DNA Mutational AnalysisEpigenesis, GeneticMutationDNA, MitochondrialDNA MethylationPoint MutationMutation, MissenseMolecular Sequence DataMitochondrial DiseasesBase SequenceCpG IslandsEpigenomicsMERRF SyndromePolymerase Chain ReactionAmino Acid SequencePromoter Regions, GeneticPhenotypeOptic Atrophies, HereditaryMutagenesis, Site-DirectedPedigreeMELAS SyndromeFrameshift MutationDNA, NeoplasmMutagenesisGene Expression Regulation, NeoplasticHistonesGene SilencingGerm-Line MutationDNA Modification MethylasesLeigh DiseaseOptic Atrophy, Hereditary, LeberRNA, Transfer, LeuSequence Analysis, DNABinding SitesAmino Acid SubstitutionDNANeoplasmsCell Line, TumorGenomic ImprintingMitochondrial MyopathiesDNA (Cytosine-5-)-MethyltransferaseProtein Structure, TertiaryTumor Suppressor ProteinsCell LineModels, MolecularHeterozygoteLac RepressorsAllelesDNA-Binding ProteinsDNA PrimersAzacitidineGenes, Tumor SuppressorExonsSequence Homology, Amino AcidTranscription FactorsModels, GeneticElectron Transport Complex IGenotypeCell Transformation, NeoplasticLoss of HeterozygosityNADH DehydrogenaseMitochondrial EncephalomyopathiesProtein BindingPolymorphism, Single-Stranded ConformationalGene DeletionTranscription, GeneticMitochondriaSequence DeletionNuclear ProteinsRNA, MessengerGenes, p16Escherichia coliLong Interspersed Nucleotide ElementsProto-Oncogene Proteins B-rafSignal TransductionReverse Transcriptase Polymerase Chain ReactionGenetic TestingColorectal NeoplasmsMutation RateRNA, Long NoncodingSequence AlignmentStructure-Activity RelationshipRNA, Transfer, LysGenomic InstabilityRepressor ProteinsMembrane ProteinsBacterial ProteinsCyclin-Dependent Kinase Inhibitor p16Conserved SequenceGene Expression RegulationCarrier Proteinsras ProteinsGene Expression ProfilingPlasmidsBeckwith-Wiedemann SyndromeRNA, Transfer, SerPolymorphism, Restriction Fragment LengthGenes, NeoplasmNucleic Acid ConformationTransfection