Dna interactions. Medical search. Frequent questions

Identification of Protein/DNA Contacts with Dimethyl Sulfate: Methylation Protection and Methylation Interference Peter E. Shaw and A. Francis Stewart 9. (nhbs.com)
This study was undertaken to evaluate whether DNA methylation can mediate the interaction between genotype and smoking in the development of anti-citrullinated peptide antibody (ACPA)-positive RA. (biomedcentral.com)
We investigated the gene-smoking interactions in DNA methylation using 393 individuals from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA). (biomedcentral.com)
Finally, mediation analysis was performed to investigate whether DNA methylation of cg21325723 mediates this gene-environment interaction on the risk of developing of ACPA-positive RA. (biomedcentral.com)
We identified and replicated one significant gene-environment interaction between rs6933349 and smoking in DNA methylation of cg21325723. (biomedcentral.com)
additive P value = 0.00027), and it is mediated through DNA methylation of cg21325723. (biomedcentral.com)
We showed that DNA methylation of cg21325723 can mediate the gene-environment interaction between rs6933349 and smoking, impacting the risk of developing ACPA-positive RA, thus being a potential regulator that integrates both internal genetic and external environmental risk factors. (biomedcentral.com)
Epigenetic modifications, such as DNA methylation, have an important role in controlling when and where genes are expressed, and can be influenced by environmental factors. (biomedcentral.com)
Therefore, we determined the percent methylation for CpG islands from DNA extracted from mononuclear blood cells of 24 male spray-painters exposed to 1,6-hexamethylene diisocyanate (HDI) monomer and HDI isocyanurate. (cdc.gov)
In this review, we identified articles aligning with the traditional epidemiologic concept of GxE, as well as several associated with newer biomarkers of exposure, such as DNA methylation (epigenetics) and telomere length. (cdc.gov)

Each of them docks with PCNA by inserting a kind of key known as a PCNA-interacting protein, or "PIP-box," which binds chemically to the PCNA and holds the docked protein on the DNA strand. (news-medical.net)
In healthy cells, p21 binds strongly with PCNA to prevent the cells from making copies of DNA until the genetic damage is repaired. (news-medical.net)
Structural analysis of the C-terminal domain reveals a dimer with a lysine-rich surface that binds DNA non-specifically and is essential for DNA condensation in vitro. (elifesciences.org)
We also determined that the RSE is the primary site of protein binding, to which CopG binds establishing interactions beyond those described in the SE-CopG tetramer co-crystals. (uam.es)
The key was a protein called replication protein A (RPA), which binds single strands during DNA replication to prevent them from folding up. (cphi-online.com)

We therefore examined whether polymorphisms in DNA base-excision repair (BER) genes, XRCC1 G399A and OGG1 C326G, were associated with CCA risk and whether they modified the effect of smoking and alcohol drinking in the Thai population. (bmj.com)
DNA repair genes, electromagnetic fields and susceptibility to acute leukemia? (emf-portal.org)
Importantly, TBL1XR1's pronounced association with several DNA Damage repair (DDR) genes was noted suggesting influence on DNA repair. (iiarjournals.org)
The TBL1XR1-DDR genes connection offers insights into potential DNA repair roles, paving avenues for innovative therapies in B-cell lymphomas. (iiarjournals.org)
We explored the functions of the genes that have been published in the literature and used GeneMANIA to investigate gene ontologies and predicted protein-interaction networks. (cdc.gov)
Understanding the interactions between our environment and our genes and how they affect health outcomes offers a multitude of potential opportunities in public health. (cdc.gov)
and the rapid evolution of genes involved in nuclearmitochondrial interactions that are implicated in spedation. (lu.se)
By understanding the molecular details of this interaction, we can identify virulence-associated microbial genes and host-defense strategies and characterize the cues to which they respond and mechanisms by which they are regulated. (medscape.com)

