identified large deletions in mitochondrial DNA in Hurthle cells in Hashimoto thyroiditis and in Hurthle cell neoplasms. (redorbit.com)
  • 15. A method according to claim 1 , characterized in that the sample DNA is only amplified by chosen PCR primers if a certain methylation state is present at a specific site in the sample DNA. (google.com)
  • Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • DNA present in neoplastic tissue. (harvard.edu)
  • The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means of restriction endonuclease analysis. (sciencemag.org)
  • This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). (scirp.org)
  • Using comparative genomic hybridization, a technique that has proven to be very sensitive for the detection of high-level DNA amplifications, we analyzed 108 cases of B-cell neoplasms (42 chronic B-cell leukemias, 5 mantle cell lymphomas, and 61 aggressive B-cell lymphomas). (uzh.ch)
  • Currently, detection and identification of soluble analytes in biological fluids is conducted by methods including bioassays, ELISA, PCR, DNA chip or strip tests. (osti.gov)
  • Described is a method for methylation detection in a DNA sample. (google.com)
  • 2012;10:272), stool assay of exfoliated molecular markers proved to be more sensitive than DNA testing on paired plasma for detection of colorectal neoplasia, and differences were most striking with early stage CRC and precancers. (aacrjournals.org)
  • Neoplasm detection by MT-sDNA was significantly higher than by fecal blood testing in these studies. (aacrjournals.org)
  • In the screening setting, effective neoplasm detection is based not only on test sensitivity but on patient compliance and test access as well. (aacrjournals.org)
  • Only poly-ubiquitination on defined lysines, mostly on K48 and K29, is related to degradation by the proteasome (referred to as the "molecular kiss of death"), while other polyubiquitinations (e.g. on K63, K11, K6 and M1) and monoubiquitinations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair. (wikipedia.org)
  • In stark contrast, ovarian neoplasms account for approximately 1% of all childhood malignancies with those affecting the epithelium being extraordinarily rare. (stanford.edu)
  • Although a number of studies have characterized the DNA binding properties of the WT1 protein, recent evidence has suggested that WT1 may also have a role in RNA metabolism. (mendeley.com)
  • A substance that inhibits or prevents the proliferation of neoplasms. (ebi.ac.uk)
  • 1 , 2 , 4 - 8 ] An antioxidant is a substance that protects cells from free radicals , which are highly reactive chemicals, often containing oxygen atoms, capable of damaging important cellular components such as DNA and lipids . (cancer.gov)
  • DNA double-strand breaks (DSBs) trigger accumulation of the MRE11-RAD50-Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex, whose retention on the DSB-flanking chromatin facilitates survival. (nih.gov)
  • The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis. (scirp.org)
  • Application of Cell-free DNA Analysis to Cancer Treatment. (harvard.edu)
  • ConclusionHerein, we describe distinct DNA methylation signatures in uterine neoplasms and show that array-based DNA methylation analysis holds promise as an ancillary tool to further characterize uterine neoplasms, especially in cases which are diagnostically challenging by conventional techniques. (medworm.com)
  • The use of DNA as a biomarker in clinical medicine for early diagnosis, prognosis and monitoring of therapy has been a significant advancement in the field. (mdpi.com)
  • In addition, use of DNA assays for clinical medicine can be significantly sensitive and specific if cancer-specific DNA alterations are tested instead of elevation of circulating DNA concentration [ 1 - 8 ]. (mdpi.com)
  • The nucleotide: DNA sequencing and its clinical application. (biomedsearch.com)
  • Integrating DNA methylation measures to improve clinical risk assessment: are we there yet? (nature.com)
  • Siravegna G, Bardelli A. Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance. (springer.com)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic disease, often presenting in the skin. (bloodjournal.org)
  • In this investigation, we show that T-oligo may mediate its DNA damage responses through the p53/p73 pathway, thereby inhibiting cellular proliferation and inducing apoptosis or senescence. (osti.gov)