Epigenesis, GeneticDNA MethylationDNA, MitochondrialMutationPoint MutationMutation, MissenseMitochondrial DiseasesMERRF SyndromeDNA Mutational AnalysisOptic Atrophies, HereditaryMELAS SyndromePedigreeFrameshift MutationPolymerase Chain ReactionLeigh DiseaseOptic Atrophy, Hereditary, LeberRNA, Transfer, LeuBase SequenceGerm-Line MutationMitochondrial MyopathiesMolecular Sequence DataDNA, NeoplasmNeoplasmsLac RepressorsPhenotypeHeterozygoteElectron Transport Complex INADH DehydrogenaseMitochondrial EncephalomyopathiesDNAPancreatic NeoplasmsGenotypeMitochondriaMutagenesisMutation RateSequence Analysis, DNARNA, Transfer, LysGenetic TestingExonsAmino Acid SequenceRNA, Transfer, SerDNA PrimersAmino Acid SubstitutionElectron Transport Complex IVPolymorphism, Restriction Fragment LengthModels, GeneticNeoplasms, Cystic, Mucinous, and SerousGene DeletionAllelesPolymorphism, Single-Stranded ConformationalGenetic Diseases, InbornSkin NeoplasmsDeafnessAgingCell LineMutagenesis, Site-DirectedAge of OnsetNeoplasms, Multiple PrimaryHomozygoteCodon, NonsenseHearing Loss, SensorineuralReactive Oxygen SpeciesOxidative PhosphorylationPolymorphism, GeneticMitochondrial Proton-Translocating ATPasesKidney NeoplasmsGenome, MitochondrialGenes, RecessiveLung NeoplasmsGenetic VariationMyeloproliferative DisordersThyroid NeoplasmsSequence DeletionNeoplasms, Second PrimaryCell RespirationHybrid CellsImmunohistochemistryOvarian NeoplasmsMitochondrial ProteinsGenes, DominantGenomic InstabilityProtein Structure, TertiaryEvolution, MolecularMice, TransgenicChromosome MappingAdenocarcinoma, MucinousEscherichia coliSuppression, GeneticCodonDNA-Binding ProteinsNeoplasm ProteinsPolymorphism, Single NucleotideModels, MolecularGenes, p53Liver NeoplasmsCell Line, TumorTranscription FactorsBinding SitesDNA DamageSequence Homology, Amino Acid