• In conclusion, our findings suggest that, in contrast to sevoflurane exposure, isoflurane increases systemic antioxidative status, protecting cells from DNA damage in rats. (unesp.br)
  • Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to isoflurane or sevoflurane. (unesp.br)
  • Now Japanese researchers have shown how environmentally damaged letters lead to transcription flaws and, ultimately, human diversity. (scientificamerican.com)
  • By fluorescently labeling monoclonal antibodies that attach to DNA sites where 8-oxoG has made its changes the researchers revealed that the oxidized guanine does not occur randomly throughout the chromosome but rather clusters in certain areas. (scientificamerican.com)
  • The researchers gave ethanol to mice and then used chromosome analysis and DNA sequencing to study genetic damage on the body by acetaldehyde, produced during the metabolic processing of alcohol. (mercola.com)
  • 9 The researchers chose to study blood stem cells since they quickly replicate and readily spread genetic damage throughout the body. (mercola.com)
  • The researchers found acetaldehyde breaks and damages DNA in blood cell stem cells, leading to rearranged chromosomes and permanently altering DNA sequences. (mercola.com)
  • As the researchers report in their paper in the November 29, 2007 online edition of Nano Letters (" DNA Damage Induced by Multi-walled Carbon Nanotubes in Mouse Embryonic Stem Cells "), the DNA damage induced by MWCNTs was indicated by Western blot analysis of 8-oxoguanine-DNA glycosylase 1 (OGG1) and by the induction of two key double-strand break repair proteins, Rad 51 and XRCC4. (medgadget.com)
  • Researchers offer the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. (redorbit.com)
  • Now, the researchers are taking advantage of another NIEHS translational program, the Environmental Polymorphisms Registry (EPR) ( http://www.niehs.nih.gov/research/clinical/join/epr/index.cfm ), an ongoing study to collect DNA samples from nearly 20,000 North Carolinians. (redorbit.com)
  • DURHAM, N.C. - For years, researchers have published papers that associate chronic stress with chromosomal damage. (eurekalert.org)
  • Now researchers at Duke University Medical Center have discovered a mechanism that helps to explain the stress response in terms of DNA damage. (eurekalert.org)
  • This schematic shows what the researchers suspect is happening to DNA molecules when exposed to strong pulses of THz radiation. (businesswire.com)
  • According to the researchers, this raised the question: "Can intense THz pulses destabilize DNA structure enough to cause DNA strand breaks? (businesswire.com)
  • In a first of its kind study, the Canadian researchers exposed laboratory-grown human skin tissue to intense pulses of THz electromagnetic radiation and have detected the telltale signs of DNA damage through a chemical marker known as phosphorylated H2AX. (businesswire.com)
  • Washington, April 01(ANI): Researchers at the National Institute of Environmental Health Sciences have offered the first evidence that DNA damage can lead to the regulation of inflammatory responses, the body's reaction to injury. (thaindian.com)
  • In blood tests, researchers observed more lesions and more mitochondrial DNA--that is, extra copies of genes--in veterans with Gulf War illness, relative to controls without the illness, suggesting excess DNA damage. (news-medical.net)
  • Greater mtDNA damage is consistent with mitochondrial dysfunction, which may contribute to symptoms of GWI, as well as persistence of this illness over time,' the researchers write. (news-medical.net)
  • Falvo explains that the researchers used a new technique developed in the lab of his team's collaborator that allowed them to evaluate the quality of the mitochondrial DNA directly from total DNA without having to isolate the mitochondria. (news-medical.net)
  • The levels of nuclear DNA damage were also elevated in the veterans with GWI, but did not reach 'statistical significance,' the researchers say. (news-medical.net)
  • Researchers highlighted the importance of understanding the DNA blueprint within stem cells citing one simple reason: when healthy stem cells are corrupted, they can give rise to cancer. (rt.com)
  • The researchers showed that, in mammalian cells, DNA damage triggers the Golgi to fragment and disperse throughout the cell. (ucsd.edu)
  • Examining the mechanism of Golgi dispersal, the researchers discovered that Golgi dispersal in response to DNA damage involves a novel signaling pathway that directly links the DNA damage response to the Golgi. (ucsd.edu)
  • Researchers from University of California San Diego School of Medicine have defined the most detailed list of genetic fingerprints of DNA-damaging processes that drive cancer development to date. (ucsd.edu)