DNABindR predicts DNA binding sites from amino acid sequences using machine learning algorithms. (wikipedia.org)
BindN: a web-based tool for efficient prediction of DNA and RNA binding sites in amino acid sequences. (wikipedia.org)
Further studies on the involvement of 5mC in development and disease require simple methods for its analysis in genomic DNA sequences of interest. (nature.com)
Comparison of DNA sequences from eggs of 3 Schistosoma species, Malawi. (cdc.gov)
Measurement of direct interactions between protein and DNA in vitro has an advantage in analyzing the binding of different transcription factors to specific DNA consensus sequences located in the gene promoters. (epigentek.com)
This project focuses on the characterization of 1-octadecanol (monoacyl C18) lipids conjugated to DNA sequences predicted to form G-quadruplex, double helix, or triple helix structures and their effect on stability. (ursinus.edu)
Pol γ "reads" sequences of mtDNA and uses them as templates to produce new copies of mtDNA in a process called DNA replication . (medlineplus.gov)
Complete genomic sequences of microbial pathogens and hosts offer sophisticated new strategies for studying host-pathogen interactions. (medscape.com)
ROESY, NOE spectroscopy in the operator DNA sequences aimed at removing the rotating frame. (lu.se)
DNA sequences used for studies of uncomplexed and complexed trp operator. (lu.se)

Because my protein is a DNA binding protein, I think that I lost some proteins fixed on genomic DNA that are found in the pellet during the step of clarification just after breaking cells. (bio.net)
Indeed, the identification of Kcnq1ot1, which targets Polycomb complexes to repressed genomic domains, and the significant overlap of ncRNAs isolated via a conventional technique suggest that RedChIP represents the way forward for studies of RNA-protein-DNA interactions in live cells. (epigenie.com)
Genomic sequencing will provide the data needed to unravel the complexities of the host-pathogen interaction. (medscape.com)

New research at Rice University is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA replication, showing for the first time how a key protein "trumps" its rivals and shuts down cell division while DNA repairs take place. (news-medical.net)
All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing cancer-fighting drugs," said lead author Yousif Shamoo, assistant professor of biochemistry and cell biology. (news-medical.net)
By deciphering the structure of two of these keys, while they were in the lock, we were able to determine their binding energies and find out how the strongest key -- the trump card -- blocks the others and shuts down DNA replication. (news-medical.net)
Shamoo and Bruning solved the structure of PCNA containing two other forms of PIP-box keys, both of which are involved in DNA replication. (news-medical.net)
There is compelling evidence that proliferating cell nuclear antigen (PCNA), a DNA sliding clamp, co-ordinates the processing and joining of Okazaki fragments during eukaryotic DNA replication. (nih.gov)
For the first time, scientists have watched proteins interact with long single-stranded DNA molecules in real time.The new method should yield insights into DNA replication and repair, the researchers say. (cphi-online.com)
The new method should yield insights into DNA replication and repair, the researchers say. (cphi-online.com)
Moreover, several association-incompetent mutants failed to complement the replication of a pol null mutant in a transient transfection assay, confirming that the Pol-UL42 interaction is necessary for virus replication in vivo and therefore a valid target for directed drug design. (ed.ac.uk)

By investigating protein-DNA interaction in vitro , it is possible to identify the genetic targets of DNA, which leads to a better understanding of cellular processes. (epigentek.com)
Amino acid changes in the BRCT domain of XRCC1 have been introduced by site-specific in vitro mutagenesis of the cDNA sequence, and the interaction with DNA ligase III has been tested by co-affinity precipitation assays. (ucl.ac.uk)

