• Interferon-alpha (IFN-alpha) and IFN-gamma regulate gene expression by tyrosine phosphorylation of several transcription factors that have the 91-kilodalton (p91) protein of interferon-stimulated gene factor-3 (ISGF-3) as a common component. (sciencemag.org)
  • Treatment of human peripheral blood monocytes or basophils with interleukin-3 (IL-3), IL-5, IL-10, or granulocyte-macrophage colony-stimulating factor (GM-CSF) activated DNA binding proteins that recognized the IFN-gamma response region (GRR) located in the promoter of the Fc gamma RI gene. (sciencemag.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • 2001). RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. (rutgers.edu)
  • It's important to realize that DNA binding proteins interact with the DNA double helix and not with unwound DNA where the individual bases are exposed. (blogspot.com)
  • Alterations in the glial function of TDP-43 are becoming increasingly associated with the neurological symptoms observed in Amyotrophic Lateral Sclerosis (ALS), however, the physiological role of this protein in the glia or the mechanisms that may lead to neurodegeneration are unknown. (sdbonline.org)
  • The RNA-processing protein TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS) , the most common adult-onset motor neuron (MN) disease. (sdbonline.org)
  • In 2006, TAR DNA-binding protein 43 (TDP-43), a highly conserved nuclear protein, was identified as the major disease protein in amyotrophic lateral sclerosis (ALS) and in the most common variant of frontotemporal lobar degeneration (FTLD), FTLD-U, which is characterized by cytoplasmic inclusions that stain positive for ubiquitin but negative for tau and alpha-synuclein. (rutgers.edu)
  • The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets of frontotemporal dementia (FTD). (jci.org)
  • The experiments presented in two recent papers represent different stages in the characterization of the telomeric DNA binding proteins. (nih.gov)
  • The first paper presents a structure-function study of the Oxytricha telomeric DNA binding proteins and the second paper shows the identification and initial characterization of a telomeric DNA binding activity from Xenopus laevis. (nih.gov)
  • I would specifically like to know if the other proteins in the system or maybe even the DNA added would somehow interfere in a gel shift assay (although I guess its no different than using cell/nuclear extracts). (bio.net)
  • The protein-binding conditions are those for gel retardation assay. (bio.net)
  • The assay effectively detected blotted DNA-binding proteins. (asm.org)
  • The segregation of DNA-binding proteins within BI and BII correlates with their distinct protein profiles and suggests that these vesicles may play different roles. (asm.org)
  • i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced. (uniprot.org)
  • Since then, rapid advances have been made in our understanding of the physiological function of TDP-43 and the role of this protein in neurodegeneration. (rutgers.edu)
  • We describe a new method for delivering a zinc finger protein directly into cells using a nanoneedle array and an ATP aptamer. (go.jp)
  • The zinc finger protein can be used for site-specific DNA modification by combining with an enzyme that can cut or modify DNA. (go.jp)
  • DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid. (wikipedia.org)
  • bZIP domain Comparison of nucleic acid simulation software DNA-binding domain Helix-loop-helix Helix-turn-helix HMG-box Leucine zipper Lexitropsin (a semi-synthetic DNA-binding ligand) Single-strand binding protein Zinc finger Created from PDB 1LMB Created from PDB 1RVA Travers, A. A. (1993). (wikipedia.org)
  • The overall rate is limited by diffusion or the rate of collisions between the DNA binding protein and the DNA. (blogspot.com)
  • It's also been known for a long time that when the search for the target site is measured in a test tube with purified repressor and purified DNA, the rate of finding the target is FASTER than simple diffusion would predict! (blogspot.com)
  • It can scan about 50 bp of DNA in a single interaction and this form of "facilitated diffusion" leads to a much quicker search for the target sequence. (blogspot.com)
  • The data can be fitted to a curve that predicts facilitead diffusion with each search covering about 45 bp of DNA. (blogspot.com)
  • Further, TDP-43 is a signature protein in one subtype of frontotemporal degeneration, FTLD-U. Currently, there are no effective drugs for these neurodegenerative diseases. (sdbonline.org)
  • repressor (and other similar DNA binding proteins) sticks non-specifically to DNA then slides along the DNA molecule looking for a target sequence. (blogspot.com)
  • DNA is a negatively charged molecule due to the phosphate found in its backbone. (wikipedia.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • In most organisms, the DNA portion of the nucleo-protein complex consists of simple tandem DNA repeats with one strand guanine rich. (nih.gov)
  • DNA-binding proteins often play important role in various processes within the cell. (hindawi.com)
  • The DNA in a cell is covered with lots of other proteins that could block sliding and the concentrations of salts (ionic strength) in the cell are different than the concentrations used in the test tube. (blogspot.com)
  • Expression of the mutant protein TDP-43(Q331K) caused dying-back of NMJs and axons, which could not be suppressed by mutations that block Wallerian degeneration. (sdbonline.org)