  • The researchers found that the resetting effect of DNA damage requires the period-4 clock protein, and that period-4 is the homolog, the Neurospora version, of the mammalian checkpoint kinase. (rxpgnews.com)
  • With the understanding that eating plants protects our DNA, and eating animals may damage it, as I talked about in previous reviews, this year Slovakian researchers measured the total number of DNA breaks in vegetarians compared to meat-eaters, led by a Dr. Krajcovicová-Kudlácková-Dr. K! (nutritionfacts.org)
  • The researchers then tested the extracts' ability to protect DNA strands against damage by hydroxide radicals. (naturalnews.com)
  • The St. Jude researchers found that ATM is activated by a signal from damaged DNA only seconds after the damage occurs. (innovations-report.com)
  • The St. Jude researchers also developed an antibody that specifically recognizes activated ATM, and thus identifies only those ATM molecules that are responding to DNA damage. (innovations-report.com)
  • University of Leicester researchers writing in the journal Chemical Research in Toxicology say they have found "convincing evidence" that cannabis smoke damages DNA and it could potentially increase the risk of cancer development in humans. (science20.com)
  • The researchers add that the ability of cannabis smoke to damage DNA has significant human health implications especially as users tend to inhale more deeply than cigarette smokers, which increases respiratory burden. (science20.com)
  • These results provide evidence for the DNA damaging potential of cannabis smoke," the researchers conclude, "implying that the consumption of cannabis cigarettes may be detrimental to human health with the possibility to initiate cancer development. (science20.com)
  • A study conducted by researchers from India's National Institute of Pharmaceutical Education and Research found that astaxanthin not only can reduce oxidation of the liver but can actually prevent DNA damage and the early stages of liver cancer development. (naturalnews.com)
  • A comprehensive understanding of both Histone H2A.X activity and the consequence of its activation can provide researchers with useful information in characterizing the DNA damage response. (luminexcorp.com)
  • Researchers in the Vetsuisse Faculty have now decoded the mechanism that repairs DNA damaged in this way. (medicalxpress.com)
  • Researchers in the Taniguchi Lab (Human Biology Division) recently expanded this understanding by identifying a protein kinase (NEK8) previously unknown to regulate DNA damage response. (fredhutch.org)
  • DNA damage repair signaling is known to be mediated by multiple kinases thus researchers performed an RNAi screen to identify any kinases not previously known to regulate this process. (fredhutch.org)
  • The protein alpha-synuclein helps repair DNA breaks in brain cells, researchers discovered. (fiercebiotech.com)
  • What's more, they could see that when the protein formed Lewy bodies, there was an increase in double-strand DNA breaks in both mice and human tissue, the researchers reported. (fiercebiotech.com)
  • A new study published by University of Leicester researchers has found 'convincing evidence' that cannabis smoke damages DNA in ways that could potentially increase the risk of cancer development in humans. (opposingviews.com)
  • Newswise - Researchers at The University of Texas MD Anderson Cancer Center have discovered that a combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair (DDR) achieved significant tumor regression in mouse models of small cell lung cancer (SCLC), suggesting a promising new approach for treating patients with this aggressive cancer. (newswise.com)
  • The discovery in yeast cells of a genetic network that guards against lethal DNA damage is a first step in the creation of a database of disease-causing combinations of mutated human genes, according to researchers at The Johns Hopkins University School of Medicine led by Jef. (news-medical.net)
  • The researchers report that the Mec1 protein monitors and repairs the machinery responsible for replicating the DNA. (scienceblog.com)
  • C. F. Arlett and A. R. Lehmann, Human disorders showing increased sensitivity to the induction of genetic damage, Ann. (springer.com)
  • The research, which appeared in the journal Proceedings of the National Academy of Sciences during the week of October 10, 2018, reveals the genetic framework controlling a complex biological process that has broad implications for understanding how plants in particular, and organisms in general, cope with DNA damage to ensure long-term health and fitness. (eurekalert.org)