This event brings together people with interest and expertise in quantitative studies of protein-nucleic acid interactions and dynamics in genetic and epigenetic regulation. (biophysics.org)
2003 ). DNA barcodes can provide information on genetic variation within and between species, rapidly assign taxonomic status across divergent lineages (Hebert and Gregory 2005 ), and identify the prey composition of predators' gut contents (Agustí et al. (springer.com)
The method for studying protein - nucleic acid interactions on HuProt arrays resembles that for protein-protein interactions and can lead to identification of novel binding proteins, complementing other physical and genetic methods and contributing to understanding of the functional pathways of nucleic acid interactomes. (cambridgeproteinarrays.com)
A recent study has found that genetic variants in mitochondrial DNA could increase the risk of developing several common diseases, as well as influencing characteristics like height and lifespan. (frontlinegenomics.com)
We inspected mitochondrial and nuclear genetic profiles to identify hybrids (and any discordance of mitochondrial and nuclear DNA data). (cdc.gov)
Repair of damaged DNA is required to maintain the integrity of genetic information. (ucl.ac.uk)
Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). (biomedcentral.com)
We found some articles related to environmental interactions with inherited genotype and others on environmental exposures that damage genetic material and initiate molecular pathways of pathogenesis. (cdc.gov)
1988). This observation stimulated further dence of the A to B-DNA conversion (Franklin & studies by biochemical and genetic methods (for Gosling, 1953). (lu.se)

Mitochondrial DNA (mtDNA) is inherited maternally and undergoes negligible population level intermolecular recombination. (frontlinegenomics.com)
If you want a complete picture of common diseases, then clearly you're going to need to factor in the influence of mitochondrial DNA. (frontlinegenomics.com)
It looks like our mitochondrial DNA is matched to our nuclear DNA to some extent - in other words, you can't just swap the mitochondria with any donor, just as you can't take a blood transfusion from anyone. (frontlinegenomics.com)
Mitochondria each contain a small amount of DNA, known as mitochondrial DNA (mtDNA), which is essential for the normal function of these structures. (medlineplus.gov)

They are weak ssDNA binding proteins with no affinity for double-stranded (ds) DNA. (nature.com)
Until now, scientists could only watch proteins interacting with double-stranded DNA or very short single strands, says Eric Greene of Columbia University, who developed the new method. (cphi-online.com)
To find a way to monitor long single strands, Greene built upon a method his team devised six years ago, which visualizes proteins binding to double-stranded DNA (Langmuir, DOI: 10.1021/la051944a). (cphi-online.com)
Also, the intercalating fluorescent dyes that label double-stranded DNA can break single strands of DNA. (cphi-online.com)
Cationic self-assembled nanogels with ethylenediamine or dipropylenetriamine groups formed complex nanoparticles with double-stranded oligo-DNA and accelerated the rate of strand exchange reaction as artificial nucleic acid chaperones. (elsevierpure.com)

The herpes simplex virus DNA polymerase is composed of two subunits, a large catalytic subunit (Pol) and a smaller subunit (UL42) that increases the processivity of the holoenzyme. (ed.ac.uk)

BindN+ is an upgraded version of BindN that applies support vector machines (SVMs) to sequence-based prediction of DNA or RNA-binding residues from biochemical features and evolutionary information. (wikipedia.org)
It intends to bridge statistical and bioinformatic characterization of representative protein-DNA systems with biophysical and biochemical approaches. (biophysics.org)
As opposed to single strand (ss) DNA binding proteins such as SSB and RPA, which protect and occlude ssDNA from recombination, RAD52/Redβ SSAPs promote recombination and share several biochemical similarities. (nature.com)
Complementary mutational and biochemical results demonstrate that these two interaction interfaces are required for complex formation both in the absence of DNA and when PCNA is topologically linked to DNA. (nih.gov)

But the technique didn't work with single-stranded DNA, which is so flexible that it often folds upon itself into extensive secondary structures that preclude protein binding. (cphi-online.com)
Using circular dichroism, DNA-DNA interactions were analyzed to confirm the formation of characteristic DNA structures upon micelle assembly. (ursinus.edu)
The telomeres are the DNA-protein structures at the ends of eukaryotic chromosomes, which serve to protect and stabilize the genome. (lu.se)
Nucleotides for which water-mediated pro- tein-DNA contacts with the bases were observed in the co-crystal structures are encircled with a continuous line. (lu.se)

