Dna binding motif. Medical search. Frequent questions

It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
Noncoding" sequences are not translated into proteins, and nucleic acids with such motifs need not deviate from the typical shape (e.g. the "B-form" DNA double helix). (wikipedia.org)
For example, many DNA binding proteins that have affinity for specific DNA binding sites bind DNA in only its double-helical form. (wikipedia.org)
Short coding motifs, which appear to lack secondary structure, include those that label proteins for delivery to particular parts of a cell, or mark them for phosphorylation. (wikipedia.org)
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. (wikipedia.org)
Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. (wikipedia.org)
DNA-binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging and transcription in the cell nucleus. (wikipedia.org)
DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid. (wikipedia.org)
Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. (wikipedia.org)
Within chromosomes, DNA is held in complexes with structural proteins. (wikipedia.org)
These proteins organize the DNA into a compact structure called chromatin. (wikipedia.org)
In eukaryotes, this structure involves DNA binding to a complex of small basic proteins called histones. (wikipedia.org)
Other non-specific DNA-binding proteins in chromatin include the high-mobility group (HMG) proteins, which bind to bent or distorted DNA. (wikipedia.org)
Biophysical studies show that these architectural HMG proteins bind, bend and loop DNA to perform its biological functions. (wikipedia.org)
A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. (wikipedia.org)
These binding proteins seem to stabilize single-stranded DNA and protect it from forming stem-loops or being degraded by nucleases. (wikipedia.org)
In contrast, other proteins have evolved to bind to specific DNA sequences. (wikipedia.org)
The specificity of these transcription factors' interactions with DNA come from the proteins making multiple contacts to the edges of the DNA bases, allowing them to read the DNA sequence. (wikipedia.org)
Mathematical descriptions of protein-DNA binding taking into account sequence-specificity, and competitive and cooperative binding of proteins of different types are usually performed with the help of the lattice models. (wikipedia.org)
Among the proteins that bind to DNA are transcription factors that activate or repress gene expression by binding to DNA motifs and histones that form part of the structure of DNA and bind to it less specifically. (wikipedia.org)
HOX proteins execute their activity by exploiting a cooperative binding to PBX proteins and DNA. (mdpi.com)
Direct visualization of single nuclear pore complex proteins using genetically-encoded probes for DNA-PAINT. (nature.com)
For decades, scientists have known that, despite its name, "junk DNA" in fact plays a critical role: While the coding genes provide blueprints for building proteins, which direct most of the body's functions, some of the noncoding sections of the genome, including regions previously dismissed as "junk," seem to turn up or down the expression of those genes. (stanford.edu)
Western blot analysis of extracts from 293 cells transfected with Bad or Bad Ser112 and/or Ser136 mutant fusion proteins, using Phospho-(Ser) 14-3-3 Binding Motif Antibody (top), Phospho-Bad (Ser136) Antibody #9295 (middle) or Phospho-Bad (Ser112) Antibody #9291 (bottom). (cellsignal.com)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, showing staining of proteins containing phosphorylated 14-3-3 binding motifs, using Phospho-(Ser) 14-3-3 Binding Motif Antibody. (cellsignal.com)
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. (fishersci.com)
H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. (fishersci.com)
Pentatricopeptide repeat (PPR) proteins are sequence-specific RNA-binding proteins that form a pervasive family of proteins conserved in yeast, plants, and humans. (rcsb.org)
Transcription is regulated through the binding of transcription factor proteins to specific cis -level regulatory sites in the DNA. (ucsc.edu)
The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
A subfamily of HELIX-TURN-HELIX DNA-binding proteins that contain a variable length loop adjacent to the HTH motif. (bvsalud.org)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