  • Exogen Biotechnology, a Berkeley, Calif.-based tech start-up, wants more than people's money to fund its genetic research-it also wants their DNA. (scientificamerican.com)
  • DNA repair efficiency dropped by between 40 and 60 percent in cells with BRIT1 knocked down that were then exposed to ionizing radiation, allowing many damaged cells to divide and pass on their genetic defects. (redorbit.com)
  • Afterwards they used chromosome analysis and DNA sequencing to study the genetic damage caused by a harmful chemical (known as acetaldehyde) produced when the body processes alcohol. (rt.com)
  • But, the experimental results show that treatment with mushroom is better than treatment with amaryl in case of genetic changes (DNA fragmentation, disappear of some base pairs and chromosome aberrations. (scirp.org)
  • However, the only type of stress that set off the sequence of events associated with impairment of a cell's genetic material - the DNA damage pathway - was exposure to radiation and chemotherapy drugs. (scienceblog.com)
  • It has been known that when genetic abnormalities occur, the cell cycle is halted so that the cell has time to fix the damage before the DNA is replicated. (scienceblog.com)
  • A way to deal with damage is to limit oneself to the study of genetic changes that are resilient to it, e.g., transversions over the commoner transitions. (blogspot.com)
  • We believe this paper is the first to propose a specific mechanism through which a hallmark of chronic stress, elevated adrenaline, could eventually cause DNA damage that is detectable," said senior author Robert J. Lefkowitz, M.D., James B. Duke Professor of Medicine and Biochemistry and a Howard Hughes Medical Institute (HHMI) investigator at Duke University Medical Center. (eurekalert.org)
  • Pacheco and her colleagues looked at how two different types of nanoparticles could cause DNA damage in the MCF-7 line of breast cancer cells. (phys.org)
  • Therefore, we predicted that if we combined PARP inhibitors or other drugs that cause DNA damage with immune therapies, we might see a much greater response to the immune therapy," said Byers. (newswise.com)
  • A theory published almost 40 years ago states that HSPC niches in terrestrial animals evolved at sites that minimize damage from ionizing radiation 9 , with the assumption that water would have provided aquatic organisms with protection from damaging ultraviolet light. (nature.com)
  • They genetically engineered fish to lack melanocyte pigmentation, and showed that UV radiation caused higher levels of DNA damage in these fish than in controls, as well as an increase in HSPC death. (nature.com)
  • The absorption spectrum of DNA shows a strong absorption for UVB radiation and a much lower absorption for UVA radiation. (wikipedia.org)
  • The team exposed both sets of plants to strong ionizing radiation to generate DNA double-strand breaks. (eurekalert.org)
  • He has found that the DNA damage from folate deficiency is equivalent to the damage from 10 times the allowable annual exposure to ionizing radiation. (nutrition.org)
  • They think it will inform our understanding of how health problems such as premature aging, cancer and other diseases are linked to DNA damage caused by lifestyle and environmental factors such as smoking and exposure to ionizing radiation. (scientificamerican.com)
  • The direct DNA damage occurs only on locations of the body that are directly exposed to UV-radiation. (wikidoc.org)
  • The human scRad9 orthologues 53BP1 and NFBD1 associate with ionizing radiation-induced foci (IRIF) at sites of DNA repair. (aacrjournals.org)
  • Scientists are warning that a water treatment widely used in developing countries could be damaging the DNA of those drinking it. (eurekalert.org)
  • Although scientists have found associations between alcohol consumption and negative health conditions such as pancreatitis and stomach cancer, what has been missing is the precise nature in which alcohol damages your body. (mercola.com)
  • Evidence of DNA-damaging compounds and DNA damage was collected by scientists based at the Masonic Cancer Center at the University of Minnesota. (genengnews.com)
  • These scientists, led by Silvia Balbo, Ph.D., assistant professor, division of environmental health sciences at the University of Minnesota, examined the saliva of e-cigarette users and found unusually high quantities of three DNA-damaging compounds, the reactive carbonyls known as formaldehyde, acrolein, and methylglyoxal. (genengnews.com)
  • Also, in comparisons of vapers and non-vapers, the scientists showed that the vapers had higher levels of DNA damage related to acrolein exposure. (genengnews.com)