In cells, they are presumably anchored at parS sites by sequence-specific interactions but must also contain many interactions with non-specific DNA (nsDNA), as well as self-association interactions that bridge ParB protomers to form DNA loops. (elifesciences.org)

Sliding clamps are ring-shaped proteins that slide along strands of DNA. (news-medical.net)
Single strand annealing proteins (SSAPs) like Redβ initiate homologous recombination by annealing complementary DNA strands. (nature.com)
The team called the method "DNA curtains" because the hundreds of aligned DNA strands-visualized by total internal reflection fluorescence microscopy-reminded them of a window curtain. (cphi-online.com)

Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. (cshlpress.com)

The proposed project aims to identify the dynamics of RNA-protein interactions during DNA damage response (DDR) using high-throughput "omics" approaches. (europa.eu)
Deoxyribnucleic Acid (DNA) damage can lead to health related issues such as developmental disorders, aging, and cancer. (ku.edu)
Because of the devastating effects that DNA damage can have, DNA repair mechanisms are of great interest yet are not completely understood. (ku.edu)
The major pathway that corrects endogenous DNA damage is base-excision repair (BER), which is mediated by sequential pair-wise protein interactions. (ucl.ac.uk)
Berberine may damage DNA in some cells. (msdmanuals.com)

a ) Conversion of the nucleobase C into the epigenetic nucleobase 5mC by DNA methyltransferases (Dnmt) using S-adenosylmethionine (SAM) as a cofactor (SAH: S-adenosylhomocystein). (nature.com)

Profiling of nucleic acid binding on HuProt human proteome microarrays can reveal interactions with the largest collection of individual human proteins available on a single slide. (cambridgeproteinarrays.com)
DNA microarrays exploit primary sequence data to measure transcript levels and detect sequence polymorphisms, for every gene, simultaneously. (medscape.com)
Cite this: Using DNA Microarrays to Study Host-Microbe Interactions - Medscape - Sep 01, 2000. (medscape.com)

However, EMSAs revealed a diminished affinity for DNA and altered cooperative properties in both mutants compared to the wild-type protein. (uam.es)
Far Western, co-affinity, co-immunoprecipitation and yeast two- hybrid analyses were employed to identify protein: protein interactions that might confirm this role. (ucl.ac.uk)

The enriched DNA was quantified by real-time PCR using SimpleChIP ® Human GAPDH Exon 1 Primers #5516 and SimpleChIP ® Human α Satellite Repeat Primers #4486. (cellsignal.com)
The enriched DNA was quantified by real-time PCR using human c-Myc promoter primers, SimpleChIP ® Human H19/Igf2 ICR Primers #5172, and SimpleChIP ® Human α Satellite Repeat Primers #4486. (cellsignal.com)

In this study, I have used various techniques to investigate interactions mediating the DNA synthesis/ligation steps of BER, to better understand the way in which DNA repair processes are co-ordinated. (ucl.ac.uk)
Researchers investigate DNA interactions with the help next-generation sequencing with a great deal of information. (bvsalud.org)

BMC Bioinformatics, 2006, 7:262 Tjong , H. and Zhou, H.-X. DISPLAR: an accurate method for predicting DNA-binding sites on protein surfaces. (wikipedia.org)
BindN+ for accurate prediction of DNA and RNA-binding residues from protein sequence features" BMC Systems Biology 2010 4(Suppl 1):S3 doi:10.1186/1752-0509-4-S1-S3 Hwang, S , Gou, Z and Kuznetsov, I.B. "DP-Bind: a web server for sequence-based prediction of DNA-binding residues in DNA-binding proteins" Bioinformatics 2007 23(5):634-636 PMID 17237068 Ahmad, S. (wikipedia.org)