Transcriptional regulation information for a gene, including any predicted DNA binding site motifs ( YeTFaSCo ) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence. (yeastgenome.org)
Recently FK506 binding protein 25 (FBP25) was also shown to non-specifically bind to DNA which helps in DNA repair. (wikipedia.org)
In humans, replication protein A is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair. (wikipedia.org)
Protein-DNA interactions occur when a protein binds a molecule of DNA, often to regulate the biological function of DNA, usually the expression of a gene. (wikipedia.org)
If you want to search for a protein sequence or a DNA motif use the Sequence Search Form . (csic.es)
The Inhibitor of DNA binding 3 ( ID3 ) is a member of the ID protein family, consisting of four members ( ID1 to ID4 ). (nature.com)
The AHDC1 protein is found in the nucleus of cells, and a region of the protein is thought to allow it to attach (bind) to DNA. (medlineplus.gov)
Based on its location and possible DNA-binding ability, researchers suspect the protein may help control the activity of other genes. (medlineplus.gov)
De novo truncating variants in the AHDC1 gene encoding the AT-hook DNA-binding motif-containing protein 1 are associated with intellectual disability and developmental delay. (medlineplus.gov)
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. (nih.gov)
Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. (nih.gov)
High-speed super-resolution imaging using protein-assisted DNA-PAINT. (nature.com)
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. (rochester.edu)
Transcription factors attach to noncoding DNA, regulating the expression of protein-coding genes. (stanford.edu)
The anchors of these loops are bound by the protein CTCF, which is required for loop formation and maintenance. (bioconductor.org)
PCNA binding partners carry short motifs known as the PCNA-interacting protein-box (PIP-box). (pasteur.fr)
In their work, the Unit of Structural Dynamics of Macromolecules presented the structure of the DNA-bound PolD-PCNA complex from P. abyssi at 3.77 Å using an integrative structural biology approach, combining cryo-EM, X-ray crystallography, protein-protein interaction measurements and activity assays. (pasteur.fr)
The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. (cdc.gov)
A key characteristic of each transcription factor protein is its DNA binding domain. (ucsc.edu)
The human GR is a modular protein composed of distinct regions illustrated in panel B in the image below, as follows: (1) The amino-terminal A/B region, also called immunogenic or N-terminal domain (NTD) and (2) the C, D, and E regions, which correspond to the DNA-binding domain, the hinge region, and the ligand-binding domain, respectively. (medscape.com)

Herein we describe how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences, even at physiological pH. (brad.ac.uk)
Additionally, mitoxantrone was found to bind i-motif forming sequences preferentially over double helical DNA. (brad.ac.uk)
This offers a new family of ligands with potential for use in experiments into the structure and function of i-motif forming DNA sequences. (brad.ac.uk)
Wright EP, Day HA, Ibrahim AM et al (2016) Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences. (brad.ac.uk)
Within a sequence or database of sequences, researchers search and find motifs using computer-based techniques of sequence analysis, such as BLAST. (wikipedia.org)
Each transcription factor binds to one specific set of DNA sequences and activates or inhibits the transcription of genes that have these sequences near their promoters. (wikipedia.org)
We have studied the interactions of the cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl)porphine (TMPyP4) with the i-motif forms of several oligonucleotides containing telomeric sequences. (ox.ac.uk)
Researchers have spent a lot of time characterizing these transcription factors and figuring out which sequences - called motifs - they like to bind to the most," Fordyce said. (stanford.edu)
In this study, we're showing that the STR sequence around the motif can have a really big effect on transcription factor binding, providing clues as to what these repeated sequences might be doing. (stanford.edu)
The experiments compared how tightly transcription factors attached to thousands of DNA sequences - those with a preferred motif, those without one, and those surrounded by random sequences or by a wide variety of STRs. (stanford.edu)
We identified several putative THA8L-binding sites, enriched with purine sequences, in the group II introns. (rcsb.org)
It is proposed that this relaxed property of finger 1 allows transcription factor Sp1 to bind various DNA sequences with high affinity. (rcsb.org)
This generally yields a large library of DNA sequences, including some that were bound by the transcription factor directly, some that were bound indirectly via interactions with other molecules, and some false positives (such as cases of nonspecific binding). (ucsc.edu)
The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replication initiator Cdc6. (imperial.ac.uk)

In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be related to biological function of the macromolecule. (wikipedia.org)
On the basis of these data, we constructed a model of THA8L-RNA binding that is dependent on two forces: one is the interaction between nucleotide bases and specific amino acids in the PPR motifs (codes), and the other is the interaction between the negatively charged RNA backbone and positively charged residues of PPR motifs. (rcsb.org)
Each DNA binding domain recognizes and interacts with DNA that matches a specific nucleotide pattern, or motif. (ucsc.edu)
sgRNAs with +67 or +85 nucleotide (nt) tracrRNA tails mediated DNA cleavage at all target sites tested, with up to fivefold higher levels of indels than the corresponding crRNA-tracrRNA duplexes ( Fig. 1b and Supplementary Fig. 1a ). (cdc.gov)

CXCL12 is a constitutively expressed chemokine which binds primarily to the CXCR4 receptor and regulates cell growth, chemotaxis, myelopoiesis, lymphopoiesis, and development of the nervous and cardiovascular systems. (haematologica.org)