  • The scientists obtained human saliva and oral cell samples from e-cigarette users and nonuser controls to screen reactive carbonyls and DNA adducts. (genengnews.com)
  • The scientists formed crystal complexes of DNA, polymerase, and oxidized nucleotides. (nih.gov)
  • Higher DNA damage may increase the risk of certain health problems, such as cancer, but scientists do not know enough yet to draw a direct causal line or reliable correlation. (scientificamerican.com)
  • Its Web site does not clearly indicate that scientists have not established dependable correlations between DNA damage and disease in most people (exceptions include certain rare hereditary diseases). (scientificamerican.com)
  • Reporting online at Nature Cell Biology this week, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center shows that BRIT1 connects with another protein complex to relax DNA's tight packaging at the site of the damage. (redorbit.com)
  • Using a newly developed highly sensitive liquid chromatography-tandem mass spectrometry method, the University of Leicester scientists say they have found clear indication that cannabis smoke damages DNA under laboratory conditions. (science20.com)
  • In their study, the scientists describe the development of a mass spectrometry method that they say provides a clear indication that cannabis smoke damages DNA under laboratory conditions. (science20.com)
  • Scientists have long wondered how the Mre11 complex executes this critical response to DNA damage. (mskcc.org)
  • Enhanced expression of p53 may also trigger cell death by apoptosis if the DNA damage is beyond repair, while under normal conditions (absence of DNA damage) p53 is expressed at low levels" he says. (medgadget.com)
  • demonstrate that following kidney epithelial cell injury, DNA repair, rather than cell proliferation, plays the central role in recovery and longevity by minimizing apoptosis, G 2 /M cell-cycle arrest, and subsequent fibrosis. (jci.org)
  • As a result of this chain of command, the damage will either be repaired, or the cell will be put out of its misery through a natural culling process called apoptosis. (mskcc.org)
  • If the damage is too severe for the cell to repair on its own, it can trigger cell death, a process known as apoptosis. (scienceblog.com)
  • PURPOSE: The purpose of this study was to determine the morphological localization, distribution, and quantity of DNA-damage-inducible transcript 4 (DDIT4 - a marker of protein degradation and apoptosis that resides within the IGF/PI3K/Akt pathway) and its influence on young and old skeletal muscle of rats following chronic high-intensity mechanical loading via stretch-shortening contractions (SSCs). (cdc.gov)
  • Over time, such DNA damage might contribute to cancer or other diseases," Bhatti added. (medicinenet.com)
  • They indicate that damage to DNA can lead to cancer and hence one should be concerned about environmental agents that react with DNA. (springer.com)
  • 2009. DNA damage, aging, and cancer. (springer.com)
  • 12 This DNA damage increases your risk for seven types of cancer, including breast and bowel cancer. (mercola.com)
  • although such damage can often be repaired by the cell, it can sometime remains untreated, and this increases the risk of cancer. (innovations-report.com)
  • However, dysregulation of DNA damage sensing can also yield an increased mutation rate, potentially causing uncontrolled cell growth and cancer. (qiagen.com)
  • He said that the publication had two main findings: humans evolved an inflammatory response when subjected to DNA damage, and the variation in TLR activity among humans suggests that some people are more prone to inflammation following DNA damage, for example, after receiving cancer therapy. (redorbit.com)
  • Stavros Garantziotis, a principal investigator in the Laboratory of Respiratory Biology (LRB) and co-author on the article, said that the publication had two main findings - humans evolved an inflammatory response when subjected to DNA damage, and the variation in TLR activity among humans suggests that some people are more prone to inflammation following DNA damage, for example, after receiving cancer therapy. (thaindian.com)
  • Nuclear DNA damage is a major cause of cancer, neurodegeneration, mitochondrial dysfunction, and many age-related diseases. (news-medical.net)
  • It doesn't necessarily mean that if your DNA damage is high, you're going to get cancer," says Steve Yannone, the Principle Scientist at Exogen and researcher at Lawrence Berkeley. (scientificamerican.com)
  • This study shows that common cancer therapeutic agents, by triggering DNA damage, activate GOLPH3. (ucsd.edu)