However, a detailed mechanistic understanding of functional PCNA:ligase I interactions has been incomplete. (nih.gov)
Here we present the co-crystal structure of yeast PCNA with a peptide encompassing the conserved PCNA interaction motif of Cdc9, yeast DNA ligase I. The Cdc9 peptide contacts both the inter-domain connector loop (IDCL) and residues near the C-terminus of PCNA. (nih.gov)
Similar to the functionally homologous human proteins, yeast RFC interacts with and inhibits Cdc9 DNA ligase whereas the addition of PCNA alleviates inhibition by RFC. (nih.gov)
The interaction of DNA ligase III with its protein partner, XRCC1, in BER was the first example of a functional interaction between BRCT modules, and the 3D structure of this XRCC1 BRCT domain has been solved. (ucl.ac.uk)
I have used DNA ligase III-XRCC1 as a model system to study BRCT domains. (ucl.ac.uk)
Reciprocal mutations in DNA ligase III were made to test the validity of using the XRCC1 BRCT domain structure to model other BRCT modules. (ucl.ac.uk)

Sgs1 is a yeast helicase protein involved in DNA repair. (cphi-online.com)
The 'BRCT' domain, first noted in the C-terminus of the product of the BRCA1 breast cancer suppressor gene (BRCA1 Carboxy Terminal), has been identified in~50 proteins involved in DNA repair/recombination/cell cycle control. (ucl.ac.uk)

The amount of immunoprecipitated DNA in each sample is represented as signal relative to the total amount of input chromatin, which is equivalent to one. (cellsignal.com)
Site-Directed Cleavage of DNA by Protein-Fe(II) EDTA Conjugates within Model Chromatin Complexes David R. Chafin and Jeffrey J. Hayes 11. (nhbs.com)
instead, they combined RNA-DNA proximity ligation ( Red-C ) with chromatin immunoprecipitation (ChIP) to create RedChIP, which identifies RNAs associated with a DNA-bound protein of interest. (epigenie.com)
DNA-binding domains, zinc fingers, leucine zippers) and histones and nonhistone proteins interacting with chromatin, all of which can influence gene expression. (cambridgeproteinarrays.com)

While RNA-DNA proximity ligation techniques map genome-wide ncRNA interactions , they don´t describe the proteins involved. (epigenie.com)

Finally, RNA-DNA sequencing reports on RNA-DNA interactions mediated by the protein and protein-DNA interactions mediated by RNAs. (epigenie.com)
High-throughput sequencing (HTS), particularly DNA metabarcoding, enables community-wide analyses of diversity and interactions at unprecedented scales and at a fraction of the cost that was previously possible. (springer.com)
We also highlight applications of the third generation sequencing technology for long read and portable DNA barcoding. (springer.com)
In the last two decades, DNA barcoding, the sequencing of short species-specific amplicons, has considerably simplified community analyses (Hebert et al. (springer.com)
However, traditional Sanger sequencing-based DNA barcoding protocols can be prohibitively expensive and laborious when large community samples have to be processed. (springer.com)
Next-Generation Sequencing to Study the DNA Interaction. (bvsalud.org)
Next-generation sequencing (NGS) has transformed genomics by allowing researchers to sequence DNA and RNA at highest speed, accuracy, and cost - effectiveness . (bvsalud.org)

Structural Basis for Biological Function (DNA-Protein Interactions) Quiz on Protein-DNA Interactions- DNA Repair, created by gina_evans0312 on 24/12/2013. (goconqr.com)

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. (cshlpress.com)

Hydroxyl Radical Footprinting of Protein-DNA Complexes Indu Jagannathan and Jeffrey J. Hayes 6. (nhbs.com)
Ethylation Interference Footprinting of DNA-Protein Complexes Iain W. Manfield and Peter G. Stockley 10. (nhbs.com)
then, a specific antibody immunoprecipitates protein-associated RNA-DNA complexes. (epigenie.com)
Binding of CopG to its target DNA generates, with a pattern of cooperativity, four well-defined complexes (CI, CII, CIII and CIV), which are supposed to correspond to 1, 2, 3 and 4 dimers bound to the operator DNA. (uam.es)