The histones form a disk-shaped complex called a nucleosome, which contains two complete turns of double-stranded DNA wrapped around its surface. (wikipedia.org)
These non-specific interactions are formed through basic residues in the histones making ionic bonds to the acidic sugar-phosphate backbone of the DNA, and are therefore largely independent of the base sequence. (wikipedia.org)
These chemical changes alter the strength of the interaction between the DNA and the histones, making the DNA more or less accessible to transcription factors and changing the rate of transcription. (wikipedia.org)
Alternatively, transcription factors can bind enzymes that modify the histones at the promoter. (wikipedia.org)
The trimethylated side chain of Lys36 (H3K36me3) is inserted into an aromatic cage similar to the "Royal" superfamily domains known to bind methylated histones. (nih.gov)
Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. (fishersci.com)
Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. (fishersci.com)

The function of DNA methylation depends on cell context and is correlated with histone modification patterns. (nih.gov)
In particular, trimethylation of Lys36 on histone H3 tail (H3K36me3) is associated with DNA methylation and elongation phase of transcription. (nih.gov)

These targets were identified based on the presence of predicted regulator binding sites or experimental regulator binding in the target promoter, and/or changes in the target gene's transcript levels in regulator mutant strains. (yeastgenome.org)
CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
Promoter analyses revealed increased hypoxia-inducible factor-2 binding to the CXCL12 promoter under hypoxic conditions. (haematologica.org)

Following crRNA and tracrRNA hybridization, SpCas9 is targeted to genomic loci matching a 20-nt guide sequence within the crRNA, immediately upstream of a required 5′-NGG protospacer adjacent motif (PAM) 11 . (cdc.gov)

This alters the accessibility of the DNA template to the polymerase. (wikipedia.org)
By using an integrative approach which combines cryo-electron microscopy and X-ray crystallography, the Unit of Structural Dynamics of Macromolecules deciphered the recruitment and cooperativity mechanisms between DNA polymerase D and PCNA. (pasteur.fr)
PolD is an archaeal replicative DNA polymerase, which is widely distributed among Archaea and has been shown to be essential for cell viability. (pasteur.fr)

DNA methylation is an important epigenetic modification involved in chromatin organization and gene expression. (nih.gov)
PWWP domains of the de novo DNA methyltransferases DNMT3A and DNMT3B read this epigenetic mark to guide DNA methylation. (nih.gov)
The model of the DNMT3A-DNMT3L heterotetramer in complex with a dinucleosome highlights the mechanism for recognition of nucleosome by DNMT3s and explains the periodicity of de novo DNA methylation. (nih.gov)
In this study, we used DNA methylation profiling to further characterize non-fluorescent glioblastomas. (bvsalud.org)
DNA was extracted from tumors and genome-wide DNA methylation patterns were analyzed using Illumina EPIC (850k) arrays. (bvsalud.org)
We did not find significant differences between DNA methylation subclasses and 5-ALA fluorescence (P = .24). (bvsalud.org)
We also show that SpCas9-mediated cleavage is unaffected by DNA methylation and that the dosage of SpCas9 and sgRNA can be titrated to minimize off-target modification. (cdc.gov)

CTCF binds a specific non-palindromic DNA sequence motif. (bioconductor.org)

DNA replication is one of the most important functions in living organisms and viruses. (pasteur.fr)
DNA polymerases (DNAPs) are the key enzymes of DNA replication and diverse DNA repair processes. (pasteur.fr)
Genomic DNA replication is carried out by so-called replicative DNAPs, which have evolved to copy the genome with high processivity and fidelity. (pasteur.fr)
Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. (pasteur.fr)
They infered that the C-terminal PIP-box, plays a dual role in binding either PCNA or primase, and could be a master switch between an initiation phase and a processive phase during replication. (pasteur.fr)
In summary, our work provides fundamental insights into DDK structure, control and selective activation of the MCM2-7 helicase during DNA replication. (imperial.ac.uk)
The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify the location of origins of DNA replication. (imperial.ac.uk)

For example, an N-glycosylation site motif can be defined as Asn, followed by anything but Pro, followed by either Ser or Thr, followed by anything but Pro residue. (wikipedia.org)

A study led by researchers at Stanford Medicine have unraveled some of the mystery of how non-coding DNA changes the level of gene expression. (stanford.edu)
But current models don't adequately explain where and when transcription factors bind to noncoding DNA to regulate gene expression. (stanford.edu)
To better understand the role of short tandem repeats in gene expression, the researchers stripped the mechanisms down to their basics: transcription factors and naked DNA. (stanford.edu)
We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. (lu.se)
and (4) how dynamic modeling of DNA-binding and gene expression data can be used to infer regulatory logic of TF circuitry. (lu.se)

One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. (cdc.gov)

function to test the "covergence rule" of CTCF-bound chromatin loops, first described in Rao et al. (bioconductor.org)