  • As we age, we accumulate breaks in our DNA-actual physical breaks in our chromosomes, which may be one of the reasons we get cancer, and why our organs tend to break down as we get older. (nutritionfacts.org)
  • NaturalNews) Extracts from the leaf of the Stevia plant have been found to be high in antioxidants that prevent the DNA damage that leads to cancer, according to a new Indian study published in the Journal of Agricultural and Food Chemistry . (naturalnews.com)
  • DNA damage has been linked to a variety of diseases, especially cancer, reproductive problems and developmental defects. (naturalnews.com)
  • John Petrini , Chair of the Molecular Biology Program at SKI, is a world expert on the mechanics of DNA repair, a topic with direct relevance to cancer. (mskcc.org)
  • DNA damage sounds bad, and indeed it can be - it's one of the main causes of cancer. (mskcc.org)
  • PNT737 targets the DNA Damage Response (DDR) network, a promising approach to treating cancer based on recent leading-edge discoveries in cancer biology,' said Dr. Nick Glover , President and CEO of ProNAi. (prnewswire.com)
  • This stress has been shown to lead to DNA damage and, eventually, to the development of liver cancer. (naturalnews.com)
  • We expect that the DNA repair mechanism discovered here will lead to less invasive approaches in cancer therapy and that it will be possible to develop new clinical tests for the early detection of certain types of cancer. (medicalxpress.com)
  • Tissue studies indicate that nanoparticles, engineered materials about a billionth of a meter in size, could damage DNA and lead to cancer, according to research presented at the 2007 Annual Meeting of the American Association for Cancer Research. (phys.org)
  • Nanowerk News ) Tissue studies indicate that nanoparticles could damage DNA and lead to cancer, according to research presented at the 2007 Annual Meeting of the American Association for Cancer Research. (nanowerk.com)
  • Further understanding of the synuclein protein family's DNA repair functions could help facilitate the development of new therapeutic targets for several important forms of neurodegeneration and cancer," they wrote. (fiercebiotech.com)
  • Byers and colleagues hope to launch clinical trials to investigate the combination approach later this year, and expect this may also be effective in other cancer types defined by increased DNA damage, such as BRCA-mutant breast and ovarian cancers . (newswise.com)
  • Chemotherapy Treatment alone with DNA damaging drugs might be as effective as chemotherapy combined with surgery in colorectal cancer (CRC) avoiding surgery complications. (clinicaltrials.gov)
  • DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. (wikipathways.org)
  • DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (wikipathways.org)
  • The biological relevance of oxidation damage is demonstrated by the cancer susceptibility of UVB-irradiated mice deficient in repair of oxidation damage, i.e. , 8-oxoguanine. (rsc.org)
  • Future studies planned by the Lefkowitz laboratory include studying mice that are placed under stress (restrained), thus creating their own adrenaline or stress reaction to learn whether the physical reactions of stress, rather than an influx of adrenaline in the lab as was done in the current study, also leads to accumulation of DNA damage. (eurekalert.org)
  • How exactly alcohol causes damage to us is controversial," study coauthor Ketan Patel of the Medical Research Council Laboratory of Molecular Biology tells The Guardian . (the-scientist.com)
  • John Petrini, Chair of the Molecular Biology Program at the Sloan Kettering Institute, studies the biology of DNA repair. (mskcc.org)
  • Together with the University of Oxford, Enni Markkanen, a veterinarian in the working group of Prof. Ulrich Hübscher from the Institute of Veterinary Biochemistry and Molecular Biology at the University of Zurich has decoded and characterized the repair mechanism for the mutated DNA bases. (medicalxpress.com)
  • Despite these successes and the clear importance of DNA damage repair, we do not have a complete molecular understanding of this process. (fredhutch.org)
  • Instead, to accommodate this problem, we implement a model in which sequences are the result of a joint process of molecular evolution and post-mortem DNA damage within a probabilistic inference framework. (blogspot.com)
  • Bits of DNA were deleted, bits were broken and we even saw parts of chromosomes being moved about and rearranged. (mercola.com)
  • Greater DNA repair capacity may explain why those eating plant-based diets appear to have fewer breaks in their chromosomes as they age. (nutritionfacts.org)
  • 2009. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. (springer.com)