We discuss amplicon-based DNA barcoding and metabarcoding for the analysis of community diversity and molecular gut content analysis for assessing predator-prey relationships. (springer.com)
However, there remains a challenge to fully understand the molecular mechanism of the gene-environment interaction in the pathogenesis RA. (biomedcentral.com)

This article also uses amino acid composition analysis to predict DNA-binding proteins, and uses structure information to improve binding site prediction. (wikipedia.org)
Electrophoretic Mobility Shift Assays for the Analysis of DNA-Protein Interactions Manon Gaudreault, Marie-Eve Gingras, Maryse Lessard, Steeve Leclerc, and Sylvain L. Guerin 3. (nhbs.com)
We then address the development of theoretical frameworks for community-level studies, and finally highlight critical gaps and future directions for DNA analysis of spider communities. (springer.com)
DNA microarray hybridization analysis stands out for its simplicity, comprehensiveness, data consistency, and high throughput. (medscape.com)
Detection of Plasmodium species by high resolution melt analysis of DNA from blood smears acquired in Southwestern Uganda. (cdc.gov)

Identify interacting proteins for your DNA/RNA molecule of interest. (cambridgeproteinarrays.com)
Appendix Figure) to identify homogenous or heterogenous ITS and 18S DNA. (cdc.gov)

They tethered fluorescent DNA molecules to lipids in a bilayer that coated the surface of a microfluidic sample chamber. (cphi-online.com)

Some methods use structural information to predict DNA-binding sites and therefore require a three-dimensional structure of the protein, while others use only sequence information and do not require protein structure in order to make a prediction. (wikipedia.org)
To gain a better understanding of possible DNA repair mechanisms, my dissertation focused on mathematical methods for understanding the interactions between DNA and proteins. (ku.edu)
Monte Carlo methods were used to simulate proteins moving with different types of non-uniform motion (e.g. backward, jumping, etc.) along the DNA. (ku.edu)

DNA-protein interactions occur via a range of binding motifs present in transcription factors and nuclear receptors (e.g. (cambridgeproteinarrays.com)
The respiratory chain is partly encoded for by mtDNA but also partly by nuclear DNA. (frontlinegenomics.com)

Maria Spies of the University of Iowa says, "The DNA curtains approach combines the benefits of single-molecule and bulk studies. (cphi-online.com)

Similar to array-based protein-protein interaction screening, the purified nucleic acid of interest is either fluorescently labelled for direct detection on the array or alternatively, a biotinylated nucleic acid can be detected by secondary incubation with fluorophore-labelled streptavidin. (cambridgeproteinarrays.com)

DISIS predicts DNA binding sites directly from the amino acid sequence and hence is applicable for all known proteins. (wikipedia.org)
The amino acid sequence of one representative TALE repeat is shown on top, with RVD amino acids 12 and 13 marked with a grey box and KQ diresidue at positions 16 and 17 involved in DNA phosphate binding in bold and underlined. (nature.com)
Amino acid sequence of the N-terminal region (NTR) is shown on the bottom with amino acids suspected to be involved in DNA phosphate binding in bold and underlined. (nature.com)

However, both TALE domains also nonspecifically interact with DNA phosphates via basic amino acids. (nature.com)
DNA is fed through the hole in the center, and the PCNA acts as a docking mechanism for other proteins that need to interact with the DNA to make repairs or copies or to take part in other genetically regulated tasks. (news-medical.net)
For the first time, scientists have watched proteins interact with long single-stranded DNA molecules in real time (Anal. (cphi-online.com)

RNase H1 generally processes the RNA- DNA hybrids through non specific interaction between HBD and the ds RNA/DNA hybrid. (asploro.com)