Phospho-(Ser) 14-3-3 Binding Motif Antibody ELISA Assay: Signal-to-noise ratio of phospho- versus nonphospho-14-3-3 binding motif peptides. (cellsignal.com)
Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)

Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. (wikidata.org)

Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA. (nih.gov)

Computational methods to identify the DNA binding sequence specificity have been proposed to make a good use of the abundant sequence data in the post-genomic era. (wikipedia.org)
function, we can compare CTCF motif orientations between pairs of genomic regions that are 1) connected by loops, 2) not connected by loops, 3) randomly chosen, or 4) not connected by loops, but matched for the strength of CTCF sites and distance between loop anchors. (bioconductor.org)
performed on genomic DNA, using a 50 nuclease PCR assay. (cdc.gov)

Identification of binding sites of EVI1 in mammalian cells. (rochester.edu)

For many transcription factors, including multiple members of FOX, HOX, and NR families, we show that human cancers accumulate fewer mutations than expected by chance that increase or decrease affinity of predicted binding sites. (biomedcentral.com)
Assessment of potential binding affinity changes induced by substitutions allows studying selection of sequence variants in binding sites in a way resembling usage of non-synonymous and synonymous substitutions in codons. (biomedcentral.com)

Structural analysis revealed that THA8L contains two extensive patches of positively charged residues next to the residues that are proposed to comprise the RNA-binding codes. (rcsb.org)
From DNA-binding analysis performed by NMR and comparison between structures determined here and previously reported structures of other zinc fingers, it was assumed that DNA recognition modes of fingers 2 and 3 would be similar to those of fingers of Zif268, in which each finger recognizes four base pairs strictly by using residues at positions -1, 2, 3, and 6 of the recognition helix. (rcsb.org)
On the contrary, finger 1 can use only two residues for DNA recognition, Lys550 and His553 at positions -1 and 3 of the helix, and has more relaxed sequence and site specificity than other Cys(2)His(2) zinc fingers. (rcsb.org)

Binding sites motifs as predicted by YeTFaSCo . (yeastgenome.org)
In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. (biomedcentral.com)
Cancer somatic mutations in binding sites of selected transcription factors have been found under positive selection. (biomedcentral.com)
Our data demonstrate negative selection against binding sites alterations and suggest that such selection pressure protects cancer cells from rewiring of regulatory circuits. (biomedcentral.com)
Photo-induced depletion of binding sites in DNA-PAINT microscopy. (nature.com)
These tracks contain transcription factor binding sites determined by ChIP-seq. (ucsc.edu)
Cdc6 binding rearranges a short α-helix in the Orc1 AAA+ domain and the Orc2 WHD, leading to the activation of the Cdc6 ATPase and the formation of the three sites for the recruitment of Mcm2-7, none of which are present in ORC alone. (imperial.ac.uk)

This work describes a new way to screen for i-motif binding compounds and several new families of ligands with potential for use in experiments into the structure and function of i-motif DNA. (researcher-app.com)
There are hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif. (brad.ac.uk)
To appreciate an understanding between the dynamics between these structures and how they can be affected by intervention with small molecule ligands, more i-motif binding compounds are required. (brad.ac.uk)

Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism. (ox.ac.uk)
Two-dimensional NOESY data prompted us to conclude that TMPyP4 binds specifically to the edge of the intercalated DNA core by a nonintercalative mechanism. (ox.ac.uk)
PolD recruits PCNA via a complex mechanism, which requires two different PIP-box motifs, a C-terminal and an internal one that has never been characterized so far. (pasteur.fr)
To understand the DNA recognition mechanism of zinc finger motifs of transcription factor Sp1, we have determined the solution structure of DNA-binding domain of the Sp1 by solution NMR techniques. (rcsb.org)

Such magnetic relaxation dispersion (MRD1) structural polymorphism of quadruplexes ( 2, 5, 6 ), but little measurements have been used to study ion binding (via 23Na is known about the energetics and kinetics of ion binding. (lu.se)

Outside of gene exons, there exist regulatory sequence motifs and motifs within the "junk", such as satellite DNA. (wikipedia.org)

He saw that changes to the transcription factor's DNA binding domain affected whether it recognized the motif and the STRs. (stanford.edu)
The researchers concluded that the transcription factors directly interact with the repetitive genetic code, attaching to it and the motif with the DNA binding domain. (stanford.edu)
Another motif, DPHK, is in the DNA-binding domain. (cdc.gov)
The DNA-binding domain of Sp1 consists of three Cys(2)His(2)-type zinc finger motifs. (rcsb.org)
Using cryo-electron microscopy and biochemical analysis we discovered that an interaction between the HBRCT domain of Dbf4 with Mcm2 serves as an anchoring point, which supports binding of DDK across the MCM2-7 double-hexamer interface and phosphorylation of Mcm4 on the opposite hexamer. (imperial.ac.uk)
The structure reveals that Cdc6 contributes to origin DNA recognition via its winged helix domain (WHD) and its initiator-specific motif. (imperial.ac.uk)