  • In the presence of damaged DNA for instance, the p53 protein is activated by protein phosphorylation as a master guardian that activates cell cycle checkpoints and triggers cell cycle arrest to provide time for the DNA damage to be repaired. (medgadget.com)
  • DNA damage activates a checkpoint signaling mechanism that arrests the cell cycle in part by inhibiting activity of cyclin-dependent kinase 2 (CDK2). (sciencemag.org)
  • ATR senses single-strand DNA breaks and DNA cross-linking and phosphorylates and activates the checkpoint protein Chk1. (jci.org)
  • He explained that 8-OH-dG is excreted in the urine when the body repairs DNA damage that occurs during normal body processes. (medicinenet.com)
  • These DNA transacting processes share common factors and use similar strategies to exert their function. (nih.gov)
  • New research shows that as your body processes alcohol, a transient toxic compound is produced that attacks DNA. (mercola.com)
  • Enzymes involved in base-excision, nucleotide excision, mismatch, double-strand break, and other DNA repair processes all respond in a pre- and post-transcriptionally regulated fashion to DNA damage. (qiagen.com)
  • DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. (medicalxpress.com)
  • Work such as this reminds us that biology is complex and there are still many things to discover - even in well-studied processes such as DNA damage repair. (fredhutch.org)
  • "Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers," Professor Patel noted. (rt.com)
  • The authors added, "It is well known that toxic substances in tobacco smoke can damage DNA and increase the risk of lung and other cancers. (science20.com)
  • This continuous formation of DNA DSBs may contribute to the genomic instability that characterizes the vast majority of human cancers. (sciencemag.org)
  • Are DNA DSBs continuously being generated in human cancers? (sciencemag.org)
  • Additionally, cancers with extensive amounts of DNA damage have been shown to respond better to immunotherapy. (newswise.com)
  • Research led by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system. (scienceblog.com)
  • While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage. (mercola.com)
  • Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to convert the energy into harmless heat very quickly. (wikipedia.org)
  • Identification of such a Golgi response reveals an unexpected pathway through DNA-PK, GOLPH3 and MYO18A that regulates cell survival following DNA damage, Field added. (ucsd.edu)
  • The notion that the clock regulates DNA-damage input and that mutation can affect the clock as well as the cell cycle is novel. (rxpgnews.com)
  • We have shown that chromosome segregation and DNA repair are partly dealt with by the same machinery. (eurekalert.org)
  • In addition to the anti-hyperglycemic action of mushrooms, the present study presents its effect on DNA damage, chromosome aberrations and sperm alternations in streptozotocin-induced diabetic rats. (scirp.org)
  • Titanium doixide and chromosome/DNA damage? (dadamo.com)
  • BTD Forums / Journal Club and Literature Review / Titanium doixide and chromosome/DNA damage? (dadamo.com)
  • She and her team examined the genotoxicity of silica and C60 fullerene nanoparticle suspensions using the alkaline single-cell gel electrophoresis assay (Comet assay) to quantify breaks in single and double stranded DNA. (phys.org)
  • Further, we investigate, the effect of annatto on DMH-induced DNA damage, by the comet assay. (greenmedinfo.com)
  • Even when the sunscreen molecules have penetrated into the skin, they protect against direct DNA damage, because the UV light is absorbed by the sunscreen and not by the DNA. (wikipedia.org)
  • The lower portion shows the H2AX molecules around the break site 1 - 3 minutes later after they are "flagged" by the attachment of a phosphate group, which signals that DNA damage has taken place. (businesswire.com)
  • Before damage, nucleoplasmic Brca2 molecules exhibit complex states of mobility, with long dwell times within a sub-fL observation volume, indicative of restricted motion. (pnas.org)
  • DNA damage significantly enhances the mobility of Brca2 molecules in the S/G2 phases of the cell cycle, via signaling through damage-activated protein kinases. (pnas.org)
  • Together, these results suggest that DNA breakage triggers the redistribution of soluble nucleoplasmic Brca2 molecules from a state of restricted diffusion, into a mobile fraction available for Rad51 binding. (pnas.org)
  • At the dawn of life the intensity of UV-light was 100 to 1000 times stronger than today and as a consequence all molecules that did not possess this natural photoprotection were destroyed and the favourable photochemical properties of all DNA on this planet are a result of this very first evolutionary selection process. (wikidoc.org)