Transcription activator-like effectors (TALEs) are DNA major-groove binding proteins widely used for genome targeting. (nature.com)
In 'DNA-Protein Interactions: Principles and Protocols, Third Edition', this vital subject is brought up to date with protocols exploring the most cutting-edge developments in the field, including in vivo and genome-wide interaction techniques. (nhbs.com)
The design and construction of a DNA microarray for any given microbial genome are straightforward. (medscape.com)

The functional importance of the interaction was confirmed by the finding that a pol mutant defective for UL42 binding retained polymerase activity, but did not synthesize longer DNA products in the presence of UL42. (ed.ac.uk)
I have also investigated a possible role of a major 3' exonuclease activity, DNase III, as a candidate DNA-editing activity for DNA polymerase β (which lacks an intrinsic 3' exonuclease function) during BER. (ucl.ac.uk)

What drug interactions occur with goldenseal? (msdmanuals.com)

Mutation of either the dimerisation or the DNA binding interface eliminates ParB-GFP foci formation in vivo. (elifesciences.org)

These 'networks' were inferred to be dynamic and poorly-ordered, consisting of several DNA loops between distally bound ParB molecules. (elifesciences.org)
When the researchers flowed buffer through the chamber, the DNA molecules diffused within the bilayer, eventually aligning along a nanofabricated barrier in the bilayer. (cphi-online.com)
When the researchers added a fluorescently labeled version of the protein to a DNA-curtains assay, it coated single-stranded DNA molecules, helping extend the DNA and keep it accessible to proteins. (cphi-online.com)
That's because, she explains, researchers can use it to visualize hundreds of single-stranded DNA molecules at the same time. (cphi-online.com)

But, he says, "Basically anything to do with DNA metabolism or DNA repair involves single-stranded DNA intermediates. (cphi-online.com)

These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
Reduced repair of these DNA lesions would constitute an important risk factor for cancer development. (bmj.com)
DNA repair processes employ numerous proteins whose efficient function depends on interactions with each other. (ucl.ac.uk)

Micelles made of these DNA-lipid conjugates were assembled via thin-film hydration, and their size was measured using dynamic light scattering. (ursinus.edu)

This model postulates both minor/major groove and intercalation interactions. (uib.no)
The minor/major groove interaction occurs at all concentration levels, the intercalation is initiated at a Oflo:GGCC ratio of 1. (uib.no)
The minor/major groove interaction and the intercalation appear to be linked. (uib.no)

As evaluated by co-immunoprecipitation experiments, the dsDNA recombination function relates to the Redα-Redβ protein-protein interaction, which requires not only contacts in the C-terminal domain but also a region near the N-terminus. (nature.com)
Also, they share a similar protein architecture based on an N-terminal ssDNA binding domain of ~180 amino acids and a C-terminal extension that in the case of RAD52 is required for homologous recombination (HR) through specific protein-protein interactions 6 . (nature.com)

Goldenseal affects how the liver processes some drugs, which may result in other important drug interactions. (msdmanuals.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)

To study how proteins might be moving along the DNA, I studied the use of the uniform motion "n-step" model. (ku.edu)

Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. (cshlpress.com)

Anatomy6

Organisms2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes32

Information Science3

Methylation10

Binds5

Genes8

Sequences10

Genomic3

Replication8

Vitro2

Genetic9

Mitochondrial4

Double-stranded5

Increases the processivity1

Biochemical4

Structures4

Sequence-Specific Interactions1

Strands3

Complementary1

Damage5

Epigenetic1

Microarrays3

Affinity2

Primers2

Investigate2

Bioinformatics2

Ligase6

Involved in DNA repair2

Chromatin4

Ligation1

Sequencing7

Structural basis1

Aspects of gene expression1

Complexes4

Molecular2

Analysis5

Identify2

Lipids1

Methods3

Nuclear2

Molecule1

Nucleic acid1

Amino acid seq3

Interact3

Hybrids1

Genome3

Polymerase2

Occur1

Vivo1

Molecules4

Metabolism1

Repair3

Conjugates1

Major-groove3

Recombination2

Drug interactions2

Study1

Processes1