We find that SpCas9 tolerates mismatches between guide RNA and target DNA at different positions in a sequence-dependent manner, sensitive to the number, position and distribution of mismatches. (cdc.gov)

Nevertheless, motifs need not be associated with a distinctive secondary structure. (wikipedia.org)
Telomeric C-rich strands can form a noncanonical intercalated DNA structure known as an i-motif. (ox.ac.uk)
TMPyP4 was found to promote the formation of the i-motif DNA structure. (ox.ac.uk)
The THA8L structure contains three P-type PPR motifs flanked by one L-type motif and one S-type motif. (rcsb.org)
Here we report the cryo-EM structure at 3.3 Å resolution of the yeast ORC-Cdc6 bound to an 85-bp ARS1 origin DNA. (imperial.ac.uk)

Site-specific labeling of affimers for DNA-PAINT microscopy. (nature.com)
Deep sequencing analyses of DNA associated with isolated nucleoli (NAD- seq) have shown that specific loci, termed nucleolus- associated domains (NADs) form frequent three- dimensional associations with nucleoli. (umassmed.edu)

In Eukarya and Archaea, their processivity is greatly enhanced by binding to the proliferative cell nuclear antigen (PCNA) that encircles the DNA. (pasteur.fr)

That is, CTCF binding motifs found at the anchors of loops tend to be oriented towards the center of the loop more often then would be expected by chance. (bioconductor.org)
These motifs tend to be short and degenerate, so even when the DNA binding motif is known, one cannot generally predict where a given transcription factor may bind. (ucsc.edu)

The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)

Predicted to be involved in negative regulation of transcription, DNA-templated. (nih.gov)
With the appropriate analysis methods, ChIP-seq can be a valuable approach for elucidating transcription factor binding and cis -level regulation. (ucsc.edu)

Importantly, THA8L has strong binding preference for single-stranded RNA over single-stranded DNA or double-stranded RNA. (rcsb.org)

16, 17 ) for B -DNA oligonucleotides. (lu.se)

Usually, however, the first letter is I, and both [RK] choices resolve to R. Since the last choice is so wide, the pattern IQxxxRGxxxR is sometimes equated with the IQ motif itself, but a more accurate description would be a consensus sequence for the IQ motif. (wikipedia.org)

Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)
EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements. (rochester.edu)

These DNA targets can occur throughout an organism's genome. (wikipedia.org)
Mechanistically, we identified the Inhibitor of DNA binding 1 and 3 ( ID1, ID3 ), drivers of cancer stemness and plasticity, as previously uncharacterized targets of transcriptional repression by ZNF148. (nature.com)

They are able to recognize motifs through contact with the double helix's major or minor groove. (wikipedia.org)

Similar to other replicative DNA polymerases, the activity of PolD is strongly stimulated through its interaction with PCNA. (pasteur.fr)

Since we have shown that TMPyP4 binds to and stabilizes the G-quadruplex form of the complementary G-rich telomeric strand, this study raises the intriguing possibility that TMPyP4 can trigger the formation of unusual DNA structures in both strands of the telomeres, which may in turn explain the recently documented biological effects of TMPyP4 in cancer cells. (ox.ac.uk)
In eukaryotes and archaea, PCNA stimulates processive DNA synthesis of both lagging and leading strands. (pasteur.fr)
The loop connects two anti-parallel strands and forms a wing when bound to DNA. (bvsalud.org)

The structures of many DNA quadru- magnetization ( 11 - 13 ). (lu.se)

Anatomy14

Organisms8

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes99

Disciplines and Occupations1

Information Science6

Proteins32

Protein20

Sequences14

Nucleotide4

Chemokine1

Histones7

Histone2

Promoter3

Upstream1

Polymerase3

Methylation7

Sequence motif1

Replication7

Site motif1

Gene expression5

Highly conserved1

Chromatin1

Peptides2

Leucine1

Superfamily1

Genomic3

Identification1

Affinity2

Residues3

Sites7

Ligands3

Mechanism4

Structural1

Exons1

Domain6

Mismatches1

Structure5

Specific2

Nuclear1

Tend2

Regulate1

Regulation2

Single-stranded1

Oligonucleotides1

Consensus1

Regulatory2

Targets2

Recognize1

Interaction1

Strands3

Structures1