  • It is presumed to be even slower for double-stranded DNA in conditions of the nucleus. (wikipedia.org)
  • Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3. (wikipathways.org)
  • Poly-ubiquitin chains via Lysine-63 residue (K63) of ubiquitin and linear poly-ubiquitin chains appear to play non-proteolytic functions and are involved in DNA repair, NF-κB activation, and Ras localization and signaling, etc. (frontiersin.org)
  • 14 This increases their risk of acetaldehyde accumulation, triggering greater DNA damage and a flushed face. (mercola.com)
  • As the level of DNA damage increases, the level of phospho-Histone H2A.X (also known as γH2AX) increases, accumulating at the sites of DNA damage. (luminexcorp.com)
  • The direct DNA damage leads to sunburn and it causes an increases melanin production. (wikidoc.org)
  • Knockdown of endogenous MEF2D with a short-hairpin RNA (shRNA) increases sensitivity to etoposide-induced DNA damage and neuronal cell death. (jneurosci.org)
  • Compared with people who don't vape, four of the five e-cigarette users showed increased DNA damage related to acrolein exposure. (genengnews.com)
  • This may suggest that DNA damage in human skin arising from intense picosecond THz pulse exposure could be quickly and efficiently repaired, therefore minimizing the risk of carcinogenesis. (businesswire.com)
  • Significantly higher SCE frequency rate and DNA damage were observed in exposed workers, but MN frequency was not markedly modified by exposure. (sigmaaldrich.com)
  • A study published in the January 30, 2014 issue of the journal Cell - led by Seth Field, MD, PhD, associate professor of medicine at UC San Diego School of Medicine - demonstrates that DNA damage triggers dramatic reorganization of the Golgi. (ucsd.edu)
  • While the early activation events that follow DNA breaks are well elucidated, the primary signal which triggers DDR remains incompletely understood. (frontiersin.org)
  • LA JOLLA--(December 13, 2018) When a building is damaged, a general contractor often oversees various subcontractors--framers, electricians, plumbers and drywall hangers--to ensure repairs are done in the correct order and on time. (eurekalert.org)
  • Fig. 2: Mechanism of damage recognition. (nature.com)
  • A second line of defense is a repair mechanism that helps repair DNA . (mercola.com)
  • The distinction between direct DNA damage and indirect DNA damage is highly relevant for the discussion of UV-induced skin damage, the mechanism of photocarcinogenesis (light induced formation of Melanoma) and the effect of sunscreens . (wikidoc.org)
  • I thought that frequent ejaculation might be a physiological mechanism to improve sperm DNA damage, while maintaining semen levels within the normal, fertile range. (rxpgnews.com)
  • Thymine dimers in human pterygium and its recurrences suggest that DNA damage is involved not only in pterygium epithelial and fibrous proliferation but also in angiogenesis and lymphangiogenesis from this ocular lesion in a still incomplete elucidated pathogenic mechanism. (molvis.org)
  • In vivo , cerebella in Mef2d knock-out mice manifest increased susceptibility to DNA damage. (jneurosci.org)
  • DNA damage and susceptibility assessment in industrial workers exposed to styrene. (sigmaaldrich.com)
  • This nuclease activity is performed by MRE-11 while RAD51 protects DNA by antagonizing MRE-11 and ensuring only short stretches of DNA are digested. (fredhutch.org)
  • But this study brings together a body of work which shows it is potentially damaging DNA, and harming reproductive success. (eurekalert.org)
  • Before they started, levels of DNA damage ranged between 15% and 98% DFI, with an average 34% DFI when measured after three days' abstinence. (rxpgnews.com)
  • But when they accumulate, the DNA polymerase adds more of them to the strand. (nih.gov)
  • R. W. Hart, R. B. Setlow, and A. D. Woodhead, Evidence that pyrimidine dmers in DNA can give rise to tumors, Proc. (springer.com)
  • Prof Hunter said: "While none of the previous studies alone are definitive, and we can't use them to determine a safe level of consumption from this review, we consider that the balance of evidence suggests there is the chance of damage to DNA. (eurekalert.org)
  • There is an urgent need for more research on this area to determine if people drinking water treated with silver have evidence of DNA damage. (eurekalert.org)
  • Although Exogen's owners acknowledge the lack of evidence linking DNA damage to disease, its marketing approach is somewhat less forthcoming. (scientificamerican.com)